Alzheimer's & Dementia
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Profiling the human hippocampal proteome at all pathologic stages of Alzheimer's diseaseAbstract Introduction We performed a comprehensive quantitative proteomics study on human hippocampus tissue involving all Braak stages to assess changes in protein abundance over the various stages of Alzheimer's disease (AD). Methods Hippocampal subareas CA1 and subiculu...
Alzheimer's & Dementia - Tập 12 - Trang 654-668 - 2016
Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's diseaseAbstract Introduction Cross‐sectional findings using the tau tracer [18 F]THK5317 (THK5317) have shown that [18 F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery...
Alzheimer's & Dementia - Tập 14 - Trang 652-663 - 2018
Association of GWAS‐linked loci with late‐onset Alzheimer's disease in a northern Han Chinese populationAbstract Objective Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU , CR1 , PICALM, BIN1 , ABCA7 , MS4A...
Alzheimer's & Dementia - Tập 9 - Trang 546-553 - 2013
Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's diseaseAbstract Introduction This clinical trial evaluates the efficacy and safety of a 6‐week course of daily neuroAD™ therapy. Methods 131 subjects between 60 and 90 years old, unmedicated for Alzheimer's disease (AD), or on stable doses of an acetylcholinesterase inhibitor and...
Alzheimer's & Dementia - Tập 16 Số 4 - Trang 641-650 - 2020
Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's diseaseAbstract Several potential disease‐modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials, conceivably because the AD subjects are already too advanced to derive clinical benefit from treatment and because diagnosis based on clinical criteria alone introduces a high misdiagnosis r...
Alzheimer's & Dementia - Tập 11 - Trang 58-69 - 2015
Prevalence of dementia subtypes in United States Medicare fee‐for‐service beneficiaries, 2011–2013Abstract Introduction Rapid growth of the older adult population requires greater epidemiologic characterization of dementia. We developed national prevalence estimates of diagnosed dementia and subtypes in the highest risk United States (US) population. Methods We analyze...
Alzheimer's & Dementia - Tập 13 - Trang 28-37 - 2017
Psychosocial stress at work is associated with increased dementia risk in late lifeAbstract Objective To test the hypothesis that high job stress during working life might lead to an increased risk of dementia and Alzheimer's disease (AD) in late life. Methods A dementia‐free cohort of 913 community dwellers, aged 75+ years, from the Kungsholmen Project,...
Alzheimer's & Dementia - Tập 8 Số 2 - Trang 114-120 - 2012
Disease‐modifying therapies in Alzheimer's diseaseAlzheimer's disease (AD) is a chronic, progressive, neurodegenerative disorder that places a substantial burden on patients, their families, and society. The disease affects approximately 5 million individuals in the United States, with an annual cost of care greater than $100 billion. During the past dozen years, several agents have been approved that enhance cogni...
Alzheimer's & Dementia - Tập 4 - Trang 65-79 - 2008
Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer's diseaseBackground Recent data have shown that in the early stages of Alzheimer's disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. Methods Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging,...
Alzheimer's & Dementia - Tập 3 - Trang 54-57 - 2007
Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaintsAbstract Background The need to recognize Alzheimer's disease (AD) as early as possible led us to evaluate the predictive value of amyloid β(1‐42) (Aβ42), total tau (tau), and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) for clinical progression in patients with subjective complaints. ...
Alzheimer's & Dementia - Tập 9 - Trang 481-487 - 2013
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