Clinical and Translational Medicine

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The role of CD133 in cancer: a concise review
Clinical and Translational Medicine - Tập 7 - Trang 1-14 - 2018
Paige M. Glumac, Aaron M. LeBeau
Despite the abundant ongoing research efforts, cancer remains one of the most challenging diseases to treat globally. Due to the heterogenous nature of cancer, one of the major clinical challenges in therapeutic development is the cancer’s ability to develop resistance. It has been hypothesized that cancer stem cells are the cause for this resistance, and targeting them will lead to tumor regressi...... hiện toàn bộ
The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
Clinical and Translational Medicine - Tập 9 - Trang 1-12 - 2020
Xinyang Li, Meiniang Wang, Xinhua Zhang, Chuxin Liu, Haitao Xiang, Mi Huang, Yingying Ma, Xiaoyan Gao, Lin Jiang, Xiaopan Liu, Bo Li, Yong Hou, Xiuqing Zhang, Shuang Yang, Naibo Yang
The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting drugs have provided an effective, but extremely expensive treatment for the management of low density lipoprotein (LDL). Our aim was to explore a cost-effective application of camelid anti-PCSK9 single domain antibodies (sdAbs), which are high variable regions of the camelid heavy chain antibodies (VHHs), as a human PCS...... hiện toàn bộ
A short‐term educational program improved physicians’ adherence to guidelines for COPD and asthma in Shanghai
Clinical and Translational Medicine - - 2012
Xuekun Fang, Shanqun Li, Lei Gao, Na Zhao, Xiangdong Wang, Chunxue Bai
AbstractBackgroundChronic pulmonary diseases such as chronic obstructive pulmonary disease (COPD) and asthma exert increasing burden on society while the management of them is far from adequate. The objective of this study is to evaluate adherence to guidelines through a patient study, and then investigate the effects of a short‐t...... hiện toàn bộ
Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
Clinical and Translational Medicine - Tập 6 - Trang 1-4 - 2017
Xiaoming Liu, William C. Cho
Immune checkpoint blockade therapy by targeting the programmed death protein 1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising clinical responses in patients with non-small cell lung cancer (NSCLC). However, owing to the dynamic expression of PD-L1, degree of mutational/neoantigen load, intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment of ...... hiện toàn bộ
Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury
Clinical and Translational Medicine - Tập 4 - Trang 1-8 - 2015
Li Ma, Ciara M. Shaver, Brandon S. Grove, Daphne B. Mitchell, Nancy E. Wickersham, Robert H. Carnahan, Tracy L. Cooper, Brittany E. Brake, Lorraine B. Ware, Julie A. Bastarache
Activation of coagulation by expression of tissue factor (TF) in the airspace is a hallmark of acute lung injury (ALI) but the timing of TF activation in relationship to increases in lung permeability and inflammation are unknown. To test the hypothesis that TF is upregulated early in the course of acute bleomycin lung injury and precedes increased permeability and inflammation we studied the earl...... hiện toàn bộ
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
Clinical and Translational Medicine - Tập 6 Số 1 - 2017
Yang Liu, Jian Wang, Jieli Li, Rui Wang, Binu Tharakan, Shenyuan L. Zhang, Carl W. Tong, Peng Xu
AbstractBackgroundCdc42 is a member of the Rho GTPase family and functions as a molecular switch in regulating cytoskeleton remodeling and cell polarity establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic lethality with heart developmental defects, including ventricular septum defects and thin ventricle wall ...... hiện toàn bộ
Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes
Clinical and Translational Medicine - Tập 7 - Trang 1-7 - 2018
Saori Maruo, Katsuhito Mori, Koka Motoyama, Miyuki Nakamura, Reina Kawarabayashi, Yoshinori Kakutani, Yuko Yamazaki, Tomoaki Morioka, Tetsuo Shoji, Masaaki Inaba, Masanori Emoto
Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin resistance. Lately, adipose tissue has gained prominence as an effector site of fetuin-A. Although fetuin-A—induced proinflammatory polarization and migration of macrophages plays a crucial role, it remains obscure whether monocyte subsets in circulation could simulate characteristics of macrophages in adipose tissues. ...... hiện toàn bộ
Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment
Clinical and Translational Medicine - Tập 7 - Trang 1-10 - 2018
Nicole Roberts, Reem Al Mubarak, David Francisco, Monica Kraft, Hong Wei Chu
Because of its advantage as a minimally invasive procedure, nasal brushings have been increasingly used and proposed as a valuable approach to study lower airway diseases in lieu of bronchial epithelial cells. However, there is limited or conflicting evidence pertaining to whether nasal samples can be surrogates to bronchial samples. The goal of the present study is to test whether nasal epithelia...... hiện toàn bộ
Ý nghĩa của kiểu hình đại thực bào trong ung thư và vật liệu sinh học Dịch bởi AI
Clinical and Translational Medicine - Tập 3 - Trang 1-13 - 2014
Hannah C Bygd, Kiva D Forsmark, Kaitlin M Bratlie
Đại thực bào từ lâu đã được biết đến với các kiểu hình không đồng nhất và khả năng biến đổi. Chúng thể hiện sự đa dạng chức năng với vai trò trong điều hòa sinh lý, sửa chữa mô, miễn dịch và bệnh tật. Có một phổ các kiểu hình đại thực bào với những chức năng hiệu ứng, các yếu tố phân tử, hồ sơ cytokine và chemokine, cũng như sự biểu hiện của thụ thể. Trong các môi trường vi mô khối u, nhóm đại thự...... hiện toàn bộ
#đại thực bào #kiểu hình đại thực bào #ung thư #vật liệu sinh học #liệu pháp ung thư #môi trường vi mô khối u #chữa lành vết thương #phản ứng với vật thể ngoại lai
Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer
Clinical and Translational Medicine - Tập 3 - Trang 1-4 - 2014
Sukhwinder Singh Sohal, Malik Quasir Mahmood, Eugene Haydn Walters
Unfortunately, the research effort directed into chronic obstructive pulmonary disease (COPD) has been disproportionately weak compared to its social importance, and indeed it is the least researched of all common chronic conditions. Tobacco smoking is the major etiological factor. Only 25% of smokers will develop “classic” COPD; in these vulnerable individuals the progression of airways disease t...... hiện toàn bộ
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