Systemic Immunity Is Required for Effective Cancer Immunotherapy

Cell - Tập 168 - Trang 487-502.e15 - 2017
Matthew H. Spitzer1,2,3,4,5, Yaron Carmi1,6, Nathan E. Reticker-Flynn1, Serena S. Kwek7, Deepthi Madhireddy2, Maria M. Martins1, Pier Federico Gherardini2, Tyler R. Prestwood1, Jonathan Chabon1, Sean C. Bendall1, Lawrence Fong7,5, Garry P. Nolan2,3, Edgar G. Engleman1,3
1Department of Pathology, Stanford University, Stanford, CA 94305, USA
2Baxter Lab in Stem Cell Biology, Department of Microbiology and Immunology, Stanford University, Stanford, CA 94305, USA
3Program in Immunology, Stanford University, Stanford, CA 94305, USA
4Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143 USA
5Helen Diller Comprehensive Cancer Center, University of California, San Francisco, San Francisco, CA 94143, USA
6Department of Pathology, The Sackler School of Medicine, Tel-Aviv University, Ramat Aviv 69978, Israel
7Division of Hematology and Oncology, Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA

Tài liệu tham khảo

Bair, 2004, Semi-supervised methods to predict patient survival from gene expression data, PLoS Biol., 2, E108, 10.1371/journal.pbio.0020108 Bandura, 2009, Mass cytometry: technique for real time single cell multitarget immunoassay based on inductively coupled plasma time-of-flight mass spectrometry, Anal. Chem., 81, 6813, 10.1021/ac901049w Bastian, M., Heymann, S., and Jacomy, M. (2009). Gephi: an open source software for exploring and manipulating networks. International AAAI Conference on Weblogs and Social Media. http://www.aaai.org/ocs/index.php/ICWSM/09/paper/view/154/1009. Bates, 2006, Quantification of regulatory T cells enables the identification of high-risk breast cancer patients and those at risk of late relapse, J. Clin. Oncol., 24, 5373, 10.1200/JCO.2006.05.9584 Bendall, 2011, Single-cell mass cytometry of differential immune and drug responses across a human hematopoietic continuum, Science, 332, 687, 10.1126/science.1198704 Bos, 2013, Transient regulatory T cell ablation deters oncogene-driven breast cancer and enhances radiotherapy, J. Exp. Med., 210, 2435, 10.1084/jem.20130762 Broz, 2014, Dissecting the tumor myeloid compartment reveals rare activating antigen-presenting cells critical for T cell immunity, Cancer Cell, 26, 638, 10.1016/j.ccell.2014.09.007 Bruggner, 2014, Automated identification of stratifying signatures in cellular subpopulations, Proc. Natl. Acad. Sci. USA, 111, E2770, 10.1073/pnas.1408792111 Bulliard, 2013, Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies, J. Exp. Med., 210, 1685, 10.1084/jem.20130573 Carmi, 2015, Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity, Nature, 521, 99, 10.1038/nature14424 Chen, 2013, Oncology meets immunology: the cancer-immunity cycle, Immunity, 39, 1, 10.1016/j.immuni.2013.07.012 Cheng, 2012, IL-2 receptor signaling is essential for the development of Klrg1+ terminally differentiated T regulatory cells, J. Immunol., 189, 1780, 10.4049/jimmunol.1103768 Cohen, 2015, Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes, J. Clin. Invest., 125, 3981, 10.1172/JCI82416 Coley, 1893, The treatment of malignant tumors by repeated inoculations of erysipelas. With a report of ten original cases, Am. J. Med. Sci., 105, 487, 10.1097/00000441-189305000-00001 Corbett, 1975, Tumor induction relationships in development of transplantable cancers of the colon in mice for chemotherapy assays, with a note on carcinogen structure, Cancer Research, 35, 2434 Curiel, 2004, Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival, Nat. Med., 10, 942, 10.1038/nm1093 Dankort, 2009, Braf(V600E) cooperates with Pten loss to induce metastatic melanoma, Nat. Genet., 