Accumulation of insoluble protein and aging

Biogerontology - Tập 3 - Trang 307-316 - 2002
Anund Hallén1
1Department of Medical Biochemistry and Microbiology, University of Uppsala, Biomedical Center, Uppsala, Sweden

Tóm tắt

It is proposed that biological aging mainly depends on a deleterious accumulation of insoluble inert protein that has escaped physiological proteolytic degradation. Intracellularly, a three-dimensional network of polypeptide chains may exclude macromolecular structures and organelles from part of the cytosolic water. In this way vital intracellular transport mechanisms may be obstructed, providing a rationale to several observations linked to aging.

Tài liệu tham khảo

Angello JC, Pendergrass WR, Norwood TH and Prothero J (1989) Cell enlargement: one possible mechanism underlying cellular senescence. J Cell Physiol 140: 288-294 Bilder D, Li M and Perrimon N (2000) Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors. Science 289: 113-116 Bjorksten J (1958) A common molecular basis for the aging syndrome. J Am Ger Soc 6: 740-749 Bodnar AG et al. (1998) Extension of life-span by introduction of telomerase into normal human cells. Science 279: 349-352 Brun A and Brunk U (1970) Histochemical indications for lysosomal localization of heavy metals in normal rat brain and liver. J Histochem Cytochem 18: 820-827 Cerami AJ (1985) Hypothesis. Glucose as a mediator of aging. J Am Ger Soc 33: 626-634 Driver C (2001) The Gompertz function does not measure ageing. Biogerontology 2: 61-65 Duesberg P (1999) Are centrosomes or aneuploidy the key to cancer? Science 284: 2091-2092 Failla G (1958) The aging process and cancerogenesis. Ann N Y Acad Sci 721: 1124-1140 Fujii N, Satoh K, Harada K and Ishibashi Y (1994) Simultaneous stereoinversion and isomerization at specific aspartic acid residues in ?A-crystallin from human lens. J Biochem 116: 663-669 Goldstein S, Stotland D and Cordeiro RAJ (1976) Decreased proteolysis and increased amino acid efflux in aging human fibroblasts. Mech Ageing Dev 5: 221-233 Gompertz B (1825) On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies. Philosophical Transactions of the Royal Society (London), Series A 115: 513-585 Gross J (1960) The properties of some soluble components of connective tissue and the influence of growth rate. In: Strehler et al. (eds) The Biology of Aging, pp 192-195. American Institute of Biological Sciences, Washington, DC Grune T (2000) Oxidative stress, aging and the proteasomal system. Biogerontology 1: 31-40 Hahn WC, Counter CM, Lundberg AS, Beijersbergen RL, Brooks MW and Weinberg RA (1999) Creation of human tumour cells with defined genetic elements. Nature 400: 464-468 Hallén A (1962) Collagen and ground substance of human interverteberal disc. Acta Chem Scand 62: 705-710 Hallén A (1986) Aging of the human intervertebral disc. 8th Scand Congr Gerontol (Tampere) Proc: 267-269 Hallén, A (1999) Accumulation of protein in aging. 4th European Congress of Gerontology. Z Gerontol Geriatrics 32, Suppl 2, Abstr 456 Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11: 298-300 Harman D (1981) The aging process. Proc Natl Acad Sci USA 78: 7124-7128 Harman D (2001) Aging: overview. Ann N Y Acad Sci 928: 1-21 Häussinger D, Roth E, Lang F and Gerok W (1993) Cellular hydration state: an important determinant of protein catabolism in health and disease. Lancet 341: 1330-1332 Hayflick L (1996) How and Why we Age. Pocket edition. Ballantine Books, New York Hayflick L and Moorehead PS (1961) The serial cultivation of human diploid cell strains. Exp Cell Res 25: 585-593 Herzfeld E and Klinger R (1917) Chemische Studien zur Physiologie und Pathologie 1. Eiweiss-chemische Grundlagen der Lebensvorgänge. Biochem Z 83: 42-61 Hipkiss AR, Brownson C and Carrier MJ (2001) Carnosine, the antiageing, antioxidant dipeptide, may react with protein carbonyl groups. Mech Ageing Dev 122: 1431-1445 Hjertén S (1962) Chromatographic separation according to size of macromolecules and cell particles on columns of agarose suspensions. Arch Biochem Biophys 99: 466-475 Hoenders HJ and Bloemendal H (1983) Lens proteins and aging. J Gerontol 38: 278-286 Johansson C, Black D, Johnell O, Odén A and Mellström D (1998) Bone mineral density is a predictor of survival. Calcif Tissue Int 63: 190-196 Jones HB (1956) A special consideration of the aging process, disease and life expectancy. Adv Biol Med Phys 4: 281-337 Kennedy BK, Austriaco Jr NR and Guarente L (1994) Daughter cells of saccharomyces cerevisiae from old mothers display a reduced life span. J Cell Biol 127: 1985-1993 Kim JH, Choy HE, Nam KH and Park SC (2001) Transglutaminasemediated crosslinking of specific core histone subunits and cellular senescence. Ann N Y Acad Sci 928: 65-70 Kipling D and Cooke HJ (1990) Hypervariable ultra-long telomeres in