BMC Biochemistry
SCOPUS (2001-2022)
1471-2091
Cơ quản chủ quản: BioMed Central Ltd.
Lĩnh vực:
BiochemistryMolecular Biology
Các bài báo tiêu biểu
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1Abstract
Background
Heparin/heparan sulfate (HS) proteoglycans are found in the extracellular matrix (ECM) and on the cell surface. A considerable body of evidence has established that heparin and heparan sulfate proteoglycans (HSPGs) interact with numerous protein ligands including fibroblast gr... ... hiện toàn bộ
Tập 7 Số 1 - 2006
Characterization of the aggregates formed during recombinant protein expression in bacteriaAbstract
Background
The first aim of the work was to analyze in detail the complexity of the aggregates formed upon overexpression of recombinant proteins in E. coli . A sucrose step gradient succeeded in separating aggregate subclasses of a GFP-GST fusion protein with s... ... hiện toàn bộ
Tập 6 Số 1 - 2005
Phân tích đặc hiệu cơ chất của phức hợp kinase protein Dbf2-Mob1 qua lựa chọn thư viện peptide và sàng lọc mảng proteome Dịch bởi AI Tóm tắt
Đặt bối cảnh
Mạng lưới thoát mitotic (MEN) là một nhóm protein tạo thành một chuỗi tín hiệu thiết yếu để các tế bào thoát khỏi quá trình phân bào trong Saccharomyces cerevisiae . MEN cũng đã được liên quan đến vai trò trong phân chia tế bào. Hai thành phần của co... ... hiện toàn bộ
Tập 6 Số 1 - 2005
#Dbf2-Mob1 #kinase protein #phân chia tế bào #tín hiệu sinh học #cơ chất phosphoryl hóa
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation siteAbstract
Background
The U2 small nuclear ribonucleoprotein particle (snRNP) component SF3b1/SAP155 is the only spliceosomal protein known to be phosphorylated concomitant with splicing catalysis. DYRK1A is a nuclear protein kinase that has been localized to the splicing factor compartment. Here w... ... hiện toàn bộ
Tập 7 Số 1 - 2006
Deubiquitylating enzymes and diseaseAbstract
Abstract
Deubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate a... ... hiện toàn bộ
- 2008
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-κB activity by blocking ubiquitination mediated proteasomal degradation of IκBα in human hepatoma cellsAbstract Background Nuclear factor kappa B (NF-κB) is a key transcription factor that plays a crucial role in host survival during infection by pathogens. Therefore, it has been a priority of many pathogens to manipulate the cellular NF-κB activity in order to create a favorable environment for their survival inside the host.... hiện toàn bộ
- 2012
Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4Abstract
Background
Insulin stimulates exocytosis of GLUT4 from an intracellular store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2 and the regulatory Sec1/Munc18 protein, Munc18c. Syntaxin ... ... hiện toàn bộ
- 2011