Clinical and Translational Medicine
SCOPUS (2016,2019-2022)SCIE-ISI
2001-1326
Cơ quản chủ quản: JOHN WILEY & SONS LTD , John Wiley & Sons Inc.
Lĩnh vực:
Medicine (miscellaneous)Molecular Medicine
Phân tích ảnh hưởng
Các bài báo tiêu biểu
EMT and tumor metastasis
- 2015
AbstractEMT and MET comprise the processes by which cells transit between
epithelial and mesenchymal states, and they play integral roles in both normal
development and cancer metastasis. This article reviews these processes and the
molecular pathways that contribute to them. First, we compare embryogenesis and
development with cancer metastasis. We then discuss the signaling pathways and
the diff...
Mitochondrial transplantation for therapeutic use
Tập 5 Số 1 - 2016
AbstractMitochondria play a key role in the homeostasis of the vast majority of
the body's cells. In the myocardium where mitochondria constitute 30 % of the
total myocardial cell volume, temporary attenuation or obstruction of blood flow
and as a result oxygen delivery to myocardial cells (ischemia) severely alters
mitochondrial structure and function. These alterations in mitochondrial
structure...
Clinical significance of monocyte heterogeneity
Tập 4 Số 1 - 2015
AbstractMonocytes are primitive hematopoietic cells that primarily arise from
the bone marrow, circulate in the peripheral blood and give rise to
differentiated macrophages. Over the past two decades, considerable attention to
monocyte diversity and macrophage polarization has provided contextual clues
into the role of myelomonocytic derivatives in human disease. Until recently,
human monocytes we...
The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassays
Tập 1 Số 1 - 2012
AbstractBackgroundOwing to its ease of collection, saliva is potentially the
sample of choice in diagnosis. Salivary biomolecules have provided a porthole in
surveying a person's health and well‐being. Our study aims were (1) to
demonstrate the effects of pre‐analytical steps, collection and pre‐processing
techniques on salivary protein detection and (2) to establish an indication of
salivary refe...
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancer
Tập 1 Số 1 - 2012
AbstractRapamycin was discovered more than thirty years ago from a soil sample
from the island of Rapa Nui. It was isolated from Streptomyces hygroscopicus and
initial characterization focused on its antifungal activities. Subsequent
characterization showed that it has immunosuppressive properties and has been
used successfully to reduce organ rejection with kidney transplantation.
Rapamycin has p...
Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
Tập 8 Số 1 - 2019
AbstractThe chemical composition of fucoidan, a kind of sulfated polysaccharide
mainly derived from brown seaweed, includes a substantial percentage of
l‐fucose. Fucoidan has various biological and pharmacological activities, such
as anti‐cancer/anti‐tumor, anti‐proliferation, anti‐inflammatory and
immune‐modulatory functions, and fucoidan‐related dietary supplements and
nutraceuticals have recent...
An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous catheters
- 2015
AbstractBackgroundCatheter‐related bloodstream infections (CRBSIs) and
catheter‐related thrombosis (CRT) are common complications of central venous
catheters (CVC), which are used to monitor patient health and deliver
medications. CVCs are subject to protein adsorption and platelet adhesion as
well as colonization by the natural skin flora (i.e. Staphylococcus aureus and
Staphylococcus epidermidis...
Mapping the translational science policy ‘valley of death’
Tập 2 Số 1 - 2013
AbstractTranslating the knowledge from biomedical science into clinical
applications that help patients has been compared to crossing a valley of death
because of the many issues that separate the bench from the bedside and threaten
to stall progress. But translation is also inhibited by a science policy
environment with its own impediments. Mapping these policy impediments give a
more complete pi...
Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathway
- 2017
AbstractCancer cells are the site of numerous metabolic and thermodynamic
abnormalities. We focus this review on the interactions between the canonical
WNT/beta‐catenin pathway and peroxisome proliferator‐activated receptor gamma
(PPAR gamma) in cancers and their implications from an energetic and metabolic
point of view. In numerous tissues, PPAR gamma activation induces inhibition of
beta‐cateni...
The dual functional role of MicroRNA‐18a (miR‐18a) in cancer development
- 2019
AbstractThe polycistronic miR‐17‐92 cluster is instrumental in physiological
processes commonly dysregulated in cancer, such as proliferation, the cell
cycle, apoptosis, and differentiation. MicroRNA‐18a (miR‐18a) is one of the most
conserved and multifunctional miRNAs in the cluster and is frequently
overexpressed in malignant tumors. Altered miR‐18a expression has been found in
various physiolog...