SUMO conjugation as regulator of the glucocorticoid receptor-FKBP51 cellular response to stress

Holsboer, 2000, The corticosteroid receptor hypothesis of depression, Neuropsychopharmacology, 23, 477, 10.1016/S0893-133X(00)00159-7

Dedovic, 2015, The cortisol awakening response and major depression: examining the evidence, Neuropsychiatr. Dis. Treat., 11, 1181, 10.2147/NDT.S62289

Dougherty, 2009, Increased waking salivary cortisol and depression risk in preschoolers: the role of maternal history of melancholic depression and early child temperament, J. Child Psychol. Psychiatry, 50, 1495, 10.1111/j.1469-7610.2009.02116.x

Burke, 2005, Depression and cortisol responses to psychological stress: a meta-analysis, Psychoneuroendocrinology, 30, 846, 10.1016/j.psyneuen.2005.02.010

Chaudieu, 2008, Abnormal reactions to environmental stress in elderly persons with anxiety disorders: evidence from a population study of diurnal cortisol changes, J. Affect. Disord., 106, 307, 10.1016/j.jad.2007.07.025

Meewisse, 2007, Cortisol and post-traumatic stress disorder in adults: systematic review and meta-analysis, Br. J. Psychiatry, 191, 387, 10.1192/bjp.bp.106.024877

Yang, 2008, Restraint stress and ethanol consumption in two mouse strains, Alcohol. Clin. Exp. Res., 32, 840, 10.1111/j.1530-0277.2008.00632.x

Charmandari, 2004, Glucocorticoids and their actions: an introduction, Ann. N. Y. Acad. Sci., 1024, 1, 10.1196/annals.1321.001

Liberman, 2007, Glucocorticoids in the regulation of transcription factors that control cytokine synthesis, Cytokine Growth Factor Rev., 18, 45, 10.1016/j.cytogfr.2007.01.005

Pratt, 1993, The role of heat shock proteins in regulating the function, folding, and trafficking of the glucocorticoid receptor, J. Biol. Chem., 268, 21455, 10.1016/S0021-9258(20)80556-0

Wochnik, 2005, FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells, J. Biol. Chem., 280, 4609, 10.1074/jbc.M407498200

Picard, 1990, Reduced levels of hsp90 compromise steroid receptor action in vivo, Nature, 348, 166, 10.1038/348166a0

Galigniana, 2001, Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus, J. Biol. Chem., 276, 14884, 10.1074/jbc.M010809200

Denny, 2000, Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding, Endocrinology, 141, 4107, 10.1210/endo.141.11.7785

Davies, 2005, Differential control of glucocorticoid receptor hormone-binding function by tetratricopeptide repeat (TPR) proteins and the immunosuppressive ligand FK506, Biochemistry, 44, 2030, 10.1021/bi048503v

Davies, 2002, A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins, J. Biol. Chem., 277, 4597, 10.1074/jbc.C100531200

Tatro, 2009, Modulation of glucocorticoid receptor nuclear translocation in neurons by immunophilins FKBP51 and FKBP52: implications for major depressive disorder, Brain Res., 1286, 1, 10.1016/j.brainres.2009.06.036

Vermeer, 2003, Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability, J. Clin. Endocrinol. Metab., 88, 277, 10.1210/jc.2002-020354

Fries, 2017, The FKBP51 glucocorticoid receptor co-chaperone: regulation, function, and implications in health and disease, Int. J. Mol. Sci., 18, 10.3390/ijms18122614

Galigniana, 2012, Regulation of the glucocorticoid response to stress-related disorders by the Hsp90-binding immunophilin FKBP51, J. Neurochem., 122, 4, 10.1111/j.1471-4159.2012.07775.x

Hahle, 2019, The many faces of FKBP51, Biomolecules, 9, 10.3390/biom9010035

Criado-Marrero, 2018, Hsp90 and FKBP51: complex regulators of psychiatric diseases, Philos. Trans. R. Soc. Lond. B Biol. Sci., 373, 10.1098/rstb.2016.0532

Matosin, 2018, Understanding the molecular mechanisms underpinning gene by environment interactions in psychiatric disorders: the FKBP5 Model, Biol. Psychiatry, 83, 821, 10.1016/j.biopsych.2018.01.021

Guo, 2014, Wrestling with stress: roles of protein SUMOylation and deSUMOylation in cell stress response, IUBMB Life, 66, 71, 10.1002/iub.1244

