Therapeutic potential of Fingolimod in triple negative breast cancer preclinical models

Translational Oncology - Tập 14 - Trang 100926 - 2021
Tristan Rupp1, Océane Pelouin1, Laurie Genest1, Christophe Legrand1, Guillaume Froget1, Vincent Castagné1
1Porsolt SAS, ZA de Glatigné, 53940 Le Genest-Saint-Isle, France

Tài liệu tham khảo

Cardoso, 2018, 4th ESO-ESMO international consensus guidelines for advanced breast cancer (ABC 4)†, Ann. Oncol., 29, 1634, 10.1093/annonc/mdy192

Harbeck, 2019, Breast cancer, Nat. Rev. Dis. Primers, 5, 1, 10.1038/s41572-019-0111-2

Dent, 2007, Triple-negative breast cancer: clinical features and patterns of recurrence, Clin. Cancer Res., 13, 4429, 10.1158/1078-0432.CCR-06-3045

Nagahashi, 2018, The role of sphingosine‐1‐phosphate in inflammation and cancer progression, Cancer Sci., 109, 3671, 10.1111/cas.13802

Pyne, 2010, Sphingosine 1-phosphate and cancer, Nat. Rev. Cancer, 10, 489, 10.1038/nrc2875

Grammatikos, 2016, Serum sphingolipidomic analyses reveal an upregulation of C16- ceramide and sphingosine-1-phosphate in hepatocellular carcinoma, Oncotarget, 7, 18095, 10.18632/oncotarget.7741

Zeng, 2016, Sphingosine-1-phosphate induced epithelial-mesenchymal transition of hepatocellular carcinoma via an MMP-7/syndecan-1/TGF-β autocrine loop, Oncotarget, 7, 63324, 10.18632/oncotarget.11450

Hirose, 2018, Generation of sphingosine-1-phosphate is enhanced in biliary tract cancer patients and is associated with lymphatic metastasis, Sci. Rep., 8, 10.1038/s41598-018-29144-9

Nagahashi, 2016, High levels of sphingolipids in human breast cancer, J. Surg. Res., 204, 435, 10.1016/j.jss.2016.05.022

Wang, 2018, Triple negative breast cancer depends on sphingosine kinase 1 (SphK1)/sphingosine-1-phosphate (S1P)/sphingosine 1-phosphate receptor 3 (S1PR3)/notch signaling for metastasis, Med. Sci. Monit., 24, 1912, 10.12659/MSM.905833

Tintore, 2019, Treatment of multiple sclerosis — success from bench to bedside, Nat. Rev. Neurol., 15, 53, 10.1038/s41582-018-0082-z

Geffken, 2018, Sphingosine kinase 1 in breast cancer, Adv. Biol. Regul., 67, 59, 10.1016/j.jbior.2017.10.005

Patmanathan, 2015, The antineoplastic properties of FTY720: evidence for the repurposing of Fingolimod, J. Cell. Mol. Med., 19, 2329, 10.1111/jcmm.12635

White, 2016, The emerging role of FTY720 (Fingolimod) in cancer treatment, Oncotarget, 7, 23106, 10.18632/oncotarget.7145

Rosa, 2013, Sphingosine kinase 1 overexpression contributes to cetuximab resistance in human colorectal cancer models, Clin. Cancer Res., 19, 138, 10.1158/1078-0432.CCR-12-1050

Ho, 2005, Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Mol. Cancer Ther., 4, 1430, 10.1158/1535-7163.MCT-05-0021

Pchejetski, 2010, FTY720 (Fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1, Cancer Res., 70, 8651, 10.1158/0008-5472.CAN-10-1388

Gstalder, 2016, FTY720 (Fingolimod) inhibits HIF1 and HIF2 signaling, promotes vascular remodeling, and chemosensitizes in renal cell carcinoma animal model, Mol. Cancer Ther., 15, 2465, 10.1158/1535-7163.MCT-16-0167

LaMontagne, 2006, Antagonism of sphingosine-1-phosphate receptors by FTY720 inhibits angiogenesis and tumor vascularization, Cancer Res., 66, 221, 10.1158/0008-5472.CAN-05-2001

