Biotechnology Journal
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Free Marine Natural Products Databases for Biotechnology and Bioengineering
Biotechnology Journal - Tập 14 Số 11 - 2019
Marine organisms and micro‐organisms are a source of natural compounds with
unique chemical features. These chemical properties are useful for the discovery
of new functions and applications of marine natural products (MNPs). To
extensively exploit the potential implementations of MNPs, they are gathered in
chemical databases that allow their study and screening for applications of
biotechnologica...
Understanding physiological responses to pre‐treatment inhibitors in ethanologenic fermentations
Biotechnology Journal - Tập 7 Số 9 - Trang 1169-1181 - 2012
AbstractAlcohol‐based liquid fuels feature significantly in the political and
social agendas of many countries, seeking energy sustainability. It is certain
that ethanol will be the entry point for many sustainable processes.
Conventional ethanol production using maize‐ and sugarcane‐based carbohydrates
with Saccharomyces cerevisiae is well established, while lignocellulose‐based
processes are rec...
Hybrid modeling for quality by design and PAT‐benefits and challenges of applications in biopharmaceutical industry
Biotechnology Journal - Tập 9 Số 6 - Trang 719-726 - 2014
AbstractThis report highlights the drivers, challenges, and enablers of the
hybrid modeling applications in biopharmaceutical industry. It is a summary of
an expert panel discussion of European academics and industrialists with
relevant scientific and engineering backgrounds. Hybrid modeling is viewed in
its broader sense, namely as the integration of different knowledge sources in
form of paramet...
Novel microfluidic platform for culturing neurons: Culturing and biochemical analysis of neuronal components
Biotechnology Journal - Tập 4 Số 11 - Trang 1573-1577 - 2009
AbstractNeurons, one of the most polarized types of cells, are typically
composed of cell bodies (soma), dendrites, and axons. Many events such as
electric signal transmission, axonal transport, and local protein synthesis
occur in the axon, so that a method for isolating axons from somata and
dendrites is required for systematically investigating these axonal events.
Based on a previously develop...
Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling
Biotechnology Journal - Tập 5 Số 9 - Trang 950-960 - 2010
AbstractOleuropein, an active constituent of olive leaf, has a variety of
pharmacological activities associated with its capacity to scavenge reactive
oxygen species. Oleuropein is also reported to have protective effects against
non‐alcoholic fatty liver disease (NAFLD) in vivo. In this study, gene
expression profiling of hepatic tissues was examined, and transcription factors
(TFs) with target g...
Less Sacrifice, More Insight: Repeated Low‐Volume Sampling of Microbioreactor Cultivations Enables Accelerated Deep Phenotyping of Microbial Strain Libraries
Biotechnology Journal - Tập 14 Số 9 - 2019
With modern genetic engineering tools, high number of potentially improved
production strains can be created in a short time. This results in a bottleneck
in the succeeding step of bioprocess development, which can be handled by
accelerating quantitative microbial phenotyping. Miniaturization and automation
are key technologies to achieve this goal. In this study, a novel workflow for
repeated low...
Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model
Biotechnology Journal - Tập 7 Số 3 - Trang 409-417 - 2012
AbstractIn vitro cell culture models of the blood–brain barrier (BBB) are
important tools used to study cellular physiology and brain disease
therapeutics. Although the number of model configurations is expanding across
neuroscience laboratories, it is not clear that any have been effectively
optimized. A sequential screening study to identify optimal primary mouse
endothelial cell parameter set p...
Protoplast isolation and transient gene expression in switchgrass, Panicum virgatum L.
Biotechnology Journal - Tập 3 Số 3 - Trang 354-359 - 2008
AbstractTransient assay systems using protoplasts have been utilized in several
plant species and are a powerful tool for rapid functional gene analysis and
biochemical manipulations. A protoplast system has not been used in switchgrass
(Panicum virgatum L.), even though it is a bioenergy crop that has received
considerable attention. Here we report the first protocol to isolate large
numbers of v...
A perfusion bioreactor system efficiently generates cell‐loaded bone substitute materials for addressing critical size bone defects
Biotechnology Journal - Tập 10 Số 11 - Trang 1727-1738 - 2015
AbstractCritical size bone defects and non‐union fractions are still challenging
to treat. Cell‐loaded bone substitutes have shown improved bone ingrowth and
bone formation. However, a lack of methods for homogenously colonizing scaffolds
limits the maximum volume of bone grafts. Additionally, therapy robustness is
impaired by heterogeneous cell populations after graft generation. Our aim was
to e...
Bioreactors in tissue engineering—principles, applications and commercial constraints
Biotechnology Journal - Tập 8 Số 3 - Trang 298-307 - 2013
AbstractBioreactor technology is vital for tissue engineering. Usually,
bioreactors are used to provide a tissue‐specific physiological in vitro
environment during tissue maturation. In addition to this most obvious
application, bioreactors have the potential to improve the efficiency of the
overall tissue‐engineering concept. To date, a variety of bioreactor systems for
tissue‐specific applicatio...
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