Diagnostic Pathology

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A case of Arrhythmogenic right ventricular cardiomyopathy without arrhythmias
Diagnostic Pathology - - 2012
Jia Wei, Jiang Tang, Liming Xia, Xinshan Chen, Dao Wen Wang
Abstract Arrhythmogenic right ventricular cardiomyopathy (ARVC) is characterized by recurrent coma, ventricular tachycardias and the replacement of the myocardium with fatty and fibrous tissue. We described a 42-year-old female patient without clinical arrhythmias which was diagnosed as ARVC by magnetic resonance imaging (MRI), but the transvenous endomyo...... hiện toàn bộ
Atypical primary biliary cholangitis results in vanishing bile duct syndrome with cutaneous xanthomas: a case report
Diagnostic Pathology - Tập 17 - Trang 1-4 - 2022
Yuebo Jia, Lin Liu, Baocheng Deng, Yu Huang, Jiaqi Zhao, Guang Bai
Vanishing bile duct syndrome (VBDS) is a rare but potentially severe acquired chronic cholestatic liver disease. Bile duct deficiency is a reduction of bile ducts in the liver, which can eventually lead to cholestatic liver disease and progress to biliary cirrhosis. Primary biliary cholangitis (PBC) is one of the causes of bile duct deficiency. In addition, 75% of PBC patients may have dyslipidemi...... hiện toàn bộ
Targeted sequencing identifies the mutational signature of double primary and metastatic malignancies: a case report
Diagnostic Pathology - Tập 14 - Trang 1-7 - 2019
Chuangzhou Rao, Liangqin Nie, Xiaobo Miao, Analyn Lizaso, Guofang Zhao
The accurate identification of the tissue of origin is critical for optimal management of cancer patients particularly those who develop multiple malignancies; however, conventional diagnostic methods at times may fail to provide conclusive diagnosis of the origin of the malignancy. Herein, we describe the use of targeted sequencing in distinguishing the primary and metastatic tumors in a patient ...... hiện toàn bộ
Ovarian cancer: diagnostic accuracy and tumor types distribution in East Africa compared to North America
Diagnostic Pathology - Tập 15 - Trang 1-11 - 2020
Peter F. Rambau, Martin Köbel, Derek Tilley, Alex Mremi, Robert Lukande, William Muller
Ovarian cancer is a spectrum of several histologically distinct tumor types that differ in etiology, response to therapy, and prognosis. In resource-limited settings, the diagnosis of ovarian cancer can be challenging. This study describes the distribution of ovarian cancer tumor types in East Africa as well as assessing the diagnostic accuracy by using contemporary methods. Data from 210 women id...... hiện toàn bộ
Histological subtypes and characteristic structures of HPV-associated oropharyngeal carcinoma; study with Japanese cases
Diagnostic Pathology - Tập 8 - Trang 1-7 - 2013
Mitsuhisa Fujimaki, Yuki Fukumura, Keiko Mitani, Aiko Kurisaki, Junkichi Yokoyama, Katsuhisa Ikeda, Takashi Yao
Human papillomavirus-associated oropharyngeal carcinoma (HPV-OPC) is clinicopathologically distinct entity from the HPV-unassociated one (nHPV-OPC). This study aimed to determine the relationship between histological subtypes of OPC and HPV status for Japanese cases and to identify histological structures of HPV-OPC. 66 OPC cases were categorized into conventional squamous cell carcinoma (SCC) and...... hiện toàn bộ
Renal oncocytoma: a comparative clinicopathologic study and fluorescent in-situ hybridization analysis of 73 cases with long-term follow-up
Diagnostic Pathology - - 2010
Marie Dvorakova, Rajiv Dhir, Sheldon Bastacky, Kathleen Cieply, Marie Acquafondata, Carol R Sherer, Tracy L Mercuri, Anil V. Parwani
Abstract Clinical studies have confirmed that renal oncocytoma (RO) is a benign neoplasm with excellent prognosis. In diagnostically challenging cases of renal oncocytic epithelial neoplasms, fluorescent in-situ hybridization (FISH) is increasingly being used and its ability to distinguish RO from chromophobe renal cell carcinoma (ChRCC) has been document...... hiện toàn bộ
Diagnostic value of clusterin immunostaining in hepatocellular carcinoma
Diagnostic Pathology - Tập 15 - Trang 1-7 - 2020
Yuan Li, Fangfang Liu, Wendi Zhou, Sharon Zhang, Peiguo Chu, Fan Lin, Hanlin L. Wang
Histologic distinction between well differentiated hepatocellular carcinoma (HCC) and benign hepatocellular mass lesions is a known challenge. Existing biomarkers are of limited diagnostic value. Our previous studies observed an enhanced canalicular expression pattern of clusterin (CLU) in HCC, which was not observed in benign hepatocellular mass lesions such as hepatocellular adenoma. The aim of ...... hiện toàn bộ
Combined evaluation of bone marrow aspirate and biopsy is superior in the prognosis of multiple myeloma
Diagnostic Pathology - Tập 5 - Trang 1-7 - 2010
Sanja Štifter, Emina Babarović, Toni Valković, Irena Seili-Bekafigo, Christophe Štemberger, Antica Načinović, Ksenija Lučin, Nives Jonjić
Estimation of plasma cell infiltrates in bone marrow aspirates (BMA) and bone marrow biopsy (BMB) is a standard method in the diagnosis and monitoring of multiple myeloma (MM). Plasma cell fraction in the bone marrow is therefore critical for the classification and optimal clinical management of patients with plasma cell dyscrasias. The aim of the study was to compare the percentage of plasma cell...... hiện toàn bộ
p16INK4a expression in retinoblastoma: a marker of differentiation grade
Diagnostic Pathology - Tập 9 - Trang 1-7 - 2014
Yue Liu, Xiufeng Zhong, Shangtao Wan, Wenxin Zhang, Jianxian Lin, Ping Zhang, Yongping Li
The tumor suppressor protein p16INK4a has been extensively studied in many tumors with very different results, ranging from its loss to its clear overexpression, which may be associated with degree of tumor differentiation and prognosis. However, its expression remains unclear in human retinoblastoma (RB), a common malignant tumor of retina in childhood. The aim of this study was to explore the ex...... hiện toàn bộ
Automatic assessment of the motor state of the Parkinson's disease patient--a case study
Diagnostic Pathology - Tập 7 - Trang 1-8 - 2012
Bozena Kostek, Katarzyna Kaszuba, Pawel Zwan, Piotr Robowski, Jaroslaw Slawek
This paper presents a novel methodology in which the Unified Parkinson's Disease Rating Scale (UPDRS) data processed with a rule-based decision algorithm is used to predict the state of the Parkinson's Disease patients. The research was carried out to investigate whether the advancement of the Parkinson's Disease can be automatically assessed. For this purpose, past and current UPDRS data from 47 ...... hiện toàn bộ
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