Langlois, 2014, AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients, Oncotarget, 5, 10529, 10.18632/oncotarget.2470

Kalhori, 2016, FTY720 (Fingolimod) attenuates basal and sphingosine-1-phosphate-evoked thyroid cancer cell invasion, Endocr. Relat. Cancer, 23, 457, 10.1530/ERC-16-0050

Nagahashi, 2018, Targeting the SphK1/S1P/S1PR1 axis that links obesity, chronic inflammation, and breast cancer metastasis, Cancer Res., 78, 1713, 10.1158/0008-5472.CAN-17-1423

Dai, 2017, Breast cancer cell line classification and its relevance with breast tumor subtyping, J. Cancer, 8, 3131, 10.7150/jca.18457

Liang, 2014, Silencing of CXCR4 sensitizes triple-negative breast cancer cells to cisplatin, Oncotarget, 6, 1020, 10.18632/oncotarget.2741

Gomes, 2019, ATR mediates cisplatin resistance in 3D-cultured breast cancer cells via translesion DNA synthesis modulation, Cell Death. Dis., 10, 1, 10.1038/s41419-019-1689-8

Marvaso, 2014, Sphingosine analog fingolimod (FTY720) increases radiation sensitivity of human breast cancer cells in vitro, Cancer Biol. Ther., 15, 797, 10.4161/cbt.28556

Liang, 2005, Silencing of CXCR4 Blocks Breast Cancer Metastasis, Cancer Res., 65, 967, 10.1158/0008-5472.967.65.3

Woo, 2015, FTY720 enhances TRAIL-mediated apoptosis by up-regulating DR5 and down-regulating Mcl-1 in cancer cells, Oncotarget, 6, 11614, 10.18632/oncotarget.3426

Nagahashi, 2012, Sphingosine-1-phosphate produced by sphingosine kinase 1 promotes breast cancer progression by stimulating angiogenesis and lymphangiogenesis, Cancer Res., 72, 726, 10.1158/0008-5472.CAN-11-2167

Hu, 2015, Cisplatin plus gemcitabine versus paclitaxel plus gemcitabine as first-line therapy for metastatic triple-negative breast cancer (CBCSG006): a randomised, open-label, multicentre, phase 3 trial, Lancet Oncol., 16, 436, 10.1016/S1470-2045(15)70064-1

Park, 2013, Inhibition of endotrophin, a cleavage product of collagen VI, confers cisplatin sensitivity to tumours, EMBO Mol. Med., 5, 935, 10.1002/emmm.201202006

Yu, 2016, Triple-layered pH-responsive micelleplexes loaded with siRNA and cisplatin prodrug for NF-Kappa B targeted treatment of metastatic breast cancer, Theranostics, 6, 14, 10.7150/thno.13515

Zanoni, 2016, 3D tumor spheroid models for in vitro therapeutic screening: a systematic approach to enhance the biological relevance of data obtained, Sci. Rep., 6, 19103, 10.1038/srep19103

Phung, 2011, Rapid generation of in vitro multicellular spheroids for the study of monoclonal antibody therapy, J. Cancer, 2, 507, 10.7150/jca.2.507

Sant, 2017, The production of 3D tumor spheroids for cancer drug discovery, Drug Discov. Today Technol., 23, 27, 10.1016/j.ddtec.2017.03.002

Swami, 2017, Prevention of breast cancer skeletal metastases with parathyroid hormone, JCI Insight, 2, 10.1172/jci.insight.90874

Kreitzburg, 2018, FTY720 enhances the anti-tumor activity of carboplatin and tamoxifen in a patient-derived xenograft model of ovarian cancer, Cancer Lett., 436, 75, 10.1016/j.canlet.2018.08.015

Stafman, 2019, PP2A activation alone and in combination with cisplatin decreases cell growth and tumor formation in human HuH6 hepatoblastoma cells, PLoS One, 14, 10.1371/journal.pone.0214469

Siddik, 2003, Cisplatin: mode of cytotoxic action and molecular basis of resistance, Oncogene, 22, 7265, 10.1038/sj.onc.1206933

