Biogerontology
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Phenotypical and morphological changes in the thymic microenvironment from ageing mice
Biogerontology - Tập 10 - Trang 311-322 - 2008
The thymus is crucial for T-cell output and the age-associated involution of this organ, is thought to have a major impact in the decline in immunity that is seen in later life. The mechanism that underlines thymic involution is not known, however, we have evidence to suggest that this is may be due to changes in the thymic microenvironment. To further test this hypothesis, we quantified the in si......
Health status, blood and anthropometrical indices from Greek old and nonagenarian subjects
Biogerontology - Tập 7 - Trang 329-337 - 2006
As the elderly population is increasing rapidly, there is a lot of scientific interest in clarifying the differential life-style, genetic, biochemical and molecular factors contributing to mortality or exceptional longevity. Within the framework of the ZINCAGE project, 249 old (60–85 years) and nonagenarian Greek subjects (≥85 years old) were recruited and anthropometrical, blood and biochemical i......
p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts
Biogerontology - Tập 10 - Trang 291-298 - 2008
Cyclooxygenase-2 and release of prostaglandin E2 are up-regulated in replicative senescence of dermal and prostate fibroblasts and in H2O2-induced premature senescence of IMR-90 lung fibroblasts expressing the catalytic subunit of telomerase. Inhibition of cyclooxygenase-2 activity by specific chemical inhibitor or siRNA attenuates the H2O2-induced increase of senescence associated β-galactosidase......
Associations of visceral fat area and physical activity levels with the risk of metabolic syndrome in postmenopausal women
Biogerontology - Tập 18 - Trang 357-366 - 2017
This study was aimed at the evaluation of relationship between visceral fat area (VFA) and physical activity (PA) with the metabolic syndrome (MetS) risk in the physically active postmenopausal women. A total of 85 attendants of the University of the Third Age (U3A) aged 62.8 ± 5.9 years (median time since menopause 11.8 y), participated in this study. VFA was assessed by bioimpedance method using......
Accumulation of insoluble protein and aging
Biogerontology - Tập 3 - Trang 307-316 - 2002
It is proposed that biological aging mainly depends on a deleterious accumulation of insoluble inert protein that has escaped physiological proteolytic degradation. Intracellularly, a three-dimensional network of polypeptide chains may exclude macromolecular structures and organelles from part of the cytosolic water. In this way vital intracellular transport mechanisms may be obstructed, providing......
Decline in the expression of C4 binding protein alpha-chain gene during ageing of the rat liver
Biogerontology - Tập 3 - Trang 207-211 - 2002
It appears that consistent changes in the levels of activity of a small cohort of genes(probably less than 1% of all active genes)occur in all mammalian cells during ageing. We have studied this phenomenon in rat liver using an optimised form of differential display. During this investigation we observed one gene which exhibited a decline in expression in livers from young adult (6 months) to aged......
Platelet dysfunction in hypercholesterolemia mice, two Alzheimer’s disease mouse models and in human patients with Alzheimer’s disease
Biogerontology - Tập 16 - Trang 543-558 - 2015
Alzheimer’s disease (AD) is a severe neurodegenerative disorder characterized mainly by accumulation of amyloid-β plaques and neurofibrillary tangles, synaptic and neuronal loss. Blood platelets contain the neurotransmitter serotonin and amyloid-precursor protein (APP), and may thus be useful as a peripheral biomarker for AD. The aim of the present study was to functionally characterize platelets......
CTT1 overexpression increases life span of calorie-restricted Saccharomyces cerevisiae deficient in Sod1
Biogerontology - Tập 16 Số 3 - Trang 343-351 - 2015
Pre- and post-conditioning hormesis in elderly mice, rats, and humans: its loss and restoration
Biogerontology - Tập 17 - Trang 681-702 - 2016
This paper assessed differences and similarities in the capacity for preconditioning (PC) and post-conditioning (PostC) to prevent ischemic reperfusion (IR) damage to the heart in the old/elderly as compared to young adult mice, rats, and humans. While PC reliably reduces myocardial ischemia-induced heart damage by about 30–60 % in young adult (2–3 months old) mice and rats, such protection begins......
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