BMC Clinical Pathology

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Tenascin-W is a better cancer biomarker than tenascin-C for most human solid tumors
BMC Clinical Pathology - Tập 12 - Trang 1-10 - 2012
Florence Brellier, Enrico Martina, Martin Degen, Nathalie Heuzé-Vourc’h, Agnès Petit, Thomas Kryza, Yves Courty, Luigi Terracciano, Christian Ruiz, Ruth Chiquet-Ehrismann
Tenascins are large glycoproteins found in the extracellular matrix of many embryonic and adult tissues. Tenascin-C is a well-studied biomarker known for its high overexpression in the stroma of most solid cancers. Tenascin-W, the least studied member of the family, is highly expressed in the stroma of colon and breast tumors and in gliomas, but not in the corresponding normal tissues. Other solid...... hiện toàn bộ
The inflammatory infiltrate in the acute stage of the dextran sulphate sodium induced colitis: B cell response differs depending on the percentage of DSS used to induce it
BMC Clinical Pathology - Tập 1 - Trang 1-11 - 2001
Liljana Stevceva, Paul Pavli, Alan J Husband, William F Doe
Experimental colitis with features similar to inflammatory bowel disease (IBD) has initially been described. A detailed analysis of inflammatory cells has not yet been described. Therefore in this study we characterized the cells involved in the acute phase of the colitis and compared those findings to what is known about human IBD. Colitis was induced in BALB/C and C57Bl6 mice by ingestion of 2.5...... hiện toàn bộ
Central nervous system tumors: a single center pathology review of 34,140 cases over 60 years
BMC Clinical Pathology - Tập 13 Số 1 - 2013
Liang Chen, Xiang Zou, Yin Wang, Ying Mao, Lei Zhou
Abstract Background Tumor epidemiology is a significant part of CNS (central nervous system) tumor studies. Reassessment of original sections can update our knowledge of tumor spectrum. Here, we discuss the features of CNS tumor pathology in a single center. ...... hiện toàn bộ
A new automated method for the determination of the Total Antioxidant Capacity (TAC) of human plasma, based on the crocin bleaching assay
BMC Clinical Pathology - Tập 2 - Trang 1-16 - 2002
Marilena Kampa, Anastasia Nistikaki, Vassilios Tsaousis, Niki Maliaraki, George Notas, Elias Castanas
Antioxidant molecules, which scavenge free radical species to prevent or delay oxidative damage of important macromolecules, membrane lipids and lipoproteins, are prevalent in plasma and other biological fluids. Among them, bilirubin, uric acid and protein thiols are the major endogenous antioxidants, while vitamins C and E, as well as a number of food-derived (poly)aromatic substances, belonging ...... hiện toàn bộ
Comparison of the sensitivity of a 24 h-shell vial assay, and conventional tube culture, in the isolation of Herpes simplex virus – 1 from corneal scrapings
BMC Clinical Pathology - Tập 2 - Trang 1-5 - 2002
Sreedharan Athmanathan, Sesha Reddy Bandlapally, Gullapalli N Rao
Herpes simplex keratitis is a sight threatening ocular infection. A rapid and specific diagnosis is essential for the institution of specific antiviral therapy and to avoid complications that can arise from misdiagnosis and inappropriate treatment. Though a variety of techniques are available, isolation of Herpes simplex virus 1 (HSV-1) in culture provides the most reliable and specific method, an...... hiện toàn bộ
Detection of collagen triple helix repeat containing-1 and nuclear factor (erythroid-derived 2)-like 3 in colorectal cancer
BMC Clinical Pathology - Tập 12 - Trang 1-12 - 2012
Marco Palma, Lissett Lopez, Margarita García, Nuria de Roja, Tamara Ruiz, Julita García, Elisabet Rosell, Carmen Vela, Paloma Rueda, María-Jose Rodriguez
Collagen Triple Helix Repeat Containing-1 (CTHRC1) and Nuclear factor (erythroid-derived 2)-like 3 (NFE2L3) may be useful biomarker candidates for the diagnosis of colorectal cancer (CRC) since they have shown an increase messenger RNA transcripts (mRNA) expression level in adenomas and colorectal tumours when compared to normal tissues. To evaluate CTHRC1 and NFE2L3 as cancer biomarkers, it was g...... hiện toàn bộ
The combined positive impact of Lean methodology and Ventana Symphony autostainer on histology lab workflow
BMC Clinical Pathology - Tập 10 - Trang 1-10 - 2010
Lewis A Hassell, Crystal F Glass, Clinton Yip, Patricia A Eneff
Histologic samples all funnel through the H&E microtomy staining area. Here manual processes intersect with semi-automated processes creating a bottleneck. We compare alternate work processes in anatomic pathology primarily in the H&E staining work cell. We established a baseline measure of H&E process impact on personnel, information management and sample flow from historical workload and product...... hiện toàn bộ
Clinico-pathological features of tuberculosis due to Mycobacterium tuberculosis Uganda genotype in patients with tuberculous lymphadenitis: a cross sectional study
BMC Clinical Pathology - Tập 14 - Trang 1-9 - 2014
Dan Wamala, Benon Asiimwe, Edgar Kigozi, Gerald Mboowa, Moses Joloba, Gunilla Kallenius
Tuberculous lymphadenitis is next to pulmonary tuberculosis as the most common cause of tuberculosis. Uganda genotype, one of the sub-lineages of Mycobacterium tuberculosis, is the most prevalent cause of pulmonary tuberculosis in Uganda. We here investigate the clinicopathological characteristics of patients with tuberculous lymphadenitis infected with M. tuberculosis Uganda genotype compared wit...... hiện toàn bộ
Prognostic and predictive significance of podocalyxin-like protein expression in pancreatic and periampullary adenocarcinoma
BMC Clinical Pathology - Tập 15 - Trang 1-13 - 2015
Margareta Heby, Jakob Elebro, Björn Nodin, Karin Jirström, Jakob Eberhard
Adenocarcinoma of the periampullary region is associated with poor prognosis and new prognostic and treatment predictive biomarkers are needed for improved treatment. Membranous expression of podocalyxin-like 1(PODXL), which is a cell-adhesion glycoprotein and stem cell marker, has been found to correlate with an aggressive tumour phenotype and adverse outcome in several cancer types. The aim of t...... hiện toàn bộ
A simple immunohistochemical panel comprising 2 conventional markers, Ki67 and p53, is a powerful tool for predicting patient outcome in luminal-type breast cancer
BMC Clinical Pathology - Tập 13 - Trang 1-11 - 2013
Takayuki Kobayashi, Keiichi Iwaya, Tomoyuki Moriya, Tamio Yamasaki, Hitoshi Tsuda, Junji Yamamoto, Osamu Matsubara
Ki67 is widely used in order to distinguish the “A” and “B” subtypes of luminal-type breast cancer. This study aimed to validate the prognostic value of adding p53 to Ki67 for characterizing luminal-type breast cancer. Immunostaining for Ki67, p53, and the molecular markers HER2, CK5/6, CK14, EGFR, FOXA1, GATA3, and P-cadherin was examined hormone receptor (HR)-positive cancer tissues from 150 pat...... hiện toàn bộ
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