Alzheimer's & Dementia

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Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's disease
Alzheimer's & Dementia - Tập 12 - Trang 654-668 - 2016
David C. Hondius, Pim van Nierop, Ka Wan Li, Jeroen J.M. Hoozemans, Roel C. van der Schors, Elise S. van Haastert, Saskia M. van der Vies, Annemieke J.M. Rozemuller, August B. Smit
AbstractIntroductionWe performed a comprehensive quantitative proteomics study on human hippocampus tissue involving all Braak stages to assess changes in protein abundance over the various stages of Alzheimer's disease (AD).MethodsHippocampal subareas CA1 and subiculu...... hiện toàn bộ
Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery
Alzheimer's & Dementia - Tập 10 - Trang 675-683 - 2014
Melissa Mathews, Erin Abner, Richard Kryscio, Gregory Jicha, Gregory Cooper, Charles Smith, Allison Caban-Holt, Frederick A. Schmitt
AbstractIntroductionThe Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.Methods... hiện toàn bộ
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease
Alzheimer's & Dementia - Tập 14 - Trang 652-663 - 2018
Antoine Leuzy, Elena Rodriguez-Vieitez, Laure Saint-Aubert, Konstantinos Chiotis, Ove Almkvist, Irina Savitcheva, My Jonasson, Mark Lubberink, Anders Wall, Gunnar Antoni, Agneta Nordberg
AbstractIntroductionCross‐sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery...... hiện toàn bộ
The oldest old and the 90+ Study
Alzheimer's & Dementia - Tập 4 - Trang S56-S59 - 2008
Claudia H. Kawas
Memories are the gifts from friends and family that stay with us forever, unless a person develops Alzheimer's disease. Leon J. Thal left many, many memories, along with his desire to create a world where people did not lose them to the ravages of dementing illnesses. Working from the bench to the clinic, he was an incomparable leader, scientist, and educator to whom many, including myself...... hiện toàn bộ
Association of GWAS‐linked loci with late‐onset Alzheimer's disease in a northern Han Chinese population
Alzheimer's & Dementia - Tập 9 - Trang 546-553 - 2013
Lan Tan, Jin-Tai Yu, Wei Zhang, Zhong-Chen Wu, Qun Zhang, Qiu-Yan Liu, Wei Wang, Hui-Fu Wang, Xiao-Ying Ma, Wei-Zhen Cui
AbstractObjectiveFive genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU, CR1, PICALM, BIN1, ABCA7, MS4A... hiện toàn bộ
Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's disease
Alzheimer's & Dementia - Tập 16 Số 4 - Trang 641-650 - 2020
Marwan N. Sabbagh, Carl Sadowsky, Babak Tousi, Marc Agronin, Gustavo Alva, Carmel Armon, Charles Bernick, Andrew P. Keegan, Stella Karantzoulis, Eyal Baror, Moran Ploznik, Álvaro Pascual‐Leone
AbstractIntroductionThis clinical trial evaluates the efficacy and safety of a 6‐week course of daily neuroAD™ therapy.Methods131 subjects between 60 and 90 years old, unmedicated for Alzheimer's disease (AD), or on stable doses of an acetylcholinesterase inhibitor and...... hiện toàn bộ
Declining incidence of dementia: A national registry‐based study over 20 years
Alzheimer's & Dementia - Tập 15 - Trang 1383-1391 - 2019
Lærke Taudorf, Ane Nørgaard, Sabrina Islamoska, Kasper Jørgensen, Thomas Munk Laursen, Gunhild Waldemar
AbstractIntroductionThe aim of this study was to investigate the registry‐based national time trends in incidence and prevalence rates of dementia from 1996 to 2015.MethodsWe assessed annual incidence and prevalence using longitudinal data from nationwide registries on...... hiện toàn bộ
Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's disease
Alzheimer's & Dementia - Tập 11 - Trang 58-69 - 2015
Kaj Blennow, Bruno Dubois, Anne M. Fagan, Piotr Lewczuk, Mony J. de Leon, Harald Hampel
AbstractSeveral potential disease‐modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials, conceivably because the AD subjects are already too advanced to derive clinical benefit from treatment and because diagnosis based on clinical criteria alone introduces a high misdiagnosis r...... hiện toàn bộ
Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohort
Alzheimer's & Dementia - Tập 12 - Trang 1226-1234 - 2016
Jeffrey L. Dage, Alexandra M.V. Wennberg, David C. Airey, Clinton E. Hagen, David S. Knopman, Mary M. Machulda, Rosebud O. Roberts, Clifford R. Jack, Ronald C. Petersen, Michelle M. Mielke
AbstractIntroductionTau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer's disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals.... hiện toàn bộ
Prevalence of dementia subtypes in United States Medicare fee‐for‐service beneficiaries, 2011–2013
Alzheimer's & Dementia - Tập 13 - Trang 28-37 - 2017
Richard A. Goodman, Kimberly A. Lochner, Madhav Thambisetty, Thomas S. Wingo, Samuel F. Posner, Shari M. Ling
AbstractIntroductionRapid growth of the older adult population requires greater epidemiologic characterization of dementia. We developed national prevalence estimates of diagnosed dementia and subtypes in the highest risk United States (US) population.MethodsWe analyze...... hiện toàn bộ
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