The Cellular Fate of Glucose and Its Relevance in Type 2 DiabetesEndocrine Reviews - Tập 25 Số 5 - Trang 807-830 - 2004
C. Bouché, Shanti Serdy, C. Ronald Kahn, Allison B. Goldfine
Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution of glucose metabolic pathways per se in the pathogenesis of the disease remains unclear. The cellular fate of glucose begins with glucose transport and phosphorylation. Subsequent pathway...... hiện toàn bộ
The Multifaceted Biology of PCSK9Endocrine Reviews - Tập 43 Số 3 - Trang 558-582 - 2022
Nabil G. Seidah, Annik Prat
Abstract
This article reviews the discovery of PCSK9, its structure–function characteristics, and its presently known and proposed novel biological functions. The major critical function of PCSK9 deduced from human and mouse studies, as well as cellular and structural analyses, is its role in increasing the levels of circulating low-density lipoprote...... hiện toàn bộ