STAT3 Target Genes Relevant to Human Cancers

Akira, 1994, Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway, Cell, 77, 63, 10.1016/0092-8674(94)90235-6

Wegenka, 1993, Acute-phase response factor, a nuclear factor binding to acute-phase response elements, is rapidly activated by interleukin-6 at the posttranslational level, Mol. Cell. Biol., 13, 276

Darnell, 1994, JAK-STAT pathways and transcriptional activation in response to ifns and other extracellular signaling proteins, Science, 264, 1415, 10.1126/science.8197455

Fu, 1999, From PTK-STAT signaling to caspase expression and apoptosis induction, Cell Death Differ., 6, 1201, 10.1038/sj.cdd.4400613

Liu, 2005, STAT3 nuclear import is independent of tyrosine phosphorylation and mediated by importin-alpha3, Proc. Natl. Acad. Sci. USA, 102, 8150, 10.1073/pnas.0501643102

Yang, 2005, Novel roles of unphosphorylated STAT3 in oncogenesis and transcriptional regulation, Cancer Res., 65, 939, 10.1158/0008-5472.939.65.3

Matikainen, 1999, Interferon-alpha activates multiple stat proteins and upregulates proliferation-associated IL-2Ralpha, c-myc, and pim-1 genes in human T cells, Blood, 93, 1980, 10.1182/blood.V93.6.1980.406k20_1980_1991

Puthier, 1999, IL-6 up-regulates Mcl-1 in human myeloma cells through JAK/STAT rather than Ras/MAP kinase pathway, Eur. J. Immunol., 29, 3945, 10.1002/(SICI)1521-4141(199912)29:12<3945::AID-IMMU3945>3.0.CO;2-O

Yu, 1995, Enhanced DNA-binding activity of a STAT3-related protein in cells transformed by the Src oncoprotein, Science, 269, 81, 10.1126/science.7541555

Wen, 1997, Mapping of STAT3 serine phosphorylation to a single residue (727) and evidence that serine phosphorylation has no influence on DNA binding of stat1 and stat3, Nucleic Acids Res., 25, 2062, 10.1093/nar/25.11.2062

Qin, 2008, Activation of signal transducer and activator of transcription 3 through a phosphomimetic serine 727 promotes prostate tumorigenesis independent of tyrosine 705 phosphorylation, Cancer Res., 68, 7736, 10.1158/0008-5472.CAN-08-1125

Bousquet, 1999, Inhibitory roles for SHP-1 and SOCS-3 following pituitary proopiomelanocortin induction by leukemia inhibitory factor, J. Clin. Investig., 104, 1277, 10.1172/JCI7924

Chung, 1997, Specific inhibition of STAT3 signal transduction by PIAS3, Science, 278, 1803, 10.1126/science.278.5344.1803

Starr, 1997, A family of cytokine-inducible inhibitors of signalling, Nature, 387, 917, 10.1038/43206

Yang, 2008, The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas, Clin. Cancer Res., 14, 8228, 10.1158/1078-0432.CCR-08-1329

Alvarez, 2007, A STAT3 gene expression signature in gliomas is associated with a poor prognosis, Transl. Oncogenomics, 2, 99, 10.4137/TOG.S1903

Lo, 2008, Constitutively activated Stat3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to iressa and alkylators, Clin. Cancer Res., 14, 6042, 10.1158/1078-0432.CCR-07-4923

Lo, 2005, Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway, Cancer Cell, 7, 575, 10.1016/j.ccr.2005.05.007

Lo, 2007, Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of twist gene expression, Cancer Res., 67, 9066, 10.1158/0008-5472.CAN-07-0575

Ecker, 2009, The dark and the bright side of STAT3: Proto-oncogene and tumor-suppressor, Front. Biosci., 14, 2944, 10.2741/3425

Clevenger, 2004, Roles and regulation of stat family transcription factors in human breast cancer, Am. J. Pathol., 165, 1449, 10.1016/S0002-9440(10)63403-7

