Vascular Endothelial Growth Factor: Basic Science and Clinical Progress
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Hamilton, 1962
Asahara, 1997, Isolation of putative progenitor endothelial cells for angiogenesis., Science, 275, 964, 10.1126/science.275.5302.964
Rafii, 2002, Contribution of marrow-derived progenitors to vascular and cardiac regeneration., Semin Cell Dev Biol, 13, 61, 10.1006/scdb.2001.0285
De Palma, 2003, Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells., Nat Med, 9, 789, 10.1038/nm871
Garcia-Barros, 2003, Tumor response to radiotherapy regulated by endothelial cell apoptosis., Science, 300, 1155, 10.1126/science.1082504
Lyden, 2001, Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth., Nat Med, 7, 1194, 10.1038/nm1101-1194
Ruzinova, 2003, Effect of angiogenesis inhibition by Id loss and the contribution of bone-marrow-derived endothelial cells in spontaneous murine tumors., Cancer Cell, 4, 277, 10.1016/S1535-6108(03)00240-X
Folkman, 1995, Angiogenesis in cancer, vascular, rheumatoid and other disease., Nat Med, 1, 27, 10.1038/nm0195-27
Garner, 1994, 1625
Palade, 1979, Structural aspects of the permeability of the microvascular endothelium., Acta Physiol Scand Suppl, 463, 11
Ferrara, 2002, VEGF and the quest for tumour angiogenesis factors., Nat Rev Cancer, 2, 795, 10.1038/nrc909
Yancopoulos, 2000, Vascular-specific growth factors and blood vessel formation., Nature, 407, 242, 10.1038/35025215
Maglione, 1991, Isolation of a human placenta cDNA coding for a protein related to the vascular permeability factor., Proc Natl Acad Sci USA, 88, 9267, 10.1073/pnas.88.20.9267
Maglione, 1993, Two alternative mRNAs coding for the angiogenic factor, placenta growth factor (PlGF), are transcribed from a single gene of chromosome 14., Oncogene, 8, 925
Olofsson, 1996, Vascular endothelial growth factor B, a novel growth factor for endothelial cells., Proc Natl Acad Sci USA, 93, 2576, 10.1073/pnas.93.6.2576
Joukov, 1996, A novel vascular endothelial growth factor, VEGF-C, is a ligand for the Flt4 (VEGFR-3) and KDR (VEGFR-2) receptor tyrosine kinases., EMBO J, 15, 1751, 10.1002/j.1460-2075.1996.tb00521.x
Lee, 1996, Vascular endothelial growth factor-related protein: a ligand and specific activator of the tyrosine kinase receptor Flt4., Proc Natl Acad Sci USA, 93, 1988, 10.1073/pnas.93.5.1988
Orlandini, 1996, Identification of a c-fos-induced gene that is related to the platelet-derived growth factor/vascular endothelial growth factor family., Proc Natl Acad Sci USA, 93, 11675, 10.1073/pnas.93.21.11675
Achen, 1998, Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4)., Proc Natl Acad Sci USA, 95, 548, 10.1073/pnas.95.2.548
Lyttle, 1994, Homologs of vascular endothelial growth factor are encoded by the poxvirus orf virus., J Virol, 68, 84, 10.1128/JVI.68.1.84-92.1994
Ogawa, 1998, A novel type of vascular endothelial growth factor, VEGF-E (NZ-7 VEGF), preferentially utilizes KDR/Flk-1 receptor and carries a potent mitotic activity without heparin-binding domain., J Biol Chem, 273, 31273, 10.1074/jbc.273.47.31273
Wise, 1999, Vascular endothelial growth factor (VEGF)-like protein from orf virus NZ2 binds to VEGFR2 and neuropilin-1., Proc Natl Acad Sci USA, 96, 3071, 10.1073/pnas.96.6.3071
Karkkainen, 2002, Lymphatic endothelium: a new frontier of metastasis research, Nat Cell Biol, 4, E2, 10.1038/ncb0102-e2
Ferrara, 1992, Molecular and biological properties of the vascular endothelial growth family of proteins., Endocr Rev, 13, 18, 10.1210/edrv-13-1-18
Ferrara, 1997, The biology of vascular endothelial growth factor., Endocr Rev, 18, 4, 10.1210/edrv.18.1.0287
Neufeld, 1999, Vascular endothelial growth factor (VEGF) and its receptors., FASEB J, 13, 9, 10.1096/fasebj.13.1.9
Robinson, 2001, The splice variants of vascular endothelial growth factor (VEGF) and their receptors., J Cell Sci, 114, 853, 10.1242/jcs.114.5.853
Dvorak, 2002, Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy., J Clin Oncol, 20, 4368, 10.1200/JCO.2002.10.088
Yang, 2003, A randomized trial of bevacizumab, an anti-VEGF antibody, for metastatic renal cancer., N Engl J Med, 349, 427, 10.1056/NEJMoa021491
Hurwitz, 2004, Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer., N Engl J Med, 350, 2335, 10.1056/NEJMoa032691
Ide, 1939, Vascularization of the Brown Pearce rabbit epithelioma transplant as seen in the transparent ear chamber., Am J Roentgenol, 42, 891
Algire, 1945, Vascular reactions of normal and malignant tissues in vivo. I. Vascular reactions of mice to wounds and to normal and neoplastic transplants., J Natl Cancer Inst, 6, 73, 10.1093/jnci/6.1.73
Michaelson, 1948, The mode of development of the vascular system of the retina with some observations on its significance for certain retinal disorders., Trans Ophthalmol Soc UK, 68, 137
Greenblatt, 1968, Tumor angiogenesis: transfilter diffusion studies in the hamster by the transparent chamber technique., J Natl Cancer Inst, 41, 111
Ehrmann, 1968, Choriocarcinoma. Transfilter stimulation of vasoproliferation in the hamster cheek pouch. Studied by light and electron microscopy., J Natl Cancer Inst, 41, 1329
Folkman, 1971, Tumor angiogenesis: therapeutic implications., N Engl J Med, 285, 1182, 10.1056/NEJM197111182852108
Folkman, 1971, Isolation of a tumor factor responsible for angiogenesis., J Exp Med, 133, 275, 10.1084/jem.133.2.275
Gospodarowicz, 1987, Structural characterization and biological functions of fibroblast growth factor., Endocr Rev, 8, 95, 10.1210/edrv-8-2-95
Thomas, 1985, Pure brain-derived acidic fibroblast growth factor is a potent angiogenic vascular endothelial cell mitogen with sequence homology to interleukin 1., Proc Natl Acad Sci USA, 82, 6409, 10.1073/pnas.82.19.6409
Esch, 1985, Primary structure of bovine pituitary basic fibroblast growth factor (FGF) and comparison with the amino-terminal sequence of bovine brain acidic FGF., Proc Natl Acad Sci USA, 82, 6507, 10.1073/pnas.82.19.6507
Jaye, 1986, Human endothelial cell growth factor: cloning, nucleotide sequence, and chromosome localization., Science, 233, 541, 10.1126/science.3523756
Abraham, 1986, Nucleotide sequence of a bovine clone encoding the angiogenic protein, basic fibroblast growth factor., Science, 233, 545, 10.1126/science.2425435
Gospodarowicz, 1978, Production of a corpus luteum angiogenic factor responsible for proliferation of capillaries and neovascularization of the corpus luteum., Proc Natl Acad Sci USA, 75, 847, 10.1073/pnas.75.2.847
Vlodavsky, 1987, Endothelial cell-derived basic fibroblast growth factor: synthesis and deposition into subendothelial extracellular matrix., Proc Natl Acad Sci USA, 84, 2292, 10.1073/pnas.84.8.2292
Matsuzaki, 1989, Monoclonal antibodies against heparin-binding growth factor II/basic fibroblast growth factor that block its biological activity: invalidity of the antibodies for tumor angiogenesis., Proc Natl Acad Sci USA, 86, 9911, 10.1073/pnas.86.24.9911
Dennis, 1990, Studies on the role of basic fibroblast growth factor in vivo: inability of neutralizing antibodies to block tumor growth., J Cell Physiol, 144, 84, 10.1002/jcp.1041440112
Miller, 2000, Compensation by fibroblast growth factor 1 (FGF1) does not account for the mild phenotypic defects observed in FGF2 null mice., Mol Cell Biol, 20, 2260, 10.1128/MCB.20.6.2260-2268.2000
Dono, 1998, Impaired cerebral cortex development and blood pressure regulation in FGF-2-deficient mice., EMBO J, 17, 4213, 10.1093/emboj/17.15.4213
Zetter, 1988, Angiogenesis. State of the art., Chest, 93, 159
Klagsbrun, 1991, Regulators of angiogenesis., Annu Rev Physiol, 53, 217, 10.1146/annurev.ph.53.030191.001245
Senger, 1983, Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid., Science, 219, 983, 10.1126/science.6823562
Senger, 1990, Purification and NH2-terminal amino acid sequence of guinea pig tumor-secreted vascular permeability factor., Cancer Res, 50, 1774
Ferrara, 1989, Pituitary follicular cells secrete a novel heparin-binding growth factor specific for vascular endothelial cells., Biochem Biophys Res Commun, 161, 851, 10.1016/0006-291X(89)92678-8
Connolly, 1989, Human vascular permeability factor. Isolation from U937 cells., J Biol Chem, 264, 20017, 10.1016/S0021-9258(19)47212-8
Leung, 1989, Vascular endothelial growth factor is a secreted angiogenic mitogen., Science, 246, 1306, 10.1126/science.2479986
