Biomedical Dermatology
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Aerobic bacteria associated with diabetic foot ulcers and their susceptibility pattern
Biomedical Dermatology - Tập 3 - Trang 1-6 - 2019
Foot ulcers in diabetes mellitus subjects cause morbidity and mortality and lead to non-traumatic amputations worldwide. Knowledge of the microbial burden in the ulcers may improve patients’ care and management. This prospective study was designed to isolate, identify and carry out antibiotic susceptibility testing on bacterial isolates associated with diabetic foot ulcers among subjects in Univer......
Anti-melanogenic activity of methanolic extract from leaves of Sorbaria sorbifolia var. stellipila Max. on α-MSH-stimulated B16 melanoma 4A5 cells
Biomedical Dermatology - Tập 4 - Trang 1-8 - 2020
Melanin is a pigment, which is widely distributed in organisms. In humans, melanin pigments determine eye, hair, and skin color and protect the skin from damage by ultraviolet radiation; however, immoderate distribution of melanin in the skin causes discoloration. In the present study, we screened methanolic extracts from leaves of 47 plant species, most of which are native to East Asia, for the i......
Transdermal delivery systems in cosmetics
Biomedical Dermatology - Tập 4 - Trang 1-12 - 2020
Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains a li......
Antioxidants as stabilizers of UV filters: an example for the UV-B filter octylmethoxycinnamate
Biomedical Dermatology - Tập 3 - Trang 1-9 - 2019
Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world’s most widely used UV-B filter in......
Hair growth-promoting effect of recombinant human sonic hedgehog proteins
Biomedical Dermatology - Tập 3 Số 1 - Trang 1-9 - 2019
Hair loss, known as alopecia, causes psychological stress and influences social interactions. At present, treatment for hair loss is somewhat limited, transient, and unpredictable. Based on the critical role of sonic hedgehog (Shh) in hair follicle development, Shh itself would be a good therapeutic candidate for the prevention of hair loss as well as promotion of hair growth. To investigate its p......
Anti-apoptotic, antioxidant and anti-aging effects of 6-shogaol on human dermal fibroblasts
Biomedical Dermatology - - 2018
Direct conversion from skin fibroblasts to functional dopaminergic neurons for biomedical application
Biomedical Dermatology - Tập 1 - Trang 1-9 - 2017
Recent progress in tissue engineering research led to the generation of different types of cells from a handful of skin tissue. Lineage reprogramming is a nascent field, which holds great potential to expand its use in regenerative medicine and disease modeling. The concept of somatic cell epigenetic stability has been fundamentally reshaped through the report of direct conversion of somatic ident......
Importance of the immune response to Mycobacterium leprae in the skin
Biomedical Dermatology - Tập 2 - Trang 1-6 - 2018
The causative agent of leprosy is Mycobacterium leprae (M. leprae), which establishes infectious lesions in the skin. Leprosy is classified based on the clinical manifestation, the host’s immune response and skin symptoms. M. leprae is an intracellular pathogen that invades keratinocytes, macrophages, dendritic cells and Schwann cells and replicates within these cells. M. leprae-infected keratinoc......
Proteomic characterization of HaCaT keratinocytes provides new insights into changes associated with SDS exposure
Biomedical Dermatology - Tập 4 - Trang 1-13 - 2020
Using human keratinocyte HaCaT cell line model, we screened for proteins that changed their content due to SDS exposure in non-toxic dose (25 μg/ml, as determined by the MTT assay and microscopic examination) during 48 h. The altered level of proteins from HaCaT keratinocytes exposed to SDS was analyzed by LC-MS/MS approach and quantified using Progenesis LC software. The Pathview map of 131 upreg......
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