Ling, 2005, Knockdown of STAT3 expression by rna interference inhibits the induction of breast tumors in immunocompetent mice, Cancer Res., 65, 2532, 10.1158/0008-5472.CAN-04-2425

Chan, 2004, Disruption of STAT3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis, J. Clin. Investig., 114, 720, 10.1172/JCI200421032

Pedranzini, 2004, STAT3 is required for the development of skin cancer, J. Clin. Investig., 114, 619, 10.1172/JCI22800

Konopka, 2008, Identification of a pten-regulated STAT3 brain tumor suppressor pathway, Genes Dev., 22, 449, 10.1101/gad.1606508

Seidel, 1995, Spacing of palindromic half sites as a determinant of selective stat (signal transducers and activators of transcription) DNA binding and transcriptional activity, Proc. Natl. Acad. Sci. USA, 92, 3041, 10.1073/pnas.92.7.3041

Yang, 2003, Independent and cooperative activation of chromosomal c-fos promoter by STAT3, J. Biol. Chem., 278, 15794, 10.1074/jbc.M213073200

Niu, 2008, Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells, Mol. Cancer Res., 6, 1099, 10.1158/1541-7786.MCR-07-2177

Kiuchi, 1999, STAT3 is required for the gp130-mediated full activation of the c-myc gene, J. Exp. Med., 189, 63, 10.1084/jem.189.1.63

Foshay, 2008, Regulation of Sox2 by STAT3 initiates commitment to the neural precursor cell fate, Stem Cells Dev., 17, 269, 10.1089/scd.2007.0098

Okumura, 2011, TRIM8 regulates nanog via Hsp90beta-mediated nuclear translocation of STAT3 in embryonic stem cells, Biochim. Biophys. Acta, 1813, 1784, 10.1016/j.bbamcr.2011.05.013

Xiong, 2012, Roles of STAT3 and ZEB1 proteins in E-cadherin down-regulation and human colorectal cancer epithelial-mesenchymal transition, J. Biol. Chem., 287, 5819, 10.1074/jbc.M111.295964

Niu, 2005, Role of STAT3 in regulating p53 expression and function, Mol. Cell. Biol., 25, 7432, 10.1128/MCB.25.17.7432-7440.2005

Wang, 2013, STAT3 is involved in esophageal carcinogenesis through regulation of Oct-1, Carcinogenesis, 34, 678, 10.1093/carcin/bgs361

Choi, 2012, Overexpression of phospholipase D enhances Bcl-2 expression by activating STAT3 through independent activation of ERK and p38MAPK in HeLa cells, Biochim. Biophys. Acta, 1823, 1082, 10.1016/j.bbamcr.2012.03.015

Becker, 2013, Mutant B-RAF-Mcl-1 survival signaling depends on the STAT3 transcription factor, Oncogene, 33, 1158, 10.1038/onc.2013.45

Liu, 2001, Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression, J. Clin. Investig., 107, 351, 10.1172/JCI9940

Landowski, 1999, Constitutive activation of STAT3 signaling confers resistance to apoptosis in human U266 myeloma cells, Immunity, 10, 105, 10.1016/S1074-7613(00)80011-4

Gritsko, 2006, Persistent activation of STAT3 signaling induces survivin gene expression and confers resistance to apoptosis in human breast cancer cells, Clin. Cancer Res., 12, 11, 10.1158/1078-0432.CCR-04-1752

Ivanov, 2001, Cooperation between STAT3 and c-Jun suppresses fas transcription, Mol. Cell, 7, 517, 10.1016/S1097-2765(01)00199-X

Madamanchi, 2001, Thrombin regulates vascular smooth muscle cell growth and heat shock proteins via the JAK-STAT pathway, J. Biol. Chem., 276, 18915, 10.1074/jbc.M008802200

Chen, 2007, Diverse effects of STAT1 on the regulation of Hsp90alpha gene under heat shock, J. Cell. Biochem., 102, 1059, 10.1002/jcb.21342

