Tenascin-C Orchestrates Glioblastoma Angiogenesis by Modulation of Pro- and Anti-angiogenic Signaling

Abéngozar, 2012, Blocking ephrinB2 with highly specific antibodies inhibits angiogenesis, lymphangiogenesis, and tumor growth, Blood, 119, 4565, 10.1182/blood-2011-09-380006 Bayless, 2011, Role of the cytoskeleton in formation and maintenance of angiogenic sprouts, J. Vasc. Res., 48, 369, 10.1159/000324751 Beacham, 2007, Preparation of extracellular matrices produced by cultured and primary fibroblasts, Curr. Protoc. Cell Biol., Chapter 10, 10.1002/0471143030.cb1009s33 Bicer, 2010, Expressions of angiogenesis associated matrix metalloproteinases and extracellular matrix proteins in cerebral vascular malformations, J. Clin. Neurosci., 17, 232, 10.1016/j.jocn.2009.06.008 Bissell, 2001, Putting tumours in context, Nat. Rev. Cancer, 1, 46, 10.1038/35094059 Brigstock, 2002, Regulation of angiogenesis and endothelial cell function by connective tissue growth factor (CTGF) and cysteine-rich 61 (CYR61), Angiogenesis, 5, 153, 10.1023/A:1023823803510 Calvo, 2013, Mechanotransduction and YAP-dependent matrix remodelling is required for the generation and maintenance of cancer-associated fibroblasts, Nat. Cell Biol., 15, 637, 10.1038/ncb2756 Campbell, 2010, Extracellular matrix proteins and tumor angiogenesis, J. Oncol., 2010, 586905 Fujimoto, 2016, Deficiency of tenascin-C and attenuation of blood-brain barrier disruption following experimental subarachnoid hemorrhage in mice, J. Neurosurg., 124, 1693, 10.3171/2015.4.JNS15484 Ghajar, 2013, The perivascular niche regulates breast tumour dormancy, Nat. Cell Biol., 15, 807, 10.1038/ncb2767 Halder, 2012, Transduction of mechanical and cytoskeletal cues by YAP and TAZ, Nat. Rev. Mol. Cell Biol., 13, 591, 10.1038/nrm3416 Hanahan, 1985, Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes, Nature, 315, 115, 10.1038/315115a0 Hanahan, 2011, Hallmarks of cancer: the next generation, Cell, 144, 646, 10.1016/j.cell.2011.02.013 Herold-Mende, 2002, Clinical impact and functional aspects of tenascin-C expression during glioma progression, Int. J. Cancer, 98, 362, 10.1002/ijc.10233 Hynes, 2009, The extracellular matrix: not just pretty fibrils, Science, 326, 1216, 10.1126/science.1176009 Jain, 2014, Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia, Cancer Cell, 26, 605, 10.1016/j.ccell.2014.10.006 Ji, 2013, Proteome profiling of exosomes derived from human primary and metastatic colorectal cancer cells reveal differential expression of key metastatic factors and signal transduction components, Proteomics, 13, 1672, 10.1002/pmic.201200562 Kalluri, 2006, Fibroblasts in cancer, Nat. Rev. Cancer, 6, 392, 10.1038/nrc1877 Kimura, 2014, Tenascin C protects aorta from acute dissection in mice, Sci. Rep., 4, 4051, 10.1038/srep04051 Kuriyama, 2011, Tenascin-C: a novel mediator of hepatic ischemia and reperfusion injury, Hepatology, 54, 2125, 10.1002/hep.24639 Lamalice, 2007, Endothelial cell migration during angiogenesis, Circ. Res., 100, 782, 10.1161/01.RES.0000259593.07661.1e Langlois, 2014, AngioMatrix, a signature of the tumor angiogenic switch-specific matrisome, correlates with poor prognosis for glioma and colorectal cancer patients, Oncotarget, 5, 10529, 10.18632/oncotarget.2470 Lin, 2008, Ephrin-B2-induced cleavage of EphB2 receptor is mediated by matrix metalloproteinases to trigger cell repulsion, J. Biol. Chem., 283, 28969, 10.1074/jbc.M804401200 Martina, 2010, Tenascin-W is a specific marker of glioma-associated blood vessels and stimulates angiogenesis in vitro, FASEB J., 24, 778, 10.1096/fj.09-140491 Martiny-Baron, 2010, The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis, Angiogenesis, 13, 259, 10.1007/s10456-010-9183-z McDonald, 2003, Imaging of angiogenesis: from microscope to clinic, Nat. Med., 9, 713, 10.1038/nm0603-713 Midwood, 2011, Advances in tenascin-C biology, Cell. Mol. Life Sci., 68, 3175, 10.1007/s00018-011-0783-6 Midwood, 2016, Tenascin-C at a glance, J. Cell Sci., 10.1242/jcs.190546 Mustafa, 2012, A proteome comparison between physiological angiogenesis and angiogenesis in glioblastoma, Mol. Cell. Proteomics, 1 Orend, 2014 Pasquale, 2010, Eph receptors and ephrins in cancer: bidirectional signalling and beyond, Nat. Rev. Cancer, 10, 165, 10.1038/nrc2806 Posern, 2002, Mutant actins demonstrate a role for unpolymerized actin in control of transcription by serum response factor, Mol. Biol. Cell, 13, 4167, 10.1091/mbc.02-05-0068 Saupe, 2013, Tenascin-C downregulates wnt inhibitor dickkopf-1, promoting tumorigenesis in a neuroendocrine tumor model, Cell Rep., 5, 482, 10.1016/j.celrep.2013.09.014 Scharenberg, 2014, TGF-β-induced differentiation into myofibroblasts involves specific regulation of two MKL1 isoforms, J. Cell Sci., 127, 1079, 10.1242/jcs.142075 Shahinian, 2014, Secretome and degradome profiling shows that Kallikrein-related peptidases 4, 5, 6, and 7 induce TGFβ-1 signaling in ovarian cancer cells, Mol. Oncol., 8, 68, 10.1016/j.molonc.2013.09.003 Siess, 1999, Lysophosphatidic acid mediates the rapid activation of platelets and endothelial cells by mildly oxidized low density lipoprotein and accumulates in human atherosclerotic lesions, Proc. Natl. Acad. Sci. USA, 96, 6931, 10.1073/pnas.96.12.6931 Tholen, 2013, Deletion of cysteine cathepsins B or L yields differential impacts on murine skin proteome and degradome, Mol. Cell. Proteomics, 12, 611, 10.1074/mcp.M112.017962 Tu, 2012, Expression of EphrinB2 and EphB4 in glioma tissues correlated to the progression of glioma and the prognosis of glioblastoma patients, Clin. Transl. Oncol., 14, 214, 10.1007/s12094-012-0786-2