Keck, 1989, Vascular permeability factor, an endothelial cell mitogen related to PDGF., Science, 246, 1309, 10.1126/science.2479987
Ferrara, 1991, The vascular endothelial growth factor family of polypeptides., J Cell Biochem, 47, 211, 10.1002/jcb.240470305
Pepper, 1992, Potent synergism between vascular endothelial growth factor and basic fibroblast growth factor in the induction of angiogenesis in vitro., Biochem Biophys Res Commun, 189, 824, 10.1016/0006-291X(92)92277-5
Pepper, 1994, In vitro angiogenic and proteolytic properties of bovine lymphatic endothelial cells., Exp Cell Res, 210, 298, 10.1006/excr.1994.1042
Nicosia, 1994, Vascular endothelial growth factor, platelet-derived growth factor and indulin-like growth factor stimulate angiogenesis in vitro., Am J Pathol, 145, 1023
Plouet, 1989, Isolation and characterization of a newly identified endothelial cell mitogen produced by AtT20 cells., EMBO J, 8, 3801, 10.1002/j.1460-2075.1989.tb08557.x
Phillips, 1994, Vascular endothelial growth factor (rhVEGF165) stimulates direct angiogenesis in the rabbit cornea., In Vivo, 8, 961
Mesri, 1995, Expression of vascular endothelial growth factor from a defective herpes simplex virus type 1 amplicon vector induces angiogenesis in mice., Circ Res, 76, 161, 10.1161/01.RES.76.2.161
Tolentino, 1996, Vascular endothelial growth factor is sufficient to produce iris neovascularization and neovascular glaucoma in a nonhuman primate., Arch Ophthalmol, 114, 964, 10.1001/archopht.1996.01100140172010
Nagy, 2002, Vascular permeability factor/vascular endothelial growth factor induces lymphangiogenesis as well as angiogenesis., J Exp Med, 196, 1497, 10.1084/jem.20021244
Ergun, 2000, CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factor., Mol Cell, 5, 311, 10.1016/S1097-2765(00)80426-8
Alon, 1995, Vascular endothelial growth factor acts as a survival factor for newly formed retinal vessels and has implications for retinopathy of prematurity., Nat Med, 1, 1024, 10.1038/nm1095-1024
Gerber, 1998, Vascular endothelial growth factor induces expression of the antiapoptotic proteins Bcl-2 and A1 in vascular endothelial cells., J Biol Chem, 273, 13313, 10.1074/jbc.273.21.13313
Gerber, 1998, VEGF regulates endothelial cell survival by the PI3-kinase/Akt signal transduction pathway. Requirement for Flk-1/KDR activation., J Biol Chem, 273, 30336, 10.1074/jbc.273.46.30336
Benjamin, 1999, Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal., J Clin Invest, 103, 159, 10.1172/JCI5028
Yuan, 1996, Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody., Proc Natl Acad Sci USA, 93, 14765, 10.1073/pnas.93.25.14765
Fujio, 1999, Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner., J Biol Chem, 274, 16349, 10.1074/jbc.274.23.16349
Tran, 1999, Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells., Biochem Biophys Res Commun, 264, 781, 10.1006/bbrc.1999.1589
Tran, 2002, A role for survivin in chemoresistance of endothelial cells mediated by VEGF., Proc Natl Acad Sci USA, 99, 4349, 10.1073/pnas.072586399
Gerber, 1999, VEGF is required for growth and survival in neonatal mice., Development, 126, 1149, 10.1242/dev.126.6.1149
Guerrin, 1995, Vasculotropin/vascular endothelial growth factor is an autocrine growth factor for human retinal pigment epithelial cells cultured in vitro., J Cell Physiol, 164, 385, 10.1002/jcp.1041640219
Oberg-Welsh, 1997, Effects of vascular endothelial growth factor on pancreatic duct cell replication and the insulin production of fetal islet-like cell clusters in vitro., Mol Cell Endocrinol, 126, 125, 10.1016/S0303-7207(96)03977-9
Sondell, 1999, Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system., J Neurosci, 19, 5731, 10.1523/JNEUROSCI.19-14-05731.1999
Compernolle, 2002, Loss of HIF-2α and inhibition of VEGF impair fetal lung maturation, whereas treatment with VEGF prevents fatal respiratory distress in premature mice., Nat Med, 8, 702, 10.1038/nm721
Lambrechts, 2003, VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death., Nat Genet, 34, 383, 10.1038/ng1211
Clauss, 1990, Vascular permeability factor: a tumor-derived polypeptide that induces endothelial cell and monocyte procoagulant activity, and promotes monocyte migration., J Exp Med, 172, 1535, 10.1084/jem.172.6.1535
Broxmeyer, 1995, Myeloid progenitor cell regulatory effects of vascular endothelial cell growth factor., Int J Hematol, 62, 203, 10.1016/0925-5710(95)00412-2
Gabrilovich, 1996, Production of vascular endothelial growth factor by human tumors inhibits the functional maturation of dendritic cells., Nat Med, 2, 1096, 10.1038/nm1096-1096
Gabrilovich, 1998, Vascular endothelial growth factor inhibits the development of dendritic cells and dramatically affects the differentiation of multiple hematopoietic lineages in vivo., Blood, 92, 4150, 10.1182/blood.V92.11.4150
Hattori, 2001, Vascular endothelial growth factor and angiopoietin-1 stimulate postnatal hematopoiesis by recruitment of vasculogenic and hematopoietic stem cells., J Exp Med, 193, 1005, 10.1084/jem.193.9.1005
Gerber, 2002, Vascular endothelial growth factor regulates hematopoietic stem cell survival by an internal autocrine loop mechanism., Nature, 417, 954, 10.1038/nature00821
Cho, 2002, Developmental control of blood cell migration by the Drosophila VEGF pathway., Cell, 108, 865, 10.1016/S0092-8674(02)00676-1
Munier, 2002, PVF2, a PDGF/VEGF-like growth factor, induces hemocyte proliferation in Drosophila larvae., EMBO Rep, 3, 1195, 10.1093/embo-reports/kvf242
Evans, 2003, Thicker than blood: conserved mechanisms in Drosophila and vertebrate hematopoiesis., Dev Cell, 5, 673, 10.1016/S1534-5807(03)00335-6
Dvorak, 1995, Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis., Am J Pathol, 146, 1029
Bates, 1996, Vascular endothelial growth factor increases hydraulic conductivity of isolated perfused microvessels, Am J Physiol, 271, H2520
Bates, 1997, Vascular endothelial growth factor increases microvascular permeability via a Ca(2+)-dependent pathway, Am J Physiol, 273, H687
Roberts, 1995, Increased microvascular permeability and endothelial fenestration induced by vascular endothelial growth factor., J Cell Sci, 108, 2369, 10.1242/jcs.108.6.2369
Esser, 1998, Vascular endothelial growth factor induces endothelial fenestrations in vitro., J Cell Biol, 140, 947, 10.1083/jcb.140.4.947
Parenti, 1998, Nitric oxide is an upstream signal of vascular endothelial growth factor-induced extracellular signal-regulated kinase1/2 activation in postcapillary endothelium., J Biol Chem, 273, 4220, 10.1074/jbc.273.7.4220
Ziche, 1999, Nitric oxide synthase lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis., J Clin Invest, 99, 2625, 10.1172/JCI119451
Morbidelli, 1996, Nitric oxide mediates mitogenic effect of VEGF on coronary venular endothelium, Am J Physiol, 270, H411
Fukumura, 2001, Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability., Proc Natl Acad Sci USA, 98, 2604, 10.1073/pnas.041359198
Dvorak, 1987, Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing., Lab Invest, 57, 673
Murata, 1992, Immunohistochemical detection of extravasated fibrinogen (fibrin) in human diabetic retina., Graefes Arch Clin Exp Ophthalmol, 230, 428, 10.1007/BF00175927
Olk, 1993
Ferrara, 1995, Vascular endothelial growth factor. The trigger for neovascularization in the eye., Lab Invest, 72, 615
Eliceiri, 1999, Selective requirement for Src kinases during VEGF-induced angiogenesis and vascular permeability., Mol Cell, 4, 915, 10.1016/S1097-2765(00)80221-X
Gratton, 2003, Selective inhibition of tumor microvascular permeability by cavtratin blocks tumor progression in mice., Cancer Cell, 4, 31, 10.1016/S1535-6108(03)00168-5
Aicher, 2003, Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells., Nat Med, 9, 1370, 10.1038/nm948
Lee, 2003, Neuropeptide Y induces ischemic angiogenesis and restores function of ischemic skeletal muscles., J Clin Invest, 111, 1853, 10.1172/JCI16929
Ku, 1993, Vascular endothelial growth factor induces EDRF-dependent relaxation in coronary arteries, Am J Physiol, 265, H586
Yang, 1996, Effects of vascular endothelial growth factor on hemodynamics and cardiac performance., J Cardiovasc Pharmacol, 27, 838, 10.1097/00005344-199606000-00011
Henry, 2003, The VIVA trial: vascular endothelial growth factor in ischemia for vascular angiogenesis., Circulation, 107, 1359, 10.1161/01.CIR.0000061911.47710.8A
Houck, 1991, The vascular endothelial growth factor family: identification of a fourth molecular species and characterization of alternative splicing of RNA., Mol Endocrinol, 5, 1806, 10.1210/mend-5-12-1806