Bromberg, 1999, STAT3 as an oncogene, Cell, 98, 295, 10.1016/S0092-8674(00)81959-5

Leslie, 2006, Cyclin D1 is transcriptionally regulated by and required for transformation by activated signal transducer and activator of transcription 3, Cancer Res., 66, 2544, 10.1158/0008-5472.CAN-05-2203

Sinibaldi, 2000, Induction of p21WAF1/CIP1 and cyclin D1 expression by the Src oncoprotein in mouse fibroblasts: Role of activated STAT3 signaling, Oncogene, 19, 5419, 10.1038/sj.onc.1203947

Schaefer, 2009, Mechanism of interferon-gamma mediated down-regulation of interleukin-10 gene expression, Mol. Immunol., 46, 1351, 10.1016/j.molimm.2008.11.015

Kortylewski, 2009, Regulation of the IL-23 and IL-12 balance by STAT3 signaling in the tumor microenvironment, Cancer Cell, 15, 114, 10.1016/j.ccr.2008.12.018

Kinjyo, 2006, Loss of SOCS3 in T helper cells resulted in reduced immune responses and hyperproduction of interleukin 10 and transforming growth factor-beta 1, J. Exp. Med., 203, 1021, 10.1084/jem.20052333

Lo, 2010, Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes, Mol. Cancer Res., 8, 232, 10.1158/1541-7786.MCR-09-0391

Itoh, 2006, Requirement of STAT3 activation for maximal collagenase-1 (MMP-1) induction by epidermal growth factor and malignant characteristics in T24 bladder cancer cells, Oncogene, 25, 1195, 10.1038/sj.onc.1209149

Xie, 2004, STAT3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis, Oncogene, 23, 3550, 10.1038/sj.onc.1207383

Liu, 2013, Stat3 regulates MMP3 in heme-induced endothelial cell apoptosis, PLoS One, 8, e71366, 10.1371/journal.pone.0071366

Song, 2008, Fra-1 and STAT3 synergistically regulate activation of human MMP-9 gene, Mol. Immun., 45, 137, 10.1016/j.molimm.2007.04.031

Snyder, 2011, Signal transducers and activators of transcription 3 (STAT3) directly regulates cytokine-induced fascin expression and is required for breast cancer cell migration, J. Biol. Chem., 286, 38886, 10.1074/jbc.M111.286245

Wu, 2004, STAT3 enhances vimentin gene expression by binding to the antisilencer element and interacting with the repressor protein, ZBP-89, Oncogene, 23, 168, 10.1038/sj.onc.1207003

Schiavone, 2009, The Rhou/Wrch1 Rho GTPase gene is a common transcriptional target of both the gp130/STAT3 and Wnt-1 pathways, Biochem. J., 421, 283, 10.1042/BJ20090061

Schuringa, 2001, c-Jun and c-Fos cooperate with STAT3 in IL-6-induced transactivation of the IL-6 respone element (IRE), Cytokine, 14, 78, 10.1006/cyto.2001.0856

Jung, 2012, Interleukin-10-induced neutrophil gelatinase-associated lipocalin production in macrophages with consequences for tumor growth, Mol. Cell. Biol., 32, 3938, 10.1128/MCB.00413-12

Bousquet, 2000, Direct regulation of pituitary proopiomelanocortin by STAT3 provides a novel mechanism for immuno-neuroendocrine interfacing, J. Clin. Investig., 106, 1417, 10.1172/JCI11182

Hagihara, 2005, Essential role of STAT3 in cytokine-driven NF-κb-mediated serum amyloid a gene expression, Genes Cells: Devoted Mol. Cell. Mech., 10, 1051, 10.1111/j.1365-2443.2005.00900.x

Niu, 2002, Constitutive STAT3 activity up-regulates vegf expression and tumor angiogenesis, Oncogene, 21, 2000, 10.1038/sj.onc.1205260

