Levels of tau protein in plasma are associated with neurodegeneration and cognitive function in a population‐based elderly cohort

Alzheimer's & Dementia - Tập 12 - Trang 1226-1234 - 2016
Jeffrey L. Dage1, Alexandra M.V. Wennberg2, David C. Airey, Clinton E. Hagen3, David S. Knopman4, Mary M. Machulda5, Rosebud O. Roberts2,4, Clifford R. Jack6, Ronald C. Petersen4, Michelle M. Mielke2,4
1Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN, USA
2Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
3Division of Biomedical Statistics and Informatics, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA
4Department of Neurology, Mayo Clinic, Rochester, MN, USA
5Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN, USA
6Department of Radiology, Mayo Clinic, Rochester, MN, USA

Tóm tắt

AbstractIntroductionTau protein levels in plasma may be a marker of neuronal damage. We examined associations between plasma tau levels and Alzheimer's disease (AD)–related magnetic resonance imaging (MRI) and positron emission tomography (PET) neuroimaging measures among nondemented individuals.MethodsParticipants included 378 cognitively normal (CN) and 161 mild cognitive impairment (MCI) individuals enrolled in the Mayo Clinic Study of Aging with concurrent neuropsychological measures and amyloid PET, fluorodeoxyglucose PET, and MRI. Baseline plasma tau levels were measured using the Quanterix Simoa‐HD1 tau assay.ResultsPlasma tau levels were higher in MCI compared with CN (4.34 vs. 4.14 pg/mL, P = .078). In regression models adjusted for age, gender, education, and APOE, higher plasma tau was associated with worse memory performance (b = −0.30, P = .02) and abnormal cortical thickness in an AD signature region (odds ratio = 1.80, P = .018).DiscussionPlasma tau is associated with cortical thickness and memory performance. Longitudinal studies will better elucidate the associations between plasma tau, neurodegeneration, and cognition.

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Alzheimer's & Dementia

Tập 12

1226-1234

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