Tischer, 1991, The human gene for vascular endothelial growth factor. Multiple protein forms are encoded through alternative exon splicing., J Biol Chem, 266, 11947, 10.1016/S0021-9258(18)99049-6
Vincenti, 1996, Assignment of the vascular endothelial growth factor gene to human chromosome 6p21.3., Circulation, 93, 1493, 10.1161/01.CIR.93.8.1493
Poltorak, 1997, VEGF145, a secreted vascular endothelial growth factor isoform that binds to extracellular matrix., J Biol Chem, 272, 7151, 10.1074/jbc.272.11.7151
Jingjing, 1999, Human Muller cells express VEGF183, a novel spliced variant of vascular endothelial growth factor., Invest Ophthalmol Vis Sci, 40, 752
Lange, 2003, VEGF162, a new heparin-binding vascular endothelial growth factor splice form that is expressed in transformed human cells., J Biol Chem, 278, 17164, 10.1074/jbc.M212224200
Bates, 2002, VEGF(165)b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma., Cancer Res, 62, 4123
Houck, 1992, Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms., J Biol Chem, 267, 26031, 10.1016/S0021-9258(18)35712-0
Muller, 1997, Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site., Proc Natl Acad Sci USA, 94, 7192, 10.1073/pnas.94.14.7192
Park, 1993, The vascular endothelial growth factor isoforms (VEGF): differential deposition into the subepithelial extracellular matrix and bioactivity of extracellular matrix-bound VEGF., Mol Biol Cell, 4, 1317, 10.1091/mbc.4.12.1317
Pepper, 2001, Extracellular proteolysis and angiogenesis., Thromb Haemost, 86, 346, 10.1055/s-0037-1616232
Plouet, 1997, Extracellular cleavage of the vascular endothelial growth factor 189-amino acid form by urokinase is required for its mitogenic effect., J Biol Chem, 272, 13390, 10.1074/jbc.272.20.13390
Keyt, 1996, The carboxyl-terminal domain (111–165) of vascular endothelial growth factor is critical for its mitogenic potency., J Biol Chem, 271, 7788, 10.1074/jbc.271.13.7788
Grunstein, 2000, Isoforms of vascular endothelial growth factor act in a coordinated fashion to recruit and expand tumor vasculature., Mol Cell Biol, 20, 7282, 10.1128/MCB.20.19.7282-7291.2000
Carmeliet, 1999, Impaired myocardial angiogenesis and ischemic cardiomyopathy in mice lacking the vascular endothelial growth factor isoforms VEGF164 and VEGF188., Nat Med, 5, 495, 10.1038/8379
Ruhrberg, 2002, Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis., Genes Dev, 16, 2684, 10.1101/gad.242002
Safran, 2003, HIF hydroxylation and the mammalian oxygen-sensing pathway., J Clin Invest, 111, 779, 10.1172/JCI200318181
Dor, 2001, Vascular endothelial growth factor and vascular adjustments to perturbations in oxygen homeostasis, Am J Physiol, 280, C1367, 10.1152/ajpcell.2001.280.6.C1367
Semenza, 2003, Angiogenesis in ischemic and neoplastic disorders., Annu Rev Med, 54, 17, 10.1146/annurev.med.54.101601.152418
Goldberg, 1994, Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin., J Biol Chem, 269, 4355, 10.1016/S0021-9258(17)41787-X
Levy, 1995, Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia., J Biol Chem, 270, 13333, 10.1074/jbc.270.22.13333
Liu, 1995, Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer., Circ Res, 77, 638, 10.1161/01.RES.77.3.638
Madan, 1993, A 24-base-pair sequence 3′ to the human erythropoietin gene contains a hypoxia-responsive transcriptional enhancer., Proc Natl Acad Sci USA, 90, 3928, 10.1073/pnas.90.9.3928
Wang, 1995, Purification and characterization of hypoxia-inducible factor 1., J Biol Chem, 270, 1230, 10.1074/jbc.270.3.1230
Semenza, 2002, Signal transduction to hypoxia-inducible factor 1., Biochem Pharmacol, 64, 993, 10.1016/S0006-2952(02)01168-1
Ema, 1997, A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1α regulates the VEGF expression and is potentially involved in lung and vascular development., Proc Natl Acad Sci USA, 94, 4273, 10.1073/pnas.94.9.4273
Mole, 2001, Regulation of HIF by the von Hippel-Lindau tumour suppressor: implications for cellular oxygen sensing., IUBMB Life, 52, 43, 10.1080/15216540252774757
Siemeister, 1996, Reversion of deregulated expression of vascular endothelial growth factor in human renal carcinoma cells by von Hippel-Lindau tumor suppressor protein., Cancer Res, 56, 2299
Iliopoulos, 1996, Negative regulation of hypoxia-inducible genes by the von Hippel-Lindau protein., Proc Natl Acad Sci USA, 93, 10595, 10.1073/pnas.93.20.10595
Ohh, 1998, The von Hippel-Lindau tumor suppressor protein is required for proper assembly of an extracellular fibronectin matrix., Mol Cell, 1, 959, 10.1016/S1097-2765(00)80096-9
Lonergan, 1998, Regulation of hypoxia-inducible mRNAs by the von Hippel-Lindau tumor suppressor protein requires binding to complexes containing elongins B/C and Cul2., Mol Cell Biol, 18, 732, 10.1128/MCB.18.2.732
Maxwell, 1999, The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis., Nature, 399, 271, 10.1038/20459
Jaakkola, 2001, Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation., Science, 292, 468, 10.1126/science.1059796
Ivan, 2001, HIF-α targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing., Science, 292, 464, 10.1126/science.1059817
Maxwell, 2002, Oxygen sensors and angiogenesis., Semin Cell Dev Biol, 13, 29, 10.1006/scdb.2001.0287
Pugh, 2003, Regulation of angiogenesis by hypoxia: role of the HIF system., Nat Med, 9, 677, 10.1038/nm0603-677
Zundel, 2000, Loss of PTEN facilitates HIF-1-mediated gene expression., Genes Dev, 14, 391, 10.1101/gad.14.4.391
Li, 1997, PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer., Science, 275, 1943, 10.1126/science.275.5308.1943
Marsh, 1997, Germline mutations in PTEN are present in Bannayan-Zonana syndrome., Nat Genet, 16, 333, 10.1038/ng0897-333
Tang, 2003, The forkhead transcription factor FOXO4 induces the down-regulation of hypoxia-inducible factor 1 α by a von Hippel-Lindau protein-independent mechanism., J Biol Chem, 278, 30125, 10.1074/jbc.M302042200
Frank, 1995, Regulation of VEGF expression in cultured keratinocytes. Implications for normal and impaired wound healing., J Biol Chem, 270, 12607, 10.1074/jbc.270.21.12607
Pertovaara, 1994, Vascular endothelial growth factor is induced in response to transforming growth factor-β in fibroblastic and epithelial cells., J Biol Chem, 269, 6271, 10.1016/S0021-9258(17)37365-9
Warren, 1996, Induction of vascular endothelial growth factor by insulin-like growth factor 1 in colorectal carcinoma., J Biol Chem, 271, 29483, 10.1074/jbc.271.46.29483
Ben-Av, 1995, Induction of vascular endothelial growth factor expression in synovial fibroblasts., FEBS Lett, 372, 83, 10.1016/0014-5793(95)00956-A
Cohen, 1996, Interleukin 6 induces the expression of vascular endothelial growth factor., J Biol Chem, 271, 736, 10.1074/jbc.271.2.736
Soh, 1996, Thyroid-stimulating hormone promotes the secretion of vascular endothelial growth factor in thyroid cancer cell lines., Surgery, 120, 944, 10.1016/S0039-6060(96)80038-9
Shifren, 1998, Corticotropin regulates vascular endothelial growth factor expression in human fetal adrenal cortical cells., J Clin Endocrinol Metab, 83, 1342
Shweiki, 1993, Patterns of expression of vascular endothelial growth factor (VEGF) and VEGF receptors in mice suggest a role in hormonally-mediated angiogenesis., J Clin Invest, 91, 2235, 10.1172/JCI116450
Ferrara, 1998, Vascular endothelial growth factor is essential for corpus luteum angiogenesis., Nat Med, 4, 336, 10.1038/nm0398-336
Christenson, 1997, Follicle-stimulating hormone and luteinizing hormone/chorionic gonadotropin stimulation of vascular endothelial growth factor production by macaque granulosa cells from pre- and periovulatory follicles., J Clin Endocrinol Metab, 82, 2135
Schwarzenbach, 2004, Gonadotropin-mediated regulation of the murine VEGF expression in MA-10 Leydig cells., J Androl, 25, 128, 10.1002/j.1939-4640.2004.tb02768.x
Stewart, 2001, Vascular endothelial growth factor expression and tumor angiogenesis are regulated by androgens in hormone responsive human prostate carcinoma: evidence for androgen dependent destabilization of vascular endothelial growth factor transcripts., J Urol, 165, 688, 10.1097/00005392-200102000-00095
Mueller, 2000, Regulation of vascular endothelial growth factor (VEGF) gene transcription by estrogen receptors α and β., Proc Natl Acad Sci USA, 97, 10972, 10.1073/pnas.200377097
