Biogerontology
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Induction of αδ- and αβ-mediated T cell responses in healthy elderly subjects after influenza vaccination
Biogerontology - - 2006
Influenza is an important cause of morbidity and mortality in the elderly and influenza vaccination has shown a decreased efficacy in aged people. Both γδ- and αβ-T cell responses, which are believed to play an important role in controlling influenza infection, are impaired during aging. The aim of this study was to evaluate the ability of influenza vaccine to induce cellular immune responses medi...... hiện toàn bộ
Emerging cellular senescence-centric understanding of immunological aging and its potential modulation through dietary bioactive components
Biogerontology - Tập 23 Số 6 - Trang 699-729 - 2022
Immunological aging is strongly associated with the observable deleterious effects of human aging. Our understanding of the causes, effects, and therapeutics of aging immune cells has long been considered within the sole purview of immunosenescence. However, it is being progressively realized that immunosenescence may not be the only determinant of immunological aging. The cellular senescence-cent...... hiện toàn bộ
Decreased frequency and proliferative response of invariant Vα24Vβ11 natural killer T (iNKT) cells in healthy elderly
Biogerontology - Tập 7 - Trang 483-492 - 2006
Invariant natural killer T (iNKT) cells represent a well-established T cell lineage characterised in humans by TCR consisting of an invariant alpha chain encoded by Vα24-JαQ genes, paired preferentially with a Vβ11 chain. iNKT cells also share some characteristics with NK cells, such as the expression of the NK-associated receptor CD161 in humans. The T cell immune response is the most dramaticall...... hiện toàn bộ
Aging Reversibility: from Thymus Graft to Vegetable Extract Treatment – Application to Cure an Age-associated Pathology
Biogerontology - Tập 6 - Trang 245-253 - 2005
Neonatal thymus graft and thymus calf extract (TME) in vivo treatment exert similar corrective actions on different mouse age-related alterations. The aim of the present paper is to investigate whether a vegetal extract, wheat sprout extract (WESPRE), could mimic the thymus action on recovering age-related alterations and if this extract can cure an age-associated pathology, the cataract in dogs. ...... hiện toàn bộ
The Failure of Dose–response Models to Predict Low Dose Effects: A Major Challenge for Biomedical, Toxicological and Aging Research
Biogerontology - - 2006
Age-related changes in skeletal muscle: changes to life-style as a therapy
Biogerontology - Tập 19 Số 6 - Trang 519-536 - 2018
As we age, there is an age-related loss in skeletal muscle mass and strength, known as sarcopenia. Sarcopenia results in a decrease in mobility and independence, as well as an increase in the risk of other morbidities and mortality. Sarcopenia is therefore a major socio-economical problem. The mechanisms behind sarcopenia are unclear and it is likely that it is a multifactorial condition with chan...... hiện toàn bộ
Metformin as a geroprotector: experimental and clinical evidence
Biogerontology - Tập 20 Số 1 - Trang 33-48 - 2019
Diet has independent effects on the pace and shape of aging in Drosophila melanogaster
Biogerontology - Tập 19 - Trang 1-12 - 2017
Studies examining how diet affects mortality risk over age typically characterise mortality using parameters such as aging rates, which condense how much and how quickly the risk of dying changes over time into a single measure. Demographers have suggested that decoupling the tempo and the magnitude of changing mortality risk may facilitate comparative analyses of mortality trajectories, but it is...... hiện toàn bộ
Longevity in vitro of human CD4+ T helper cell clonesderived from young donors and elderly donors, or fromprogenitor cells: age-associated differences in cellsurface molecule expression and cytokine secretion
Biogerontology - Tập 1 - Trang 247-254 - 2000
The effectiveness of the adaptive immune system reliesupon extensive proliferation of an initially smallnumber of antigen-specific T cells. At the end of asuccessful response, the majority die by apoptosis anda small minority joins the memory cell pool. Uponre-challenge with antigen, these memory cells mustagain undergo clonal expansion in order to mediate aneffective response. Thus, T cells are s...... hiện toàn bộ
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