Huang, 2013, STAT1 activation by venous malformations mutant Tie2-R849W antagonizes VEGF-A-mediated angiogenic response partly via reduced bFGF production, Angiogenesis, 16, 207, 10.1007/s10456-012-9313-x

Hung, 2001, Co-operative effect of c-Src tyrosine kinase and STAT3 in activation of hepatocyte growth factor expression in mammary carcinoma cells, J. Biol. Chem., 276, 12395, 10.1074/jbc.M010715200

Nakagawa, 2013, Prevention of Reg I-induced beta-cell apoptosis by IL-6/dexamethasone through activation of HGF gene regulation, Biochim. Biophys. Acta, 1833, 2988, 10.1016/j.bbamcr.2013.08.004

Xu, 2005, Targeting STAT3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways, Oncogene, 24, 5552, 10.1038/sj.onc.1208719

Przanowski, 2013, The signal transducers STAT1 and STAT3 and their novel target JMJD3 drive the expression of inflammatory genes in microglia, J. Mol. Med., 92, 239, 10.1007/s00109-013-1090-5

Hamilton, 2011, Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells, Mol. Cancer Res., 9, 1718, 10.1158/1541-7786.MCR-10-0210

Lee, 2010, STAT3-induced s1pr1 expression is crucial for persistent STAT3 activation in tumors, Nat. Med., 16, 1421, 10.1038/nm.2250

Ahmad, R., Rajabi, H., Kosugi, M., Joshi, M.D., Alam, M., Vasir, B., Kawano, T., Kharbanda, S., and Kufe, D. (2011). MUC1-C oncoprotein promotes STAT3 activation in an autoinductive regulatory loop. Sci. Signal., 4.

Gaemers, 2001, A STAT-responsive element in the promoter of the episialin/MUC1 gene is involved in its overexpression in carcinoma cells, J. Biol. Chem., 276, 6191, 10.1074/jbc.M009449200

Oh, 2011, STAT3 protein promotes T-cell survival and inhibits interleukin-2 production through up-regulation of class o forkhead transcription factors, J. Biol. Chem., 286, 30888, 10.1074/jbc.M111.253500

Zorn, 2006, IL-2 regulates Foxp3 expression in human CD4+CD25+ regulatory T cells through a STAT-dependent mechanism and induces the expansion of these cells in vivo, Blood, 108, 1571, 10.1182/blood-2006-02-004747

Haviland, 2011, Necdin, a negative growth regulator, is a novel STAT3 target gene down-regulated in human cancer, PLoS One, 6, e24923, 10.1371/journal.pone.0024923

Bellido, 1998, Transcriptional activation of the p21 WAF1,CIP1,SDI1 gene by interleukin-6 type cytokines: A prerequisite for their pro-differentiating and anti-apoptotic effects on human osteoblastic cells, J. Biol. Chem., 273, 21137, 10.1074/jbc.273.33.21137

Chin, 1996, Cell growth arrest and induction of cyclin-dependent kinase inhibitor p21 WAF1/CIP1 mediated by STAT1, Science, 272, 719, 10.1126/science.272.5262.719

Giraud, 2002, Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a, J. Biol. Chem., 277, 8004, 10.1074/jbc.M111486200

Abell, 2005, STAT3-induced apoptosis requires a molecular switch in PI(3)K subunit composition, Nat. Cell Biol., 7, 392, 10.1038/ncb1242

Cheng, 2003, A critical role for STAT3 signaling in immune tolerance, Immunity, 19, 425, 10.1016/S1074-7613(03)00232-2

Kang, 2012, Intracellular interaction of interleukin (IL)-32alpha with protein kinase cepsilon (pkcepsilon) and STAT3 protein augments IL-6 production in THP-1 promonocytic cells, J. Biol. Chem., 287, 35556, 10.1074/jbc.M112.400911

Wang, 2004, Regulation of the innate and adaptive immune responses by STAT-3 signaling in tumor cells, Nat. Med., 10, 48, 10.1038/nm976