Mueller, 2003, Progestins activate vascular endothelial growth factor gene transcription in endometrial adenocarcinoma cells., Fertil Steril, 79, 386, 10.1016/S0015-0282(02)04577-6
Grugel, 1995, Both v-Ha-Ras and v-Raf stimulate expression of the vascular endothelial growth factor in NIH 3T3 cells., J Biol Chem, 270, 25915, 10.1074/jbc.270.43.25915
Okada, 1998, Impact of oncogenes in tumor angiogenesis: mutant K-ras up-regulation of vascular endothelial growth factor/vascular permeability factor is necessary, but not sufficient for tumorigenicity of human colorectal carcinoma cells., Proc Natl Acad Sci USA, 95, 3609, 10.1073/pnas.95.7.3609
Shi, 1999, Oncogenic ras fails to restore an in vivo oncogenic phenotype in embryonic stem cells lacking VEGF., Biochem Biophys Res Commun, 254, 480, 10.1006/bbrc.1998.9966
Zhang, 2001, Regulation of vascular endothelial growth factor by the Wnt and K-ras pathways in colonic neoplasia., Cancer Res, 61, 6050
Seno, 2002, Cyclooxygenase 2- and prostaglandin E(2) receptor EP(2)-dependent angiogenesis in Apc(δ716) mouse intestinal polyps., Cancer Res, 62, 506
Williams, 2000, Host cyclooxygenase-2 modulates carcinoma growth., J Clin Invest, 105, 1589, 10.1172/JCI9621
Sonoshita, 2001, Acceleration of intestinal polyposis through prostaglandin receptor EP2 in Apc(δ 716) knockout mice., Nat Med, 7, 1048, 10.1038/nm0901-1048
Amano, 2003, Host prostaglandin E(2)-EP3 signaling regulates tumor-associated angiogenesis and tumor growth., J Exp Med, 197, 221, 10.1084/jem.20021408
Plouet, 1990, Characterization of the receptors for vasculotropin on bovine adrenal cortex-derived capillary endothelial cells., J Biol Chem, 265, 22071, 10.1016/S0021-9258(18)45668-2
Vaisman, 1990, Characterization of the receptors for vascular endothelial growth factor., J Biol Chem, 265, 19461, 10.1016/S0021-9258(17)45395-6
Jakeman, 1992, Binding sites for vascular endothelial growth factor are localized on endothelial cells in adult rat tissues., J Clin Invest, 89, 244, 10.1172/JCI115568
Jakeman, 1993, Developmental expression of binding sites and mRNA for vascular endothelial growth factor suggests a role for this protein in vasculogenesis and angiogenesis., Endocrinology, 133, 848, 10.1210/endo.133.2.7688292
Shen, 1993, Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes., Blood, 81, 2767, 10.1182/blood.V81.10.2767.bloodjournal81102767
Shibuya, 1990, Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase (flt) closely related to the fms family., Oncogene, 8, 519
Matthews, 1991, A receptor tyrosine kinase cDNA isolated from a population of enriched primitive hematopoietic cells and exhibiting close genetic linkage to c-kit., Proc Natl Acad Sci USA, 88, 9026, 10.1073/pnas.88.20.9026
Terman, 1991, Identification of a new endothelial cell growth factor receptor tyrosine kinase., Oncogene, 6, 1677
Pajusola, 1992, FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines., Cancer Res, 52, 5738
de Vries, 1992, The fms-like tyrosine kinase, a receptor for vascular endothelial growth factor., Science, 255, 989, 10.1126/science.1312256
Gerber, 1997, Differential transcriptional regulation of the two VEGF receptor genes. Flt-1, but not Flk-1/KDR, is up-regulated by hypoxia., J Biol Chem, 272, 23659, 10.1074/jbc.272.38.23659
Park, 1994, Placenta growth factor. Potentiation of vascular endothelial growth factor bioactivity, in vitro and in vivo, and high affinity binding to Flt-1 but not to Flk-1/KDR., J Biol Chem, 269, 25646, 10.1016/S0021-9258(18)47298-5
Olofsson, 1998, Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells., Proc Natl Acad Sci USA, 95, 11709, 10.1073/pnas.95.20.11709
Kendall, 1993, Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor., Proc Natl Acad Sci USA, 90, 10705, 10.1073/pnas.90.22.10705
Davis-Smyth, 1996, The second immunoglobulin-like domain of the VEGF tyrosine kinase receptor Flt-1 determines ligand binding and may initiate a signal transduction cascade., EMBO J, 15, 4919, 10.1002/j.1460-2075.1996.tb00872.x
Barleon, 1997, Mapping of the sites for ligand binding and receptor dimerization at the extracellular domain of the vascular endothelial growth factor receptor FLT-1., J Biol Chem, 272, 10382, 10.1074/jbc.272.16.10382
Davis-Smyth, 1998, Mapping the charged residues in the second immunoglobulin-like domain of the vascular endothelial growth factor/placenta growth factor receptor Flt-1 required for binding and structural stability., J Biol Chem, 273, 3216, 10.1074/jbc.273.6.3216
Wiesmann, 1997, Crystal structure at 1.7 A resolution of VEGF in complex with domain 2 of the Flt-1 receptor., Cell, 91, 695, 10.1016/S0092-8674(00)80456-0
Waltenberger, 1994, Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor., J Biol Chem, 269, 26988, 10.1016/S0021-9258(18)47116-5
Carmeliet, 2001, Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions., Nat Med, 7, 575, 10.1038/87904
Gille, 2000, A repressor sequence in the juxtamembrane domain of Flt-1 (VEGFR-1) constitutively inhibits VEGF-dependent PI 3 kinase activation and endothelial cell migration., EMBO J, 19, 4064, 10.1093/emboj/19.15.4064
Zeng, 2001, Vascular permeability factor (VPF)/vascular endothelial growth factor (VEGF) peceptor-1 down-modulates VPF/VEGF receptor-2-mediated endothelial cell proliferation, but not migration, through phosphatidylinositol 3-kinase-dependent pathways., J Biol Chem, 276, 26969, 10.1074/jbc.M103213200
Landgren, 1998, Placenta growth factor stimulates MAP kinase and mitogenicity but not phospholipase C-γ and migration of endothelial cells expressing Flt 1., Oncogene, 16, 359, 10.1038/sj.onc.1201545
Maru, 1998, Flt-1, a receptor for vascular endothelial growth factor, has transforming and morphogenic potentials., Oncogene, 16, 2585, 10.1038/sj.onc.1201786
Autiero, 2003, Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1., Nat Med, 9, 936, 10.1038/nm884
Christinger, 2004, The crystal structure of PlGF in complex with domain 2 of VEGFR-1., J Biol Chem, 279, 10382, 10.1074/jbc.M313237200
Fong, 1995, Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium., Nature, 376, 66, 10.1038/376066a0
Fong, 1999, Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice., Development, 126, 3015, 10.1242/dev.126.13.3015
Hiratsuka, 1998, Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice., Proc Natl Acad Sci USA, 4, 9349, 10.1073/pnas.95.16.9349
Barleon, 1996, Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1., Blood, 87, 3336, 10.1182/blood.V87.8.3336.bloodjournal8783336
Selvaraj, 2003, Mechanism of monocyte activation and expression of proinflammatory cytochemokines by placenta growth factor., Blood, 102, 1515, 10.1182/blood-2002-11-3423
Hiratsuka, 2001, Involvement of Flt-1 tyrosine kinase (vascular endothelial growth factor receptor-1) in pathological angiogenesis., Cancer Res, 61, 1207
Hiratsuka, 2002, MMP9 induction by vascular endothelial growth factor receptor-1 is involved in lung-specific metastasis., Cancer Cell, 2, 289, 10.1016/S1535-6108(02)00153-8
Hattori, 2002, Placental growth factor reconstitutes hematopoiesis by recruiting VEGFR1(+) stem cells from bone-marrow microenvironment., Nat Med, 8, 841, 10.1038/nm740
Luttun, 2002, Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1., Nat Med, 8, 831, 10.1038/nm731
Pipp, 2003, VEGFR-1-selective VEGF homologue PlGF is arteriogenic: evidence for a monocyte-mediated mechanism., Circ Res, 92, 378, 10.1161/01.RES.0000057997.77714.72
LeCouter, 2003, Angiogenesis-independent endothelial protection of liver: role of VEGFR-1., Science, 299, 890, 10.1126/science.1079562
Matsumoto, 2001, Liver organogenesis promoted by endothelial cells prior to vascular function., Science, 294, 559, 10.1126/science.1063889
Lammert, 2001, Induction of pancreatic differentiation by signals from blood vessels., Science, 294, 564, 10.1126/science.1064344
Terman, 1992, Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor., Biochem Biophys Res Commun, 187, 1579, 10.1016/0006-291X(92)90483-2
Quinn, 1993, Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium., Proc Natl Acad Sci USA, 90, 7533, 10.1073/pnas.90.16.7533
Millauer, 1993, High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis., Cell, 72, 835, 10.1016/0092-8674(93)90573-9
Shalaby, 1995, Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice., Nature, 376, 62, 10.1038/376062a0
Kabrun, 1997, Flk-1 expression defines a population of early embryonic hematopoietic precursors., Development, 124, 2039, 10.1242/dev.124.10.2039
