Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages

Immunobiology - Tập 223 - Trang 634-647 - 2018
Wei Chen1,2, Rafik M. Ghobrial1,3, Xian C. Li1,3, Malgorzata Kloc1,3,4
1Houston Methodist Research Institute, Houston, TX, USA
2Department of Nephrology, Second Xiangya Hospital, Central South University, Changsha 410011, China
3Weill Cornell Medical College, 407 E 61st St, New York, USA
4University of Texas, MD Anderson Cancer Center, Department of Genetics, Houston, TX, USA

Tài liệu tham khảo

Anastasiadou, 2016, The multiple sclerosis drug fingolimod (FTY720) stimulates neuronal gene expression, axonal growth and regeneration, Exp. Neurol., 279, 243, 10.1016/j.expneurol.2016.03.012 Bonnardel, 2017, Developmental control of macrophage function, Curr. Opin. Immunol., 50, 64, 10.1016/j.coi.2017.12.001 Brinkmann, 2004, FTY720: sphingosine 1-phosphate receptor-1 in the control of lymphocyte egress and endothelial barrier function, Am. J. Transpl., 4, 1019, 10.1111/j.1600-6143.2004.00476.x Chen, 2017, Rho-specific Guanine nucleotide exchange factors (Rho-GEFs) inhibition affects macrophage phenotype and disrupts Golgi complex, Int. J. Biochem. Cell Biol., 93, 12, 10.1016/j.biocel.2017.10.009 Di Dario, 2015, Myeloid cells as target of fingolimod action in multiple sclerosis, Neurol. Neuroimmunol. Neuroinflamm., 2, e157, 10.1212/NXI.0000000000000157 El Azzouzi, 2016, Metalloproteinase MT1-MMP islets act as memory devices for podosome reemergence, J. Cell. Biol., 213, 109, 10.1083/jcb.201510043 Gordon, 2014, RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells, Cell. Signal., 26, 461, 10.1016/j.cellsig.2013.11.035 Gucciardo, 2016, Proactive for invasion: reuse of matrix metalloproteinase for structural memory, J. Cell. Biol., 213, 11, 10.1083/jcb.201603066 Guertin, 2009, The pharmacology of mTOR inhibition, Sci. Signal., 2, pe24, 10.1126/scisignal.267pe24 Guertin, 2006, Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCalpha, but not S6K1, Dev. Cell, 11, 859, 10.1016/j.devcel.2006.10.007 Gulhati, 2011, mTORC1 and mTORC2 regulate EMT, motility and metastasis of colorectal cancer via RhoA and Rac-1 signaling pathways, Cancer Res., 71, 3246, 10.1158/0008-5472.CAN-10-4058 Hou, 2016, Fingolimod ameliorates the development of experimental autoimmune encephalomyelitis by inhibiting Akt–mTOR axis in mice, Int. Immunopharmacol., 30, 171, 10.1016/j.intimp.2015.11.024 Ishida, 2007, p21-activated kinase 1 is activated through the mammalian target of rapamycin/p70 S6 kinase pathway and regulates the replication of hepatitis C virus in human hepatoma cells, J. Biol. Chem., 282, 11836, 10.1074/jbc.M610106200 Iwatake, 2017, The Rho-specific guanine nucleotide exchange factor Plekhg5 modulates cell polarity, adhesion, migration, and podosome organization in macrophages and osteoclasts, Exp. Cell. Res., 359, 415, 10.1016/j.yexcr.2017.08.025 Jeruschke, 2013, Protective effects of the mTOR inhibitor everolimus on cytoskeletal injury in human podocytes are mediated by RhoA signaling, PLoS One, 8, e55980, 10.1371/journal.pone.0055980 Ke, 2013, Unique catalytic activities and scaffolding of p21 activated kinase-1 in cardiovascular signaling, Front. Pharmacol., 4, 116, 10.3389/fphar.2013.00116 Kloc, 2014, Chronic allograft rejection: a significant hurdle to transplant success, Burns Trauma, 2, 3, 10.4103/2321-3868.121646 Kloc, 2014, RhoA cytoskeletal pathway to transplantation, J Immunol. Clin. Res., 