BMC Biochemistry
SCOPUS (2000-2019)
1471-2091
Cơ quản chủ quản: BioMed Central Ltd.
Lĩnh vực:
BiochemistryMolecular Biology
Phân tích ảnh hưởng
Các bài báo tiêu biểu
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
Tập 7 Số 1 - 2006
Abstract Background Heparin/heparan sulfate (HS) proteoglycans are found in the
extracellular matrix (ECM) and on the cell surface. A considerable body of
evidence has established that heparin and heparan sulfate proteoglycans (HSPGs)
interact with numerous protein ligands including fibroblast growth factors,
vascular endothelial growth factor (VEGF), cytokines, and chemokines. These
interactions ...
Characterization of the aggregates formed during recombinant protein expression in bacteria
Tập 6 Số 1 - 2005
Abstract Background The first aim of the work was to analyze in detail the
complexity of the aggregates formed upon overexpression of recombinant proteins
in E. coli. A sucrose step gradient succeeded in separating aggregate subclasses
of a GFP-GST fusion protein with specific biochemical and biophysical features,
providing a novel approach for studying recombinant protein aggregates. Results
The ...
Phân tích đặc hiệu cơ chất của phức hợp kinase protein Dbf2-Mob1 qua lựa chọn thư viện peptide và sàng lọc mảng proteome Dịch bởi AI
Tập 6 Số 1 - 2005
Tóm tắt Đặt bối cảnh Mạng lưới thoát mitotic (MEN) là một nhóm protein tạo thành
một chuỗi tín hiệu thiết yếu để các tế bào thoát khỏi quá trình phân bào trong
Saccharomyces cerevisiae. MEN cũng đã được liên quan đến vai trò trong phân chia
tế bào. Hai thành phần của con đường tín hiệu này là kinase protein Dbf2 và đối
tác liên kết của nó cần thiết cho hoạt động kinase, Mob1. Các thành phần của ME...
#Dbf2-Mob1 #kinase protein #phân chia tế bào #tín hiệu sinh học #cơ chất phosphoryl hóa
The protein kinase DYRK1A phosphorylates the splicing factor SF3b1/SAP155 at Thr434, a novel in vivo phosphorylation site
Tập 7 Số 1 - 2006
Abstract Background The U2 small nuclear ribonucleoprotein particle (snRNP)
component SF3b1/SAP155 is the only spliceosomal protein known to be
phosphorylated concomitant with splicing catalysis. DYRK1A is a nuclear protein
kinase that has been localized to the splicing factor compartment. Here we
describe the identification of DYRK1A as a protein kinase that phosphorylates
SF3b1 in vitro and in c...
Deubiquitylating enzymes and disease
- 2008
Abstract Abstract Deubiquitylating enzymes (DUBs) can hydrolyze a peptide,
amide, ester or thiolester bond at the C-terminus of UBIQ (ubiquitin), including
the post-translationally formed branched peptide bonds in mono- or
multi-ubiquitylated conjugates. DUBs thus have the potential to regulate any
UBIQ-mediated cellular process, the two best characterized being proteolysis and
protein trafficking...
The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-κB activity by blocking ubiquitination mediated proteasomal degradation of IκBα in human hepatoma cells
- 2012
AbstractBackgroundNuclear factor kappa B (NF-κB) is a key transcription factor
that plays a crucial role in host survival during infection by pathogens.
Therefore, it has been a priority of many pathogens to manipulate the cellular
NF-κB activity in order to create a favorable environment for their survival
inside the host.ResultsWe observed that heterologous expression of the open
reading frame 2...
Tyrosine phosphorylation of Munc18c on residue 521 abrogates binding to Syntaxin 4
- 2011
Abstract Background Insulin stimulates exocytosis of GLUT4 from an intracellular
store to the cell surface of fat and muscle cells. Fusion of GLUT4-containing
vesicles with the plasma membrane requires the SNARE proteins Syntaxin 4, VAMP2
and the regulatory Sec1/Munc18 protein, Munc18c. Syntaxin 4 and Munc18c form a
complex that is disrupted upon insulin treatment of adipocytes. Munc18c is
tyrosin...