Associations of visceral fat area and physical activity levels with the risk of metabolic syndrome in postmenopausal women
Tóm tắt
This study was aimed at the evaluation of relationship between visceral fat area (VFA) and physical activity (PA) with the metabolic syndrome (MetS) risk in the physically active postmenopausal women. A total of 85 attendants of the University of the Third Age (U3A) aged 62.8 ± 5.9 years (median time since menopause 11.8 y), participated in this study. VFA was assessed by bioimpedance method using InBody 720 analyzer. PA was assessed using the ActiGraph GT1 M accelerometer. Fasting levels of serum lipids (TG, HDL), serum glucose, waist circumference (WC) and blood pressure were measured to diagnose MetS according to NCEP-ATP III criteria. In 73 out of 85 participants the VFA exceeded the upper normal level of 100 cm2, however, in almost a half of this group (n = 36) with elevated VFA (139.5 ± 26.1 cm2 on average), only 2 out of 5 criteria for MetS diagnosis were met. Participants were physically active, making on average 10,919 ± 3435 steps/day. The risk of MetS occurrence in women with VFA > 100 cm2 was twelve times higher (OR 12.33; CI 95% [1.5; 99.8]) than in the group with VFA < 100 cm2. The participants from the group with the highest PA level (≥12,500 steps/day) were at almost 4 times lower risk for MetS, than their less active counterparts (OR 3.84; CI 95% [1.27;11.64]). Increased level of VFA is a strong risk factor for the MetS in postmenopausal women, however high level of regular PA above the threshold of 12,500 steps/day may substantially reduce it.
Tài liệu tham khảo
Alberti KGMM, Eckel RH, Grundy SM et al (2009) Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 120:1640–1645. doi:10.1161/CIRCULATIONAHA.109.192644
Aoyagi Y, Shephard RJ (2010) Habitual physical activity and health in the elderly: the Nakanojo Study. Geriatr Gerontol Int 10(Suppl 1):S236–S243. doi:10.1111/j.1447-0594.2010.00589.x
Bentley-Lewis R, Koruda K, Seely EW (2007) The metabolic syndrome in women. Nat Clin Pract Endocrinol Metab 3:696–704. doi:10.1038/ncpendmet0616
Biospace (2004) InBody 720—The precision body composition analyzer (User’s Manual). Seul, Korea
Carr DB, Utzschneider KM, Hull RL et al (2004) Intra-abdominal fat is a major determinant of the National Cholesterol Education Program Adult Treatment Panel III criteria for the metabolic syndrome. Diabetes 53:2087–2094
Cho GJ, Lee JH, Park HT et al (2008) Postmenopausal status according to years since menopause as an independent risk factor for the metabolic syndrome. Menopause 15:524–529. doi:10.1097/gme.0b013e3181559860
Chodzko-Zajko WJ, Proctor DN, Fiatarone Singh MA et al (2009) American College of Sports Medicine position stand. Exercise and physical activity for older adults. Med Sci Sports Exerc 41:1510–1530. doi:10.1249/MSS.0b013e3181a0c95c
Choi BC, Pak AW, Choi JC, Choi EC (2007) Daily step goal of 10,000 steps: a literature review. Clin Invest Med 30:E146–E151
Després J-P, Poirier P, Bergeron J et al (2008) From individual risk factors and the metabolic syndrome to global cardiometabolic risk. Eur Heart J Suppl 10:B24–B33. doi:10.1093/eurheartj/sum041
Esliger DW, Copeland JL, Barnes JD, Tremblay MS (2005) Standardizing and optimizing the use of accelerometer data for free-living physical activity monitoring. J Phys Act Health 2:366–383
Fox CS, Massaro JM, Hoffmann U et al (2007) Abdominal visceral and subcutaneous adipose tissue compartments: association with metabolic risk factors in the Framingham Heart Study. Circulation 116:39–48. doi:10.1161/CIRCULATIONAHA.106.675355
Franklin BA, Kahn JK, Gordon NF, Bonow RO (2004) A cardioprotective “polypill”? Independent and additive benefits of lifestyle modification. Am J Cardiol 94:162–166. doi:10.1016/j.amjcard.2004.03.053
Frömel K, Svozil Z, Chmelík F et al (2016) The role of physical education lessons and recesses in school lifestyle of adolescents. J Sch Health 86:143–151. doi:10.1111/josh.12362
Garber CE, Blissmer B, Deschenes MR et al (2011) American College of Sports Medicine position stand. Quantity and quality of exercise for developing and maintaining cardiorespiratory, musculoskeletal, and neuromotor fitness in apparently healthy adults: guidance for prescribing exercise. Med Sci Sports Exerc 43:1334–1359. doi:10.1249/MSS.0b013e318213fefb
Genuth S, Alberti KGMM, Bennett P et al (2003) Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167
Grundy SM, Brewer HB, Cleeman JI et al (2004) Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association conference on scientific issues related to definition. Circulation 109:433–438. doi:10.1161/01.CIR.0000111245.75752.C6
Grundy SM, Cleeman JI, Daniels SR et al (2005) Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112:2735–2752. doi:10.1161/CIRCULATIONAHA.105.169404
Hayes L, Pearce MS, Firbank MJ et al (2010) Do obese but metabolically normal women differ in intra-abdominal fat and physical activity levels from those with the expected metabolic abnormalities? A cross-sectional study. BMC Public Health 10:723. doi:10.1186/1471-2458-10-723
