Genetics of cell and axon migrations in Caenorhabditis elegans

Development (Cambridge) - Tập 100 Số 3 - Trang 365-382 - 1987
Edward M. Hedgecock1, Joseph G. Culotti2, David H. Hall3, Brian D. Stern1
11Department of Cell Biology, Roche Institute of Molecular Biology, Nutley, New Jersey 07110, USA
22Department of Molecular Immunology and Neurobiology, Mount Sinai Hospital Research Institute, Toronto, Ontario M5G 1X5, Canada
33Department of Neuroscience, Albert Einstein College of Medicine, Bronx, New York 10461, USA

Tóm tắt

ABSTRACT The Caenorhabditis elegans epidermis comprises 78 cells which cover the external surface of the embryo as a single cell layer. These cells secrete the cuticle from their exterior faces and support the body wall muscles and most of the nervous system on their interior faces. The epidermal cells arise by autonomous embryonic cell lineages but show regulative interactions after their assembly into an epithelium. It is believed that the various epidermal cells express different kinds or amounts of surface molecules that govern their mutual assembly and also guide the attachments and migrations of the underlying body muscles and neurones. The first muscles and neurones may in turn express new surface molecules that refine later cell movements. Mutations in some 30 known genes disrupt the movements of cells or axons along the body wall.

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Tài liệu tham khảo

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Development (Cambridge)

Tập 100 Số 3

365-382

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