Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumorsBMC Clinical Pathology - Tập 12 - Trang 1-10 - 2012
Florence Brellier, Enrico Martina, Martin Degen, Nathalie Heuzé-Vourc’h, Agnès Petit, Thomas Kryza, Yves Courty, Luigi Terracciano, Christian Ruiz, Ruth Chiquet-Ehrismann
Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid...... hiện toàn bộ
Central nervous system tumors: a single center pathology review of 34,140 cases over 60 yearsBMC Clinical Pathology - Tập 13 Số 1 - 2013
Liang Chen, Xiang Zou, Yin Wang, Ying Mao, Lei Zhou
Abstract
Background
Tumor epidemiology is a significant part of CNS (central nervous system) tumor studies. Reassessment of original sections can update our knowledge of tumor spectrum. Here, we discuss the features of CNS tumor pathology in a single center.
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A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assayBMC Clinical Pathology - Tập 2 - Trang 1-16 - 2002
Marilena Kampa, Anastasia Nistikaki, Vassilios Tsaousis, Niki Maliaraki, George Notas, Elias Castanas
Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluids. Among them, bilirubin, uric acid and protein thiols are the major endogenous antioxidants, while vitamins C and E, as well as a number of food-derived (poly)aromatic substances, belonging ...... hiện toàn bộ
Detection of collagen triple helix repeat containing-1 and nuclear factor (erythroid-derived 2)-like 3 in colorectal cancerBMC Clinical Pathology - Tập 12 - Trang 1-12 - 2012
Marco Palma, Lissett Lopez, Margarita García, Nuria de Roja, Tamara Ruiz, Julita García, Elisabet Rosell, Carmen Vela, Paloma Rueda, María-Jose Rodriguez
Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 (NFE2L3) may be useful biomarker candidates for the diagnosis of colorectal cancer (CRC) since they have shown an increase messenger RNA transcripts (mRNA) expression level in adenomas and colorectal tumours when compared to normal tissues. To evaluate CTHRC1 and NFE2L3 as cancer biomarkers, it was g...... hiện toàn bộ
The combined positive impact of Lean methodology and Ventana Symphony autostainer on histology lab workflowBMC Clinical Pathology - Tập 10 - Trang 1-10 - 2010
Lewis A Hassell, Crystal F Glass, Clinton Yip, Patricia A Eneff
Histologic samples all funnel through the H&E microtomy staining area. Here manual processes intersect with semi-automated processes creating a bottleneck. We compare alternate work processes in anatomic pathology primarily in the H&E staining work cell. We established a baseline measure of H&E process impact on personnel, information management and sample flow from historical workload and product...... hiện toàn bộ
Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinomaBMC Clinical Pathology - Tập 15 - Trang 1-13 - 2015
Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström, Jakob Eberhard
Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like 1(PODXL), which is a cell-adhesion glycoprotein and stem cell marker, has been found to correlate with an aggressive tumour phenotype and adverse outcome in several cancer types. The aim of t...... hiện toàn bộ
A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancerBMC Clinical Pathology - Tập 13 - Trang 1-11 - 2013
Takayuki Kobayashi, Keiichi Iwaya, Tomoyuki Moriya, Tamio Yamasaki, Hitoshi Tsuda, Junji Yamamoto, Osamu Matsubara
Ki67 is widely used in order to distinguish the “A” and “B” subtypes of luminal-type breast cancer. This study aimed to validate the prognostic value of adding p53 to Ki67 for characterizing luminal-type breast cancer. Immunostaining for Ki67, p53, and the molecular markers HER2, CK5/6, CK14, EGFR, FOXA1, GATA3, and P-cadherin was examined hormone receptor (HR)-positive cancer tissues from 150 pat...... hiện toàn bộ