Endocrine Reviews
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EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals
Endocrine Reviews - Tập 36 Số 6 - Trang E1-E150 - 2015
The Molecular Mechanisms Underlying the Regulation of the Biological Activity of Corticotropin-Releasing Hormone Receptors: Implications for Physiology and Pathophysiology The CRH receptor (CRH-R) is a member of the secretin family of G protein-coupled receptors. Wide expression of CRH-Rs in the central nervous system and periphery ensures that their cognate agonists, the family of CRH-like peptides, are capable of exerting a wide spectrum of actions that underpin their critical role in integrating the stress response and coordinating the activity of fundamental physiological functions, such as the regulation of the cardiovascular system, energy balance, and homeostasis. Two types of mammal CRH-R exist, CRH-R1 and CRH-R2, each with unique splicing patterns and remarkably distinct pharmacological properties, but similar signaling properties, probably reflecting their distinct and sometimes contrasting biological functions. The regulation of CRH-R expression and activity is not fully elucidated, and we only now begin to fully understand the impact on mammalian pathophysiology. The focus of this review is the current and evolving understanding of the molecular mechanisms controlling CRH-R biological activity and functional flexibility. This shows notable tissue-specific characteristics, highlighted by their ability to couple to distinct G proteins and activate tissue-specific signaling cascades. The type of activating agonist, receptor, and target cell appears to play a major role in determining the overall signaling and biological responses in health and disease.
Endocrine Reviews - Tập 27 Số 3 - Trang 260-286 - 2006
The Roles of Prolactin, Growth Hormone, Insulin-Like Growth Factor-I, and Thyroid Hormones in Lymphocyte Development and Function: Insights from Genetic Models of Hormone and Hormone Receptor Deficiency
Endocrine Reviews - Tập 21 Số 3 - Trang 292-312 - 2000
The Somatogenic Hormones and Insulin-Like Growth Factor-1: Stimulators of Lymphopoiesis and Immune Function
Endocrine Reviews - Tập 18 Số 2 - Trang 157-179 - 1997
Progestogens Used in Postmenopausal Hormone Therapy: Differences in Their Pharmacological Properties, Intracellular Actions, and Clinical Effects
Endocrine Reviews - Tập 34 Số 2 - Trang 171-208 - 2013
Hormonal Contraception and HIV-1 Acquisition: Biological Mechanisms
Endocrine Reviews - Tập 39 Số 1 - Trang 36-78 - 2018
The Endocrinology and Developmental Biology of the Prostate*
Endocrine Reviews - Tập 8 Số 3 - Trang 338-362 - 1987
The Cellular Fate of Glucose and Its Relevance in Type 2 Diabetes Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution of glucose metabolic pathways per se in the pathogenesis of the disease remains unclear. The cellular fate of glucose begins with glucose transport and phosphorylation. Subsequent pathways of glucose utilization include aerobic and anaerobic glycolysis, glycogen formation, and conversion to other intermediates in the hexose phosphate or hexosamine biosynthesis pathways. Abnormalities in each pathway may occur in diabetic subjects; however, it is unclear whether perturbations in these may lead to diabetes or are a consequence of the multiple metabolic abnormalities found in the disease. This review is focused on the cellular fate of glucose and relevance to human type 2 diabetes.
Endocrine Reviews - Tập 25 Số 5 - Trang 807-830 - 2004
Peptidomimetic Regulation of Growth Hormone Secretion
Endocrine Reviews - Tập 18 Số 5 - Trang 621-645 - 1997
Progestin Regulation of Cellular Proliferation*
Endocrine Reviews - Tập 11 Số 2 - Trang 266-301 - 1990
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