Cancers

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HPV Associated Head and Neck Cancer
Cancers - Tập 8 Số 8 - Trang 75
Tara Spence, Jeff Bruce, Kenneth W. Yip, Fei‐Fei Liu
Head and neck cancers (HNCs) are a highly heterogeneous group of tumours that are associated with diverse clinical outcomes. Recent evidence has demonstrated that human papillomavirus (HPV) is involved in up to 25% of HNCs; particularly in the oropharyngeal carcinoma (OPC) subtype where it can account for up to 60% of such cases. HPVs are double-stranded DNA viruses that infect epithelial ...... hiện toàn bộ
The Role of Extracellular HSP70 in the Function of Tumor-Associated Immune Cells
Cancers - Tập 13 Số 18 - Trang 4721
Manuel Linder, Elke Pogge von Strandmann
Extracellular vesicles released by tumor cells (T-EVs) are known to contain danger-associated molecular patterns (DAMPs), which are released in response to cellular stress to alert the immune system to the dangerous cell. Part of this defense mechanism is the heat shock protein 70 (HSP70), and HSP70-positive T-EVs are known to trigger anti-tumor immune responses. Moreover, extracellular HS...... hiện toàn bộ
Glucose Metabolism and Oxidative Stress in Hepatocellular Carcinoma: Role and Possible Implications in Novel Therapeutic Strategies
Cancers - Tập 12 Số 6 - Trang 1668
Monica Mossenta, Davide Busato, Michele Dal Bo, Giuseppe Toffoli
Hepatocellular carcinoma (HCC) metabolism is redirected to glycolysis to enhance the production of metabolic compounds employed by cancer cells to produce proteins, lipids, and nucleotides in order to maintain a high proliferative rate. This mechanism drives towards uncontrolled growth and causes a further increase in reactive oxygen species (ROS), which could lead to cell death. HCC overc...... hiện toàn bộ
Mucins and Pancreatic Cancer
Cancers - Tập 2 Số 4 - Trang 1794-1812
Nicolas Jonckheere, Nicolas Skrypek, Isabelle Van Seuningen
Pancreatic cancer is characterized by an often dramatic outcome (five year survival < 5%) related to a late diagnosis and a lack of efficient therapy. Therefore, clinicians desperately need new biomarkers and new therapeutic tools to develop new efficient therapies. Mucins belong to an ever increasing family of O-glycoproteins. Secreted mucins are the main component of mucus protecting ...... hiện toàn bộ
Molecular Classification to Prognosticate Response in Medically Managed Endometrial Cancers and Endometrial Intraepithelial Neoplasia
Cancers - Tập 13 Số 11 - Trang 2847
Allison Puechl, Daniel Spinosa, Andrew Berchuck, Angeles Alvarez Secord, Kerry E. Drury, Gloria Broadwater, Janice Wong, Regina Whitaker, Nicolas Devos, David L. Corcoran, Kyle C. Strickland, Rebecca A. Previs
Background: The aim of this study was to evaluate whether molecular classification prognosticates treatment response in women with endometrial cancers and endometrial intraepithelial neoplasia (EIN) treated with levonorgestrel intrauterine system (LNG-IUS). Methods: Patients treated with LNG-IUS for endometrial cancer or EIN from 2013 to 2018 were evaluated. Using immunohistochemistry and ...... hiện toàn bộ
Circulating Cell-Free DNA-Based Liquid Biopsy Markers for the Non-Invasive Prognosis and Monitoring of Metastatic Pancreatic Cancer
Cancers - Tập 12 Số 7 - Trang 1754
Marta Toledano‐Fonseca, María Teresa Cano, Elizabeth Inga, Rosa María Rodríguez-Alonso, María Auxiliadora Gómez‐España, Silvia Guil‐Luna, Rafael Mena‐Osuna, Juan de la Haba, Antonio Rodríguez‐Ariza, Enrique Aranda
Liquid biopsy may assist in the management of cancer patients, which can be particularly applicable in pancreatic ductal adenocarcinoma (PDAC). In this study, we investigated the utility of circulating cell-free DNA (cfDNA)-based markers as prognostic tools in metastatic PDAC. Plasma was obtained from 61 metastatic PDAC patients, and cfDNA levels and fragmentation were determined. BEAMing ...... hiện toàn bộ
Long-Term Outcome and Comparison of Treatment Modalities of Temporal Bone Paragangliomas
Cancers - Tập 13 Số 20 - Trang 5083
Erdem Yıldız, Valerie Dahm, Wolfgang Gstœttner, Karl Rössler, Belinda Bauer, Alexander Wressnegger, Ursula Nemec, Brigitte Gatterbauer, Christian Matula, Christoph Arnoldner
Introduction: Temporal bone paragangliomas are rare tumors with high vascularization and usually benign entity. A variety of modalities, including gross total resection, subtotal resection, conventional or stereotactic radiotherapy including gamma-knife, embolization, and wait-and-scan strategy can be considered. The aim of this study was to compare long-term outcomes of different primary ...... hiện toàn bộ
Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) Induces Intracellular Ca2+ Release through the Two-Pore Channel TPC1 in Metastatic Colorectal Cancer Cells
Cancers - Tập 11 Số 4 - Trang 542
Pawan Faris, Giorgia Pellavio, Federica Ferulli, Francesca Di Nezza, Mudhir Sabir Shekha, Dmitry Lim, Marcello Maestri, Germano Guerra, Luigi Ambrosone, Paolo Pedrazzoli, Umberto Laforenza, Daniela Montagna, Francesco Moccia
Nicotinic acid adenine dinucleotide phosphate (NAADP) gates two-pore channels 1 and 2 (TPC1 and TPC2) to elicit endo-lysosomal (EL) Ca2+ release. NAADP-induced EL Ca2+ signals may be amplified by the endoplasmic reticulum (ER) through the Ca2+-induced Ca2+ release mechanism (CICR). Herein, we aimed at assessing for the first time the role of EL Ca2+ signaling in primary cultures of human m...... hiện toàn bộ
Targeted Therapy for Biliary Tract Cancer
Cancers - Tập 3 Số 2 - Trang 2243-2254
Junji Furuse, Takuji Okusaka
It is necessary to establish effective chemotherapy to improve the survival of patients with biliary tract cancer, because most of these patients are unsuitable candidates for surgery, and even patients undergoing curative surgery often have recurrence. Recently, the combination of cisplatin plus gemcitabine was reported to show survival benefits over gemcitabine alone in randomized clinic...... hiện toàn bộ
Nanoparticles Loaded with the BET Inhibitor JQ1 Block the Growth of Triple Negative Breast Cancer Cells In Vitro and In Vivo
Cancers - Tập 12 Số 1 - Trang 91
Valentina Maggisano, Marilena Celano, Rocco Malivindi, Ines Barone, Donato Cosco, Catia Mio, Chiara Mignogna, Salvatore Panza, Giuseppe Damante, Massimo Fresta, Sebastiano Andò, Diego Russo, Stefania Catalano, Stefania Bulotta
Inhibition of bromo-and extra-terminal domain (BET) proteins, epigenetic regulators of genes involved in cell viability, has been efficiently tested in preclinical models of triple negative breast cancer (TNBC). However, the use of the selective BET-inhibitor JQ1 on humans is limited by its very short half-life. Herein, we developed, characterized and tested a novel formulation of nanopart...... hiện toàn bộ
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