Development (Cambridge)

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans
Development (Cambridge) - Tập 126 Số 1 - Trang 37-49 - 1999
Julin Maloof, Jennifer Whangbo, Jeanne M. Harris, Gregg D. Jongeward, Cynthia Kenyon
ABSTRACT The specification of body pattern along the anteroposterior (A/P) body axis is achieved largely by the actions of conserved clusters of Hox genes. Limiting expression of these genes to localized regional domains and controlling the precise patterns of expression within those domains is critically important for normal patterning. Here we repo...... hiện toàn bộ
unc-53controls longitudinal migration inC. elegans
Development (Cambridge) - Tập 129 Số 14 - Trang 3367-3379 - 2002
Eve G. Stringham, Nathalie Pujol, Joël Vandekerckhove, Thierry Bogaert
Cell migration and outgrowth are thought to be based on analogous mechanisms that require repeated cycles of process extension, reading and integration of multiple directional signals, followed by stabilisation in a preferred direction, and renewed extension. We have characterised a C. elegans gene, unc-53, that appears to act cell autonomously in the migration and outgrowth of muscles, ax...... hiện toàn bộ
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1
Development (Cambridge) - Tập 136 Số 4 - Trang 563-574 - 2009
Kim L. Schmidt, Nancy Marcus-Gueret, Adetayo Olumide Adeleye, Jordan Webber, David L. Baillie, Eve G. Stringham
The shape changes that are required to position a cell to migrate or grow out in a particular direction involve a coordinated reorganization of the actin cytoskeleton. Although it is known that the ARP2/3 complex nucleates actin filament assembly, exactly how the information from guidance cues is integrated to elicit ARP2/3-mediated remodeling during outgrowth remains vague. Previous studi...... hiện toàn bộ
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb
Development (Cambridge) - Tập 126 Số 23 - Trang 5515-5522 - 1999
Ramón Merino, Joaquín Rodríguez‐León, D. Macías, Y. Gañán, Aris N. Economides, Juan M. Hurlé
Abstract In this study, we have analyzed the expression and function of Gremlin in the developing avian limb. Gremlin is a member of the DAN family of BMP antagonists highly conserved through evolution able to bind and block BMP2, BMP4 and BMP7. At early stages of development, gremlin is expressed in the dorsal and ventral mesoderm in a pattern compl...... hiện toàn bộ
Antibodies against mouse nerve growth factor interfere in vivo with the development of avian sensory and sympathetic neurones
Development (Cambridge) - Tập 103 Số 3 - Trang 545-552 - 1988
Hermann Rohrer, Magdalena Hofer, Rainer Hellweg, Sigrun I. Korsching, August D. Stehle, Siawusch Saadat, H. Thoenen
Abstract The monoclonal antibody 27/21 directed against mouse nerve growth factor (NGF) interferes in vivo with the survival of sensory dorsal root ganglion (DRG) neurones during the development of the quail embryo: the number of DRG neurones at embryonic day 11 (Ell) was reduced by about 30 % in embryos treated with the antibody between E3 and Ell. ...... hiện toàn bộ
Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity
Development (Cambridge) - Tập 109 Số 2 - Trang 461-471 - 1990
Margaret R. Byers, Gina C. Schatteman, Mark Bothwell
ABSTRACT We have used immunocytochemistry to analyse expression of nerve growth factor receptor (NGFR) in developing, aging and injured molar teeth of rats. The patterns of NGFR immunoreactivity (IR) in developing epithelia and mesenchyme matched the location of NGFR mRNA assayed by in situ hybridization with a complementary S35-labeled RNA probe. Th...... hiện toàn bộ
Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat
Development (Cambridge) - Tập 113 Số 2 - Trang 455-470 - 1991
Christopher S. von Bartheld, Susan L. Patterson, Josef G. Heuer, Esther F. Wheeler, Mark Bothwell, Edwin W. Rubel
ABSTRACT The expression of nerve growth factor receptors (NGFRs) was studied in the developing inner ear with in situ hybridization in chick embryos and with immunocytochemistry in rat embryos to determine sites of possible functions of NGF or NGF-like molecules in inner ear development. NGFR expression in the chick otocyst and acoustic ganglion is c...... hiện toàn bộ
Activity and expression pattern of cyclin-dependent kinase 5 in the embryonic mouse nervous system
Development (Cambridge) - Tập 119 Số 4 - Trang 1029-1040 - 1993
Li‐Huei Tsai, Takao Takahashi, Verne S. Caviness, Ed Harlow
ABSTRACT Cyclin-dependent kinase 5 (cdk5) was originally isolated on the basis of its close primary sequence homology to the human cdc2 serine/threonine kinase, the prototype of the cyclin-dependent kinases. While kinase activities of both cdc2 and cdk2 are detected in proliferating cells and are essential for cells to progress through the key transi...... hiện toàn bộ
Dkk2 plays an essential role in the corneal fate of the ocular surface epithelium
Development (Cambridge) - Tập 133 Số 11 - Trang 2149-2154 - 2006
Mahua Mukhopadhyay, Marat Gorivodsky, Svetlana Shtrom, Alexander Grinberg, Christoph Niehrs, María I. Morasso, Heiner Westphal
The Dkk family of secreted cysteine-rich proteins regulates Wnt/β-catenin signaling by interacting with the Wnt co-receptor Lrp5/6. Here, we show that Dkk2-mediated repression of the Wnt/β-catenin pathway is essential to promote differentiation of the corneal epithelial progenitor cells into a non-keratinizing stratified epithelium. Complete transformation of the corneal epithelium into a ...... hiện toàn bộ
Specification of the vertebrate eye by a network of eye field transcription factors
Development (Cambridge) - Tập 130 Số 21 - Trang 5155-5167 - 2003
Michael E. Zuber, Gaia Gestri, Andrea S. Viczian, Giuseppina Barsacchi, William A. Harris
Several eye-field transcription factors (EFTFs) are expressed in the anterior region of the vertebrate neural plate and are essential for eye formation. The Xenopus EFTFs ET, Rx1, Pax6, Six3, Lhx2, tlland Optx2 are expressed in a dynamic, overlapping pattern in the presumptive eye field. Expression of an EFTF cocktail with Otx2 is sufficient to induce ectopic eyes outside the nervous syste...... hiện toàn bộ
Tổng số: 771   
  • 1
  • 2
  • 3
  • 4
  • 5
  • 6
  • 10