Biotechnology Journal
SCIE-ISI SCOPUS (2006-2025)
1860-7314
1860-6768
Đức
Cơ quản chủ quản: WILEY-V C H VERLAG GMBH , Wiley-VCH Verlag
Lĩnh vực:
Medicine (miscellaneous)Molecular MedicineApplied Microbiology and Biotechnology
Các bài báo tiêu biểu
Biobutanol: An attractive biofuel
Tập 2 Số 12 - Trang 1525-1534 - 2007
AbstractBiofuels are an attractive means to prevent a further increase of carbon
dioxide emissions. Currently, gasoline is blended with ethanol at various
percentages. However, butanol has several advantages over ethanol, such as
higher energy content, lower water absorption, better blending ability, and use
in conventional combustion engines without modification. Like ethanol, it can be
produced ...
PEGylation of therapeutic proteins
Tập 5 Số 1 - Trang 113-128 - 2010
AbstractSince the first PEGylated product was approved by the Food and Drug
Administration in 1990, PEGylation has been widely used as a post‐production
modification methodology for improving biomedical efficacy and physicochemical
properties of therapeutic proteins. Applicability and safety of this technology
have been proven by use of various PEGylated pharmaceuticals for many years. It
is expec...
Advanced biofuel production in microbes
Tập 5 Số 2 - Trang 147-162 - 2010
AbstractThe cost‐effective production of biofuels from renewable materials will
begin to address energy security and climate change concerns. Ethanol, naturally
produced by microorganisms, is currently the major biofuel in the transportation
sector. However, its low energy content and incompatibility with existing fuel
distribution and storage infrastructure limits its economic use in the future.
...
Microfluidics Based Point‐of‐Care Diagnostics
Tập 13 Số 1 - 2018
Point‐of‐care (POC) diagnostic devices have been predicted to provide a boon in
health care especially in the diagnosis and detection of diseases. POC devices
have been found to have many advantages like a rapid and precise response,
portability, low cost, and non‐requirement of specialized equipment. The major
objective of a POC diagnostic research is to develop a chip‐based,
self‐containing mini...
Manufacturing of recombinant therapeutic proteins in microbial systems
Tập 1 Số 2 - Trang 164-186 - 2006
AbstractRecombinant therapeutic proteins have gained enormous importance for
clinical applications. The first recombinant products have been produced in E.
coli more than 20 years ago. Although with the advent of antibody‐based
therapeutics mammalian expression systems have experienced a major boost,
microbial expression systems continue to be widely used in industry. Their
intrinsic advantages, s...
Camelina as a sustainable oilseed crop: Contributions of plant breeding and genetic engineering
Tập 10 Số 4 - Trang 525-535 - 2015
AbstractCamelina is an underutilized Brassicaceae oilseed plant with a
considerable agronomic potential for biofuel and vegetable oil production in
temperate regions. In contrast to most Brassicaceae, camelina is resistant to
alternaria black spot and other diseases and pests. Sequencing of the camelina
genome revealed an undifferentiated allohexaploid genome with a comparatively
large number of g...
Metagenomics: Concept, methodology, ecological inference and recent advances
Tập 4 Số 4 - Trang 480-494 - 2009
AbstractMicroorganisms constitute two third of the Earth's biological diversity.
As many as 99% of the microorganisms present in certain environments cannot be
cultured by standard techniques. Culture‐independent methods are required to
understand the genetic diversity, population structure and ecological roles of
the majority of organisms. Metagenomics is the genomic analysis of
microorganisms by...
Systematic microcarrier screening and agitated culture conditions improves human mesenchymal stem cell yield in bioreactors
Tập 11 Số 4 - Trang 473-486 - 2016
AbstractProduction of human mesenchymal stem cells for allogeneic cell therapies
requires scalable, cost‐effective manufacturing processes. Microcarriers enable
the culture of anchorage‐dependent cells in stirred‐tank bioreactors. However,
no robust, transferable methodology for microcarrier selection exists, with
studies providing little or no reason explaining why a microcarrier was
employed. We...
Towards automated production and drug sensitivity testing using scaffold‐free spherical tumor microtissues
Tập 6 Số 12 - Trang 1488-1496 - 2011
AbstractAlthough the relevance of three‐dimensional (3‐D) culture has been
recognized for years and exploited at an academic level, its translation to
industrial applications has been slow. The development of reliable
high‐throughput technologies is clearly a prerequisite for the industrial
implementation of 3‐D models. In this study the robustness of spherical
microtissue production and drug test...
Towards dynamic metabolic flux analysis in CHO cell cultures
Tập 7 Số 1 - Trang 61-74 - 2012
AbstractChinese hamster ovary (CHO) cells are the most widely used mammalian
cell line for biopharmaceutical production, with a total global market
approaching $100 billion per year. In the pharmaceutical industry CHO cells are
grown in fed‐batch culture, where cellular metabolism is characterized by high
glucose and glutamine uptake rates combined with high rates of ammonium and
lactate secretion...