Kenji Uchimura, Megumi Morimoto‐Tomita, Annette Bistrup, Jessica Li, Malcolm Lyon, John T. Gallagher, Shingo Kajimura, Steven D. Rosen
AbstractBackgroundHeparin/heparan sulfate (HS) proteoglycans are found in the extracellular matrix (ECM) and on the cell surface. A considerable body of evidence has established that heparin and heparan sulfate proteoglycans (HSPGs) interact with numerous protein ligands including fibroblast gr...... hiện toàn bộ
AbstractBackgroundThe first aim of the work was to analyze in detail the complexity of the aggregates formed upon overexpression of recombinant proteins in E. coli. A sucrose step gradient succeeded in separating aggregate subclasses of a GFP-GST fusion protein with s...... hiện toàn bộ
Angie S. Mah, Andrew E. H. Elia, Geeta Devgan, Jason Ptacek, Mike Schutkowski, M Snyder, Michael B. Yaffe, Raymond J. Deshaies
Tóm tắtĐặt bối cảnhMạng lưới thoát mitotic (MEN) là một nhóm protein tạo thành một chuỗi tín hiệu thiết yếu để các tế bào thoát khỏi quá trình phân bào trong Saccharomyces cerevisiae. MEN cũng đã được liên quan đến vai trò trong phân chia tế bào. Hai thành phần của co...... hiện toàn bộ
#Dbf2-Mob1 #kinase protein #phân chia tế bào #tín hiệu sinh học #cơ chất phosphoryl hóa
Katrin de Graaf, Hanna Czajkowska, Sabine Rottmann, Len C. Packman, Richard Lilischkis, Bernhard Lüscher, Walter Becker
AbstractBackgroundThe U2 small nuclear ribonucleoprotein particle (snRNP) component SF3b1/SAP155 is the only spliceosomal protein known to be phosphorylated concomitant with splicing catalysis. DYRK1A is a nuclear protein kinase that has been localized to the splicing factor compartment. Here w...... hiện toàn bộ
AbstractAbstractDeubiquitylating enzymes (DUBs) can hydrolyze a peptide, amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including the post-translationally formed branched peptide bonds in mono- or multi-ubiquitylated conjugates. DUBs thus have the potential to regulate a...... hiện toàn bộ
AbstractBackgroundNuclear factor kappa B (NF-κB) is a key transcription factor that plays a crucial role in host survival during infection by pathogens. Therefore, it has been a priority of many pathogens to manipulate the cellular NF-κB activity in order to create a favorable environment for their survival inside the host.... hiện toàn bộ
AbstractBackgroundInsulin stimulates exocytosis of GLUT4 from an intracellular store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2 and the regulatory Sec1/Munc18 protein, Munc18c. Syntaxin ...... hiện toàn bộ