Biotechnology Journal

Công bố khoa học tiêu biểu

* Dữ liệu chỉ mang tính chất tham khảo

Sắp xếp:  
Understanding physiological responses to pre‐treatment inhibitors in ethanologenic fermentations
Biotechnology Journal - Tập 7 Số 9 - Trang 1169-1181 - 2012
Mark Taylor, Inonge Mulako, Marla Trindade, Don A. Cowan
AbstractAlcohol‐based liquid fuels feature significantly in the political and social agendas of many countries, seeking energy sustainability. It is certain that ethanol will be the entry point for many sustainable processes. Conventional ethanol production using maize‐ and sugarcane‐based carbohydrates with Saccharomyces cerevisiae is well established, while ligno...... hiện toàn bộ
Hybrid modeling for quality by design and PAT‐benefits and challenges of applications in biopharmaceutical industry
Biotechnology Journal - Tập 9 Số 6 - Trang 719-726 - 2014
Moritz von Stosch, Steven Davy, Kjell François, Vytautas Galvanauskas, Jan‐Martijn Hamelink, A. Luebbert, Martin J. Mayer, Rui Oliveira, Ronan O’Kennedy, P.D. Rice, Jarka Glassey
AbstractThis report highlights the drivers, challenges, and enablers of the hybrid modeling applications in biopharmaceutical industry. It is a summary of an expert panel discussion of European academics and industrialists with relevant scientific and engineering backgrounds. Hybrid modeling is viewed in its broader sense, namely as the integration of different kno...... hiện toàn bộ
Hepatoprotective effect of oleuropein in mice: Mechanisms uncovered by gene expression profiling
Biotechnology Journal - Tập 5 Số 9 - Trang 950-960 - 2010
Yunjung Kim, Youngshim Choi, Taesun Park
AbstractOleuropein, an active constituent of olive leaf, has a variety of pharmacological activities associated with its capacity to scavenge reactive oxygen species. Oleuropein is also reported to have protective effects against non‐alcoholic fatty liver disease (NAFLD) in vivo. In this study, gene expression profiling of hepatic tissues...... hiện toàn bộ
Less Sacrifice, More Insight: Repeated Low‐Volume Sampling of Microbioreactor Cultivations Enables Accelerated Deep Phenotyping of Microbial Strain Libraries
Biotechnology Journal - Tập 14 Số 9 - 2019
Johannes Hemmerich, Niklas Tenhaef, Carmen Steffens, Jannick Kappelmann, Marc Weiske, Sebastian J. Reich, Wolfgang Wiechert, Marco Oldiges, Stephan Noack
With modern genetic engineering tools, high number of potentially improved production strains can be created in a short time. This results in a bottleneck in the succeeding step of bioprocess development, which can be handled by accelerating quantitative microbial phenotyping. Miniaturization and automation are key technologies to achieve this goal. In this study, a...... hiện toàn bộ
Optimization of endothelial cell growth in a murine in vitro blood–brain barrier model
Biotechnology Journal - Tập 7 Số 3 - Trang 409-417 - 2012
Diane Wuest, Kelvin H. Lee
AbstractIn vitro cell culture models of the blood–brain barrier (BBB) are important tools used to study cellular physiology and brain disease therapeutics. Although the number of model configurations is expanding across neuroscience laboratories, it is not clear that any have been effectively optimized. A sequential screening study to identify optimal primary mouse...... hiện toàn bộ
A perfusion bioreactor system efficiently generates cell‐loaded bone substitute materials for addressing critical size bone defects
Biotechnology Journal - Tập 10 Số 11 - Trang 1727-1738 - 2015
Claudia Kleinhans, Ramkumar Ramani Mohan, Gabriele Vacun, Thomas Schwarz, Barbara Haller, Yang Sun, Alexander Kahlig, Petra J. Kluger, Anna Finne‐Wistrand, Heike Walles, Jan Hansmann
AbstractCritical size bone defects and non‐union fractions are still challenging to treat. Cell‐loaded bone substitutes have shown improved bone ingrowth and bone formation. However, a lack of methods for homogenously colonizing scaffolds limits the maximum volume of bone grafts. Additionally, therapy robustness is impaired by heterogeneous cell populations after g...... hiện toàn bộ
Bioreactors in tissue engineering—principles, applications and commercial constraints
Biotechnology Journal - Tập 8 Số 3 - Trang 298-307 - 2013
Jan Hansmann, Florian Groeber, Alexander Kahlig, Claudia Kleinhans, Heike Walles
AbstractBioreactor technology is vital for tissue engineering. Usually, bioreactors are used to provide a tissue‐specific physiological in vitro environment during tissue maturation. In addition to this most obvious application, bioreactors have the potential to improve the efficiency of the overall tissue‐engineering concept. To date, a variety of bioreactor syste...... hiện toàn bộ
Eukaryotic metabolism: Measuring compartment fluxes
Biotechnology Journal - Tập 6 Số 9 - Trang 1071-1085 - 2011
Judith Wahrheit, Averina Nicolae, Elmar Heinzle
AbstractMetabolic compartmentation represents a major characteristic of eukaryotic cells. The analysis of compartmented metabolic networks is complicated by separation and parallelization of pathways, intracellular transport, and the need for regulatory systems to mediate communication between interdependent compartments. Metabolic flux analysis (MFA) has the poten...... hiện toàn bộ
Towards automated production and drug sensitivity testing using scaffold‐free spherical tumor microtissues
Biotechnology Journal - Tập 6 Số 12 - Trang 1488-1496 - 2011
Maren Drewitz, Marianne M. Helbling, Nicole Fried, Manuela Bieri, Wolfgang Moritz, Jan Lichtenberg, Jens M. Kelm
AbstractAlthough the relevance of three‐dimensional (3‐D) culture has been recognized for years and exploited at an academic level, its translation to industrial applications has been slow. The development of reliable high‐throughput technologies is clearly a prerequisite for the industrial implementation of 3‐D models. In this study the robustness of spherical mic...... hiện toàn bộ
Arrayed cellular environments for stem cells and regenerative medicine
Biotechnology Journal - Tập 8 Số 2 - Trang 167-179 - 2013
Drew M. Titmarsh, Huaying Chen, Ernst J. Wolvetang, Justin J. Cooper‐White
AbstractThe behavior and composition of both multipotent and pluripotent stem cell populations are exquisitely controlled by a complex, spatiotemporally variable interplay of physico‐chemical, extracellular matrix, cell‐cell interaction, and soluble factor cues that collectively define the stem cell niche. The push for stem cell‐based regenerative medicine models a...... hiện toàn bộ
Tổng số: 40   
  • 1
  • 2
  • 3
  • 4