Biogerontology
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Platelet dysfunction in hypercholesterolemia mice, two Alzheimer’s disease mouse models and in human patients with Alzheimer’s disease
Biogerontology - Tập 16 - Trang 543-558 - 2015
Alzheimer’s disease (AD) is a severe neurodegenerative disorder characterized mainly by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss. Blood platelets contain the neurotransmitter serotonin and amyloid-precursor protein (APP), and may thus be useful as a peripheral biomarker for AD. The aim of the present study was to functionally characterize platelets......
Expression of NKp30, NKp46 and DNAM-1 activating receptors on resting and IL-2 activated NK cells from healthy donors according to CMV-serostatus and age
Biogerontology - Tập 16 - Trang 671-683 - 2015
Human natural killer (NK) cells are innate lymphoid cells with capacity to kill tumor cells and virus-infected cells. According to the expression of CD56 and CD16 several NK cell subsets have been identified, a major CD56dimCD16+ subpopulation characterized by higher cytotoxic capacity, two CD56bright subsets (CD16−and CD16+) that represent different maturation stages and the fourth CD56−CD16+ sub......
Sex-related differences in behavioural markers in adult mice for the prediction of lifespan
Biogerontology - Tập 22 - Trang 49-62 - 2020
Finding biomarkers to assess the rate of ageing and consequently, to forecast individual lifespan is a challenge in ageing research. We recently published a mathematical model for lifespan prediction in adult female mice using behavioural parameters such as internal locomotion and time spent in open arms in the hole board (HB) and elevated plus maze (EPM) tests, respectively. Nevertheless, it is s......
Peripheral non-enzymatic antioxidant changes with human aging: A selective status report
Biogerontology - - 2001
Oxidative stress is thought to be involved in the agingprocess in aerobic organisms and to play a role in thepathogenesis of several disease states. Since free radicals areextremely reactive, shortly half-lived and therefore verydifficult to measure directly, oxidative stress has been mainlystudied through the search of indirect biomarkers of freeradical-induced damage. In aerobic organisms, oxida......
The influence of biological sex in human skeletal muscle transcriptome during ageing
Biogerontology - - Trang 1-18 - 2023
Sex is a crucial biological variable, and influence of biological sex on the change of gene expression in ageing skeletal muscle has not yet been fully revealed. In this study, the mRNA expression profiles were obtained from the Gene Expression Omnibus database. Key genes were identified by differential expression analysis and weighted gene co-expression network analysis. The gene set enrichment a......
The influence of dietary fat source on liver and skeletal muscle mitochondrial modifications and lifespan changes in calorie-restricted mice
Biogerontology - Tập 16 - Trang 655-670 - 2015
The Membrane Theory of Aging proposes that lifespan is inversely related to the level of unsaturation in membrane phospholipids. Calorie restriction (CR) without malnutrition extends lifespan in many model organisms, which may be related to alterations in membrane phospholipids fatty acids. During the last few years our research focused on studying how altering the predominant fat source affects ......
A-to-I RNA editing does not change with age in the healthy male rat brain
Biogerontology - Tập 14 - Trang 395-400 - 2013
RNA editing is a post-transcriptional process, which results in base substitution modifications to RNA. It is an important process in generating protein diversity through amino acid substitution and the modulation of splicing events. Previous studies have suggested a link between gene-specific reductions in adenosine to inosine RNA editing and aging in the human brain. Here we demonstrate that cha......
Fisetin, a potential skin rejuvenation drug that eliminates senescent cells in the dermis
Biogerontology - - Trang 1-15 - 2023
Accumulation of senescent fibroblasts, chronic inflammation, and collagen remodeling due to aging-related secretory phenotypes have been hypothesized to cause age-related skin aging, which results in wrinkles and loss of skin elasticity, thus compromising appearance attractiveness. However, the rejuvenating effects of removing senescent cells from the human skin and the efficacy of related therape......
The NF-κB-like factor DIF could explain some positive effects of a mild stress on longevity, behavioral aging, and resistance to strong stresses in Drosophila melanogaster
Biogerontology - Tập 13 Số 4 - Trang 445-455 - 2012
The nexus between peroxisome abundance and chronological ageing in Saccharomyces cerevisiae
Biogerontology - Tập 24 Số 1 - Trang 81-97 - 2023
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