Fuh, 1998, Requirements for binding and signaling of the kinase domain receptor for vascular endothelial growth factor., J Biol Chem, 273, 11197, 10.1074/jbc.273.18.11197
Matsumoto, 2001, VEGF receptor signal transduction., Sci STKE 112 RE, 21, 1
Takahashi, 2001, A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-γ and DNA synthesis in vascular endothelial cells., EMBO J, 20, 2768, 10.1093/emboj/20.11.2768
Guo, 1995, Vascular endothelial cell growth factor promotes tyrosine phosphorylation of mediators of signal transduction that contain SH2 domains. Association with endothelial cell proliferation., J Biol Chem, 270, 6729, 10.1074/jbc.270.12.6729
Byzova, 2000, A mechanism for modulation of cellular responses to VEGF: activation of the integrins., Mol Cell, 6, 851
Takahashi, 1999, VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells., Oncogene, 18, 2221, 10.1038/sj.onc.1202527
Wu, 2000, Utilization of distinct signaling pathways by receptors for vascular endothelial cell growth factor and other mitogens in the induction of endothelial cell proliferation., J Biol Chem, 275, 5096, 10.1074/jbc.275.7.5096
Gille, 2001, Analysis of biological effects and signaling properties of Flt-1 (VEGFR-1) and KDR (VEGFR-2). A reassessment using novel receptor-specific VEGF mutants., J Biol Chem, 276, 3222, 10.1074/jbc.M002016200
Yamazaki, 2003, Snake venom VEGFs exhibit potent activity through their specific recognition of KDR (VEGF receptor 2)., J Biol Chem, 278, 51985, 10.1074/jbc.C300454200
Morales-Ruiz, 2000, Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt., Circ Res, 86, 892, 10.1161/01.RES.86.8.892
Adini, 2002, Placental growth factor is a survival factor for tumor endothelial cells and macrophages., Cancer Res, 62, 2749
Soker, 1996, Characterization of novel vascular endothelial growth factor (VEGF) receptors on tumor cells that bind VEGF165 via its exon 7-encoded domain., J Biol Chem, 271, 5761, 10.1074/jbc.271.10.5761
Soker, 1998, Neuropilin-1 is expressed by endothelial and tumor cells as an isoform-specific receptor for vascular endothelial growth factor., Cell, 92, 735, 10.1016/S0092-8674(00)81402-6
Neufeld, 2002, The neuropilins: multifunctional semaphorin and VEGF receptors that modulate axon guidance and angiogenesis., Trends Cardiovas Med, 12, 13, 10.1016/S1050-1738(01)00140-2
Fuh, 2000, The interaction of neuropilin-1 with vascular endothelial growth factor and its receptor flt-1., J Biol Chem, 275, 26690, 10.1016/S0021-9258(19)61431-6
Miao, 1999, Neuropilin-1 mediates collapsin-1/semaphorin III inhibition of endothelial cell motility: functional competition of collapsin-1 and vascular endothelial growth factor-165., J Cell Biol, 146, 233
Tamagnone, 1999, Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates., Cell, 99, 71, 10.1016/S0092-8674(00)80063-X
Bagri, 2002, Neuropilins as Semaphorin receptors: in vivo functions in neuronal cell migration and axon guidance., Adv Exp Med Biol, 515, 13, 10.1007/978-1-4615-0119-0_2
Kawasaki, 1999, A requirement for neuropilin-1 in embryonic vessel formation., Development, 126, 4895, 10.1242/dev.126.21.4895
Lee, 2002, Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish., Proc Natl Acad Sci USA, 99, 10470, 10.1073/pnas.162366299
Yuan, 2002, Abnormal lymphatic vessel development in neuropilin 2 mutant mice., Development, 129, 4797, 10.1242/dev.129.20.4797
Carmeliet, 1996, Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele., Nature, 380, 435, 10.1038/380435a0
Ferrara, 1996, Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene., Nature, 380, 439, 10.1038/380439a0
Haigh, 2003, Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling., Dev Biol, 262, 225, 10.1016/S0012-1606(03)00356-7
Raab, 2004, Impaired brain angiogenesis and neuronal apoptosis induced by conditional homozygous inactivation of vascular endothelial growth factor., Thromb Haemost, 91, 595, 10.1160/TH03-09-0582
Miquerol, 2000, Embryonic development is disrupted by modest increases in vascular endothelial growth factor gene expression., Development, 127, 3941, 10.1242/dev.127.18.3941
Bellomo, 2000, Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia, Circ Res, 86, E29, 10.1161/01.RES.86.2.e29
Karkkainen, 2004, Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins., Nat Immunol, 5, 74, 10.1038/ni1013
Kitamoto, 1997, Vascular endothelial growth factor is an essential molecule for mouse kidney development: glomerulogenesis and nephrogenesis., J Clin Invest, 99, 2351, 10.1172/JCI119416
Eremina, 2003, Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases., J Clin Invest, 111, 707, 10.1172/JCI17423
Ostendorf, 1999, VEGF(165) mediates glomerular endothelial repair., J Clin Invest, 104, 913, 10.1172/JCI6740
Sugimoto, 2003, Neutralization of circulating vascular endothelial growth factor (VEGF) by anti-VEGF antibodies and soluble VEGF receptor 1 (sFlt-1) induces proteinuria., J Biol Chem, 278, 12605, 10.1074/jbc.C300012200
Ryan, 1999, Preclinical safety evaluation of rhuMAbVEGF, an antiangiogenic humanized monoclonal antibody., Toxicol Pathol, 27, 78, 10.1177/019262339902700115
Kabbinavar, 2003, Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer., J Clin Oncol, 21, 60, 10.1200/JCO.2003.10.066
Poole, 1991, 179
Gerber, 1999, VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation., Nat Med, 5, 623, 10.1038/9467
Carlevaro, 2000, Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation., J Cell Sci, 113, 59, 10.1242/jcs.113.1.59
Deckers, 2002, Bone morphogenetic proteins stimulate angiogenesis through osteoblast-derived vascular endothelial growth factor A., Endocrinology, 143, 1545, 10.1210/endo.143.4.8719
Bouletreau, 2002, Hypoxia and VEGF up-regulate BMP-2 mRNA and protein expression in microvascular endothelial cells: implications for fracture healing., Plast Reconstr Surg, 109, 2384, 10.1097/00006534-200206000-00033
Vu, 1998, MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes., Cell, 93, 411, 10.1016/S0092-8674(00)81169-1
Bergers, 2000, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis., Nat Cell Biol, 2, 737, 10.1038/35036374
Street, 2002, Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover., Proc Natl Acad Sci USA, 99, 9656, 10.1073/pnas.152324099
Colnot, 2003, Altered fracture repair in the absence of MMP9., Development, 130, 4123, 10.1242/dev.00559
Mayr-Wohlfart, 2002, Vascular endothelial growth factor stimulates chemotactic migration of primary human osteoblasts., Bone, 30, 472, 10.1016/S8756-3282(01)00690-1
Engsig, 2000, Matrix metalloproteinase 9 and vascular endothelial growth factor are essential for osteoclast recruitment into developing long bones., J Cell Biol, 151, 879, 10.1083/jcb.151.4.879
Carano, 2003, Angiogenesis and bone repair., Drug Discov Today, 8, 980, 10.1016/S1359-6446(03)02866-6
Haigh, 2000, Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state., Development, 127, 1445, 10.1242/dev.127.7.1445
Zelzer, 2002, Skeletal defects in VEGF(120/120) mice reveal multiple roles for VEGF in skeletogenesis., Development, 129, 1893, 10.1242/dev.129.8.1893
Bassett, 1943, The changes in the vascular pattern of the ovary of the albino rat during the estrous cycle., Am J Anat, 73, 251, 10.1002/aja.1000730206
Zeleznik, 1981, Gonadotropin-binding sites in the rhesus monkey ovary: role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle., Endocrinology, 109, 356, 10.1210/endo-109-2-356
Carr, 1981, The role of lipoproteins in the regulation of progesterone secretion by the corpus luteum., Fertil Steril, 38, 303, 10.1016/S0015-0282(16)46511-8
Goede, 1998, Analysis of blood vessel maturation processes during cyclic ovarian angiogenesis., Lab Invest, 78, 1385
Maisonpierre, 1997, Angiopoietin-2, a natural antagonist for Tie-2 that disrupts in vivo angiogenesis., Science, 277, 55, 10.1126/science.277.5322.55
Phillips, 1990, Vascular endothelial growth factor is expressed in rat corpus luteum., Endocrinology, 127, 965, 10.1210/endo-127-2-965
Ravindranath, 1992, Vascular endothelial growth factor messenger ribonucleic acid expression in the primate ovary., Endocrinology, 131, 254, 10.1210/endo.131.1.1612003
Zimmermann, 2001, Short-term administration of antivascular endothelial growth factor antibody in the late follicular phase delays follicular development in the rhesus monkey., J Clin Endocrinol Metab, 86, 768
Zimmermann, 2001, Preovulatory treatment of mice with anti-VEGF receptor 2 antibody inhibits angiogenesis in corpora lutea., Microvasc Res, 62, 15, 10.1006/mvre.2001.2312
