Longitudinal uncoupling of cerebral perfusion, glucose metabolism, and tau deposition in Alzheimer's disease

Alzheimer's & Dementia - Tập 14 - Trang 652-663 - 2018
Antoine Leuzy1, Elena Rodriguez-Vieitez1, Laure Saint-Aubert1, Konstantinos Chiotis1, Ove Almkvist1,2,3, Irina Savitcheva4, My Jonasson5,6, Mark Lubberink5,6, Anders Wall5,7, Gunnar Antoni7, Agneta Nordberg1,2
1Division of Translational Alzheimer Neurobiology, Department of Neurobiology, Care Sciences, and Society, Karolinska Institutet, Stockholm, Sweden
2Department of Geriatric Medicine, Karolinska University Hospital, Huddinge, Sweden
3Department of Psychology, Stockholm University, Stockholm, Sweden
4Department of Radiology, Karolinska University Hospital, Huddinge, Sweden
5Radiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden
6Department of Medical Physics, Uppsala University Hospital, Uppsala, Sweden
7Department of Medicinal Chemistry, Uppsala University, Uppsala, Sweden

Tóm tắt

AbstractIntroduction

Cross‐sectional findings using the tau tracer [18F]THK5317 (THK5317) have shown that [18F]fluorodeoxyglucose (FDG) positron emission tomography (PET) data can be approximated using perfusion measures (early‐frame standardized uptake value ratio; ratio of tracer delivery in target to reference regions). In this way, a single PET study can provide both functional and molecular information.

Methods

We included 16 patients with Alzheimer's disease who completed follow‐up THK5317 and FDG studies 17 months after baseline investigations. Linear mixed‐effects models and annual percentage change maps were used to examine longitudinal change.

Results

Limited spatial overlap was observed between areas showing declines in THK5317 perfusion measures and FDG. Minimal overlap was seen between areas showing functional change and those showing increased retention of THK5317.

Discussion

Our findings suggest a spatiotemporal offset between functional changes and tau pathology and a partial uncoupling between perfusion and metabolism, possibly as a function of Alzheimer's disease severity.


Tài liệu tham khảo

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Alzheimer's & Dementia

Tập 14

652-663

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