Johnson, 2004, Protein modification by SUMO, Annu. Rev. Biochem., 73, 355, 10.1146/annurev.biochem.73.011303.074118

Hay, 2005, SUMO: a history of modification, Mol. Cell, 18, 1, 10.1016/j.molcel.2005.03.012

Flotho, 2013, Sumoylation: a regulatory protein modification in health and disease, Annu. Rev. Biochem., 82, 357, 10.1146/annurev-biochem-061909-093311

Kumar, 2005, Gene regulation by the glucocorticoid receptor: structure: function relationship, J. Steroid Biochem. Mol. Biol., 94, 383, 10.1016/j.jsbmb.2004.12.046

Beck, 2009, Crosstalk in inflammation: the interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatases, Endocr. Rev., 30, 830, 10.1210/er.2009-0013

Glass, 1997, Nuclear receptor coactivators, Curr. Opin. Cell Biol., 9, 222, 10.1016/S0955-0674(97)80066-X

Bledsoe, 2002, Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition, Cell, 110, 93, 10.1016/S0092-8674(02)00817-6

Picard, 1987, Two signals mediate hormone-dependent nuclear localization of the glucocorticoid receptor, EMBO J., 6, 3333, 10.1002/j.1460-2075.1987.tb02654.x

Dostert, 2004, Negative glucocorticoid receptor response elements and their role in glucocorticoid action, Curr. Pharm. Des., 10, 2807, 10.2174/1381612043383601

Hudson, 2013, The structural basis of direct glucocorticoid-mediated transrepression, Nat. Struct. Mol. Biol., 20, 53, 10.1038/nsmb.2456

Costas, 2000, Transrepression of NF-kappaB is not required for glucocorticoid-mediated protection of TNF-alpha-induced apoptosis on fibroblasts, Biochim. Biophys. Acta, 1499, 122, 10.1016/S0167-4889(00)00113-0

Cain, 2017, Immune regulation by glucocorticoids, Nat. Rev. Immunol., 17, 233, 10.1038/nri.2017.1

Rogatsky, 2006, Glucocorticoid modulation of cytokine signaling, Tissue Antigens, 68, 1, 10.1111/j.1399-0039.2006.00599.x

Liden, 2000, Glucocorticoid effects on NF-kappaB binding in the transcription of the ICAM-1 gene, Biochem. Biophys. Res. Commun., 273, 1008, 10.1006/bbrc.2000.3079

Liberman, 2007, The activated glucocorticoid receptor inhibits the transcription factor T-bet by direct protein-protein interaction, FASEB J., 21, 1177, 10.1096/fj.06-7452com

Liberman, 2009, Glucocorticoids inhibit GATA-3 phosphorylation and activity in T cells, FASEB J., 23, 1558, 10.1096/fj.08-121236

Liberman, 2018, Regulatory and mechanistic actions of glucocorticoids on t and inflammatory cells, Front. Endocrinol. (Lausanne), 9, 235, 10.3389/fendo.2018.00235

Ayroldi, 2001, Modulation of T-cell activation by the glucocorticoid-induced leucine zipper factor via inhibition of nuclear factor kappaB, Blood, 98, 743, 10.1182/blood.V98.3.743

Presman, 2014, Live cell imaging unveils multiple domain requirements for in vivo dimerization of the glucocorticoid receptor, PLoS Biol., 12, 10.1371/journal.pbio.1001813

Clark, 2012, Maps and legends: the quest for dissociated ligands of the glucocorticoid receptor, Pharmacol. Ther., 134, 54, 10.1016/j.pharmthera.2011.12.004

Petta, 2016, The interactome of the glucocorticoid receptor and its influence on the actions of glucocorticoids in combatting inflammatory and infectious diseases, Microbiol. Mol. Biol. Rev., 80, 495, 10.1128/MMBR.00064-15

Presman, 2017, More than meets the dimer: What is the quaternary structure of the glucocorticoid receptor?, Transcription, 8, 32, 10.1080/21541264.2016.1249045

Grad, 2007, The glucocorticoid responses are shaped by molecular chaperones, Mol. Cell. Endocrinol., 275, 2, 10.1016/j.mce.2007.05.018