Fraser, 2000, Suppression of luteal angiogenesis in the primate after neutralization of vascular endothelial growth factor., Endocrinology, 141, 995, 10.1210/endo.141.3.7369
Hazzard, 2002, Injection of soluble vascular endothelial growth factor receptor 1 into the preovulatory follicle disrupts ovulation and subsequent luteal function in rhesus monkeys., Biol Reprod, 67, 1305, 10.1095/biolreprod67.4.1305
Rowe, 2002, Angiogenesis in the corpus luteum of early pregnancy in the marmoset and the effects of vascular endothelial growth factor immunoneutralization on establishment of pregnancy., Biol Reprod, 67, 1180, 10.1095/biolreprod67.4.1180
LeCouter, 2001, Identification of an angiogenic mitogen selective for endocrine gland endothelium., Nature, 412, 877, 10.1038/35091000
LeCouter, 2002, Endocrine gland-derived VEGF and the emerging hypothesis of organ-specific regulation of angiogenesis., Nat Med, 8, 913, 10.1038/nm0902-913
Ferrara, 2003, Differential expression of the angiogenic factor genes VEGF and EG-VEGF in normal and polycystic human ovaries., Am J Pathol, 162, 1881, 10.1016/S0002-9440(10)64322-2
LeCouter, 2003, Mouse endocrine-gland derived vascular endothelial growth factor. A distinct expression pattern from its human ortholog suggests different roles as a regulator of organ-specific angiogenesis., Endocrinology, 144, 2606, 10.1210/en.2002-0146
Luo, 1994, A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation., Cell, 77, 481, 10.1016/0092-8674(94)90211-9
Sadovsky, 1995, Mice deficient in the orphan receptor steroidogenic factor 1 lack adrenal glands and gonads but express P450 side-chain-cleavage enzyme in the placenta and have normal embryonic serum levels of corticosteroids., Proc Natl Acad Sci USA, 92, 10939, 10.1073/pnas.92.24.10939
Parker, 2002, Steroidogenic factor 1: an essential mediator of endocrine development., Recent Prog Horm Res, 57, 19, 10.1210/rp.57.1.19
Lasley, 1994, Strategies of ovarian function of importance to gynecologic investigations., J Soc Gynecol Investig, 1, 247, 10.1177/107155769400100402
Fraser, 2000, Angiogenesis and its control in the female reproductive system., Br Med Bull, 56, 787, 10.1258/0007142001903364
Lammert, 2003, Role of VEGF-A in vascularization of pancreatic islets., Curr Biol, 13, 1070, 10.1016/S0960-9822(03)00378-6
Volm, 1997, Angiogenic growth factors and their receptors in non-small cell lung carcinomas and their relationships to drug response in vitro., Anticancer Res, 17, 99
Volm, 1997, Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer., Int J Cancer, 74, 64, 10.1002/(SICI)1097-0215(19970220)74:1<64::AID-IJC11>3.0.CO;2-I
Brown, 1995, Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer., Hum Pathol, 26, 86, 10.1016/0046-8177(95)90119-1
Yoshiji, 1996, Expression of vascular endothelial growth factor, its receptor, and other angiogenic factors in human breast cancer., Cancer Res, 56, 2013
Brown, 1993, Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in adenocarcinomas of the gastrointestinal tract., Cancer Res, 53, 4727
Suzuki, 1996, Expression of vascular permeability factor/vascular endothelial growth factor in human hepatocellular carcinoma., Cancer Res, 56, 3004
Ellis, 1998, Vessel counts and vascular endothelial growth factor expression in pancreatic adenocarcinoma., Eur J Cancer, 34, 337, 10.1016/S0959-8049(97)10068-5
Uchida, 1998, In oesophageal squamous cell carcinoma vascular endothelial growth factor is associated with p53 mutation, advanced stage and poor prognosis., Br J Cancer, 77, 1704, 10.1038/bjc.1998.281
Brown, 1993, Increased expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in kidney and bladder carcinomas., Am J Pathol, 143, 1255
Nicol, 1997, Vascular endothelial growth factor expression is increased in renal cell carcinoma., J Urol, 157, 1482, 10.1016/S0022-5347(01)65028-6
Tomisawa, 1999, Expression pattern of vascular endothelial growth factor isoform is closely correlated with tumour stage and vascularisation in renal cell carcinoma., Eur J Cancer, 35, 133, 10.1016/S0959-8049(98)00278-0
Olson, 1994, Vascular permeability factor gene expression in normal and neoplastic human ovaries., Cancer Res, 54, 276
Sowter, 1997, Expression and localization of the vascular endothelial growth factor family in ovarian epithelial tumors., Lab Invest, 77, 607
Yamamoto, 1997, Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels., Br J Cancer, 76, 1221, 10.1038/bjc.1997.537
Guidi, 1996, Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in endometrial carcinoma., Cancer, 78, 454, 10.1002/(SICI)1097-0142(19960801)78:3<454::AID-CNCR12>3.0.CO;2-Y
Shweiki, 1992, Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis., Nature, 359, 843, 10.1038/359843a0
Plate, 1992, Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo., Nature, 359, 845, 10.1038/359845a0
Phillips, 1993, Intense focal expression of vascular endothelial growth factor mRNA in human intracranial neoplasms: association with regions of necrosis., Int J Oncol, 2, 913
Berkman, 1993, Expression of the vascular permeability factor/vascular endothelial growth factor gene in central nervous system neoplasms., J Clin Invest, 91, 153, 10.1172/JCI116165
Wizigmann Voos, 1995, Up-regulation of vascular endothelial growth factor and its receptors in von Hippel-Lindau disease-associated and sporadic hemangioblastomas., Cancer Res, 155, 1358
Lloyd, 1999, Vascular endothelial growth factor (VEGF) expression in human pituitary adenomas and carcinomas., Endocr Pathol, 10, 229, 10.1007/BF02738884
Soh, 1997, Vascular endothelial growth factor expression is higher in differentiated thyroid cancer than in normal or benign thyroid., J Clin Endocrinol Metab, 82, 3741
Klein, 2001, Increased expression of the vascular endothelial growth factor is a pejorative prognosis marker in papillary thyroid carcinoma., J Clin Endocrinol Metab, 86, 656, 10.1210/jcem.86.2.7226
Kim, 1993, Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumor growth in vivo., Nature, 362, 841, 10.1038/362841a0
Warren, 1995, Regulation by vascular endothelial growth factor of human colon cancer tumorigenesis in a mouse model of experimental liver metastasis., J Clin Invest, 95, 1789, 10.1172/JCI117857
Melnyk, 1996, Vascular endothelial growth factor promotes tumor dissemination by a mechanism distinct from its effect on primary tumor growth., Cancer Res, 56, 921
Asano, 1995, Inhibition of tumor growth and metastasis by an immunoneutralizing monoclonal antibody to human vascular endothelial growth factor/vascular permeability factor 121., Cancer Res, 55, 5296
Borgstrom, 1996, Complete inhibition of angiogenesis and growth of microtumors by anti-vascular endothelial growth factor neutralizing antibody: novel concepts of angiostatic therapy from intravital videomicroscopy., Cancer Res, 56, 4032
Borgstrom, 1998, Neutralizing anti-vascular endothelial growth factor antibody completely inhibits angiogenesis and growth of human prostate carcinoma micro tumors in vivo., Prostate, 35, 1, 10.1002/(SICI)1097-0045(19980401)35:1<1::AID-PROS1>3.0.CO;2-O
Mesiano, 1998, Role of vascular endothelial growth factor in ovarian cancer: inhibition of ascites formation by immunoneutralization., Am J Pathol, 153, 1249, 10.1016/S0002-9440(10)65669-6
Borgstrom, 1999, Importance of VEGF for breast cancer angiogenesis in vivo: implications from intravital microscopy of combination treatments with an anti-VEGF neutralizing monoclonal antibody and doxorubicin., Anticancer Res, 19, 4203
Millauer, 1994, Glioblastoma growth inhibited in vivo by a dominant-negative Flk-1 mutant., Nature, 367, 576, 10.1038/367576a0
Strawn, 1996, Flk-1 as a target for tumor growth inhibition., Cancer Res, 56, 3540
Wood, 2000, PTK787/ZK 222584, a novel and potent inhibitor of vascular endothelial growth factor receptor tyrosine kinases, impairs vascular endothelial growth factor-induced responses and tumor growth after oral administration., Cancer Res, 60, 2178
Wedge, 2000, ZD4190: an orally active inhibitor of vascular endothelial growth factor signaling with broad-spectrum antitumor efficacy., Cancer Res, 60, 970
Saleh, 1996, Inhibition of growth of C6 glioma cells in vivo by expression of antisense vascular endothelial growth factor sequence., Cancer Res, 56, 393
