Clinical and Translational Medicine

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The gut microbiome and response to immune checkpoint inhibitors: preclinical and clinical strategies
Clinical and Translational Medicine - Tập 8 - Trang 1-14 - 2019
Jun Gong, Alexander Chehrazi-Raffle, Veronica Placencio-Hickok, Michelle Guan, Andrew Hendifar, Ravi Salgia
There is growing interest in identifying predictive biomarkers for inhibitors of programmed cell death protein 1 receptor (PD-1), programmed death ligand 1 (PD-L1), and cytotoxic T-lymphocyte associated protein 4 (CTLA-4). Given the links between the stool microbiota, anticancer immunosurveillance, and general health, the composition of the gut microbiome has recently undergone investigation as a ...... hiện toàn bộ
Dose-dependent Effect of Statin Therapy on Circulating CXCL12 Levels in Patients with Hyperlipidemia
Clinical and Translational Medicine - Tập 1 - Trang 1-5 - 2012
Will Camnitz, Marie D Burdick, Robert M Strieter, Borna Mehrad, Ellen C Keeley
HMG-CoA reductase inhibitors (statins) have pleiotropic effects that are independent of cholesterol-lowering, including a dose-dependent effect on angiogenesis. Angiogenesis plays a critical role both in vascularization of the chronically ischemic myocardium and in stabilization of atherosclerotic plaques. Chemokines, a family of structurally-related cytokine molecules, exert diverse biological fu...... hiện toàn bộ
Hallmarks of epithelial to mesenchymal transition are detectable in Crohn’s disease associated intestinal fibrosis
Clinical and Translational Medicine - - 2015
Michael Scharl, Nicole Huber, Silvia Lang, Alois Fürst, Ekkehard Jehle, Gerhard Rogler
Intestinal fibrosis and subsequent stricture formation represent frequent complications of Crohn’s disease (CD). In many organs, fibrosis develops as a result of epithelial to mesenchymal transition (EMT). Recent studies suggested that EMT could be involved in intestinal fibrosis as a result of chronic inflammation. Here, we investigated whether EMT might be involved in stricture formation in CD p...... hiện toàn bộ
Clinical applications of fucoidan in translational medicine for adjuvant cancer therapy
Clinical and Translational Medicine - Tập 8 Số 1 - 2019
Han‐Shui Hsu, Pai‐An Hwang
AbstractThe chemical composition of fucoidan, a kind of sulfated polysaccharide mainly derived from brown seaweed, includes a substantial percentage of l‐fucose. Fucoidan has various biological and pharmacological activities, such as anti‐cancer/anti‐tumor, anti‐proliferation, anti‐inflammatory and immune‐modulatory functions, and fucoidan‐relate...... hiện toàn bộ
The role of CD133 in cancer: a concise review
Clinical and Translational Medicine - Tập 7 - Trang 1-14 - 2018
Paige M. Glumac, Aaron M. LeBeau
Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeutic development is the cancer’s ability to develop resistance. It has been hypothesized that cancer stem cells are the cause for this resistance, and targeting them will lead to tumor regressi...... hiện toàn bộ
The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
Clinical and Translational Medicine - Tập 9 - Trang 1-12 - 2020
Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang, Naibo Yang
The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim was to explore a cost-effective application of camelid anti-PCSK9 single domain antibodies (sdAbs), which are high variable regions of the camelid heavy chain antibodies (VHHs), as a human PCS...... hiện toàn bộ
A short‐term educational program improved physicians’ adherence to guidelines for COPD and asthma in Shanghai
Clinical and Translational Medicine - - 2012
Xuekun Fang, Shanqun Li, Lei Gao, Na Zhao, Xiangdong Wang, Chunxue Bai
AbstractBackgroundChronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and asthma exert increasing burden on society while the management of them is far from adequate. The objective of this study is to evaluate adherence to guidelines through a patient study, and then investigate the effects of a short‐t...... hiện toàn bộ
Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
Clinical and Translational Medicine - Tập 6 - Trang 1-4 - 2017
Xiaoming Liu, William C. Cho
Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell lung cancer (NSCLC). However, owing to the dynamic expression of PD-L1, degree of mutational/neoantigen load, intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment of ...... hiện toàn bộ
Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury
Clinical and Translational Medicine - Tập 4 - Trang 1-8 - 2015
Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware, Julie A. Bastarache
Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and inflammation are unknown. To test the hypothesis that TF is upregulated early in the course of acute bleomycin lung injury and precedes increased permeability and inflammation we studied the earl...... hiện toàn bộ
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
Clinical and Translational Medicine - Tập 6 Số 1 - 2017
Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong, Peng Xu
AbstractBackgroundCdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart developmental defects, including ventricular septum defects and thin ventricle wall ...... hiện toàn bộ
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