Chappell, 2000, STAT proteins play a role in tumor necrosis factor alpha gene expression, Shock, 14, 400, 10.1097/00024382-200014030-00027

Kusaba, 2005, Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (MTOR), J. Biol. Chem., 280, 1037, 10.1074/jbc.M405204200

Yang, 2007, Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NF-κb, Genes Dev., 21, 1396, 10.1101/gad.1553707

Zhang, 1996, STAT3 participates in transcriptional activation of the C-reactive protein gene by interleukin-6, J. Biol. Chem., 271, 9503, 10.1074/jbc.271.16.9503

Han, 2013, STAT1 gene expression is enhanced by nuclear EGFR and HER2 via cooperation with STAT3, Mol. Carcinog., 52, 959, 10.1002/mc.21936

Durant, 2010, Diverse targets of the transcription factor STAT3 contribute to T cell pathogenicity and homeostasis, Immunity, 32, 605, 10.1016/j.immuni.2010.05.003

Thomas, 2012, Conserved intergenic elements and DNA methylation cooperate to regulate transcription at the IL17 locus, J. Biol. Chem., 287, 25049, 10.1074/jbc.M112.351916

Adamson, 2013, Tissue inhibitor of metalloproteinase 1 is preferentially expressed in th1 and Th17 T-helper cell subsets and is a direct stat target gene, PLoS One, 8, e59367, 10.1371/journal.pone.0059367

Bugno, 1995, Identification of the interleukin-6/oncostatin m response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1) promoter, Nucleic Acids Res., 23, 5041, 10.1093/nar/23.24.5041

Coffer, 1995, Transcriptional regulation of the junB promoter: Analysis of STAT-mediated signal transduction, Oncogene, 10, 985

Barre, 2005, The STAT3 transcription factor is a target for the Myc and riboblastoma proteins on the CDC25a promoter, J. Biol. Chem., 280, 15673, 10.1074/jbc.M413203200

Shaulian, 2010, Ap-1—the jun proteins: Oncogenes or tumor suppressors in disguise?, Cell. Signal., 22, 894, 10.1016/j.cellsig.2009.12.008

Weidemann, 2008, Biology of HIF-1α, Cell Death Differ., 15, 621, 10.1038/cdd.2008.12

Jung, 2005, STAT3 is a potential modulator of HIF-1-mediated VEGF expression in human renal carcinoma cells, FASEB J., 19, 1296, 10.1096/fj.04-3099fje

Ji, 2012, Clinical implications of cancer stem cell biology in hepatocellular carcinoma, Semin. Oncol., 39, 461, 10.1053/j.seminoncol.2012.05.011

Hindley, 2013, The cell cycle and pluripotency, Biochem. J., 451, 135, 10.1042/BJ20121627

Philip, 2013, HIF expression and the role of hypoxic microenvironments within primary tumours as protective sites driving cancer stem cell renewal and metastatic progression, Carcinogenesis, 34, 1699, 10.1093/carcin/bgt209

Liu, 2012, Emt-activating transcription factors in cancer: Beyond emt and tumor invasiveness, Cell. Mol. Life Sci., 69, 3429, 10.1007/s00018-012-1122-2

Kang, 2009, Stem cells, stress, metabolism and cancer: A drama in two octs, Trends Biochem. Sci., 34, 491, 10.1016/j.tibs.2009.06.003

Obinata, 2012, Oct1 regulates cell growth of LNCaP cells and is a prognostic factor for prostate cancer, Int. J. Cancer J. Int. Cancer, 130, 1021, 10.1002/ijc.26043

Wang, 2013, Targeting cancer stem cells: Emerging role of Nanog transcription factor, Onco Targets Ther., 6, 1207

Levine, 2009, The first 30 years of p53: Growing ever more complex, Nat. Rev. Cancer, 9, 749, 10.1038/nrc2723