Oku, 1998, Tumor growth modulation by sense and antisense vascular endothelial growth factor gene expression: effects on angiogenesis, vascular permeability, blood volume, blood flow, fluorodeoxyglucose uptake, and proliferation of human melanoma intracerebral xenografts., Cancer Res, 58, 4185
Prewett, 1999, Antivascular endothelial growth factor receptor (fetal liver kinase 1) monoclonal antibody inhibits tumor angiogenesis., Cancer Res, 59, 5209
Kong, 1998, Regional suppression of tumor growth by in vivo transfer of a cDNA encoding a secreted form of the extracellular domain of the flt-1 vascular endothelial growth factor receptor., Hum Gene Ther, 9, 823, 10.1089/hum.1998.9.6-823
Goldman, 1998, Paracrine expression of a native soluble vascular endothelial growth factor receptor inhibits tumor growth, metastasis, and mortality rate., Proc Natl Acad Sci USA, 95, 8795, 10.1073/pnas.95.15.8795
Gerber, 2000, Complete inhibition of rhabdomyosarcoma xenograft growth and neovascularization requires blockade of both tumor and host vascular endothelial growth factor., Cancer Res, 60, 6253
Kuo, 2001, Comparative evaluation of the antitumor activity of antiangiogenic proteins delivered by gene transfer., Proc Natl Acad Sci USA, 98, 4605, 10.1073/pnas.081615298
Holash, 2002, VEGF-Trap: a VEGF blocker with potent antitumor effects., Proc Natl Acad Sci USA, 99, 11393, 10.1073/pnas.172398299
Soh, 2000, Neutralizing vascular endothelial growth factor activity inhibits thyroid cancer growth in vivo., Surgery, 128, 1059, 10.1067/msy.2000.110430
Schoenberger, 2003, Effects of PTK787/ZK222584 a tyrosine kinase inhibitor on the growth of a poorly differentiated thyroid carcinoma. An animal study., Endocrinology, 145, 1031, 10.1210/en.2003-1228
Fukumura, 1998, Tumor induction of VEGF promoter activity in stromal cells., Cell, 94, 715, 10.1016/S0092-8674(00)81731-6
Tsuzuki, 2000, Vascular endothelial growth factor (VEGF) modulation by targeting hypoxia-inducible factor-1α→hypoxia response element→ VEGF cascade differentially regulates vascular response and growth rate in tumors., Cancer Res, 60, 6248
Kishimoto, 2000, In vivo detection of human vascular endothelial growth factor promoter activity in transgenic mouse skin., Am J Pathol, 157, 103, 10.1016/S0002-9440(10)64522-1
Inoue, 2002, VEGF-A has a critical, nonredundant role in angiogenic switching and pancreatic β cell carcinogenesis., Cancer Cell, 1, 193, 10.1016/S1535-6108(02)00031-4
Klement, 2000, Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity, J Clin Invest, 105, R15, 10.1172/JCI8829
Lee, 2000, Anti-vascular endothelial growth factor treatment augments tumor radiation response under normoxic or hypoxic conditions., Cancer Res, 60, 5565
Kozin, 2001, Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts., Cancer Res, 61, 39
Jain, 2001, Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy., Nat Med, 7, 987, 10.1038/nm0901-987
Pham, 1998, Magnetic resonance imaging detects suppression of tumor vascular permeability after administration of antibody to vascular endothelial growth factor., Cancer Invest, 16, 225, 10.3109/07357909809039771
Willett, 2004, Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer., Nat Med, 10, 145, 10.1038/nm988
Presta, 1997, Humanization of an anti-VEGF monoclonal antibody for the therapy of solid tumors and other disorders., Cancer Res, 57, 4593
Gerber, 2003, The role of VEGF in normal and neoplastic hematopoiesis., J Mol Med, 81, 20, 10.1007/s00109-002-0397-4
Smolich, 2001, The antiangiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts., Blood, 97, 1413, 10.1182/blood.V97.5.1413
Dias, 2000, Autocrine stimulation of VEGFR-2 activates human leukemic cell growth and migration., J Clin Invest, 106, 511, 10.1172/JCI8978
Fiedler, 2003, A phase II clinical study of SU5416 in patients with refractory acute myeloid leukemia., Blood, 102, 2763, 10.1182/blood-2002-10-2998
Patz, 1980, Studies on retinal neovascularization., Invest Ophthalmol Vis Sci, 19, 1133
Stone, 1995, Development of retinal vasculature is mediated by hypoxia-induced vascular endothelial growth factor (VEGF) expression by neuroglia., J Neurosci, 15, 4738, 10.1523/JNEUROSCI.15-07-04738.1995
Benjamin, 1998, A plasticity window for blood vessel remodelling is defined by pericyte coverage of the preformed endothelial network and is regulated by PDGF-B and VEGF., Development, 125, 1591, 10.1242/dev.125.9.1591
Lindhal, 1997, Pericyte loss and microaneurysm formation in PDGF-B-deficient mice., Science, 277, 242, 10.1126/science.277.5323.242
Miller, 1994, Vascular endothelial growth factor/vascular permeability factor is temporally and spatially correlated with ocular angiogenesis in a primate model., Am J Pathol, 145, 574
Pierce, 1996, Regulation of vascular endothelial growth factor by oxygen in a model of retinopathy of prematurity., Arch Ophthalmol, 114, 1219, 10.1001/archopht.1996.01100140419009
Aiello, 1994, Vascular endothelial growth factor in ocular fluid of patients with diabetic retinopathy and other retinal disorders., N Engl J Med, 331, 1480, 10.1056/NEJM199412013312203
Malecaze, 1994, Detection of vascular endothelial growth factor mRNA and vascular endothelial growth factor-like activity in proliferative diabetic retinopathy., Arch Ophthalmol, 112, 1476, 10.1001/archopht.1994.01090230090028
Aiello, 1995, Suppression of retinal neovascularization in vivo by inhibition of vascular endothelial growth factor (VEGF) using soluble VEGF-receptor chimeric proteins., Proc Natl Acad Sci USA, 92, 10457, 10.1073/pnas.92.23.10457
Adamis, 1996, Inhibition of vascular endothelial growth factor prevents retinal ischemia-associated iris neovascularization in a nonhuman primate., Arch Ophthalmol, 114, 66, 10.1001/archopht.1996.01100130062010
Robinson, 1996, Oligodeoxynucleotides inhibit retinal neovascularization in a murine model of proliferative retinopathy., Proc Natl Acad Sci USA, 93, 4851, 10.1073/pnas.93.10.4851
Ozaki, 2000, Blockade of vascular endothelial cell growth factor receptor signaling is sufficient to completely prevent retinal neovascularization., Am J Pathol, 156, 697, 10.1016/S0002-9440(10)64773-6
Suzuma, 2002, Characterization of protein kinase C β isoform’s action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization., Proc Natl Acad Sci USA, 99, 721, 10.1073/pnas.022644499
Lopez, 1996, Transdifferentiated retinal pigment epithelial cells are immunoreactive for vascular endothelial growth factor in surgically excised age-related macular degeneration-related choroidal neovascular membranes., Invest Ophthalmol Vis Sci, 37, 855
Campochiaro, 2003, Ocular neovascularization: a valuable model system., Oncogene, 22, 6537, 10.1038/sj.onc.1206773
Chen, 1999, Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen., J Mol Biol, 293, 865, 10.1006/jmbi.1999.3192
Ruckman, 1998, 2′-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domain., J Biol Chem, 273, 20556, 10.1074/jbc.273.32.20556
Krzystolik, 2002, Prevention of experimental choroidal neovascularization with intravitreal anti-vascular endothelial growth factor antibody fragment., Arch Ophthalmol, 120, 338, 10.1001/archopht.120.3.338
Zheng, 2001, Contribution of vascular endothelial growth factor in the neovascularization process during the pathogenesis of herpetic stromal keratitis., J Virol, 75, 9828, 10.1128/JVI.75.20.9828-9835.2001
Detmar, 1995, Keratinocyte-derived vascular permeability factor (vascular endothelial growth factor) is a potent mitogen for dermal microvascular endothelial cells., J Invest Dermatol, 105, 44, 10.1111/1523-1747.ep12312542
Detmar, 1998, Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice., J Invest Dermatol, 111, 1, 10.1046/j.1523-1747.1998.00262.x
Cramer, 2003, HIF1α is essential for myeloid cell-mediated inflammation., Cell, 112, 645, 10.1016/S0092-8674(03)00154-5
Koch, 1994, Vascular endothelial growth factor: a cytokine modulating endothelial function in rheumatoid arthritis., J Immunol, 152, 4149, 10.4049/jimmunol.152.8.4149
Fava, 1994, Vascular permeability factor/endothelial growth factor (VPF/VEGF): accumulation and expression in human synovial fluids and rheumatoid synovial tissue., J Exp Med, 180, 341, 10.1084/jem.180.1.341
Miotla, 2000, Treatment with soluble VEGF receptor reduces disease severity in murine collagen-induced arthritis., Lab Invest, 80, 1195, 10.1038/labinvest.3780127
Sone, 2001, Neutralization of vascular endothelial growth factor prevents collagen-induced arthritis and ameliorates established disease in mice., Biochem Biophys Res Commun, 281, 562, 10.1006/bbrc.2001.4395
