Use of antimicrobial resistance information and prescribing guidance for management of urinary tract infections: survey of general practitioners in the West Midlands

BMC Infectious Diseases - Tập 16 - Trang 1-6 - 2016
Dean Ironmonger1, Obaghe Edeghere1, Savita Gossain2, Peter M. Hawkey2,3
1Field Epidemiology Service, Public Health England, Birmingham, UK
2Public Health Laboratory, Public Health England, Heart of England NHS Foundation Trust, Birmingham, UK
3Institute of Microbiology and Infection, Biosciences, University of Birmingham, Birmingham, UK

Tóm tắt

There is a marked variation in both antibiotic prescribing practice and urine sampling rates for diagnostic microbiology across general practices in England. To help understand factors driving this variation, we undertook a survey in 2012/13 to determine sampling protocols and antibiotic formularies used by general practitioners (GPs) for managing urinary tract infections (UTIs) in the West Midlands region of England. Cross-sectional survey of all eligible general practices in the West Midlands region of England undertaken in November 2012. GPs were invited to complete an online survey questionnaire to gather information on policies used within the practice for urine sampling for microbiological examination, and the source of antibiotic formularies used to guide treatment of UTIs. The questionnaire also gathered information on how they would manage five hypothetical clinical scenarios encountered in the community. The response rate was 11.3 % (409/3635 GPs), equivalent to a practice response rate of 26 % (248/950). Only 50 % of GPs reported having a practice policy for urine sampling. Although there was good agreement from GPs regarding collecting specimens in scenarios symbolising treatment failure (98 %), UTI in an adult male (98 %) and asymptomatic UTI in pregnancy (97 %), there was variation in GPs requesting a specimen for the scenarios involving a suspected uncomplicated urinary tract infection (UTI) and an asymptomatic catheterised elderly patient; with 40 and 38 % respectively indicating they would collect a specimen for microbiological examination. Standardised evidence based clinical management policies and antibiotic formularies for GPs should be readily available. This will promote the rational use of diagnostic microbiology services, improve antimicrobial stewardship and aid the interpretation of ongoing antimicrobial resistance surveillance.

Tài liệu tham khảo

CDC. Antibiotic Resistance Threats in the United States, 2013. http://www.cdc.gov/drugresistance/threat-report-2013/pdf/ar-threats-2013-508.pdf. Accessed 16 Dec 2015. Department of Health. UK five year antimicrobial resistance strategy 2013 to 2018. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/244058/20130902_UK_5_year_AMR_strategy.pdf. Accessed 16 Dec 2015. Ironmonger D, Edeghere O, Gossain S, Bains A, Hawkey PM. Am Web: a novel interactive web tool for antimicrobial resistance surveillance, applicable to both community and hospital patients. J Antimicrob Chemother. 2013;68:2406–13. Hillier S, Bell J, Heginbothom M, Roberts Z, Dunstan F, Howard A, et al. When do general practitioners request urine specimens for microbiology analysis? The applicability of antibiotic resistance surveillance based on routinely collected data. J Antimicrob Chemother. 2006;58:1303–6. McNulty CA, Bowen J, Clark G, Charlett A, Cartwright K. How should general practitioners investigate suspected urinary tract infection? variations in laboratory-confirmed bacteriuria in south west England. Commun Dis Public Health. 2004;7:220–6. Petersen I, Hayward AC. Antibacterial prescribing in primary care. J Antimicrob Chemother. 2007;60 Suppl 1:i43–7. Shapiro DJ, Hicks LA, Pavia AT, Hersh AL. Antibiotic prescribing for adults in ambulatory care in the USA, 2007–09. J Antimicrob Chemother. 2014;69:234–40. Wang KY, Seed P, Schofield P, Ibrahim S, Ashworth M. Which practices are high antibiotic prescribers? a cross-sectional analysis. Br J Gen Pract. 2009;59:e315–20. Public Health England. Antimicrobial surveillance programme antimicrobial utilisation and resistance (ESPAUR) report 2015. 10-10-2014. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/477962/ESPAUR_Report_2015.pdf. Accessed 16 Dec 2015. Bell BG, Schellevis F, Stobberingh E, Goossens H, Pringle M. A systematic review and meta-analysis of the effects of antibiotic consumption on antibiotic resistance. BMC Infect Dis. 2014;14:13. Costelloe C, Metcalfe C, Lovering A, Mant D, Hay AD. Effect of antibiotic prescribing in primary care on antimicrobial resistance in individual patients: systematic review and meta-analysis. BMJ. 2010;340:c2096. Howard AJ, Magee JT, Fitzgerald KA, Dunstan FD. Factors associated with antibiotic resistance in coliform organisms from community urinary tract infection in Wales. J Antimicrob Chemother. 2001;47:305–13. Vellinga A, Tansey S, Hanahoe B, Bennett K, Murphy AW, Cormican M. Trimethoprim and ciprofloxacin resistance and prescribing in urinary tract infection associated with Escherichia coli: a multilevel model. J Antimicrob Chemother. 2012;67:2523–30. Hawker JI, Smith S, Smith GE, Morbey R, Johnson AP, Fleming DM, et al. Trends in antibiotic prescribing in primary care for clinical syndromes subject to national recommendations to reduce antibiotic resistance, UK 1995–2011: analysis of a large database of primary care consultations. J Antimicrob Chemother. 2014;69:3423–30. Health and Social Care Information Centre. General and Personal Medical Services, England - 2002–2012. http://www.hscic.gov.uk/catalogue/PUB09536. Accessed 16 Dec 2015. Public Health England. Urinary tract infection: diagnosis guide for primary care. https://www.gov.uk/government/publications/urinary-tract-infection-diagnosis. Accessed 16 Dec 2015. NICE guidelines. Clinical Knowledge Summaries. Urinary tract infection (lower) - women. 2015. http://cks.nice.org.uk/urinary-tract-infection-lower-women#!scenario:1. Accessed 16 Dec 2016. Hummers-Pradier E, Ohse AM, Koch M, Heizmann WR, Kochen MM. Management of urinary tract infections in female general practice patients. Fam Pract. 2005;22:71–7. Gupta K, Hooton TM, Stamm WE. Increasing antimicrobial resistance and the management of uncomplicated community-acquired urinary tract infections. Ann Intern Med. 2001;135:41–50. Coenen S, Michiels B, Renard D, Denekens J, Van RP. Antibiotic prescribing for acute cough: the effect of perceived patient demand. Br J Gen Pract. 2006;56:183–90.