Biogerontology
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The role of autophagy in genetic pathways influencing ageing
Biogerontology - Tập 12 Số 5 - Trang 377-386 - 2011
Shared Ageing Research Models (ShARM): a new facility to support ageing research
Biogerontology - Tập 14 - Trang 789-794 - 2013
In order to manage the rise in life expectancy and the concomitant increased
occurrence of age-related diseases, research into ageing has become a strategic
priority. Mouse models are commonly utilised as they share high homology with
humans and show many similar signs and diseases of ageing. However, the time and
cost needed to rear aged cohorts can limit research opportunities. Sharing of
resour...
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
Biogerontology - Tập 20 - Trang 1-16 - 2018
Aging is a biological process characterized by a progressive functional decline
in tissues and organs, which eventually leads to mortality. Telomeres, the
repetitive DNA repeat sequences at the end of linear eukaryotic chromosomes
protecting chromosome ends from degradation and illegitimate recombination, play
a crucial role in cell fate and aging. Due to the mechanism of replication,
telomeres sh...
Gompertz law and aging as exclusion effects
Biogerontology - Tập 8 - Trang 605-612 - 2007
The exponential increase with age in mortality rate, the Gompertz law, indicates
that the decrease in vitality and viability linked to aging depends on phenomena
with exponential or logarithmic dynamics. Gompertz slope (α) is assumed to be a
measure of aging rate, provided the studied cohort is homogeneous and in a
supporting environment. The law provides no clue about the cause of aging, but
may ...
Phenotypical and morphological changes in the thymic microenvironment from ageing mice
Biogerontology - Tập 10 - Trang 311-322 - 2008
The thymus is crucial for T-cell output and the age-associated involution of
this organ, is thought to have a major impact in the decline in immunity that is
seen in later life. The mechanism that underlines thymic involution is not
known, however, we have evidence to suggest that this is may be due to changes
in the thymic microenvironment. To further test this hypothesis, we quantified
the in si...
The effect of age and calorie restriction on HIF-1-responsive genes in aged liver
Biogerontology - Tập 6 - Trang 27-37 - 2005
Hypoxia inducible factor-1 (HIF-1) regulates transactivation of several genes in
response to hypoxia condition. We explore hepatic HIF-1 responsive gene
regulation during aging and the age-related changes of the HIF-1 related gene
activation in young and old rats. Results indicate that the aging process
induces the activation of HIF-1α, which is accompanied by increased HIF-1 DNA
binding. This inc...
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes
Biogerontology - - 2022
AbstractIncreasing age has a major detrimental impact on female fertility,
which, with an ageing population, has major sociological implications. This
impact is primarily mediated through deteriorating quality of the oocyte.
Deteriorating oocyte quality with biological age is the greatest rate-limiting
factor to female fertility. Here we have used label-free, non-invasive
multi-spectral imaging to...
A mild cold stress that increases resistance to heat lowers FOXO translocation in Drosophila melanogaster
Biogerontology - Tập 18 - Trang 791-801 - 2017
Previous studies have shown that subjecting Drosophila melanogaster flies to a
mild stress at young or middle age can increase lifespan and resistance to
severe stresses throughout life and that the NF-κB-like transcription factor
DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O
(dFOXO) transcription factor could explain some of these effects. The present
study showed t...
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