Elbi, 2004, Molecular chaperones function as steroid receptor nuclear mobility factors, Proc. Natl. Acad. Sci. USA, 101, 2876, 10.1073/pnas.0400116101

Vandevyver, 2012, On the trail of the glucocorticoid receptor: into the nucleus and back, Traffic, 13, 364, 10.1111/j.1600-0854.2011.01288.x

Denis, 1989, The Mr approximately 90,000 heat shock protein: an important modulator of ligand and DNA-binding properties of the glucocorticoid receptor, Cancer Res., 49, 2275s

Sanchez, 2012, Chaperoning steroidal physiology: lessons from mouse genetic models of Hsp90 and its cochaperones, Biochim. Biophys. Acta, 1823, 722, 10.1016/j.bbamcr.2011.11.006

Schopf, 2017, The HSP90 chaperone machinery, Nat. Rev. Mol. Cell Biol., 18, 345, 10.1038/nrm.2017.20

Schulke, 2010, Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors, PLoS ONE, 5, 10.1371/journal.pone.0011717

Scheufler, 2000, Structure of TPR domain-peptide complexes: critical elements in the assembly of the Hsp70-Hsp90 multichaperone machine, Cell, 101, 199, 10.1016/S0092-8674(00)80830-2

Hildenbrand, 2011, Hsp90 can accommodate the simultaneous binding of the FKBP52 and HOP proteins, Oncotarget, 2, 43, 10.18632/oncotarget.225

Harst, 2005, Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation, Biochem. J., 387, 789, 10.1042/BJ20041283

Zuehlke, 2010, Hsp90 and co-chaperones twist the functions of diverse client proteins, Biopolymers, 93, 211, 10.1002/bip.21292

Sahasrabudhe, 2017, The plasticity of the Hsp90 co-chaperone system, Mol. Cell, 67, 10.1016/j.molcel.2017.08.004

Morishima, 2003, The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex, J. Biol. Chem., 278, 48754, 10.1074/jbc.M309814200

Murphy, 2003, Visualization and mechanism of assembly of a glucocorticoid receptor.Hsp70 complex that is primed for subsequent Hsp90-dependent opening of the steroid binding cleft, J. Biol. Chem., 278, 34764, 10.1074/jbc.M304469200

Ebong, 2016, The interchange of immunophilins leads to parallel pathways and different intermediates in the assembly of Hsp90 glucocorticoid receptor complexes, Cell Discov., 2, 16002, 10.1038/celldisc.2016.2

Soroka, 2012, Conformational switching of the molecular chaperone Hsp90 via regulated phosphorylation, Mol. Cell, 45, 517, 10.1016/j.molcel.2011.12.031

Wandinger, 2006, The phosphatase Ppt1 is a dedicated regulator of the molecular chaperone Hsp90, EMBO J., 25, 367, 10.1038/sj.emboj.7600930

Hinds, 2011, Protein phosphatase 5 mediates lipid metabolism through reciprocal control of glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma (PPARgamma), J. Biol. Chem., 286, 42911, 10.1074/jbc.M111.311662

Riggs, 2007, Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling, Mol. Cell. Biol., 27, 8658, 10.1128/MCB.00985-07

Storer, 2011, FKBP51 and FKBP52 in signaling and disease, Trends Endocrinol. Metab., 22, 481, 10.1016/j.tem.2011.08.001

Sinars, 2003, Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes, Proc. Natl. Acad. Sci. USA, 100, 868, 10.1073/pnas.0231020100

Wu, 2004, 3D structure of human FK506-binding protein 52: implications for the assembly of the glucocorticoid receptor/Hsp90/immunophilin heterocomplex, Proc. Natl. Acad. Sci. USA, 101, 8348, 10.1073/pnas.0305969101

Pirkl, 2001, Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40, J. Mol. Biol., 308, 795, 10.1006/jmbi.2001.4595

Brinker, 2002, Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes, J. Biol. Chem., 277, 19265, 10.1074/jbc.M109002200

Cheung-Flynn, 2003, C-terminal sequences outside the tetratricopeptide repeat domain of FKBP51 and FKBP52 cause differential binding to Hsp90, J. Biol. Chem., 278, 17388, 10.1074/jbc.M300955200

Vreeburg, 2009, Major depressive disorder and hypothalamic-pituitary-adrenal axis activity: results from a large cohort study, Arch. Gen. Psychiatry, 66, 617, 10.1001/archgenpsychiatry.2009.50

