Free Marine Natural Products Databases for Biotechnology and Bioengineering

Biotechnology Journal - Tập 14 Số 11 - 2019
Arménio Jorge Moura Barbosa1, Ana C. A. Roque1
1UCIBIO, Departamento de Química, Faculdade de Ciências e Tecnologia Universidade Nova de Lisboa 2829‐516 Caparica Portugal

Tóm tắt

Marine organisms and micro‐organisms are a source of natural compounds with unique chemical features. These chemical properties are useful for the discovery of new functions and applications of marine natural products (MNPs). To extensively exploit the potential implementations of MNPs, they are gathered in chemical databases that allow their study and screening for applications of biotechnological interest. However, the classification of MNPs is currently poor in generic chemical databases. The present availability of free‐access‐focused MNP databases is scarce and the molecular diversity of these databases is still very low when compared to the paid‐access ones. In this review paper, the current scenario of free‐access MNP databases is presented as well as the hindrances involved in their development, mainly compound dereplication. Examples and opportunities for using freely accessible MNP databases in several important areas of biotechnology are also assessed. The scope of this paper is, as well, to notify the latent potential of these information sources for the discovery and development of new MNPs in biotechnology, and push future efforts to develop a public domain MNP database freely available for the scientific community.

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Tài liệu tham khảo

10.4155/fmc.11.118

10.3389/fmars.2015.00124

10.3390/md9040514

10.3390/md13010202

10.1039/C7NP00052A

10.1039/C6NP00124F

10.1055/s-0034-1383001

10.2741/s490

10.1039/C6EE01493C

Blue biotechnology https://ec.europa.eu/maritimeaffairs/policy/biotechnology_en(accessed: January 2019).

10.1016/j.tibtech.2017.10.011

10.1016/j.tibtech.2018.02.015

10.1093/nar/gkx1036

MarinLit http://pubs.rsc.org/marinlit(accessed: January 2019).

10.2174/156802612800166710

10.3390/md16070236

10.1016/j.copbio.2016.02.021

10.3390/md13052694

10.3390/md14030062

10.7554/eLife.24214

10.1021/acschembio.8b00389

10.1038/nbt.4187

10.1021/acs.jcim.7b00341

10.1021/acs.jcim.8b00125

10.1021/np400413s

10.3390/md15080253

B.V. Elsevier 2019. Reaxys Elsevier Life Sciences IP Limited.https://www.reaxys.com

10.1021/ci049714

10.1021/acs.jcim.5b00559

10.1093/nar/gkv951

10.1093/nar/gkw1074

ChemSpider http://www.chemspider.com(accessed: January 2019).

Dictionary of Marine Natural Products http://dmnp.chemnetbase.com/(accessed: January 2019).

10.1007/978-90-481-3834-0_6

10.3389/fmars.2014.00038

10.1021/acs.jnatprod.6b01093

10.1021/ci010111x

10.6026/97320630003142

10.6026/97320630005361

Sripathy R., 2015, J. Adv. Bioinf. Appl. Res., 6, 33

Seaweed Metabolite Database http://www.swmd.co.in(accessed: January 2019).

10.2174/1389203716666150505234923

10.1021/acs.jcim.8b00044

10.1146/annurev-matsci-070214-020823

10.1016/j.bcp.2018.07.050

10.3390/md13106336

10.3390/md12021066

10.3390/md11010146

10.1016/j.biotechadv.2011.03.001

10.1179/1743280412Y.0000000002

10.3389/fbioe.2014.00090

10.2533/chimia.2017.646

10.1002/med.21474

10.4103/0975-7406.171700

10.3390/molecules22071037

10.3390/md15040099

10.3389/fphar.2018.00777

10.3389/fmicb.2017.02536

10.1016/j.bmcl.2016.11.018

10.3390/md13063479

10.3390/v10070348

10.1021/acs.accounts.5b00004

10.3390/md16120478

10.1016/j.etap.2016.09.023

10.3390/md14030042

10.3390/md14020038

10.1201/b10120

10.3390/md202073

10.1021/jf960746

10.1021/jf0207880

10.3389/fmars.2014.00066

10.1111/1541-4337.12136

10.1007/s10811-013-9983-9

10.3389/fnut.2018.00058

10.1016/j.jff.2018.08.009

10.1002/jsfa.6023

10.3390/md9061056

10.1186/s40538-014-0014-0

Venkatesan J., 2015, Springer Handbook of Marine Biotechnology, 1195, 10.1007/978-3-642-53971-8_53

10.1016/B978-1-78242-086-6.00001-7

Kim S., 2017, Marine Biomaterials: Characterization, Isolation, and Applications

10.3390/md14020029

10.1016/j.tibtech.2011.11.003

10.1089/omi.2013.0025

10.1038/s41598-018-30660-x

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Biotechnology Journal

Tập 14 Số 11

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