Diagnostic accuracy and practice effects in the National Alzheimer's Coordinating Center Uniform Data Set neuropsychological battery

Alzheimer's & Dementia - Tập 10 - Trang 675-683 - 2014
Melissa Mathews1,2, Erin Abner1,3, Richard Kryscio1,3, Gregory Jicha1,2, Gregory Cooper1,4, Charles Smith1,2, Allison Caban-Holt1,5, Frederick A. Schmitt1,5,2
1Sanders-Brown Center on Aging, University of Kentucky, Lexington, KY, USA
2Department of Neurology, University of Kentucky, Lexington, KY, USA
3Department of Statistics and Biostatistics, University of Kentucky, Lexington, KY, USA
4Baptist Neurology Center, University of Kentucky, Lexington, KY, USA
5Department of Behavioral Science, University of Kentucky, Lexington, KY, USA

Tóm tắt

AbstractIntroductionThe Uniform Data Set (UDS) neuropsychological battery is frequently used in clinical studies. However, practice effects, effectiveness as a measure of global cognitive functioning, and detection of mild cognitive impairment have not been examined.MethodsA normative total score for the UDS has been developed. Linear discriminant analysis determined classification accuracy in identifying cognitively normal and impaired groups. Practice effects were examined in cognitively normal and cognitively impaired groups.ResultsThe total score differentiates between cognitively normal participants and those with dementia, but does not accurately identify individuals with mild cognitive impairment (MCI). Mean total scores for test‐exposed participants were significantly higher than test‐naive participants in both the normal and MCI groups and were higher, but not significantly so, in the dementia group.ConclusionThe total score's classification accuracy discriminates between cognitively normal versus participants who have dementia. The total score appears subject to practice effects.

Tài liệu tham khảo

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Alzheimer's & Dementia

Tập 10

675-683

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