The Cellular Fate of Glucose and Its Relevance in Type 2 DiabetesEndocrine Reviews - Tập 25 Số 5 - Trang 807-830 - 2004
C. Bouché, Shanti Serdy, C. Ronald Kahn, Allison B. Goldfine
Type 2 diabetes is a complex disorder with diminished insulin secretion and
insulin action contributing to the hyperglycemia and wide range of metabolic
defects that underlie the disease. The contribution of glucose metabolic
pathways per se in the pathogenesis of the disease remains unclear. The cellular
fate of glucose begins with glucose transport and phosphorylation. Subsequent
pathways of glu... hiện toàn bộ
The Multifaceted Biology of PCSK9Endocrine Reviews - Tập 43 Số 3 - Trang 558-582 - 2022
Nabil G. Seidah, Annik Prat
Abstract This article reviews the discovery of PCSK9, its structure–function
characteristics, and its presently known and proposed novel biological
functions. The major critical function of PCSK9 deduced from human and mouse
studies, as well as cellular and structural analyses, is its role in increasing
the levels of circulating low-density lipoprotein (LDL)-cholesterol (LDLc), via
its ability to ... hiện toàn bộ