Chao, 1998, Mcl-1 is an immediate-early gene activated by the granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathway and is one component of the GM-CSF viability response, Mol. Cell. Biol., 18, 4883, 10.1128/MCB.18.8.4883

Wang, 1999, The antiapoptotic gene mcl-1 is up-regulated by the phosphatidylinositol 3-kinase/AKT signaling pathway through a transcription factor complex containing creb, Mol. Cell. Biol., 19, 6195, 10.1128/MCB.19.9.6195

Oskay Halacli, S., Halacli, B., and Altundag, K. (2013). The significance of heat shock proteins in breast cancer therapy. Med. Oncol., 30.

Bertoli, 2013, Control of cell cycle transcription during G1 and S phases, Nat. Rev. Mol. Cell Biol., 14, 518, 10.1038/nrm3629

Kortylewski, 2005, Inhibiting STAT3 signaling in the hematopoietic system elicits multicomponent antitumor immunity, Nat. Med., 11, 1314, 10.1038/nm1325

Kitamura, 2005, IL-6-STAT3 controls intracellular MHC class II αβ dimer level through cathepsin s activity in dendritic cells, Immunity, 23, 491, 10.1016/j.immuni.2005.09.010

Benkhart, 2000, Role of STAT3 in lipopolysaccharide-induced IL-10 gene expression, J. Immunol., 165, 1612, 10.4049/jimmunol.165.3.1612

Lotzerich, 2003, IFN-α induces the human IL-10 gene by recruiting both ifn regulatory factor 1 and STAT3, J. Immunol., 171, 285, 10.4049/jimmunol.171.1.285

Langowski, 2006, IL-23 promotes tumour incidence and growth, Nature, 442, 461, 10.1038/nature04808

Cheng, 2013, Role of cyclooxygenase-2 in gastric cancer development and progression, World J. Gastroenterol., 19, 7361, 10.3748/wjg.v19.i42.7361

Zugowski, 2011, STAT3 controls matrix metalloproteinase-1 expression in colon carcinoma cells by both direct and AP-1-mediated interaction with the MMP-1 promoter, Biol. Chem., 392, 449, 10.1515/bc.2011.038

Dechow, 2004, Requirement of matrix metalloproteinase-9 for the transformation of human mammary epithelial cells by STAT3-c, Proc. Natl. Acad. Sci. USA, 101, 10602, 10.1073/pnas.0404100101

Chen, 2010, Migrastatin analogues target fascin to block tumour metastasis, Nature, 464, 1062, 10.1038/nature08978

Chuang, 2007, The atypical Rho family GTPase Wrch-1 regulates focal adhesion formation and cell migration, J. Cell Sci., 120, 1927, 10.1242/jcs.03456

Ory, 2007, Identification of a bipartite focal adhesion localization signal in Rhou/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration, Biol. Cell, 99, 701, 10.1042/BC20070058

Kobayashi, 2007, Endothelial cell adhesion molecules and cancer progression, Curr. Med. Chem., 14, 377, 10.2174/092986707779941032

Veitonmaki, 2013, A human icam-1 antibody isolated by a function-first approach has potent macrophage-dependent antimyeloma activity in vivo, Cancer Cell, 23, 502, 10.1016/j.ccr.2013.02.026

Zhu, 2013, Expression and role of icam-1 in the occurrence and development of hepatocellular carcinoma, Asian Pac. J. Cancer Prev., 14, 1579, 10.7314/APJCP.2013.14.3.1579

Chakraborty, 2012, The multifaceted roles of neutrophil gelatinase associated lipocalin (NGAL) in inflammation and cancer, Biochim. Biophys. Acta, 1826, 129

Sherbet, 2005, Hormonal influences on cancer progression and prognosis, Vitam. Horm., 71, 147, 10.1016/S0083-6729(05)71006-2

Malle, 2009, Serum amyloid A: An acute-phase protein involved in tumour pathogenesis, Cell. Mol. Life Sci., 66, 9, 10.1007/s00018-008-8321-x

