BMC Infectious Diseases
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Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial
BMC Infectious Diseases - Tập 17 - Trang 1-9 - 2017
Severe malaria is a medical emergency associated with high mortality. Adequate
treatment requires initial parenteral therapy for fast parasite clearance
followed by longer acting oral antimalarial drugs for cure and prevention of
recrudescence. In a randomized controlled clinical trial, we evaluated the
42-day parasitological outcomes of severe malaria treatment with intravenous
artesunate (AS) or...
Prolonged oral vancomycin for secondary prophylaxis of relapsing Clostridium difficile infection
BMC Infectious Diseases - Tập 19 - Trang 1-4 - 2019
Clostridium difficile infection (CDI) is an important cause of diarrhea and
continues to be a major burden within healthcare institutions and in the
community. For a small subset of patients with frequently relapsing CDI who do
not have access to fecal microbiota transplantation (FMT), or fail FMT, there
are no clear treatment recommendations. We review our experience with prolonged
oral vancomyci...
Evaluation of a hand-held far-ultraviolet radiation device for decontamination of Clostridium difficile and other healthcare-associated pathogens
BMC Infectious Diseases - - 2012
Abstract Background Environmental surfaces play an important role in
transmission of healthcare-associated pathogens. There is a need for new
disinfection methods that are effective against Clostridium difficile spores,
but also safe and rapid. The Sterilray™ Disinfection Wand device is a hand-held
room decontamination technology that utilizes far-ultraviolet radiation
(185-230 nm) to kill pathoge...
Treatment outcomes in palliative care: the TOPCare study. A mixed methods phase III randomised controlled trial to assess the effectiveness of a nurse-led palliative care intervention for HIV positive patients on antiretroviral therapy
BMC Infectious Diseases - Tập 12 - Trang 1-10 - 2012
Patients with HIV/AIDS on Antiretroviral Therapy (ART) suffer from physical,
psychological and spiritual problems. Despite international policy explicitly
stating that a multidimensional approach such as palliative care should be
delivered throughout the disease trajectory and alongside treatment, the
effectiveness of this approach has not been tested in ART-experienced
populations. This mixed met...
Use of antimicrobial resistance information and prescribing guidance for management of urinary tract infections: survey of general practitioners in the West Midlands
BMC Infectious Diseases - Tập 16 - Trang 1-6 - 2016
There is a marked variation in both antibiotic prescribing practice and urine
sampling rates for diagnostic microbiology across general practices in England.
To help understand factors driving this variation, we undertook a survey in
2012/13 to determine sampling protocols and antibiotic formularies used by
general practitioners (GPs) for managing urinary tract infections (UTIs) in the
West Midlan...
Daptomycin Therapy for Osteomyelitis: A Retrospective Study
BMC Infectious Diseases - Tập 12 - Trang 1-6 - 2012
Daptomycin is a rapidly bactericidal agent with broad coverage against
Gram-positive organisms, including Staphylococcus aureus, the most frequent
cause of osteomyelitis. The objective of this study was to describe the clinical
outcome of patients with non-hardware associated osteomyelitis, and the safety
profile of daptomycin in the treatment of these infections. All patients with
osteomyelitis, ...
Comparison and evaluation of experimental mediastinitis models: precolonized foreign body implants and bacterial suspension inoculation seems promising
BMC Infectious Diseases - Tập 6 - Trang 1-7 - 2006
Post-sternotomy mediastinitis (PSM) is a devastating surgical complication
affecting 1–3% of patients that undergo cardiac surgery. Staphylococcus aureus
is one of the most commonly encountered bacterial pathogen cultured from
mediastinal samples obtained from patients with PSM. A component of the membrane
of the gram positive bacteria, lipoteichoic acid, stimulates the blood monocytes
and macroph...
Construction of the influenza A virus transmission tree in a college-based population: co-transmission and interactions between influenza A viruses
BMC Infectious Diseases - Tập 16 - Trang 1-8 - 2016
Co-infection of different influenza A viruses is known to occur but how viruses
interact within co-infection remains unknown. An outbreak in a college campus
during the 2009 pandemic involved two subtypes of influenza A: persons infected
with pandemic A/H1N1; persons infected with seasonal A/H3N2 viruses; and persons
infected with both at the same time (co-infection). This provides data to
analyse...
Molecular characterization of ocular dirofilariasis: a case report of Dirofilaria immitis in south-eastern Iran
BMC Infectious Diseases - Tập 20 - Trang 1-5 - 2020
Dirofilariasis is a zoonotic parasitic infection transmitted from animals to
humans by culicid mosquitoes. Although the disease can be caused by Dirofilaria
spp. including Dirofilaria immitis and Dirofilaria repens, human ocular
dirofilariasis due to D. immitis is relatively rare in the world. This study was
aimed to present a case of ocular dirofilariasis caused by D. immitis in
southeastern Iran...
Epidemiology of bloodstream infections in patients with acute myeloid leukemia undergoing levofloxacin prophylaxis
BMC Infectious Diseases - Tập 13 - Trang 1-5 - 2013
Infections are a common cause of morbidity and mortality in patients with acute
myeloid leukemia (AML). The evidence for efficacy of antibiotic prophylaxis in
reducing the mortality rates and the incidence of bacterial infections was also
reported by a systematic review published by Cochrane in 2012. The objective of
our study was to report the incidence and the etiology of bloodstream infections
...
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