Alzheimer's & Dementia
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Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's diseaseAbstract Introduction This clinical trial evaluates the efficacy and safety of a 6‐week course of daily neuroAD™ therapy. Methods 131 subjects between 60 and 90 years old, unmedicated for Alzheimer's disease (AD), or on stable doses of an acetylcholinesterase inhibitor and...
Alzheimer's & Dementia - Tập 16 Số 4 - Trang 641-650 - 2020
Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's diseaseAbstract Several potential disease‐modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials, conceivably because the AD subjects are already too advanced to derive clinical benefit from treatment and because diagnosis based on clinical criteria alone introduces a high misdiagnosis r...
Alzheimer's & Dementia - Tập 11 - Trang 58-69 - 2015
Prevalence of dementia subtypes in United States Medicare fee‐for‐service beneficiaries, 2011–2013Abstract Introduction Rapid growth of the older adult population requires greater epidemiologic characterization of dementia. We developed national prevalence estimates of diagnosed dementia and subtypes in the highest risk United States (US) population. Methods We analyze...
Alzheimer's & Dementia - Tập 13 - Trang 28-37 - 2017
Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer's diseaseBackground Recent data have shown that in the early stages of Alzheimer's disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. Methods Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging,...
Alzheimer's & Dementia - Tập 3 - Trang 54-57 - 2007
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability
Alzheimer's & Dementia - Tập 12 - Trang 633 - 2016
Introduction Loss of synapses best correlates to cognitive deficits in Alzheimer's disease (AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic pathology. Although a number of clinical pathologic studies have been performed with limited sample size, there are no systematic studies encompassing large samples. Therefore, we performed a meta-analysis study. Methods ......
#Alzheimer's disease #Endosomal/lysosomal pathway #Meta-analysis #Synapse markers #Synapse number
Imaging‐based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairmentAbstract The mild cognitive impairment (MCI) stage of Alzheimer's disease (AD) may be optimal for clinical trials to test potential treatments for preventing or delaying decline to dementia. However, MCI is heterogeneous in that not all cases progress to dementia within the time frame of a trial and some may not have underlying AD pathology. ...
Alzheimer's & Dementia - Tập 11 - Trang 1489-1499 - 2015
Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriersBackground We sought to determine if the APOE ε4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. Methods Twenty‐four healthy young adults, i.e., 12 carriers and 12 n...
Alzheimer's & Dementia - Tập 6 - Trang 303-311 - 2010
Physician outpatient contacts and hospitalizations among cognitively impaired elderlyBackground This study examined how physician contacts and hospitalizations vary in relation to cognitive function level among community‐residing older adults. Methods Analysis of the 1998 wave of the Health and Retirement Survey (HRS) was conducted to create three levels of cognitive function amo...
Alzheimer's & Dementia - Tập 5 - Trang 30-42 - 2009
An inflammatory and trophic disconnect biomarker profile revealed in Down syndrome plasma: Relation to cognitive decline and longitudinal evaluationAbstract Introduction Given that Alzheimer's pathology develops silently over decades in Down syndrome (DS), prognostic biomarkers of dementia are a major need. Methods We investigated the plasma levels of Aβ, proNGF, tPA, neuroserpin, metallo‐proteases and inflammatory mo...
Alzheimer's & Dementia - Tập 12 - Trang 1132-1148 - 2016
Rethinking the Food and Drug Administration's 2013 guidance on developing drugs for early‐stage Alzheimer's diseaseAbstract The February 2013 Food and Drug Administration (FDA) draft guidance for developing drugs for early‐stage Alzheimer's disease (AD) creates certain challenges as they guide toward the use of one cognitive outcome to gain accelerated marketing approval for preclinical AD drugs, and a composite clinical scale – the Clinical Dementia Rati...
Alzheimer's & Dementia - Tập 10 - Trang 247-250 - 2014
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