Afuwape, 2003, Adenoviral delivery of soluble VEGF receptor 1 (sFlt-1) abrogates disease activity in murine collagen-induced arthritis., Gene Ther, 10, 1950, 10.1038/sj.gt.3302104
Matsumoto, 2002, Possible involvement of the vascular endothelial growth factor-Flt-1-focal adhesion kinase pathway in chemotaxis and the cell proliferation of osteoclast precursor cells in arthritic joints., J Immunol, 168, 5824, 10.4049/jimmunol.168.11.5824
Autiero, 2003, Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders., J Thromb Haemost, 1, 1356, 10.1046/j.1538-7836.2003.00263.x
Oura, 2003, A critical role of placental growth factor in the induction of inflammation and edema formation., Blood, 101, 560, 10.1182/blood-2002-05-1516
Reinders, 2003, Proinflammatory functions of vascular endothelial growth factor in alloimmunity., J Clin Invest, 112, 1655, 10.1172/JCI17712
Monacci, 1993, Expression of vascular permeability factor/vascular endothelial growth factor in normal rat tissues, Am J Physiol, 264, C995, 10.1152/ajpcell.1993.264.4.C995
Kovacs, 1996, VEGF and flt. Expression time kinetics in rat brain infarct., Stroke, 27, 1865, 10.1161/01.STR.27.10.1865
Hayashi, 1997, Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats., Stroke, 28, 2039, 10.1161/01.STR.28.10.2039
Lennmyr, 1998, Expression of vascular endothelial growth factor (VEGF) and its receptors (Flt-1 and Flk-1) following permanent and transient occlusion of the middle cerebral artery in the rat., J Neuropathol Exp Neurol, 57, 874, 10.1097/00005072-199809000-00009
van Bruggen, 1999, VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain., J Clin Invest, 104, 1613, 10.1172/JCI8218
Paul, 2001, Src deficiency or blockade of Src activity in mice provides cerebral protection following stroke., Nat Med, 7, 222, 10.1038/84675
Sun, 2003, VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia., J Clin Invest, 111, 1843, 10.1172/JCI200317977
Harrigan, 2003, Effects of intraventricular infusion of vascular endothelial growth factor on cerebral blood flow, edema, and infarct volume., Acta Neurochir (Wien), 145, 49, 10.1007/s00701-002-1035-1
Goldzieher, 1962, The polycystic ovary. I. Clinical and histologic features., J Clin Endocrinol Metab, 22, 325, 10.1210/jcem-22-3-325
Yen, 1996, 1117
Dewailly, 1994, Ovarian stromal hypertrophy in hyperandrogenic women., Clin Endocrinol (Oxf), 41, 557, 10.1111/j.1365-2265.1994.tb01818.x
Fulghesu, 2001, A new ultrasound criterion for the diagnosis of polycystic ovary syndrome: the ovarian stroma/total area ratio., Fertil Steril, 76, 326, 10.1016/S0015-0282(01)01919-7
Dunaif, 2001, Current concepts in the polycystic ovary syndrome., Annu Rev Med, 52, 401, 10.1146/annurev.med.52.1.401
Tulandi, 2000, Effects of laparoscopic ovarian drilling on serum vascular endothelial growth factor and on insulin responses to the oral glucose tolerance test in women with polycystic ovary syndrome., Fertil Steril, 74, 585, 10.1016/S0015-0282(00)00684-1
Agrawal, 1998, Serum vascular endothelial growth factor concentrations and ovarian stromal blood flow are increased in women with polycystic ovaries., Hum Reprod, 13, 651, 10.1093/humrep/13.3.651
Kamat, 1995, Expression of vascular permeability factor/vascular endothelial growth factor by human granulosa and theca lutein cells. Role in corpus luteum development., Am J Pathol, 146, 157
McClure, 1994, Vascular endothelial growth factor as a capillary permeability agent in ovarian hyperstimulation syndrome., Lancet, 344, 235, 10.1016/S0140-6736(94)93001-5
Levin, 1998, Role of vascular endothelial cell growth factor in ovarian hyperstimulation syndrome., J Clin Invest, 102, 1978, 10.1172/JCI4814
Engel, 1972, Ovarian hyperstimulation syndrome: report of one case with notes on pathogenesis and treatment., Am J Obstet Gynecol, 112, 1052, 10.1016/0002-9378(72)90180-9
Haning, 1985, Pathophysiology of the ovarian hyperstimulation syndrome., Obstet Gynecol, 166, 220
Kemmann, 1981, Induction of ovulation with menotropins in women with polycystic ovary syndrome., Am J Obstet Gynecol, 141, 58, 10.1016/0002-9378(81)90675-X
Kobayashi, 1998, The kallikrein-kinin system, but not vascular endothelial growth factor, plays a role in the increased vascular permeability associated with ovarian hyperstimulation syndrome., J Mol Endocrinol, 20, 363, 10.1677/jme.0.0200363
McLaren, 1996, Vascular endothelial growth factor is produced by peritoneal fluid macrophages in endometriosis and is regulated by ovarian steroids., J Clin Invest, 98, 482, 10.1172/JCI118815
Shifren, 1996, Ovarian steroid regulation of vascular endothelial growth factor in the human endometrium: implications for angiogenesis during the menstrual cycle and in the pathogenesis of endometriosis., J Clin Endocrinol Metab, 81, 3112
Hull, 2003, Antiangiogenic agents are effective inhibitors of endometriosis., J Clin Endocrinol Metab, 88, 2889, 10.1210/jc.2002-021912
Maynard, 2003, Excess placental soluble fms-like tyrosine kinase 1 (sFlt1) may contribute to endothelial dysfunction, hypertension, and proteinuria in preeclampsia., J Clin Invest, 111, 649, 10.1172/JCI17189
Levine, 2004, Circulating angiogenic factors and the risk of preeclampsia., N Engl J Med, 350, 672, 10.1056/NEJMoa031884
Graor, 1991, Interventional treatment of peripheral vascular disease, St., Louis, Mosby
Takeshita, 1994, Therapeutic angiogenesis: a single intra-arterial bolus of vascular endothelial growth factor augments collateral vessel formation in a rabbit ischemic hind-limb model., J Clin Invest, 93, 662, 10.1172/JCI117018
Takeshita, 1996, Gene transfer of naked DNA encoding for three isoforms of vascular endothelial growth factor stimulates collateral development in vivo., Lab Invest, 75, 487
Takeshita, 1996, Therapeutic angiogenesis following arterial gene transfer of vascular endothelial growth factor in a rabbit model of hindlimb ischemia., Biochem Biophys Res Commun, 227, 628, 10.1006/bbrc.1996.1556
Bauters, 1995, Recovery of disturbed endothelium-dependent flow in the collateral-perfused rabbit ischemic hindlimb after administration of vascular endothelial growth factor., Circulation, 91, 2802, 10.1161/01.CIR.91.11.2802
Mack, 1998, Salvage angiogenesis induced by adenovirus-mediated gene transfer of vascular endothelial growth factor protects against ischemic vascular occlusion., J Vasc Surg, 27, 699, 10.1016/S0741-5214(98)70236-8
Schratzberger, 2000, Favorable effect of VEGF gene transfer on ischemic peripheral neuropathy., Nat Med, 6, 405, 10.1038/74664
Harada, 1996, Vascular endothelial growth factor administration in chronic myocardial ischemia, Am J Physiol, 270, H1791
Mack, 1998, Biologic bypass with the use of adenovirus-mediated gene transfer of the complementary deoxyribonucleic acid for vascular endothelial growth factor 121 improves myocardial perfusion and function in the ischemic porcine heart., J Thor Cardiovasc Surg, 115, 168, 10.1016/S0022-5223(98)70455-6
Isner, 1996, Clinical evidence of angiogenesis after arterial gene transfer of phVEGF165 in patient with ischaemic limb., Lancet, 348, 370, 10.1016/S0140-6736(96)03361-2
Baumgartner, 1998, Constitutive expression of phVEGF165 after intramuscular gene transfer promotes collateral vessel development in patients with critical limb ischemia., Circulation, 97, 1114, 10.1161/01.CIR.97.12.1114
Losordo, 1998, Gene therapy for myocardial angiogenesis: initial clinical results with direct myocardial injection of phVEGF165 as sole therapy for myocardial ischemia., Circulation, 98, 2800, 10.1161/01.CIR.98.25.2800
Makinen, 2002, Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, double-blinded phase II study., Mol Ther, 6, 127, 10.1006/mthe.2002.0638
Dor, 2002, Conditional switching of VEGF provides new insights into adult neovascularization and pro-angiogenic therapy., EMBO J, 21, 1939, 10.1093/emboj/21.8.1939
Thurston, 2000, Angiopoietin-1 protects the adult vasculature against plasma leakage., Nat Med, 6, 460, 10.1038/74725
Cao, 2003, Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2., Nat Med, 9, 604, 10.1038/nm848
Tarkka, 2003, Adenoviral VEGF-A gene transfer induces angiogenesis and promotes bone formation in healing osseous tissues., J Gene Med, 5, 560, 10.1002/jgm.392
Garber, 2002, Angiogenesis inhibitors suffer new setback., Nat Biotechnol, 20, 1067, 10.1038/nbt1102-1067
Kerbel, 2002, Clinical translation of angiogenesis inhibitors., Nat Rev Cancer, 2, 727, 10.1038/nrc905