Cancers

SCIE-ISI SCOPUS (2009-2023)

  2072-6694

 

  Thụy Sĩ

Cơ quản chủ quản:  Multidisciplinary Digital Publishing Institute (MDPI) , MDPI

Lĩnh vực:
Cancer ResearchOncology

Các bài báo tiêu biểu

Drug Resistance in Cancer: An Overview
Tập 6 Số 3 - Trang 1769-1792
Genevieve Housman, Shannon Byler, Sarah Heerboth, K Lapińska, Mckenna Longacre, Nicole Snyder, Sibaji Sarkar
Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current knowledge of mechanisms that promote or enable drug resistance, such as drug inactivation, drug target alteration, drug efflux, DNA damage repair, cell death inhibition...... hiện toàn bộ
Cisplatin as an Anti-Tumor Drug: Cellular Mechanisms of Activity, Drug Resistance and Induced Side Effects
Tập 3 Số 1 - Trang 1351-1371
Ana-Maria Florea, Dietrich Büsselberg
Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity, e.g., by interference with transcription and/or DNA replication mechanisms. Additionally, cisplatin damages tumors via induction of apoptosis, mediated by the activation of various signal transduction pathways, in...... hiện toàn bộ
Epidermal Growth Factor Receptor Cell Proliferation Signaling Pathways
Tập 9 Số 5 - Trang 52
Ping Wee, Zhixiang Wang
The epidermal growth factor receptor (EGFR) is a receptor tyrosine kinase that is commonly upregulated in cancers such as in non-small-cell lung cancer, metastatic colorectal cancer, glioblastoma, head and neck cancer, pancreatic cancer, and breast cancer. Various mechanisms mediate the upregulation of EGFR activity, including common mutations and truncations to its extracellular domain, s...... hiện toàn bộ
Tumor-Associated Macrophages as Major Players in the Tumor Microenvironment
Tập 6 Số 3 - Trang 1670-1690
Theerawut Chanmee, Pawared Ontong, Kenjiro Konno, Naoki Itano
During tumor progression, circulating monocytes and macrophages are actively recruited into tumors where they alter the tumor microenvironment to accelerate tumor progression. Macrophages shift their functional phenotypes in response to various microenvironmental signals generated from tumor and stromal cells. Based on their function, macrophages are divided broadly into two categories: cl...... hiện toàn bộ
Review of Indications of FDA-Approved Immune Checkpoint Inhibitors per NCCN Guidelines with the Level of Evidence
Tập 12 Số 3 - Trang 738
Raju Vaddepally, Prakash Kharel, Ramesh Kumar Pandey, Rohan Garje, Abhinav Chandra
Cancer is associated with higher morbidity and mortality and is the second leading cause of death in the US. Further, in some nations, cancer has overtaken heart disease as the leading cause of mortality. Identification of molecular mechanisms by which cancerous cells evade T cell-mediated cytotoxic damage has led to the modern era of immunotherapy in cancer treatment. Agents that release ...... hiện toàn bộ
Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions
Tập 9 Số 2 - Trang 19
Demian van Straten, Vida Mashayekhi, Henk de Bruijn, Sabrina Oliveira, Dominic J. Robinson
Photodynamic therapy (PDT) is a clinically approved cancer therapy, based on a photochemical reaction between a light activatable molecule or photosensitizer, light, and molecular oxygen. When these three harmless components are present together, reactive oxygen species are formed. These can directly damage cells and/or vasculature, and induce inflammatory and immune responses. PDT is a tw...... hiện toàn bộ
Assessment of the Evolution of Cancer Treatment Therapies
Tập 3 Số 3 - Trang 3279-3330
Manuel Arruebo, Nuria Vilaboa, Berta Sáez, J. Lambea, A. Trés, M. Valladares, África González‐Fernández
Cancer therapy has been characterized throughout history by ups and downs, not only due to the ineffectiveness of treatments and side effects, but also by hope and the reality of complete remission and cure in many cases. Within the therapeutic arsenal, alongside surgery in the case of solid tumors, are the antitumor drugs and radiation that have been the treatment of choice in some instan...... hiện toàn bộ
STAT3 Target Genes Relevant to Human Cancers
Tập 6 Số 2 - Trang 897-925
Richard L. Carpenter, Hui‐Wen Lo
Since its discovery, the STAT3 transcription factor has been extensively studied for its function as a transcriptional regulator and its role as a mediator of development, normal physiology, and pathology of many diseases, including cancers. These efforts have uncovered an array of genes that can be positively and negatively regulated by STAT3, alone and in cooperation with other transcrip...... hiện toàn bộ
Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis
Tập 9 Số 12 - Trang 171
Trung Vu, Pran K. Datta
Epithelial to mesenchymal transition (EMT) is a process during which cells lose their epithelial characteristics, for instance cell polarity and cell–cell contact, and gain mesenchymal properties, such as increased motility. In colorectal cancer (CRC), EMT is associated with an invasive or metastatic phenotype. In this review, we discuss recent studies exploring novel regulation mechanisms...... hiện toàn bộ
The Epithelial-to-Mesenchymal Transition in Cancer
Tập 10 Số 2 - Trang 52
Joëlle Roche
The epithelial-to-mesenchymal transition (EMT) occurs during normal embryonic development, tissue regeneration, organ fibrosis, and wound healing.[...]