mice. Nature 347: 400-402 Ku H-H, Brunk UT and Sohal RS (1993) Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species. Free Radical Biol Med 15: 621-627 Lansing AI (1947a) A transmissible, cumulative, and reversible factor in aging. J Gerontol 2: 228-239 Lansing AI (1947b) The general physiology of aging-A review. J Gerontol 2: 327-338 Laurent TC (1963) The interaction between polysaccharides and other macromolecules 5. The solubility of proteins in the presence of dextran. Biochem J 89: 253-257 Laurent TC (1964) The interaction between polysaccharides and other macromolecules 9. The exclusion of molecules from hyaluronic acid gels and solutions. Biochem J 93: 106-112 Laurent TC and Killander J (1964) A theory of gel filtration and its experimental verification. J Chromatogr 14: 317-330 Lengauer C, Kinzler KW and Vogelstein B (1998) Genetic instabilities in human cancers. Nature 396: 643-649 Lim IK, Hong KW, Kwak IH, Yoon G and Park SC (2001) Translocation inefficiency of intracellular proteins in senescence of human diploid fibroblasts. Ann N Y Acad Sci 928: 176-181 Lutz HU, Bussolino F, Flepp R, Fasler S, Stammler P, Kazatchkine MD and Arese P (1987) Naturally occuring anti-band-3 antibodies and complement together mediate phagocytosis of oxidatively stressed human erythrocytes. Proc Natl Acad Sci USA 84: 7368-7372 Macieira-Coelho A (1966) Action of cortisone on human fibroblasts in vitro. Experentia 22: 390-391 Masoro EJ, Yo BP and Bertrand HA (1982) Action of food restriction in delaying the aging process. Proc Natl Acad Sci USA 79: 4239-4241 Masoro EJ (1993) Dietary restriction and aging. J Am Ger Soc 41: 994-999 Masters PM, Bada JL and Zigler Jr JS (1978) Aspartic acid racemization in heavy molecular weight crystallins and waterinsoluble protein from normal human lenses and cataracts. Proc Natl Acad Sci USA 75: 1204-1208 McCarter RJ and Palmer J (1992) Energy metabolism and aging: a lifelong study of Fischer 344 rats. Am J Physiol 263: E448-E452 McCay CM, Crowell MF and Maynard LA (1935) The effect of retarded growth upon the length of life span and upon the ultimate body size. J Nutrition 10: 63-79 Morris CJOR and Morris P (1971) Molecular-sieve chromatography and electrophoresis in polyacrylamide gels. Biochem J 124: 517-528 Ogston AG (1958) The spaces in a uniform random suspension of fibres. Trans Faraday Soc 54: 1754-1757 Orr-Weaver TL and Weinberg RA (1998) A checkpoint on the road to cancer. Nature 392: 223-224 Peifer M (2000) Travel bulletin-traffic jams cause tumors. Science 289: 67-69 Rasoamanantena P, Labat-Robert J and Goldstein S (1993) Variations de la biosynthèse et quantification de l'ARNm de la fibronectine humaine au cours du vieillissement en culture. C R Soc Biol 187: 238-246 Robert L and Labat-Robert J (2000) Aging of connective tissues: from genetic to epigenetic mechanisms. Biogerontology 1: 123-131 Röhme D (1981) Evidence for a relationship between longevity of mammalian species and life spans of normal fibroblasts in vitro and erythrocytes in vivo. Proc Natl Acad Sci USA 78: 5009-5013 Rosenberger RF (1991) Senescence and the accumulation of abnormal proteins. Mutat Res 256: 255-262 Schliwa M, van Blerkom J and Porter KR (1981) Stabilization of the cytoplasmic ground substance in detergent-opened cells and structural and biochemical analysis of its composition. Proc Natl Acad Sci 78: 4329-4333 Sohal RS and Weindruch R (1996) Oxidative stress, caloric restriction, and aging. Science 273: 59-63 Stadtman ER (1992) Protein oxidation and aging. Science 257: 1220-1224 Stadtman ER (2001) Protein oxidation in aging and age-related diseases. Ann N Y Acad Sci 928: 22-38 Strehler BL (1977) Time Cells and Aging, 2nd edn. Academic Press Strehler BL and Mildvan AS (1960) General theory of mortality and aging. Science 132: 14-21 Terman A and Brunk UT (1998) Lipofuscin: mechanisms of formation and increase with age. APMIS 106: 265-276 Tyner SD et al. (2002) p53 mutant mice that display early ageingassociated phenotypes. Nature 415: 45-53 Vaupel JW et al. (1998) Biodemographic trajectories of longevity. Science 280: 855-860 Verzár F (1958) Problems of general biology of aging. J Gerontol 1(Suppl): 6-16 Verzár F (1963) The aging of collagen. Sci Am 208 (4): 104-114 Vrieling H (2001) Mitotic maneuvers in the light. Nature Genet 28: 101-102 Vorobtsova I, Semenov A, Timofeyeva N, Kanayeva A and Zvereva I (2001) An investigation of the age-dependency of chromosome abnormalities in human populations exposed to low-dose ionising radiation. Mech Ageing Dev 122: 1373-1382 Wang K-M, Rose NR, Bartholomew EA, Balzer M, Berde K and Foldvary M (1970) Changes of enzymic activities in human diplod cell line WI-38 at various passages. Exp Cell Res 61: 357-364 Yu C-E et al. (1996) Positional cloning of the Werner syndrome gene. Science 272: 258-262