Varghese, 2001, The hypothalamic-pituitary-adrenal axis in major depressive disorder: a brief primer for primary care physicians, Prim Care Companion J. Clin. Psychiatry, 3, 151, 10.4088/PCC.v03n0401

Juruena, 2003, Molecular mechanisms of glucocorticoid receptor sensitivity and relevance to affective disorders, Acta Neuropsychiatr., 15, 354, 10.1046/j.1601-5215.2003.00051.x

Herman, 2016, Regulation of the hypothalamic-pituitary-adrenocortical stress response, Compr. Physiol., 6, 603, 10.1002/cphy.c150015

McQuade, 2000, Future therapeutic targets in mood disorders: the glucocorticoid receptor, Br. J. Psychiatry, 177, 390, 10.1192/bjp.177.5.390

Scharf, 2011, Expression and regulation of the Fkbp5 gene in the adult mouse brain, PLoS ONE, 6, 10.1371/journal.pone.0016883

Hartmann, 2015, Pharmacological inhibition of the psychiatric risk factor FKBP51 has anxiolytic properties, J. Neurosci., 35, 9007, 10.1523/JNEUROSCI.4024-14.2015

Jinwal, 2010, The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules, J. Neurosci., 30, 591, 10.1523/JNEUROSCI.4815-09.2010

Oroz, 2018, Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex, Nat. Commun., 9, 4532, 10.1038/s41467-018-06880-0

Blair, 2013, Accelerated neurodegeneration through chaperone-mediated oligomerization of tau, J. Clin. Invest., 123, 4158, 10.1172/JCI69003

Xie, 2010, Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder, Neuropsychopharmacology, 35, 1684, 10.1038/npp.2010.37

Klengel, 2013, Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions, Nat. Neurosci., 16, 33, 10.1038/nn.3275

Sabbagh, 2018, Targeting the FKBP51/GR/Hsp90 complex to identify functionally relevant treatments for depression and PTSD, ACS Chem. Biol., 13, 2288, 10.1021/acschembio.8b00454

Kolos, 2018, FKBP Ligands-Where We Are and Where to Go?, Front. Pharmacol., 9, 1425, 10.3389/fphar.2018.01425

Pohlmann, 2018, Pharmacological modulation of the psychiatric risk factor FKBP51 alters efficiency of common antidepressant drugs, Front. Behav. Neurosci., 12, 262, 10.3389/fnbeh.2018.00262

Maiaru, 2018, The stress regulator FKBP51: a novel and promising druggable target for the treatment of persistent pain states across sexes, Pain, 159, 1224, 10.1097/j.pain.0000000000001204

O'Leary, 2011, A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51, PLoS ONE, 6, 10.1371/journal.pone.0024840

Sabbagh, 2014, Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency, PLoS ONE, 9, 10.1371/journal.pone.0107241

Hartmann, 2012, The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress, Neuropharmacology, 62, 332, 10.1016/j.neuropharm.2011.07.041

Gassen, 2019, Is there a role of autophagy in depression and antidepressant action?, Front. Psychiatry, 10, 337, 10.3389/fpsyt.2019.00337

Zschocke, 2011, Antidepressants encounter autophagy in neural cells, Autophagy, 7, 1247, 10.4161/auto.7.10.16520

Rossi, 2009, Desmethylclomipramine induces the accumulation of autophagy markers by blocking autophagic flux, J. Cell Sci., 122, 3330, 10.1242/jcs.048181

Ma, 2013, Antidepressant desipramine leads to C6 glioma cell autophagy: implication for the adjuvant therapy of cancer, Anticancer Agents Med. Chem., 13, 254, 10.2174/1871520611313020011

Chen, 2012, Accumulation of an antidepressant in vesiculogenic membranes of yeast cells triggers autophagy, PLoS ONE, 7, 10.1371/journal.pone.0034024

Gassen, 2014, Association of FKBP51 with priming of autophagy pathways and mediation of antidepressant treatment response: evidence in cells, mice, and humans, PLoS Med., 11, 10.1371/journal.pmed.1001755

Lekman, 2008, The FKBP5-gene in depression and treatment response–an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) Cohort, Biol. Psychiatry, 63, 1103, 10.1016/j.biopsych.2007.10.026