2, 1012 Linder, 2015, Tools of the trade: podosomes as multipurpose organelles of monocytic cells, Cell. Mol. Life Sci., 72, 121, 10.1007/s00018-014-1731-z Liu, 2010, Rapamycin inhibits cytoskeleton reorganization and cell motility by suppressing RhoA expression and activity, J. Biol. Chem., 285, 38362, 10.1074/jbc.M110.141168 Liu, 2016, Macrophages as effectors of acute and chronic allograft injury, Curr. Transpl. Rep., 3, 303, 10.1007/s40472-016-0130-9 Liu, 2016, Dissonant response of M0/M2 and M1 bone marrow derived macrophages to RhoA pathway interference, Cell Tissue Res., 366, 707, 10.1007/s00441-016-2491-x Liu, 2016, Mouse macrophage polarity and ROCK1 activity depend on RhoA and non-apoptotic Caspase 3, Exp. Cell Res., 341, 225, 10.1016/j.yexcr.2016.02.004 Liu, 2016, ROCK inhibition impedes macrophage polarity and functions, Cell. Immunol., 300, 54, 10.1016/j.cellimm.2015.12.005 Liu, 2017, Macrophage/monocyte-specific deletion of RhoA down-regulates fractalkine receptor and inhibits chronic rejection of mouse cardiac allografts, J Heart Lung Transpl., 36, 340, 10.1016/j.healun.2016.08.011 Mayhew, 2007, Identification of phosphorylation sites in PIX and PAK1, J. Cell Sci., 120, 3911, 10.1242/jcs.008177 Md Hashim, 2013, Hypoxia-induced invadopodia formation: a role for β-PIX, Open Biol., 3, 120159, 10.1098/rsob.120159 Pignatelli, 2012, Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion, J. Biol. Chem., 287, 37309, 10.1074/jbc.M112.385229 ten Klooster, 2006, Targeting and activation of Rac-1 are mediated by the exchange factor –Pix, J. Cell. Biol., 172, 759, 10.1083/jcb.200509096 Thompson, 2013, Mechanically activated Fyn utilizes mTORC2 to regulate RhoA and adipogenesis in mesenchymal stem cells, Stem Cells, 31, 2528, 10.1002/stem.1476 van Helden, 2008, PGE2-mediated podosome loss in dendritic cells is dependent on actomyosin contraction downstream of the RhoA–Rho-kinase axis, J. Cell Sci., 121, 1096, 10.1242/jcs.020289 Veillat, 2015, Podosomes: multipurpose organelles?, Int. J. Biochem. Cell Biol., 65, 52, 10.1016/j.biocel.2015.05.020 Wang, 2009, GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma, Arterioscler. Thromb. Vasc. Biol., 29, 202, 10.1161/ATVBAHA.108.174391 Weaver, 2003, Integration of signals to the Arp2/3 complex, Curr. Opin. Cell Biol., 15, 23, 10.1016/S0955-0674(02)00015-7 Webb, 2005, PAK1 induces podosome formation in A7r5 vascular smooth muscle cells in a PAK-interacting exchange factor-dependent manner, Am. J. Physiol. Cell Physiol., 289, C898, 10.1152/ajpcell.00095.2005 Xin, 2006, The immunomodulator FTY720 and its phosphorylated derivative activate the Smad signalling cascade and upregulate connective tissue growth factor and collagen type IV expression in renal mesangial cells, Br. J. Pharmacol., 147, 164, 10.1038/sj.bjp.0706452 Yang, 2015, Sphingosine 1-phosphate receptor 2 and 3 mediate bone marrow-derived Monocyte/Macrophage motility in cholestatic liver injury in mice, Sci. Rep., 5, 13423, 10.1038/srep13423 Zhang, 2012, ROCK1 inhibitor abrogates chronic rejection in rat cardiac model system, Open J. Organ Transp. Surg., 2, 46, 10.4236/ojots.2012.24012 Zhang, 2013, Abrogation of chronic rejection in rat model system involves modulation of the mTORC1 and mTORC2 pathways, Transplantation, 96, 782, 10.1097/TP.0b013e3182a2034f Zhou, 2006, FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase, Cancer Lett., 233, 36, 10.1016/j.canlet.2005.02.039