Clinical and Translational Medicine
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The role of CD133 in cancer: a concise review
Clinical and Translational Medicine - Tập 7 - Trang 1-14 - 2018
Despite the abundant ongoing research efforts, cancer remains one of the most
challenging diseases to treat globally. Due to the heterogenous nature of
cancer, one of the major clinical challenges in therapeutic development is the
cancer’s ability to develop resistance. It has been hypothesized that cancer
stem cells are the cause for this resistance, and targeting them will lead to
tumor regressi...
The novel llama-human chimeric antibody has potent effect in lowering LDL-c levels in hPCSK9 transgenic rats
Clinical and Translational Medicine - Tập 9 - Trang 1-12 - 2020
The advent of proprotein convertase subtilisin/kexin type 9 (PCSK9)–inhibiting
drugs have provided an effective, but extremely expensive treatment for the
management of low density lipoprotein (LDL). Our aim was to explore a
cost-effective application of camelid anti-PCSK9 single domain antibodies
(sdAbs), which are high variable regions of the camelid heavy chain antibodies
(VHHs), as a human PCS...
A short‐term educational program improved physicians’ adherence to guidelines for COPD and asthma in Shanghai
Clinical and Translational Medicine - - 2012
AbstractBackgroundChronic pulmonary diseases such as chronic obstructive
pulmonary disease (COPD) and asthma exert increasing burden on society while the
management of them is far from adequate. The objective of this study is to
evaluate adherence to guidelines through a patient study, and then investigate
the effects of a short‐term quality improvement educational program among
clinicians in Shan...
Precision medicine in immune checkpoint blockade therapy for non-small cell lung cancer
Clinical and Translational Medicine - Tập 6 - Trang 1-4 - 2017
Immune checkpoint blockade therapy by targeting the programmed death protein
1/programmed death ligand 1 (PD-L1) axis using antibodies has yielded promising
clinical responses in patients with non-small cell lung cancer (NSCLC). However,
owing to the dynamic expression of PD-L1, degree of mutational/neoantigen load,
intratumoral heterogeneity, infiltrated immune cells of tumor microenvironment
of ...
Kinetics of lung tissue factor expression and procoagulant activity in bleomycin induced acute lung injury
Clinical and Translational Medicine - Tập 4 - Trang 1-8 - 2015
Activation of coagulation by expression of tissue factor (TF) in the airspace is
a hallmark of acute lung injury (ALI) but the timing of TF activation in
relationship to increases in lung permeability and inflammation are unknown. To
test the hypothesis that TF is upregulated early in the course of acute
bleomycin lung injury and precedes increased permeability and inflammation we
studied the earl...
Deletion of Cdc42 in embryonic cardiomyocytes results in right ventricle hypoplasia
Clinical and Translational Medicine - Tập 6 Số 1 - 2017
AbstractBackgroundCdc42 is a member of the Rho GTPase family and functions as a
molecular switch in regulating cytoskeleton remodeling and cell polarity
establishment. Inactivating Cdc42 in cardiomyocytes resulted in embryonic
lethality with heart developmental defects, including ventricular septum defects
and thin ventricle wall syndrome.FindingsIn this study, we have generated a
Cdc42 cardiomyoc...
Correlation analysis of monocyte subsets and insulin resistance considering fetuin-A involvement in patients with type 2 diabetes
Clinical and Translational Medicine - Tập 7 - Trang 1-7 - 2018
Fetuin-A is a multifunctional circulating glycoprotein that can induce insulin
resistance. Lately, adipose tissue has gained prominence as an effector site of
fetuin-A. Although fetuin-A—induced proinflammatory polarization and migration
of macrophages plays a crucial role, it remains obscure whether monocyte subsets
in circulation could simulate characteristics of macrophages in adipose tissues.
...
Comparison of paired human nasal and bronchial airway epithelial cell responses to rhinovirus infection and IL-13 treatment
Clinical and Translational Medicine - Tập 7 - Trang 1-10 - 2018
Because of its advantage as a minimally invasive procedure, nasal brushings have
been increasingly used and proposed as a valuable approach to study lower airway
diseases in lieu of bronchial epithelial cells. However, there is limited or
conflicting evidence pertaining to whether nasal samples can be surrogates to
bronchial samples. The goal of the present study is to test whether nasal
epithelia...
Ý nghĩa của kiểu hình đại thực bào trong ung thư và vật liệu sinh học Dịch bởi AI
Clinical and Translational Medicine - Tập 3 - Trang 1-13 - 2014
Đại thực bào từ lâu đã được biết đến với các kiểu hình không đồng nhất và khả
năng biến đổi. Chúng thể hiện sự đa dạng chức năng với vai trò trong điều hòa
sinh lý, sửa chữa mô, miễn dịch và bệnh tật. Có một phổ các kiểu hình đại thực
bào với những chức năng hiệu ứng, các yếu tố phân tử, hồ sơ cytokine và
chemokine, cũng như sự biểu hiện của thụ thể. Trong các môi trường vi mô khối u,
nhóm đại thự...
#đại thực bào #kiểu hình đại thực bào #ung thư #vật liệu sinh học #liệu pháp ung thư #môi trường vi mô khối u #chữa lành vết thương #phản ứng với vật thể ngoại lai
Clinical significance of epithelial mesenchymal transition (EMT) in chronic obstructive pulmonary disease (COPD): potential target for prevention of airway fibrosis and lung cancer
Clinical and Translational Medicine - Tập 3 - Trang 1-4 - 2014
Unfortunately, the research effort directed into chronic obstructive pulmonary
disease (COPD) has been disproportionately weak compared to its social
importance, and indeed it is the least researched of all common chronic
conditions. Tobacco smoking is the major etiological factor. Only 25% of smokers
will develop “classic” COPD; in these vulnerable individuals the progression of
airways disease t...
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