Ising, 2019, FKBP5 gene expression predicts antidepressant treatment outcome in depression, Int. J. Mol. Sci., 20, 10.3390/ijms20030485

Blair, 2019, The disease-associated chaperone FKBP51 impairs cognitive function by accelerating AMPA receptor recycling, eNeuro, 6, 10.1523/ENEURO.0242-18.2019

Gareau, 2010, The SUMO pathway: emerging mechanisms that shape specificity, conjugation and recognition, Nat. Rev. Mol. Cell Biol., 11, 861, 10.1038/nrm3011

Schorova, 2016, Sumoylation in synaptic function and dysfunction, Front. Synaptic Neurosci., 8, 9, 10.3389/fnsyn.2016.00009

Wang, 2014, Neuron-specific Sumo1-3 knockdown in mice impairs episodic and fear memories, J. Psychiatry Neurosci., 39, 259, 10.1503/jpn.130148

Anderson, 2017, Sumoylation: implications for neurodegenerative diseases, Adv. Exp. Med. Biol., 963, 261, 10.1007/978-3-319-50044-7_16

Henley, 2014, Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction, Physiol. Rev., 94, 1249, 10.1152/physrev.00008.2014

Loriol, 2013, Activity-dependent regulation of the sumoylation machinery in rat hippocampal neurons, Biol. Cell, 105, 30, 10.1111/boc.201200016

Feligioni, 2009, Protein SUMOylation modulates calcium influx and glutamate release from presynaptic terminals, Eur. J. Neurosci., 29, 1348, 10.1111/j.1460-9568.2009.06692.x

Jaafari, 2013, SUMOylation is required for glycine-induced increases in AMPA receptor surface expression (ChemLTP) in hippocampal neurons, PLoS ONE, 8, 10.1371/journal.pone.0052345

Chao, 2008, SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis, J. Cell Biol., 182, 141, 10.1083/jcb.200712094

Chamberlain, 2012, SUMOylation and phosphorylation of GluK2 regulate kainate receptor trafficking and synaptic plasticity, Nat. Neurosci., 15, 845, 10.1038/nn.3089

Shalizi, 2007, PIASx is a MEF2 SUMO E3 ligase that promotes postsynaptic dendritic morphogenesis, J. Neurosci., 27, 10037, 10.1523/JNEUROSCI.0361-07.2007

Martin, 2007, SUMOylation regulates kainate-receptor-mediated synaptic transmission, Nature, 447, 321, 10.1038/nature05736

Tempe, 2008, SUMO under stress, Biochem. Soc. Trans., 36, 874, 10.1042/BST0360874

Leitao, 2011, The SUMO E3-ligase PIAS1 couples reactive oxygen species-dependent JNK activation to oxidative cell death, FASEB J., 25, 3416, 10.1096/fj.11-186346

Bossis, 2006, Regulation of SUMOylation by reversible oxidation of SUMO conjugating enzymes, Mol. Cell, 21, 349, 10.1016/j.molcel.2005.12.019

Xu, 2008, Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation, FASEB J., 22, 127, 10.1096/fj.06-7871com

Yang, 2008, Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation, J. Cereb. Blood Flow Metab., 28, 892, 10.1038/sj.jcbfm.9600601

Yang, 2008, Transient global cerebral ischemia induces a massive increase in protein sumoylation, J. Cereb. Blood Flow Metab., 28, 269, 10.1038/sj.jcbfm.9600523

Bernstock, 2018, SUMOylation in brain ischemia: Patterns, targets, and translational implications, J. Cereb. Blood Flow Metab., 38, 5, 10.1177/0271678X17742260

Zhang, 2017, Neuron-specific SUMO knockdown suppresses global gene expression response and worsens functional outcome after transient forebrain ischemia in mice, Neuroscience, 343, 190, 10.1016/j.neuroscience.2016.11.036

Martin, 2009, PARP-1 transcriptional activity is regulated by sumoylation upon heat shock, EMBO J., 28, 3534, 10.1038/emboj.2009.279

Cai, 2010, Hypoxia inactivates the VHL tumor suppressor through PIASy-mediated SUMO modification, PLoS ONE, 5, 10.1371/journal.pone.0009720

Sahin, 2014, Interferon controls SUMO availability via the Lin28 and let-7 axis to impede virus replication, Nat. Commun., 5, 4187, 10.1038/ncomms5187