Deng, 2013, STAT3 is associated with lymph node metastasis in gastric cancer, Tumour Biol., 34, 2791, 10.1007/s13277-013-0837-5

Huang, 2013, Activation of the STAT3 signaling pathway is associated with poor survival in diffuse large B-cell lymphoma treated with R-chop, J. Clin. Oncol., 31, 4520, 10.1200/JCO.2012.45.6004

Xu, 2014, A meta-analysis of STAT3 and phospho-STAT3 expression and survival of patients with non-small-cell lung cancer, Eur. J. Surg. Oncol., 40, 311, 10.1016/j.ejso.2013.11.012

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Megeney, 1996, bFGF and LIF signaling activates STAT3 in proliferating myoblasts, Dev. Genet., 19, 139, 10.1002/(SICI)1520-6408(1996)19:2<139::AID-DVG5>3.0.CO;2-A

Cheung, 2013, Diverse mechanisms of AKT pathway activation in human malignancy, Curr. Cancer Drug Targets, 13, 234, 10.2174/1568009611313030002

Carnero, 2013, Pim kinases in cancer: Diagnostic, prognostic and treatment opportunities, Biochem. Pharmacol., 85, 629, 10.1016/j.bcp.2012.09.018

Shirogane, 1999, Synergistic roles for Pim-1 and c-Myc in STAT3-mediated cell cycle progression and antiapoptosis, Immunity, 11, 709, 10.1016/S1074-7613(00)80145-4

Mizoguchi, 2002, Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice, Gastroenterology, 122, 134, 10.1053/gast.2002.30347

Kunkel, 2013, Targeting the sphingosine-1-phosphate axis in cancer, inflammation and beyond, Nat. Rev. Drug Discov., 12, 688, 10.1038/nrd4099

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Zhang, 2011, Foxo family members in cancer, Cancer Biol. Ther., 12, 253, 10.4161/cbt.12.4.15954

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Asai, 2013, Necdin, a p53 target gene, in stem cells, Oncotarget, 4, 806, 10.18632/oncotarget.997

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Chapman, 1999, Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of STAT3, Genes Dev., 13, 2604, 10.1101/gad.13.19.2604

Allin, 2011, Elevated c-reactive protein in the diagnosis, prognosis, and cause of cancer, Crit. Rev. Clin. Lab. Sci., 48, 155, 10.3109/10408363.2011.599831

Kolev, 2011, Complement in cancer and cancer immunotherapy, Arch. Immunol. Ther. Exp., 59, 407, 10.1007/s00005-011-0146-x

Koromilas, 2013, The tumor suppressor function of STAT1 in breast cancer, JAK-STAT, 2, e23353, 10.4161/jkst.23353

Ernst, 2008, STAT3 and STAT1 mediate IL-11-dependent and inflammation-associated gastric tumorigenesis in gp130 receptor mutant mice, J. Clin. Investig., 118, 1727

Harrington, 2005, Interleukin 17-producing CD4+ effector t cells develop via a lineage distinct from the T helper type 1 and 2 lineages, Nat. Immunol., 6, 1123, 10.1038/ni1254

Park, 2005, A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17, Nat. Immunol., 6, 1133, 10.1038/ni1261

Qi, 2013, Correlation between Th17 cells and tumor microenvironment, Cell. Immunol., 285, 18, 10.1016/j.cellimm.2013.06.001

Ye, 2013, The role and regulation of human Th17 cells in tumor immunity, Am. J. Pathol., 182, 10, 10.1016/j.ajpath.2012.08.041

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Janakiram, 2012, Inos-selective inhibitors for cancer prevention: Promise and progress, Future Med. Chem., 4, 2193, 10.4155/fmc.12.168

Johnson, 2012, Phosphatases driving mitosis: Pushing the gas and lifting the brakes, Prog. Mol. Biol. Transl. Sci., 106, 327, 10.1016/B978-0-12-396456-4.00008-0