BMC Clinical Pathology
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High expression of EphA3 (erythropoietin-producing hepatocellular A3) in gastric cancer is associated with metastasis and poor survival
BMC Clinical Pathology - Tập 17 - Trang 1-7 - 2017
As the major subfamily of receptor tyrosine, erythropoietin-producing hepatocellular (Eph) receptor has been related to progression and prognosis in different types of tumors. However, the role and mechanism of EPHA3 in gastric cancer is still not well understood. Specimen were collected from 202 patients who underwent gastric resection for gastric adenocarcinoma. The expression of EphA3 was studi...... hiện toàn bộ
Dual color chromogenic in situ hybridization for determination of HER2 status in breast cancer: a large comparative study to current state of the art fluorescence in situ hybridization
BMC Clinical Pathology - Tập 12 - Trang 1-7 - 2012
Chromogenic in situ hybridization (CISH) is fast becoming a well established technique for easy and sensitive determination of HER2 gene status in breast cancer. However, for the chromogenic method to achieve status as a safe and reliable technique, the method needs to be validated against already known and validated FISH techniques. Here it is reported from a comparative study where HER2 gene sta...... hiện toàn bộ
Relapsed angioimmunoblastic T-cell lymphoma with acquired expression of CD20: a case report and review of the literature
BMC Clinical Pathology - Tập 13 - Trang 1-6 - 2013
Angioimmunoblastic T-cell lymphoma is one of the most common types of peripheral T-cell lymphomas, usually presenting at an older age with an aggressive clinical course. Its characteristic morphological presentation and follicular helper T-cell phenotype help to distinguish it from other T-cell lymphomas. We recently encountered the unique case of a 63-year old patient with relapsed tumour-cell ri...... hiện toàn bộ
Limb girdle muscular dystrophy type 2G with myopathic-neurogenic motor unit potentials and a novel muscle image pattern
BMC Clinical Pathology - Tập 14 Số 1 - 2014
Methyl-binding domain protein-based DNA isolation from human blood serum combines DNA analyses and serum-autoantibody testingAbstract
Background
Circulating cell free DNA in serum as well as serum-autoantibodies and the serum proteome have great potential to contribute to early cancer diagnostics via non invasive blood tests. However, most DNA preparation protocols destroy the protein fraction and therefore do not allo... ... hiện toàn bộ
BMC Clinical Pathology - Tập 11 Số 1 - 2011
Elevated expression of LSD1 (Lysine-specific demethylase 1) during tumour progression from pre-invasive to invasive ductal carcinoma of the breast
BMC Clinical Pathology - Tập 12 - Trang 1-7 - 2012
Lysine-specific demethylase1 (LSD1) is a nuclear protein which belongs to the aminooxidase-enzymes playing an important role in controlling gene expression. It has also been found highly expressed in several human malignancies including breast carcinoma. Our aim was to detect LSD1 expression also in pre-invasive neoplasias of the breast. In the current study we therefore analysed LSD1 protein expr...... hiện toàn bộ
Effects of EDTA and Sodium Citrate on hormone measurements by fluorometric (FIA) and immunofluorometric (IFMA) methods
BMC Clinical Pathology - Tập 2 Số 1 - 2002
A simple and cost-effective method of DNA extraction from small formalin-fixed paraffin-embedded tissue for molecular oncologic testing
BMC Clinical Pathology - Tập 14 - Trang 1-10 - 2014
Extraction of DNA from formalin-fixed, paraffin-embedded (FFPE) tissue is a critical step in molecular oncologic testing. As molecular oncology testing becomes more important for prognostic and therapeutic decision making and tissue specimens become smaller due to earlier detection of suspicious lesions and the use of fine needle aspiration methods for tissue collection, it becomes more challengin...... hiện toàn bộ
Cerebrospinal fluid pleocytosis level as a diagnostic predictor? A cross-sectional study
BMC Clinical Pathology - Tập 17 - Trang 1-8 - 2017
Lumbar puncture with quantification of leukocytes and differential count of cellular subsets in the cerebrospinal fluid is a standard procedure in cases of suspected neuroinfectious conditions. However, a number of non-infectious causes may result in a low leukocyte number (0–1000 cells/ml). We wanted to assess the diagnostic diversity of unselected adult patients with pleocytosis in the cerebrosp...... hiện toàn bộ
Clinical significance of HER2 and EGFR expression in colorectal cancer patients with ovarian metastasis
BMC Clinical Pathology - Tập 19 - Trang 1-8 - 2019
EGFR and HER2 overexpression has been reported to play important roles in colorectal cancer (CRC) development and metastasis. Ovarian metastasis is rare yet is one of the most malignant metastases of CRC, but very few studies have focused on its biological features. This study aimed to investigate the expression of EGFR and HER2 in ovarian metastases of CRC and to reveal their clinical significanc...... hiện toàn bộ
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