Huang PL (2009) A comprehensive definition for metabolic syndrome. Dis Model Mech 2:231–237. doi:10.1242/dmm.001180
Janssen I, Powell LH, Crawford S et al (2008) Menopause and the metabolic syndrome: the Study of Women’s Health Across the Nation. Arch Intern Med 168:1568–1575. doi:10.1001/archinte.168.14.1568
Kang SH, Cho KH, Park JW, Do JY (2015) Comparison of waist to height ratio and body indices for prediction of metabolic disturbances in the Korean population: the Korean National Health and Nutrition Examination Survey 2008–2011. BMC Endocr Disord. doi:10.1186/s12902-015-0075-5
Kim HI, Kim JT, Yu SH et al (2011) Gender differences in diagnostic values of visceral fat area and waist circumference for predicting metabolic syndrome in Koreans. J Korean Med Sci 26:906–913. doi:10.3346/jkms.2011.26.7.906
Kroemeke A, Zając-Gawlak I, Pośpiech D et al (2014) Postmenopausal obesity: 12,500 steps per day as a remedy? Relationships between body composition and daily steps in postmenopausal women. Menopause Rev 4:227–232. doi:10.5114/pm.2014.44998
Krumm EM, Dessieux OL, Andrews P, Thompson DL (2006) The relationship between daily steps and body composition in postmenopausal women. J Womens Health 15:202–210
Manini TM, Pahor M (2009) Physical activity and maintaining physical function in older adults. Br J Sports Med 43:28–31. doi:10.1136/bjsm.2008.053736
Matsuzawa Y, Funahashi T, Nakamura T (2011) The concept of metabolic syndrome: contribution of visceral fat accumulation and its molecular mechanism. J Atheroscler Thromb 18:629–639
Mosca L (2007) Guidelines for prevention of cardiovascular disease in women: a summary of recommendations. Prev Cardiol 10(Suppl 4):19–25
Mosca L, Banka CL, Benjamin EJ et al (2007) Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation 115:1481–1501. doi:10.1161/CIRCULATIONAHA.107.181546
National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) (2002) Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults [Adult Treatment Panel III] final report. Circulation 106:3143–3421
Ogawa H, Fujitani K, Tsujinaka T et al (2011) InBody 720 as a new method of evaluating visceral obesity. Hepatogastroenterology 58:42–44
Park E, Kim J (2015) Gender- and age-specific prevalence of metabolic syndrome among Korean adults: analysis of the fifth Korean National Health and Nutrition Examination Survey. J Cardiovasc Nurs 30:256–266. doi:10.1097/JCN.0000000000000142
Park Y-W, Zhu S, Palaniappan L et al (2003) The metabolic syndrome: prevalence and associated risk factor findings in the US population from the Third National Health and Nutrition Examination Survey, 1988-1994. Arch Intern Med 163:427–436
Park KS, Lee D-H, Lee J et al (2016) Comparison between two methods of bioelectrical impedance analyses for accuracy in measuring abdominal visceral fat area. J Diabetes Complic 30:343–349. doi:10.1016/j.jdiacomp.2015.10.014
Peppa M, Koliaki C, Dimitriadis G (2013) Body composition as an important determinant of metabolic syndrome in postmenopausal women. Endocrinol Metab Syndr. doi:10.4172/2161-1017.S1-009
Piché M-E, Lapointe A, Weisnagel SJ et al (2008) Regional body fat distribution and metabolic profile in postmenopausal women. Metabolism 57:1101–1107. doi:10.1016/j.metabol.2008.03.015
Pickhardt PJ, Jee Y, O’Connor SD, del Rio AM (2012) Visceral adiposity and hepatic steatosis at abdominal CT: association with the metabolic synd rome. AJR Am J Roentgenol 198:1100–1107. doi:10.2214/AJR.11.7361
Reaven GM (2005) The insulin resistance syndrome: definition and dietary approaches to treatment. Annu Rev Nutr 25:391–406. doi:10.1146/annurev.nutr.24.012003.132155
Rigo JC, Vieira JL, Dalacorte RR, Reichert CL (2009) Prevalence of metabolic syndrome in an elderly community: comparison between three diagnostic methods. Arq Bras Cardiol 93:85–91
Thompson PD, Buchner D, Pina IL et al (2003) Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 107:3109–3116. doi:10.1161/01.CIR.0000075572.40158.77
Tudor-Locke C, Bassett DR (2004) How many steps/day are enough? Preliminary pedometer indices for public health. Sports Med Auckl NZ 34:1–8
Tudor-Locke C, Hatano Y, Pangrazi RP, Kang M (2008) Revisiting “how many steps are enough?”. Med Sci Sports Exerc 40:S537–S543. doi:10.1249/MSS.0b013e31817c7133
Tudor-Locke C, Craig CL, Aoyagi Y et al (2011a) How many steps/day are enough? For older adults and special populations. Int J Behav Nutr Phys Act 8:80. doi:10.1186/1479-5868-8-80
Tudor-Locke C, Craig CL, Brown WJ et al (2011b) How many steps/day are enough? For adults. Int J Behav Nutr Phys Act 8:79. doi:10.1186/1479-5868-8-79
Zając-Gawlak I, Pośpiech D, Kroemeke A et al (2016) Physical activity, body composition and general health status of physically active students of the University of the Third Age (U3A). Arch Gerontol Geriatr 64:66–74. doi:10.1016/j.archger.2016.01.008
Ziaei S, Mohseni H (2013) Correlation between Hormonal Statuses and Metabolic Syndrome in Postmenopausal Women. J Family Reprod Health 7:63–66