Biotechnology Journal

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Understanding physiological responses to pre‐treatment inhibitors in ethanologenic fermentations
Biotechnology Journal - Tập 7 Số 9 - Trang 1169-1181 - 2012
Mark Taylor, Inonge Mulako, Marla Trindade, Don A. Cowan
AbstractAlcohol‐based liquid fuels feature significantly in the political and social agendas of many countries, seeking energy sustainability. It is certain that ethanol will be the entry point for many sustainable processes. Conventional ethanol production using maize‐ and sugarcane‐based carbohydrates with Saccharomyces cerevisiae is well established, while ligno...... hiện toàn bộ
Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model
Biotechnology Journal - Tập 7 Số 3 - Trang 409-417 - 2012
Diane Wuest, Kelvin H. Lee
AbstractIn vitro cell culture models of the blood–brain barrier (BBB) are important tools used to study cellular physiology and brain disease therapeutics. Although the number of model configurations is expanding across neuroscience laboratories, it is not clear that any have been effectively optimized. A sequential screening study to identify optimal primary mouse...... hiện toàn bộ
Bioreactors in tissue engineering—principles, applications and commercial constraints
Biotechnology Journal - Tập 8 Số 3 - Trang 298-307 - 2013
Jan Hansmann, Florian Groeber, Alexander Kahlig, Claudia Kleinhans, Heike Walles
AbstractBioreactor technology is vital for tissue engineering. Usually, bioreactors are used to provide a tissue‐specific physiological in vitro environment during tissue maturation. In addition to this most obvious application, bioreactors have the potential to improve the efficiency of the overall tissue‐engineering concept. To date, a variety of bioreactor syste...... hiện toàn bộ
Eukaryotic metabolism: Measuring compartment fluxes
Biotechnology Journal - Tập 6 Số 9 - Trang 1071-1085 - 2011
Judith Wahrheit, Averina Nicolae, Elmar Heinzle
AbstractMetabolic compartmentation represents a major characteristic of eukaryotic cells. The analysis of compartmented metabolic networks is complicated by separation and parallelization of pathways, intracellular transport, and the need for regulatory systems to mediate communication between interdependent compartments. Metabolic flux analysis (MFA) has the poten...... hiện toàn bộ
Arrayed cellular environments for stem cells and regenerative medicine
Biotechnology Journal - Tập 8 Số 2 - Trang 167-179 - 2013
Drew M. Titmarsh, Huaying Chen, Ernst J. Wolvetang, Justin J. Cooper‐White
AbstractThe behavior and composition of both multipotent and pluripotent stem cell populations are exquisitely controlled by a complex, spatiotemporally variable interplay of physico‐chemical, extracellular matrix, cell‐cell interaction, and soluble factor cues that collectively define the stem cell niche. The push for stem cell‐based regenerative medicine models a...... hiện toàn bộ
Enantioselective reduction of pentoxifylline to lisofylline using whole‐cell Lactobacillus kefiri biotransformation
Biotechnology Journal - Tập 2 Số 4 - Trang 492-496 - 2007
Elżbieta Pękala, Anna Godawska‐Matysik, Dorota Żelaszczyk
AbstractLisofylline (LSF) is a drug candidate that has been under investigation for acute respiratory distress syndrome, acute lung injury, septic shock and mucositis. As LSF is not commercially available in our country, we produced it for pharmacokinetic studies. In the present work whole‐cell reduction of pentoxifylline [1‐(5‐oxohexyl)‐3,5‐dimethylxanthine] to LS...... hiện toàn bộ
Manufacturing of recombinant therapeutic proteins in microbial systems
Biotechnology Journal - Tập 1 Số 2 - Trang 164-186 - 2006
Klaus Graumann, Andreas Premstaller
AbstractRecombinant therapeutic proteins have gained enormous importance for clinical applications. The first recombinant products have been produced in E. coli more than 20 years ago. Although with the advent of antibody‐based therapeutics mammalian expression systems have experienced a major boost, microbial expression systems continue to be widely used in indust...... hiện toàn bộ
PEGylation of therapeutic proteins
Biotechnology Journal - Tập 5 Số 1 - Trang 113-128 - 2010
Simona Jevševar, Menči Kunstelj, Vladka Gaberc Porekar
AbstractSince the first PEGylated product was approved by the Food and Drug Administration in 1990, PEGylation has been widely used as a post‐production modification methodology for improving biomedical efficacy and physicochemical properties of therapeutic proteins. Applicability and safety of this technology have been proven by use of various PEGylated pharmaceut...... hiện toàn bộ
Free Marine Natural Products Databases for Biotechnology and Bioengineering
Biotechnology Journal - Tập 14 Số 11 - 2019
Arménio Jorge Moura Barbosa, Ana C. A. Roque
Marine organisms and micro‐organisms are a source of natural compounds with unique chemical features. These chemical properties are useful for the discovery of new functions and applications of marine natural products (MNPs). To extensively exploit the potential implementations of MNPs, they are gathered in chemical databases that allow their study and screening for applications of biotech...... hiện toàn bộ
Hybrid modeling for quality by design and PAT‐benefits and challenges of applications in biopharmaceutical industry
Biotechnology Journal - Tập 9 Số 6 - Trang 719-726 - 2014
Moritz von Stosch, Steven Davy, Kjell François, Vytautas Galvanauskas, Jan‐Martijn Hamelink, A. Luebbert, Martin J. Mayer, Rui Oliveira, Ronan O’Kennedy, P.D. Rice, Jarka Glassey
AbstractThis report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different kno...... hiện toàn bộ
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