Alzheimer's & Dementia
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Frequency and longitudinal clinical outcomes of Alzheimer's AT(N) biomarker profiles: A longitudinal studyAbstract Introduction We aimed to estimate the frequency of each AT(N) (β‐amyloid deposition [A], pathologic tau [T], and neurodegeneration [N]) profile in different clinical diagnosis groups and to describe the longitudinal change in clinical outcomes of individuals in each group. Methods... hiện toàn bộ
Alzheimer's & Dementia - Tập 15 - Trang 1208-1217 - 2019
Markers of Alzheimer's disease in a population attending a memory clinicBackground New marker‐based criteria for the diagnosis of Alzheimer's disease (AD) were recently proposed. We describe their operational translation in 144 consecutive patients referred to our Memory Clinic. Methods Visual ratings of hippocampal atrophy and of cortical glucose hypometabolism in m...
Alzheimer's & Dementia - Tập 5 - Trang 307-317 - 2009
[18F]flutemetamol amyloid positron emission tomography in preclinical and symptomatic Alzheimer's disease: Specific detection of advanced phases of amyloid‐β pathologyAbstract Background Amyloid positron emission tomography (PET) has become an important tool to identify amyloid‐β (Aβ) pathology in Alzheimer's disease (AD) patients. Here, we determined the diagnostic value of the amyloid PET tracer [18 F]flutemetamol in relation to Aβ pathology at autopsy. ... hiện toàn bộ
Alzheimer's & Dementia - Tập 11 - Trang 975-985 - 2015
Florbetapir positron emission tomography and cerebrospinal fluid biomarkersAbstract Background We evaluated the relationship between florbetapir‐F18 positron emission tomography (FBP PET) and cerebrospinal fluid (CSF) biomarkers. Methods Alzheimer's Disease Neuroimaging Initiative‐Grand Opportunity and Alzheimer's Disease Neuroimaging Initiative ...
Alzheimer's & Dementia - Tập 11 - Trang 986-993 - 2015
Mild cognitive impairment and cognitive impairment, no dementia: Part A, concept and diagnosisMild cognitive impairment (MCI) and cognitive impairment, no dementia (CIND) are controversial emerging terms that encompass the clinical state between elderly normal cognition and dementia. This article reviews recent work on the classification of MCI and CIND, their prognosis, and diagnostic approaches and presents evidence‐based recommendations approved at the me...
Alzheimer's & Dementia - Tập 3 - Trang 266-282 - 2007
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's diseaseAbstract Introduction Cross‐sectional findings using the tau tracer [18 F]THK5317 (THK5317) have shown that [18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery...
Alzheimer's & Dementia - Tập 14 - Trang 652-663 - 2018
Subjective memory complaints, education, and risk of Alzheimer's diseaseBackground Subjective memory complaints are common in the elderly. Although memory complaints are associated with an increased risk of Alzheimer's disease in persons with cognitive impairment as well as in persons with normal cognition, they are commonly considered of less importance than objective cognitive measures. We hypothesized that the clinical rele...
Alzheimer's & Dementia - Tập 3 - Trang 92-97 - 2007
Commentary on “A roadmap for the prevention of dementia II. Leon Thal Symposium 2008.” The Multidomain Alzheimer Preventive Trial (MAPT): A new approach to the prevention of Alzheimer's diseaseBackground Because no effective curative approaches are available, preventive approaches in the field of Alzheimer's disease (AD) are needed. We present the design of the ongoing Multidomain Alzheimer Preventive Trial (MAPT) Study. Several previous studies suggested that many factors may be involved in the occurrence of AD at late ages. Because of the prob...
Alzheimer's & Dementia - Tập 5 - Trang 114-121 - 2009
Role of biomarkers in studies of presymptomatic Alzheimer's diseaseBackground Biomarkers that have been developed largely for the study of patients with clinically diagnosed Alzheimer's disease (AD) can also be used in the study of cognitively normal individuals who may harbor underlying AD pathology. Methods A meeting of invited experts on AD biomarkers was hel...
Alzheimer's & Dementia - Tập 1 - Trang 145-151 - 2005
Neuropsychiatric symptoms as risk factors of dementia in a Mexican population: A 10/66 Dementia Research Group studyAbstract Introduction Cognitive and/or memory impairment are the main clinical markers currently used to identify subjects at risk of developing dementia. This study aimed to explore the relationship between the presence of neuropsychiatric symptoms and dementia incidence. Methods... hiện toàn bộ
Alzheimer's & Dementia - Tập 14 - Trang 271-279 - 2018
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