Philip Newsholme, Joaquim Procópio, Manuela Maria Ramos Lima, Tânia Cristina Pithon‐Curi, Rui Curi
AbstractGlucose is widely accepted as the primary nutrient for maintenance and
promotion of cell function. However, we propose that the 5‐carbon amino acids,
glutamine and glutamate, should be considered to be equally important for
maintenance and promotion of cell function. The functions of glutamine are many
and include: substrate for protein synthesis, anabolic precursor for muscle
growth, acid... hiện toàn bộ
AbstractThe effect of aging on the glutathione redox system was evaluated in
this study. For this purpose, we determined reduced glutathione (GSH) and
oxidized glutathione (GSSG) in whole blood, glutathione peroxidase (GPx) and
glutathione reductase (GSSGR) in erythrocytes and selenium (Se) in plasma in 176
healthy individuals. We also calculated GSH/GSSG molar ratios. These subjects
were divided ... hiện toàn bộ
Ramazan Memişoğulları, Seyithan Taysı, Ebubekîr Bakan, İlyas Çapoğlu
AbstractDiabetes Mellitus (DM), a state of chronic hyperglycaemia, is a common
disease affecting over 124 million individuals worldwide. In this study,
erythrocyte glutathione levels, lipid peroxidation, superoxide dismutase,
catalase, and glutathione peroxidase and some extracellular antioxidant protein
levels of patients with type II diabetes mellitus and healthy controls were
investigated. Thir... hiện toàn bộ
AbstractArachidonic acid is a polyunsaturated fatty acid that mediates
inflammation and the functioning of several organs and systems either directly
or upon its conversion into eicosanoids. However, arachidonic acid is found to
be cytotoxic in vitro at concentrations that overlap physiological ones. It is
tempting therefore to speculate that arachidonic acid may be a physiological
inducer of apop... hiện toàn bộ
AbstractThe production of hydrogen peroxide was measured by following the
oxidation of dichlorofluorescein (DCFH) entrapped into platelets. Resting
platelets produced nanomolar quantities of DCF, which was proportional to the
concentration of platelets and was steady during 1 h of incubation. A
significant increase of basal DCF fluorescence was induced by stimuli namely
thrombin, arachidonic acid,... hiện toàn bộ
Grape seed proanthocyanidins (GSPE) and ginkgo biloba extract (EGb761) are
considered to have protective effects against several diseases. The
cardiotoxicity of doxorubicin (DOX) has been reported to be associated with
oxidative damage. This study was conducted to evaluate the cardioprotective
effects of GSPE and EGb761 against DOX‐induced heart injury in rats. DOX was
administered as a single i.p... hiện toàn bộ
S. Asha Devi, R. Vani, M. V. V. Subramanyam, R. Shiva Shankar, Kadirvelu Jeevaratnam
AbstractThis study was aimed at determining the effect of vitamin E, vitamin C,
and carnitine on intermittent hypobaric‐hypoxia‐induced oxidative stress (OS) in
erythrocytes. For this purpose, male Wistar rats of 4 months of age were orally
supplemented with one of the antioxidants prior to exposure to altitudes of
5700 m or 6300 m. Hemoglobin (Hb) and OS indices such as osmotic fragility and
hemo... hiện toàn bộ