Clinical and Translational Medicine
SCOPUS (SonsInc.)SCIE-ISI
2001-1326
Cơ quản chủ quản: JOHN WILEY & SONS LTD , John Wiley & Sons Inc.
Lĩnh vực:
Medicine (miscellaneous)Molecular Medicine
Các bài báo tiêu biểu
EMT and tumor metastasisAbstract EMT and MET comprise the processes by which cells transit between epithelial and mesenchymal states, and they play integral roles in both normal development and cancer metastasis. This article reviews these processes and the molecular pathways that contribute to them. First, we compare embryogenesis and development with cancer metastasis. We then discuss th... ...
- 2015
Mitochondrial transplantation for therapeutic useAbstract Mitochondria play a key role in the homeostasis of the vast majority of the body's cells. In the myocardium where mitochondria constitute 30 % of the total myocardial cell volume, temporary attenuation or obstruction of blood flow and as a result oxygen delivery to myocardial cells (ischemia) severely alters mitochondrial structure and function. These alter... ...
Tập 5 Số 1 - 2016
The impact of saliva collection and processing methods on CRP, IgE, and Myoglobin immunoassaysAbstract Background Owing to its ease of collection, saliva is potentially the sample of choice in diagnosis. Salivary biomolecules have provided a porthole in surveying a person's health and well‐being. Our study aims were (1) to demonstrate the effects of pre‐analytical steps, collection and pre‐processing techniques on salivary p...
Tập 1 Số 1 - 2012
Clinical significance of monocyte heterogeneityAbstract Monocytes are primitive hematopoietic cells that primarily arise from the bone marrow, circulate in the peripheral blood and give rise to differentiated macrophages. Over the past two decades, considerable attention to monocyte diversity and macrophage polarization has provided contextual clues into the role of myelomonocytic derivatives in human disease. U... ...
Tập 4 Số 1 - 2015
Rapamycin and mTOR: a serendipitous discovery and implications for breast cancerAbstract Rapamycin was discovered more than thirty years ago from a soil sample from the island of Rapa Nui. It was isolated from Streptomyces hygroscopicus and initial characterization focused on its antifungal activities. Subsequent characterization showed that it has immunosuppressive properties and has been used successfully to reduce organ rejection with kidney... ...
Tập 1 Số 1 - 2012
Clinical applications of fucoidan in translational medicine for adjuvant cancer therapyAbstract The chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l ‐fucose. Fucoidan has various biological and pharmacological activities, such as anti‐cancer/anti‐tumor, anti‐proliferation, anti‐inflammatory and immune‐modulatory functions, and fucoidan‐relate... ...
Tập 8 Số 1 - 2019
An engineered micropattern to reduce bacterial colonization, platelet adhesion and fibrin sheath formation for improved biocompatibility of central venous cathetersAbstract Background Catheter‐related bloodstream infections (CRBSIs) and catheter‐related thrombosis (CRT) are common complications of central venous catheters (CVC), which are used to monitor patient health and deliver medications. CVCs are subject to protein adsorption and platelet adhesion as well as colonization by the natural s...
- 2015
Mapping the translational science policy ‘valley of death’Abstract Translating the knowledge from biomedical science into clinical applications that help patients has been compared to crossing a valley of death because of the many issues that separate the bench from the bedside and threaten to stall progress. But translation is also inhibited by a science policy environment with its own impediments. Mapping these policy im... ...
Tập 2 Số 1 - 2013
Thermodynamics in cancers: opposing interactions between PPAR gamma and the canonical WNT/beta‐catenin pathwayAbstract Cancer cells are the site of numerous metabolic and thermodynamic abnormalities. We focus this review on the interactions between the canonical WNT/beta‐catenin pathway and peroxisome proliferator‐activated receptor gamma (PPAR gamma) in cancers and their implications from an energetic and metabolic point of view. In numerous tissues, PPAR gamma activation ... ...
- 2017
The dual functional role of MicroRNA‐18a (miR‐18a) in cancer developmentAbstract The polycistronic miR‐17‐92 cluster is instrumental in physiological processes commonly dysregulated in cancer, such as proliferation, the cell cycle, apoptosis, and differentiation. MicroRNA‐18a (miR‐18a) is one of the most conserved and multifunctional miRNAs in the cluster and is frequently overexpressed in malignant tumors. Altered miR‐18a expression ha... ...
- 2019