Alzheimer's & Dementia
Công bố khoa học tiêu biểu
* Dữ liệu chỉ mang tính chất tham khảo
Sắp xếp:
Association of GWAS‐linked loci with late‐onset Alzheimer's disease in a northern Han Chinese populationAbstract Objective Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU , CR1 , PICALM, BIN1 , ABCA7 , MS4A...
Alzheimer's & Dementia - Tập 9 - Trang 546-553 - 2013
Effects of a combined transcranial magnetic stimulation (TMS) and cognitive training intervention in patients with Alzheimer's diseaseAbstract Introduction This clinical trial evaluates the efficacy and safety of a 6‐week course of daily neuroAD™ therapy. Methods 131 subjects between 60 and 90 years old, unmedicated for Alzheimer's disease (AD), or on stable doses of an acetylcholinesterase inhibitor and...
Alzheimer's & Dementia - Tập 16 Số 4 - Trang 641-650 - 2020
Clinical utility of cerebrospinal fluid biomarkers in the diagnosis of early Alzheimer's diseaseAbstract Several potential disease‐modifying drugs for Alzheimer's disease (AD) have failed to show any effect on disease progression in clinical trials, conceivably because the AD subjects are already too advanced to derive clinical benefit from treatment and because diagnosis based on clinical criteria alone introduces a high misdiagnosis r...
Alzheimer's & Dementia - Tập 11 - Trang 58-69 - 2015
Prevalence of dementia subtypes in United States Medicare fee‐for‐service beneficiaries, 2011–2013Abstract Introduction Rapid growth of the older adult population requires greater epidemiologic characterization of dementia. We developed national prevalence estimates of diagnosed dementia and subtypes in the highest risk United States (US) population. Methods We analyze...
Alzheimer's & Dementia - Tập 13 - Trang 28-37 - 2017
Greater frequency of subcortical lesions in severely demented patients with early onset Alzheimer's diseaseBackground Recent data have shown that in the early stages of Alzheimer's disease (AD), vascular brain lesions might promote the progression of cognitive decline or might even precede neuronal damage. Methods Ischemic brain lesions, recognized on computed tomography or magnetic resonance imaging,...
Alzheimer's & Dementia - Tập 3 - Trang 54-57 - 2007
Cerebrospinal fluid Aβ42 is the best predictor of clinical progression in patients with subjective complaintsAbstract Background The need to recognize Alzheimer's disease (AD) as early as possible led us to evaluate the predictive value of amyloid β(1‐42) (Aβ42), total tau (tau), and phosphorylated tau (ptau) in cerebrospinal fluid (CSF) for clinical progression in patients with subjective complaints. ...
Alzheimer's & Dementia - Tập 9 - Trang 481-487 - 2013
Meta-analysis of synaptic pathology in Alzheimer's disease reveals selective molecular vesicular machinery vulnerability
Alzheimer's & Dementia - Tập 12 - Trang 633 - 2016
Introduction Loss of synapses best correlates to cognitive deficits in Alzheimer's disease (AD) in which oligomeric neurotoxic species of amyloid-β appears to contribute synaptic pathology. Although a number of clinical pathologic studies have been performed with limited sample size, there are no systematic studies encompassing large samples. Therefore, we performed a meta-analysis study. Methods ......
#Alzheimer's disease #Endosomal/lysosomal pathway #Meta-analysis #Synapse markers #Synapse number
Imaging‐based enrichment criteria using deep learning algorithms for efficient clinical trials in mild cognitive impairmentAbstract The mild cognitive impairment (MCI) stage of Alzheimer's disease (AD) may be optimal for clinical trials to test potential treatments for preventing or delaying decline to dementia. However, MCI is heterogeneous in that not all cases progress to dementia within the time frame of a trial and some may not have underlying AD pathology. ...
Alzheimer's & Dementia - Tập 11 - Trang 1489-1499 - 2015
Temporal lobe functional activity and connectivity in young adult APOE ɛ4 carriersBackground We sought to determine if the APOE ε4 allele influences both the functional activation and connectivity of the medial temporal lobes (MTLs) during successful memory encoding in young adults. Methods Twenty‐four healthy young adults, i.e., 12 carriers and 12 n...
Alzheimer's & Dementia - Tập 6 - Trang 303-311 - 2010
Leisure‐time physical activity sustained since midlife and preservation of cognitive function: The Atherosclerosis Risk in Communities StudyAbstract Introduction We tested the hypotheses that higher levels of and persistence of midlife leisure‐time physical activity (LTPA) are associated long‐term with lower cognitive decline and less incident dementia. Methods A total of 10,705 participants (mean age: 60 year...
Alzheimer's & Dementia - Tập 15 - Trang 273-281 - 2019
Tổng số: 681
- 1
- 2
- 3
- 4
- 5
- 6
- 10