Development (Cambridge)

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pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans
Development (Cambridge) - Tập 126 Số 1 - Trang 1-11 - 1999
Hiroaki Tabara, Russell J. Hill, Craig C. Mello, James R Priess, Yuji Kohara
ABSTRACT Germ cells arise during early C. elegans embryogenesis from an invariant sequence of asymmetric divisions that separate germ cell precursors from somatic precursors. We show that maternal-effect lethal mutations in the gene pos-1 cause germ cell precursors to inappropriately adopt somatic cell fates. During early embryogenesis, pos-1 mRNA an...... hiện toàn bộ
A Wnt signaling pathway controls Hox gene expression and neuroblast migration in C. elegans
Development (Cambridge) - Tập 126 Số 1 - Trang 37-49 - 1999
Julin Maloof, Jennifer Whangbo, Jeanne M. Harris, Gregg D. Jongeward, Cynthia Kenyon
ABSTRACT The specification of body pattern along the anteroposterior (A/P) body axis is achieved largely by the actions of conserved clusters of Hox genes. Limiting expression of these genes to localized regional domains and controlling the precise patterns of expression within those domains is critically important for normal patterning. Here we repo...... hiện toàn bộ
unc-53controls longitudinal migration inC. elegans
Development (Cambridge) - Tập 129 Số 14 - Trang 3367-3379 - 2002
Eve G. Stringham, Nathalie Pujol, Joël Vandekerckhove, Thierry Bogaert
Cell migration and outgrowth are thought to be based on analogous mechanisms that require repeated cycles of process extension, reading and integration of multiple directional signals, followed by stabilisation in a preferred direction, and renewed extension. We have characterised a C. elegans gene, unc-53, that appears to act cell autonomously in the migration and outgrowth of muscles, ax...... hiện toàn bộ
Genetics of cell and axon migrations in Caenorhabditis elegans
Development (Cambridge) - Tập 100 Số 3 - Trang 365-382 - 1987
Edward M. Hedgecock, Joseph G. Culotti, David H. Hall, Brian D. Stern
ABSTRACT The Caenorhabditis elegans epidermis comprises 78 cells which cover the external surface of the embryo as a single cell layer. These cells secrete the cuticle from their exterior faces and support the body wall muscles and most of the nervous system on their interior faces. The epidermal cells arise by autonomous embryonic cell lineages but ...... hiện toàn bộ
Semaphorin 1a and semaphorin 1b are required for correct epidermal cell positioning and adhesion during morphogenesis inC. elegans
Development (Cambridge) - Tập 129 Số 9 - Trang 2065-2078 - 2002
Val E Ginzburg, Peter J. Roy, Joseph G. Culotti
The semaphorin family comprises secreted and transmembrane proteins involved in axon guidance and cell migration. We have isolated and characterized deletion mutants of C. elegans semaphorin 1a (Ce-sema-1a or smp-1) and semaphorin 1b (Ce-sema-1b or smp-2) genes. Both mutants exhibit defects in epidermal functions. For example, the R1.a-derived ray precursor cells frequently fail to change ...... hiện toàn bộ
The cell migration molecule UNC-53/NAV2 is linked to the ARP2/3 complex by ABI-1
Development (Cambridge) - Tập 136 Số 4 - Trang 563-574 - 2009
Kim L. Schmidt, Nancy Marcus-Gueret, Adetayo Olumide Adeleye, Jordan Webber, David L. Baillie, Eve G. Stringham
The shape changes that are required to position a cell to migrate or grow out in a particular direction involve a coordinated reorganization of the actin cytoskeleton. Although it is known that the ARP2/3 complex nucleates actin filament assembly, exactly how the information from guidance cues is integrated to elicit ARP2/3-mediated remodeling during outgrowth remains vague. Previous studi...... hiện toàn bộ
Abi plays an opposing role to Abl inDrosophilaaxonogenesis and synaptogenesis
Development (Cambridge) - Tập 136 Số 18 - Trang 3099-3107 - 2009
Tzu‐Yang Lin, Chiu-Hui Huang, Hsiu-Hua Kao, Gunn‐Guang Liou, Shih‐Rung Yeh, Chih-Ming Cheng, Mei‐Hsin Chen, Rong‐Long Pan, Jyh‐Lyh Juang
Abl tyrosine kinase (Abl) regulates axon guidance by modulating actin dynamics. Abelson interacting protein (Abi), originally identified as a kinase substrate of Abl, also plays a key role in actin dynamics, yet its role with respect to Abl in the developing nervous system remains unclear. Here we show that mutations in abi disrupt axonal patterning in the developing Drosophila central ner...... hiện toàn bộ
mab-20 encodes Semaphorin-2a and is required to prevent ectopic cell contacts during epidermal morphogenesis in Caenorhabditis elegans
Development (Cambridge) - Tập 127 Số 4 - Trang 755-767 - 2000
Peter J. Roy, Hong Zheng, Charles E. Warren, Joseph G. Culotti
ABSTRACT The Semaphorins are a family of secreted and transmembrane proteins known to elicit growth cone repulsion and collapse. We made and characterized a putative null mutant of the C. elegans gene semaphorin-2a (Ce-sema-2a). This mutant failed to complement mutants of mab-20 (Baird, S. E., Fitch, D. H., Kassem, I. A. A. and Emmons, S. W. (1991) D...... hiện toàn bộ
The BMP antagonist Gremlin regulates outgrowth, chondrogenesis and programmed cell death in the developing limb
Development (Cambridge) - Tập 126 Số 23 - Trang 5515-5522 - 1999
Ramón Merino, Joaquín Rodríguez‐León, D. Macías, Y. Gañán, Aris N. Economides, Juan M. Hurlé
Abstract In this study, we have analyzed the expression and function of Gremlin in the developing avian limb. Gremlin is a member of the DAN family of BMP antagonists highly conserved through evolution able to bind and block BMP2, BMP4 and BMP7. At early stages of development, gremlin is expressed in the dorsal and ventral mesoderm in a pattern compl...... hiện toàn bộ
BDNF increases synapse density in dendrites of developing tectal neurons in vivo
Development (Cambridge) - Tập 133 Số 13 - Trang 2477-2486 - 2006
Analiza Lontok Sanchez, Benjamin J. Matthews, Margarita M. Meynard, Bing Hu, Sana Javed, Susana Cohen-Cory
Neuronal connections are established through a series of developmental events that involve close communication between pre- and postsynaptic neurons. In the visual system, BDNF modulates the development of neuronal connectivity by influencing presynaptic retinal ganglion cell (RGC) axons. Increasing BDNF levels in the optic tectum of Xenopus tadpoles significantly increases both axon arbor...... hiện toàn bộ
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