Transdermal delivery systems in cosmetics

Biomedical Dermatology - Tập 4 - Trang 1-12 - 2020
Byel Kim1,2, Hang-Eui Cho1,3, Sun He Moon1,4, Hyun-Jung Ahn1,5, Seunghee Bae1, Hyun-Dae Cho3, Sungkwan An1
1Department of Cosmetics Engineering, Graduate School of Konkuk University, Seoul, Republic of Korea
2UH R&D, Incheon, Republic of Korea
3Creative Innovation Research Center, Cosmecca Korea, Co., Ltd, Seongnam-si, Republic of Korea
4Yeosiya Beauty Academy, Seoul, Republic of Korea
5Amorepacific Corporation, Seoul, Republic of Korea

Tóm tắt

Transdermal delivery systems have been intensively studied over the past 2 decades, with the focus on overcoming the skin barrier for more effective application of pharmaceutical and cosmetic products. Although the cosmeceutical industry has made a substantial progress in the development and incorporation of new and effective actives in their products, the barrier function of the skin remains a limiting factor in the penetration and absorption of these actives. Enhancement via modification of the stratum corneum by hydration, acting of chemical enhancers on the structure of stratum corneum lipids, and partitioning and solubility effects are described. This review summarizes the advances in the development and mechanisms of action of chemical components that act as permeation enhancers, as well as the advances in appropriate vehicles, such as gels, emulsions, and vesicular delivery systems, that can be used for effective transdermal delivery.

Tài liệu tham khảo

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