Cancers
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HPV Associated Head and Neck Cancer
Cancers - Tập 8 Số 8 - Trang 75
Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that
are associated with diverse clinical outcomes. Recent evidence has demonstrated
that human papillomavirus (HPV) is involved in up to 25% of HNCs; particularly
in the oropharyngeal carcinoma (OPC) subtype where it can account for up to 60%
of such cases. HPVs are double-stranded DNA viruses that infect epithelial
cells; n...
The Role of Extracellular HSP70 in the Function of Tumor-Associated Immune Cells
Cancers - Tập 13 Số 18 - Trang 4721
Extracellular vesicles released by tumor cells (T-EVs) are known to contain
danger-associated molecular patterns (DAMPs), which are released in response to
cellular stress to alert the immune system to the dangerous cell. Part of this
defense mechanism is the heat shock protein 70 (HSP70), and HSP70-positive T-EVs
are known to trigger anti-tumor immune responses. Moreover, extracellular HSP70
acts...
Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies
Cancers - Tập 12 Số 6 - Trang 1668
Hepatocellular carcinoma (HCC) metabolism is redirected to glycolysis to enhance
the production of metabolic compounds employed by cancer cells to produce
proteins, lipids, and nucleotides in order to maintain a high proliferative
rate. This mechanism drives towards uncontrolled growth and causes a further
increase in reactive oxygen species (ROS), which could lead to cell death. HCC
overcomes the...
Mucins and Pancreatic Cancer
Cancers - Tập 2 Số 4 - Trang 1794-1812
Pancreatic cancer is characterized by an often dramatic outcome (five year
survival < 5%) related to a late diagnosis and a lack of efficient therapy.
Therefore, clinicians desperately need new biomarkers and new therapeutic tools
to develop new efficient therapies. Mucins belong to an ever increasing family
of O-glycoproteins. Secreted mucins are the main component of mucus protecting
the epithel...
Atypical Histiocytoid Cells and Multinucleated Giant Cells in Fine-Needle Aspiration Cytology of the Thyroid Predict Lymph Node Metastasis of Papillary Thyroid Carcinoma
Cancers - Tập 11 Số 6 - Trang 816
Preoperative detection of cervical lymph node metastasis in papillary thyroid
carcinoma (PTC) is crucial for determining the surgical strategy to prevent
locoregional recurrence of the disease. We identified the cytological predictors
of lymph node metastasis in 222 consecutive patients with PTC using fine-needle
aspiration cytology (FNAC) of the thyroid. Cervical lymph node metastases
occurred in...
Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia
Cancers - Tập 13 Số 11 - Trang 2847
Background: The aim of this study was to evaluate whether molecular
classification prognosticates treatment response in women with endometrial
cancers and endometrial intraepithelial neoplasia (EIN) treated with
levonorgestrel intrauterine system (LNG-IUS). Methods: Patients treated with
LNG-IUS for endometrial cancer or EIN from 2013 to 2018 were evaluated. Using
immunohistochemistry and single g...
Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer
Cancers - Tập 12 Số 7 - Trang 1754
Liquid biopsy may assist in the management of cancer patients, which can be
particularly applicable in pancreatic ductal adenocarcinoma (PDAC). In this
study, we investigated the utility of circulating cell-free DNA (cfDNA)-based
markers as prognostic tools in metastatic PDAC. Plasma was obtained from 61
metastatic PDAC patients, and cfDNA levels and fragmentation were determined.
BEAMing techniqu...
Long-Term Outcome and Comparison of Treatment Modalities of Temporal Bone Paragangliomas
Cancers - Tập 13 Số 20 - Trang 5083
Introduction: Temporal bone paragangliomas are rare tumors with high
vascularization and usually benign entity. A variety of modalities, including
gross total resection, subtotal resection, conventional or stereotactic
radiotherapy including gamma-knife, embolization, and wait-and-scan strategy can
be considered. The aim of this study was to compare long-term outcomes of
different primary treatmen...
Lysophospholipid Signaling in the Epithelial Ovarian Cancer Tumor Microenvironment
Cancers - Tập 10 Số 7 - Trang 227
As one of the important cancer hallmarks, metabolism reprogramming, including
lipid metabolism alterations, occurs in tumor cells and the tumor
microenvironment (TME). It plays an important role in tumorigenesis,
progression, and metastasis. Lipids, and several lysophospholipids in
particular, are elevated in the blood, ascites, and/or epithelial ovarian cancer
(EOC) tissues, making them not only ...
Roles of StearoylCoA Desaturase-1 in the Regulation of Cancer Cell Growth, Survival and Tumorigenesis
Cancers - Tập 3 Số 2 - Trang 2462-2477
The development and maintenance of defining features of cancer, such as
unremitting cell proliferation, evasion of programmed cell death, and the
capacity for colonizing local tissues and distant organs, demand a massive
production of structural, signaling and energy-storing lipid biomolecules of
appropriate fatty acid composition. Due to constitutive activation of fatty acid
biosynthesis, cancer ...
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