41, 544, 10.1038/ng.356 Finck, 2013, Normalization of mass cytometry data with bead standards, Cytometry A, 83, 483, 10.1002/cyto.a.22271 Gabrilovich, 2012, Coordinated regulation of myeloid cells by tumours, Nat. Rev. Immunol., 12, 253, 10.1038/nri3175 Haeryfar, 2004, Thy-1: more than a mouse pan-T cell marker, J. Immunol., 173, 3581, 10.4049/jimmunol.173.6.3581 Hänninen, 2011, Ly6C supports preferential homing of central memory CD8+ T cells into lymph nodes, Eur. J. Immunol., 41, 634, 10.1002/eji.201040760 Herbst, 2014, Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients, Nature, 515, 563, 10.1038/nature14011 Hotson, 2016, Coordinate actions of innate immune responses oppose those of the adaptive immune system during Salmonella infection of mice, Sci Signal, 12 Ideker, 2012, Differential network biology, Mol. Syst. Biol., 8, 565, 10.1038/msb.2011.99 Im, 2016, Defining CD8(+) T cells that provide the proliferative burst after PD-1 therapy, Nature, 537, 417, 10.1038/nature19330 Jiang, 2015, T-cell exhaustion in the tumor microenvironment, Cell Death Dis., 6, e1792, 10.1038/cddis.2015.162 Kantoff, 2010, Sipuleucel-T immunotherapy for castration-resistant prostate cancer, N. Engl. J. Med., 363, 411, 10.1056/NEJMoa1001294 Kvistborg, 2014, Anti-CTLA-4 therapy broadens the melanoma-reactive CD8+ T cell response, Sci. Transl. Med., 6, 254ra128, 10.1126/scitranslmed.3008918 Kwek, 2015, GM-CSF and ipilimumab therapy in metastatic melanoma: Clinical outcomes and immunologic responses, OncoImmunology, 5, e1101204, 10.1080/2162402X.2015.1101204 Matloubian, 2004, Lymphocyte egress from thymus and peripheral lymphoid organs is dependent on S1P receptor 1, Nature, 427, 355, 10.1038/nature02284 Pelletier, 2010, Plasma cells negatively regulate the follicular helper T cell program, Nat. Immunol., 11, 1110, 10.1038/ni.1954 Porter, 2011, Chimeric antigen receptor-modified T cells in chronic lymphoid leukemia, N. Engl. J. Med., 365, 725, 10.1056/NEJMoa1103849 Restifo, 2012, Adoptive immunotherapy for cancer: harnessing the T cell response, Nat. Rev. Immunol., 12, 269, 10.1038/nri3191 Rosenberg, 2014, Decade in review-cancer immunotherapy: entering the mainstream of cancer treatment, Nat. Rev. Clin. Oncol., 11, 630, 10.1038/nrclinonc.2014.174 Simpson, 2013, Fc-dependent depletion of tumor-infiltrating regulatory T cells co-defines the efficacy of anti-CTLA-4 therapy against melanoma, J. Exp. Med., 210, 1695, 10.1084/jem.20130579 Spitzer, 2015, IMMUNOLOGY. An interactive reference framework for modeling a dynamic immune system, Science, 349, 1259425, 10.1126/science.1259425 Spranger, 2014, Mechanism of tumor rejection with doublets of CTLA-4, PD-1/PD-L1, or IDO blockade involves restored IL-2 production and proliferation of CD8(+) T cells directly within the tumor microenvironment, J. Immunother. Cancer, 2, 3, 10.1186/2051-1426-2-3 Swain, 2012, Expanding roles for CD4+ T cells in immunity to viruses, Nat. Rev. Immunol., 12, 136, 10.1038/nri3152 Topalian, 2015, Immune checkpoint blockade: a common denominator approach to cancer therapy, Cancer Cell, 27, 450, 10.1016/j.ccell.2015.03.001 Tran, 2014, Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancer, Science, 344, 641, 10.1126/science.1251102 Wherry, 2007, Molecular signature of CD8+ T cell exhaustion during chronic viral infection, Immunity, 27, 670, 10.1016/j.immuni.2007.09.006 Xie, 2010, Naive tumor-specific CD4(+) T cells differentiated in vivo eradicate established melanoma, J. Exp. Med., 207, 651, 10.1084/jem.20091921 Zunder, 2015, Palladium-based mass tag cell barcoding with a doublet-filtering scheme and single-cell deconvolution algorithm, Nat. Protoc., 10, 316, 10.1038/nprot.2015.020