Cancers

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HPV Associated Head and Neck Cancer
Cancers - Tập 8 Số 8 - Trang 75
Tara Spence, Jeff Bruce, Kenneth W. Yip, Fei‐Fei Liu
Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that are associated with diverse clinical outcomes. Recent evidence has demonstrated that human papillomavirus (HPV) is involved in up to 25% of HNCs; particularly in the oropharyngeal carcinoma (OPC) subtype where it can account for up to 60% of such cases. HPVs are double-stranded DNA viruses that infect epithelial ...... hiện toàn bộ
Long-Term Outcome and Comparison of Treatment Modalities of Temporal Bone Paragangliomas
Cancers - Tập 13 Số 20 - Trang 5083
Erdem Yıldız, Valerie Dahm, Wolfgang Gstœttner, Karl Rössler, Belinda Bauer, Alexander Wressnegger, Ursula Nemec, Brigitte Gatterbauer, Christian Matula, Christoph Arnoldner
Introduction: Temporal bone paragangliomas are rare tumors with high vascularization and usually benign entity. A variety of modalities, including gross total resection, subtotal resection, conventional or stereotactic radiotherapy including gamma-knife, embolization, and wait-and-scan strategy can be considered. The aim of this study was to compare long-term outcomes of different primary ...... hiện toàn bộ
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells
Cancers - Tập 11 Số 4 - Trang 542
Pawan Faris, Giorgia Pellavio, Federica Ferulli, Francesca Di Nezza, Mudhir Sabir Shekha, Dmitry Lim, Marcello Maestri, Germano Guerra, Luigi Ambrosone, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia
Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced EL Ca2+ signals may be amplified by the endoplasmic reticulum (ER) through the Ca2+-induced Ca2+ release mechanism (CICR). Herein, we aimed at assessing for the first time the role of EL Ca2+ signaling in primary cultures of human m...... hiện toàn bộ
Targeted Therapy for Biliary Tract Cancer
Cancers - Tập 3 Số 2 - Trang 2243-2254
Junji Furuse, Takuji Okusaka
It is necessary to establish effective chemotherapy to improve the survival of patients with biliary tract cancer, because most of these patients are unsuitable candidates for surgery, and even patients undergoing curative surgery often have recurrence. Recently, the combination of cisplatin plus gemcitabine was reported to show survival benefits over gemcitabine alone in randomized clinic...... hiện toàn bộ
Breast Cancer Tumor Stroma: Cellular Components, Phenotypic Heterogeneity, Intercellular Communication, Prognostic Implications and Therapeutic Opportunities
Cancers - Tập 11 Số 5 - Trang 664
Noemí Eiró, Luis O. González, María Fraile, Sandra Cid, J. Schneider, Francisco J. Vizoso
Although the mechanisms underlying the genesis and progression of breast cancer are better understood than ever, it is still the most frequent malignant tumor in women and one of the leading causes of cancer death. Therefore, we need to establish new approaches that lead us to better understand the prognosis of this heterogeneous systemic disease and to propose new therapeutic strategies. ...... hiện toàn bộ
Therapeutic Targeting of Hyaluronan in the Tumor Stroma
Cancers - Tập 4 Số 3 - Trang 873-903
Anne Kultti, Xiaoming Li, Ping Jiang, Curtis B. Thompson, Gary Frost, H. Michael Shepard
The tumor stroma, consisting of non-malignant cells and the extracellular matrix, undergoes significant quantitative and qualitative changes throughout malignant transformation and tumor progression. With increasing recognition of the role of the tumor microenvironment in disease progression, stromal components of the tumor have become attractive targets for therapeutic intervention. Strom...... hiện toàn bộ
CPT1A Over-Expression Increases Reactive Oxygen Species in the Mitochondria and Promotes Antioxidant Defenses in Prostate Cancer
Cancers - Tập 12 Số 11 - Trang 3431
Molishree Joshi, Jihye Kim, Angelo D’Alessandro, Emily Monk, Kimberley D. Bruce, Hanan Elajaili, Eva Nozik‐Grayck, Andrew Goodspeed, James C. Costello, Isabel R. Schlaepfer
Cancers reprogram their metabolism to adapt to environmental changes. In this study, we examined the consequences of altered expression of the mitochondrial enzyme carnitine palmitoyl transferase I (CPT1A) in prostate cancer (PCa) cell models. Using transcriptomic and metabolomic analyses, we compared LNCaP-C4-2 cell lines with depleted (knockdown (KD)) or increased (overexpression (OE)) C...... hiện toàn bộ
Targeting Cancer Stem Cells in Triple-Negative Breast Cancer
Cancers - Tập 11 Số 7 - Trang 965
Park, Choi, Jeong‐Seok Nam
Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer that lacks targeted therapy options, and patients diagnosed with TNBC have poorer outcomes than patients with other breast cancer subtypes. Emerging evidence suggests that breast cancer stem cells (BCSCs), which have tumor-initiating potential and possess self-renewal capacity, may be responsible for this poo...... hiện toàn bộ
Esophageal Cancer-Derived Extracellular Vesicle miR-21-5p Contributes to EMT of ESCC Cells by Disorganizing Macrophage Polarization
Cancers - Tập 13 Số 16 - Trang 4122
Jing Song, Peiyan Yang, Xiuwen Li, Xinyi Zhu, Mengxin Liu, Xuexin Duan, Ran Liu
The disorganized polarization of tumor-associated macrophages (TAMs) exerts a critical effect on tumor progression. MicroRNAs (miRNAs) in extracellular vesicles (EVs) secreted from cancer cells may contribute to this process. However, the relationship between TAMs and EVs-miRNAs-mediated regulation in esophageal squamous cell carcinoma (ESCC) remains unclear. In the present study, immunoaf...... hiện toàn bộ
Peritoneal Metastasis: Current Status and Treatment Options
Cancers - Tập 14 Số 1 - Trang 60
Lilian Roth, Linda Russo, Sima Ulugoel, Rafael Freire dos Santos, Eva Breuer, Anurag Gupta, Kuno Lehmann
Peritoneal metastasis (PM) originating from gastrointestinal cancer was considered a terminal disease until recently. The advent of better systemic treatment, a better understanding of prognostic factors, and finally, the advent of novel loco-regional therapies, has opened the door for the multimodal treatment of PM. These strategies, including radical surgery and hyperthermic intraperiton...... hiện toàn bộ
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