Garner, 2018, FTY720 decreases tumorigenesis in group 3 medulloblastoma patient-derived xenografts, Sci. Rep., 8, 10.1038/s41598-018-25263-5

Zhang, 2014, FTY720 reduces migration and invasion of human glioblastoma cell lines via inhibiting the PI3K/AKT/mTOR/p70S6K signaling pathway, Tumor Biol., 35, 10707, 10.1007/s13277-014-2386-y

Lee, 2005, FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clin. Cancer Res., 11, 8458, 10.1158/1078-0432.CCR-05-0447

Pereira, 2013, FTY720 induces apoptosis in B16F10-NEX2 murine melanoma cells, limits metastatic development in vivo, and modulates the immune system, Clinics (Sao Paulo), 68, 1018, 10.6061/clinics/2013(07)21

Vishnoi, 2019, The identification of a TNBC liver metastasis gene signature by sequential CTC-xenograft modeling, Mol. Oncol., 13, 1913, 10.1002/1878-0261.12533

Koedoot, 2019, Uncovering the signaling landscape controlling breast cancer cell migration identifies novel metastasis driver genes, Nat. Commun., 10, 1, 10.1038/s41467-019-11020-3

Tseng, 2013, Distant metastasis in triple-negative breast cancer, Neoplasma, 60, 290, 10.4149/neo_2013_038

Beider, 2017, The sphingosine-1-phosphate modulator FTY720 targets multiple myeloma via the CXCR4/CXCL12 pathway, Clin. Cancer Res., 23, 1733, 10.1158/1078-0432.CCR-15-2618

Herrmann, 2016, Identification of gene expression patterns crucially involved in experimental autoimmune encephalomyelitis and multiple sclerosis, Dis. Model. Mech., 9, 1211, 10.1242/dmm.025536

Allam, 2018, Fingolimod interrupts the cross talk between estrogen metabolism and sphingolipid metabolism within prostate cancer cells, Toxicol. Lett., 291, 77, 10.1016/j.toxlet.2018.04.008

Spranger, 2014, Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8+ T cells directly within the tumor microenvironment, J. Immunother. Cancer, 2, 3, 10.1186/2051-1426-2-3

Snelder, 2014, Translational pharmacokinetic modeling of fingolimod (FTY720) as a paradigm compound subject to sphingosine kinase-mediated phosphorylation, Drug Metab. Dispos., 42, 1367, 10.1124/dmd.113.056770

Nirogi, 2017, Incurred sample reanalysis of fingolimod and fingolimod phosphate in blood: stability evaluation and application to a rat pharmacokinetic study, Bioanalysis, 9, 565, 10.4155/bio-2016-0308

Kovarik, 2004, Multiple-Dose FTY720: tolerability, pharmacokinetics, and lymphocyte responses in healthy subjects, J. Clin. Pharmacol., 44, 532, 10.1177/0091270004264165

Center for Drug Evaluation and Research [CDER]. Application number: 22-527. Clinical pharmacology and biopharmaceutics review(s) [online]. Available from URL: http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/022527Orig1s000clinpharmr.pdf [Accessed 2020 Nov 8] n.d.

Wu, 2018, Targeted co-delivery of Beclin 1 siRNA and FTY720 to hepatocellular carcinoma by calcium phosphate nanoparticles for enhanced anticancer efficacy, Int. J. Nanomed., 13, 1265, 10.2147/IJN.S156328

Galluzzi, 2012, Molecular mechanisms of cisplatin resistance, Oncogene, 31, 1869, 10.1038/onc.2011.384

Feng, 2015, Near infrared light-actuated gold nanorods with cisplatin-polypeptide wrapping for targeted therapy of triple negative breast cancer, Nanoscale, 7, 14854, 10.1039/C5NR03693C

Yoshii, 2017, Neurological safety of fingolimod: an updated review, Clin. Exp. Neuroimmunol., 8, 233, 10.1111/cen3.12397

Hait, 2015, The phosphorylated prodrug FTY720 is a histone deacetylase inhibitor that reactivates ERα expression and enhances hormonal therapy for breast cancer, Oncogenesis, 4, e156, 10.1038/oncsis.2015.16