Biogerontology
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The role of autophagy in genetic pathways influencing ageing
Biogerontology - Tập 12 Số 5 - Trang 377-386 - 2011
Shared Ageing Research Models (ShARM): a new facility to support ageing research
Biogerontology - Tập 14 - Trang 789-794 - 2013
In order to manage the rise in life expectancy and the concomitant increased occurrence of age-related diseases, research into ageing has become a strategic priority. Mouse models are commonly utilised as they share high homology with humans and show many similar signs and diseases of ageing. However, the time and cost needed to rear aged cohorts can limit research opportunities. Sharing of resour......
Telomere and its role in the aging pathways: telomere shortening, cell senescence and mitochondria dysfunction
Biogerontology - Tập 20 - Trang 1-16 - 2018
Aging is a biological process characterized by a progressive functional decline in tissues and organs, which eventually leads to mortality. Telomeres, the repetitive DNA repeat sequences at the end of linear eukaryotic chromosomes protecting chromosome ends from degradation and illegitimate recombination, play a crucial role in cell fate and aging. Due to the mechanism of replication, telomeres sh......
Gompertz law and aging as exclusion effects
Biogerontology - Tập 8 - Trang 605-612 - 2007
The exponential increase with age in mortality rate, the Gompertz law, indicates that the decrease in vitality and viability linked to aging depends on phenomena with exponential or logarithmic dynamics. Gompertz slope (α) is assumed to be a measure of aging rate, provided the studied cohort is homogeneous and in a supporting environment. The law provides no clue about the cause of aging, but may ......
Phenotypical and morphological changes in the thymic microenvironment from ageing mice
Biogerontology - Tập 10 - Trang 311-322 - 2008
The thymus is crucial for T-cell output and the age-associated involution of this organ, is thought to have a major impact in the decline in immunity that is seen in later life. The mechanism that underlines thymic involution is not known, however, we have evidence to suggest that this is may be due to changes in the thymic microenvironment. To further test this hypothesis, we quantified the in si......
The effect of age and calorie restriction on HIF-1-responsive genes in aged liver
Biogerontology - Tập 6 - Trang 27-37 - 2005
Hypoxia inducible factor-1 (HIF-1) regulates transactivation of several genes in response to hypoxia condition. We explore hepatic HIF-1 responsive gene regulation during aging and the age-related changes of the HIF-1 related gene activation in young and old rats. Results indicate that the aging process induces the activation of HIF-1α, which is accompanied by increased HIF-1 DNA binding. This inc......
Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytesAbstract Increasing age has a major detrimental impact on female fertility, which, with an ageing population, has major sociological implications. This impact is primarily mediated through deteriorating quality of the oocyte. Deteriorating oocyte quality with biological age is the greatest rate-limiting factor to female fertility. Here we have used label-free, non-i... ...
Biogerontology - - 2022
A mild cold stress that increases resistance to heat lowers FOXO translocation in Drosophila melanogaster
Biogerontology - Tập 18 - Trang 791-801 - 2017
Previous studies have shown that subjecting Drosophila melanogaster flies to a mild stress at young or middle age can increase lifespan and resistance to severe stresses throughout life and that the NF-κB-like transcription factor DIF, the 70 kDa heat-shock proteins, and the Drosophila Forkhead box class O (dFOXO) transcription factor could explain some of these effects. The present study showed t......
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