Schneider Aguirre, 2013, Inflammatory mediators increase SUMOylation of retinoid X receptor alpha in a c-Jun N-terminal kinase-dependent manner in human hepatocellular carcinoma cells, Mol. Pharmacol., 84, 218, 10.1124/mol.113.085555

Tirard, 2012, In vivo localization and identification of SUMOylated proteins in the brain of His6-HA-SUMO1 knock-in mice, Proc. Natl. Acad. Sci. USA, 109, 21122, 10.1073/pnas.1215366110

Oakley, 2011, Cellular processing of the glucocorticoid receptor gene and protein: new mechanisms for generating tissue-specific actions of glucocorticoids, J. Biol. Chem., 286, 3177, 10.1074/jbc.R110.179325

John, 2008, Interaction of the glucocorticoid receptor with the chromatin landscape, Mol. Cell, 29, 611, 10.1016/j.molcel.2008.02.010

John, 2011, Chromatin accessibility pre-determines glucocorticoid receptor binding patterns, Nat. Genet., 43, 264, 10.1038/ng.759

Antunica-Noguerol, 2014, The interplay between the glucocorticoid receptor activity and post-translational modifications in the immune and neuroendocrine system, Adv. Neuroimmune Biol., 5, 19, 10.3233/NIB-140083

Antunica-Noguerol, 2016, The activity of the glucocorticoid receptor is regulated by SUMO conjugation to FKBP51, Cell Death Differ., 23, 1579, 10.1038/cdd.2016.44

Luo, 2017, USP49 negatively regulates tumorigenesis and chemoresistance through FKBP51-AKT signaling, EMBO J., 36, 1434, 10.15252/embj.201695669

Le Drean, 2002, Potentiation of glucocorticoid receptor transcriptional activity by sumoylation, Endocrinology, 143, 3482, 10.1210/en.2002-220135

Tian, 2002, Small ubiquitin-related modifier-1 (SUMO-1) modification of the glucocorticoid receptor, Biochem. J., 367, 907, 10.1042/bj20021085

Golebiowski, 2009, System-wide changes to SUMO modifications in response to heat shock, Sci Signal, 2, ra24, 10.1126/scisignal.2000282

Druker, 2013, RSUME enhances glucocorticoid receptor SUMOylation and transcriptional activity, Mol. Cell. Biol., 33, 2116, 10.1128/MCB.01470-12

Holmstrom, 2008, SUMO-mediated inhibition of glucocorticoid receptor synergistic activity depends on stable assembly at the promoter but not on DAXX, Mol. Endocrinol., 22, 2061, 10.1210/me.2007-0581

Iniguez-Lluhi, 2000, A common motif within the negative regulatory regions of multiple factors inhibits their transcriptional synergy, Mol. Cell. Biol., 20, 6040, 10.1128/MCB.20.16.6040-6050.2000

Holmstrom, 2003, Direct and distinguishable inhibitory roles for SUMO isoforms in the control of transcriptional synergy, Proc. Natl. Acad. Sci. USA, 100, 15758, 10.1073/pnas.2136933100

Edwards, 1992, Heat shock alters the composition of heteromeric steroid receptor complexes and enhances receptor activity in vivo, Biochemistry, 31, 2482, 10.1021/bi00124a007

Paakinaho, 2014, SUMOylation regulates the chromatin occupancy and anti-proliferative gene programs of glucocorticoid receptor, Nucleic Acids Res., 42, 1575, 10.1093/nar/gkt1033

Kotaja, 2000, ARIP3 (androgen receptor-interacting protein 3) and other PIAS (protein inhibitor of activated STAT) proteins differ in their ability to modulate steroid receptor-dependent transcriptional activation, Mol. Endocrinol., 14, 1986, 10.1210/mend.14.12.0569

Tirard, 2004, The manifold actions of the protein inhibitor of activated STAT proteins on the transcriptional activity of mineralocorticoid and glucocorticoid receptors in neural cells, J. Mol. Endocrinol., 32, 825, 10.1677/jme.0.0320825

Davies, 2008, Cross talk of signaling pathways in the regulation of the glucocorticoid receptor function, Mol. Endocrinol., 22, 1331, 10.1210/me.2007-0360

Boonying, 2019, Pink1 regulates FKBP5 interaction with AKT/PHLPP and protects neurons from neurotoxin stress induced by MPP, J. Neurochem., 10.1111/jnc.14683