Antioxidant status and lipid peroxidation in type II diabetes mellitus

Cell Biochemistry and Function - Tập 21 Số 3 - Trang 291-296 - 2003
Ramazan Memişoğulları1, Seyithan Taysı1, Ebubekîr Bakan1, İlyas Çapoğlu2
1Department of Biochemistry, Medical School, Atatürk University, Erzurum, Turkey
2Department of Internal Medicine, Medical School, Atatürk University, Erzurum, Turkey

Tóm tắt

AbstractDiabetes Mellitus (DM), a state of chronic hyperglycaemia, is a common disease affecting over 124 million individuals worldwide. In this study, erythrocyte glutathione levels, lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase and some extracellular antioxidant protein levels of patients with type II diabetes mellitus and healthy controls were investigated. Thirty‐eight patients (21 males; with age of mean ± SD, 53.1 ± 9.7 years) and 18 clinically healthy subjects (10 males; with age of mean ± SD, 49.3 ± 15.2 years) were included in the study. Levels of erythrocyte lipid peroxidation, serum ceruloplasmin and glucose levels, HbA1C levels, and erythrocyte catalase activity were significantly increased, whereas serum albumin and transferrin levels, erythrocyte glutathione levels, and glutathione peroxidase activity were significantly decreased compared to those of controls. There was no significant difference in superoxide dismutase activity compared to controls. The results suggest that the antioxidant deficiency and excessive peroxide‐mediated damage may appear in non‐insulin dependent diabetes mellitus. Copyright © 2003 John Wiley & Sons, Ltd.

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Cell Biochemistry and Function

Tập 21 Số 3

291-296

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