Cell Biochemistry and Function
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Inhibition of nonstructural protein 15 of SARS‐CoV‐2 by golden spice: A computational insight
Cell Biochemistry and Function - Tập 40 Số 8 - Trang 926-934 - 2022
AbstractThe quick widespread of the coronavirus and speedy upsurge in the tally
of cases demand the fast development of effective drugs. The uridine‐directed
endoribonuclease activity of nonstructural protein 15 (Nsp15) of the coronavirus
is responsible for the invasion of the host immune system. Therefore, developing
potential inhibitors against Nsp15 is a promising strategy. In this concern, the...
Glutamine and glutamate—their central role in cell metabolism and function
Cell Biochemistry and Function - Tập 21 Số 1 - Trang 1-9 - 2003
AbstractGlucose is widely accepted as the primary nutrient for maintenance and
promotion of cell function. However, we propose that the 5‐carbon amino acids,
glutamine and glutamate, should be considered to be equally important for
maintenance and promotion of cell function. The functions of glutamine are many
and include: substrate for protein synthesis, anabolic precursor for muscle
growth, acid...
Modification of frequency augmentation‐potentiation by GTPγS in the frog neuromuscular junction
Cell Biochemistry and Function - Tập 13 Số 2 - Trang 105-109 - 1995
AbstractThe effect of modifiers of guanine nucleotide‐binding proteins (G
proteins) on the frequency augmentation‐potentiation of transmitter release were
studied in the frog neuromuscular junction. Using GenetransferR as a carrier the
mean quantal content of the endplate potential increased by penetration of GTPγS
into the presynaptic nerve terminal. Neither GTPγS alone nor carrier alone had
any ...
Intermittent hypobaric hypoxia‐induced oxidative stress in rat erythrocytes: protective effects of vitamin E, vitamin C, and carnitine
Cell Biochemistry and Function - Tập 25 Số 2 - Trang 221-231 - 2007
AbstractThis study was aimed at determining the effect of vitamin E, vitamin C,
and carnitine on intermittent hypobaric‐hypoxia‐induced oxidative stress (OS) in
erythrocytes. For this purpose, male Wistar rats of 4 months of age were orally
supplemented with one of the antioxidants prior to exposure to altitudes of
5700 m or 6300 m. Hemoglobin (Hb) and OS indices such as osmotic fragility and
hemo...
PPARγ inhibits inflammatory reaction in oxidative stress induced human diploid fibloblast
Cell Biochemistry and Function - Tập 28 Số 6 - Trang 490-496 - 2010
AbstractThe ageing of an inevitable life function is an unavoidable regressive
physical process. Peroxisome proliferator‐activated receptors (PPARs) are
members of the nuclear hormone receptor family. PPARγ plays an important role in
regulating several metabolic pathways. Recently, PPARγ has been implicated in
inflammatory responses and age‐related diseases. The aim of this study was to
determine ...
Clofibrate feeding increases cytoplasmic but not mitochondrial malic enzyme activity in rat kidney cortex
Cell Biochemistry and Function - Tập 7 Số 2 - Trang 97-103 - 1989
AbstractAdministration of clofibrate for 21 days to rats increased the malic
enzyme activity in the kidney cortex by about 80 per cent. This effect seems to
be specific since the drug did not alter significantly the activity either of
lactate dehydrogenase, citrate synthase or total mitochondrial protein content
in this organ.The increase in activity of malic enzyme in the 13 000 g
supernatant (ex...
Antioxidant and antiapoptotic effects of proanthocyanidin and ginkgo biloba extract against doxorubicin‐induced cardiac injury in rats
Cell Biochemistry and Function - Tập 31 Số 4 - Trang 344-351 - 2013
Grape seed proanthocyanidins (GSPE) and ginkgo biloba extract (EGb761) are
considered to have protective effects against several diseases. The
cardiotoxicity of doxorubicin (DOX) has been reported to be associated with
oxidative damage. This study was conducted to evaluate the cardioprotective
effects of GSPE and EGb761 against DOX‐induced heart injury in rats. DOX was
administered as a single i.p...
Effect of progesterone on the expression of GABAA receptor subunits in the prefrontal cortex of rats: implications of sex differences and brain hemisphere
Cell Biochemistry and Function - Tập 30 Số 8 - Trang 696-700 - 2012
Progesterone is a neuroactive hormone with non‐genomic effects on GABAA
receptors (GABAAR). Changes in the expression of GABAAR subunits are related to
depressive‐like behaviors in rats. Moreover, sex differences and depressive
behaviors have been associated with prefrontal brain asymmetry in rodents and
humans. Thus, our objective was to investigate the effect of progesterone on the
GABAAR α1 and...
Down‐regulation of semaphorin 3F in rat retinal ganglion cells in response to optic nerve crush
Cell Biochemistry and Function - Tập 34 Số 5 - Trang 378-384 - 2016
Glaucoma is characterized by degeneration of optic nerve axons and death of
retinal ganglion cells (RGCs). Nerve crush and axotomy of the optic nerve are
studied as models of RGC death in glaucoma and of axon regeneration. The
mechanisms underlying the response of RGCs to axonal injury remain unclear,
however. We have now examined the effects of optic nerve crush on the expression
of members of th...
Expression and immunohistochemical localization of Cdc2 and P70S6K in different stages of mouse germ cells
Cell Biochemistry and Function - Tập 24 Số 2 - Trang 113-117 - 2006
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