The Cellular Fate of Glucose and Its Relevance in Type 2 DiabetesEndocrine Reviews - Tập 25 Số 5 - Trang 807-830 - 2004
C. Bouché, Shanti Serdy, C. Ronald Kahn, Allison B. Goldfine
Type 2 diabetes is a complex disorder with diminished insulin secretion and insulin action contributing to the hyperglycemia and wide range of metabolic defects that underlie the disease. The contribution of glucose metabolic pathways per se in the pathogenesis of the disease remains unclear. The cellular fate of glucose begins with glucose transport and phosphorylation. Subsequent pathway...... hiện toàn bộ