Cancers
SCIE-ISI SCOPUS (2009-2025)
2072-6694
Thụy Sĩ
Cơ quản chủ quản: Multidisciplinary Digital Publishing Institute (MDPI) , MDPI
Lĩnh vực:
Cancer ResearchOncology
Các bài báo tiêu biểu
Drug Resistance in Cancer: An OverviewCancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition... ...
Tập 6 Số 3 - Trang 1769-1792
Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side EffectsPlatinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity, e.g., by interference with transcription and/or DNA replication mechanisms. Additionally, cisplatin damages tumors via induction of apoptosis, mediated by the activation of various signal transduction pathways, in... ...
Tập 3 Số 1 - Trang 1351-1371
Epidermal Growth Factor Receptor Cell Proliferation Signaling PathwaysThe epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast cancer. Various mechanisms mediate the upregulation of EGFR activity, including common mutations and truncations to its extracellular domain, s... ...
Tập 9 Số 5 - Trang 52
Tumor-Associated Macrophages as Major Players in the Tumor MicroenvironmentDuring tumor progression, circulating monocytes and macrophages are actively recruited into tumors where they alter the tumor microenvironment to accelerate tumor progression. Macrophages shift their functional phenotypes in response to various microenvironmental signals generated from tumor and stromal cells. Based on their function, macrophages are divided broadly into two categories: cl... ...
Tập 6 Số 3 - Trang 1670-1690
Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of EvidenceCancer is associated with higher morbidity and mortality and is the second leading cause of death in the US. Further, in some nations, cancer has overtaken heart disease as the leading cause of mortality. Identification of molecular mechanisms by which cancerous cells evade T cell-mediated cytotoxic damage has led to the modern era of immunotherapy in cancer treatment. Agents that release ... ...
Tập 12 Số 3 - Trang 738
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future DirectionsPhotodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a tw... ...
Tập 9 Số 2 - Trang 19
Assessment of the Evolution of Cancer Treatment TherapiesCancer therapy has been characterized throughout history by ups and downs, not only due to the ineffectiveness of treatments and side effects, but also by hope and the reality of complete remission and cure in many cases. Within the therapeutic arsenal, alongside surgery in the case of solid tumors, are the antitumor drugs and radiation that have been the treatment of choice in some instan... ...
Tập 3 Số 3 - Trang 3279-3330
STAT3 Target Genes Relevant to Human CancersSince its discovery, the STAT3 transcription factor has been extensively studied for its function as a transcriptional regulator and its role as a mediator of development, normal physiology, and pathology of many diseases, including cancers. These efforts have uncovered an array of genes that can be positively and negatively regulated by STAT3, alone and in cooperation with other transcrip... ...
Tập 6 Số 2 - Trang 897-925
Regulation of EMT in Colorectal Cancer: A Culprit in MetastasisEpithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance cell polarity and cell–cell contact, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. In this review, we discuss recent studies exploring novel regulation mechanisms... ...
Tập 9 Số 12 - Trang 171
The Epithelial-to-Mesenchymal Transition in CancerThe epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...]
Tập 10 Số 2 - Trang 52