The Search for Safer Glucocorticoid Receptor Ligands

Endocrine Reviews - Tập 26 Số 3 - Trang 452-464 - 2005
Jonathan Rosen1, Jeffrey N. Miner1
1Department of Molecular and Cell Biology, Ligand Pharmaceuticals, San Diego, California 92121

Tóm tắt

Từ khóa


Tài liệu tham khảo

Diamond, 1990, Transcription factor interactions: selectors of positive or negative regulation from a single DNA element., Science, 249, 1266, 10.1126/science.2119054

Heck, 1997, IκB α-independent downregulation of NF-κB activity by glucocorticoid receptor., EMBO J, 16, 4698, 10.1093/emboj/16.15.4698

Reichardt, 1998, DNA binding of the glucocorticoid receptor is not essential for survival., Cell, 93, 531, 10.1016/S0092-8674(00)81183-6

Joels, 1998, Corticosteroids in the brain. Cellular and molecular actions., Mol Neurobiol, 17, 87, 10.1007/BF02802026

Bodine, 1990, The glucocorticoid receptor and its endogenous regulators., Receptor, 1, 83

Galigniana, 1998, Heat shock protein 90-dependent (geldanamycin-inhibited) movement of the glucocorticoid receptor through the cytoplasm to the nucleus requires intact cytoskeleton., Mol Endocrinol, 12, 1903, 10.1210/mend.12.12.0204

Caamano, 1998, A conserved proline in the hsp90 binding region of the glucocorticoid receptor is required for hsp90 heterocomplex stabilization and receptor signaling., J Biol Chem, 273, 20473, 10.1074/jbc.273.32.20473

Pratt, 1988, A region in the steroid binding domain determines formation of the non-DNA-binding, 9 S glucocorticoid receptor complex., J Biol Chem, 263, 267, 10.1016/S0021-9258(19)57388-4

Pratt, 1993, The hsp56 immunophilin component of steroid receptor heterocomplexes: could this be the elusive nuclear localization signal-binding protein?, J Steroid Biochem Mol Biol, 46, 269, 10.1016/0960-0760(93)90216-J

Evans, 1988, The steroid and thyroid hormone receptor superfamily., Science, 240, 889, 10.1126/science.3283939

Jenkins, 2001, Novel glucocorticoid receptor coactivator effector mechanisms., Trends Endocrinol Metab, 12, 122, 10.1016/S1043-2760(00)00357-X

Hansel, 2004, How do we measure the effectiveness of inhaled corticosteroids in clinical studies?, Respir Med, 98, S9, 10.1016/j.rmed.2004.07.010

Heuck, 2000, A randomised controlled trial of short term growth and collagen turnover in asthmatics treated with inhaled formoterol and budesonide., Arch Dis Child, 83, 334, 10.1136/adc.83.4.334

Heuck, 1997, Short-term growth and collagen turnover in asthmatic adolescents treated with the inhaled glucocorticoid budesonide., Steroids, 62, 659, 10.1016/S0039-128X(97)00053-6

Orth, 1998, 517

Deeg, 1990, Management of acute graft-versus-host disease., Bone Marrow Transplant, 6, 1

Schleimer, 1989, An assessment of the effects of glucocorticoids on degranulation, chemotaxis, binding to vascular endothelium and formation of leukotriene B4 by purified human neutrophils., J Pharmacol Exp Ther, 250, 598

Axelrod, 1989, 845

Axelrod, 1979, 809

Axelrod, 1976, Glucocorticoid therapy., Medicine (Baltimore), 55, 39, 10.1097/00005792-197601000-00003

Axelrod, 1984, Stress hormones: their interaction and regulation., Science, 224, 452, 10.1126/science.6143403

Lukert, 1996, 533

Ralston, 1999, Pathogenesis and management of corticosteroid-induced osteoporosis., Curr Opin Oncol Endocr Metab Invest Drugs, 1, 25

Adinoff, 1983, Steroid-induced fractures and bone loss in patients with asthma., N Engl J Med, 309, 265, 10.1056/NEJM198308043090502

McEvoy, 1998, Association between corticosteroid use and vertebral fractures in older men with chronic obstructive pulmonary disease., Am J Respir Crit Care Med, 157, 704, 10.1164/ajrccm.157.3.9703080

Lane, 1998, Corticosteroid-resistant bronchial asthma is associated with increased c-fos expression in monocytes and T lymphocytes., J Clin Invest, 102, 2156, 10.1172/JCI2680

Lane, 1998, Bone loss in rheumatoid arthritis: what role does inflammation play?, J Rheumatol, 25, 1251

Reid, 1996, Testosterone therapy in glucocorticoid-treated men., Arch Intern Med, 156, 1173, 10.1001/archinte.1996.00440100065008

Shane, 1998, Prevention of bone loss after heart transplantation with antiresorptive therapy: a pilot study., J Heart Lung Transplant, 17, 1089

Shane, 1999, Bone loss and fracture after lung transplantation., Transplantation, 68, 220, 10.1097/00007890-199907270-00010

Staa, 2000, Oral corticosteroids and fracture risk: relationship to daily and cumulative doses., Rheumatology (Oxford), 39, 1383, 10.1093/rheumatology/39.12.1383

Crilly, 1978, Hormonal status in normal, osteoporotic and corticosteroid-treated postmenopausal women., J R Soc Med, 71, 733, 10.1177/014107687807101006

Doerr, 1976, Cortisol-induced suppression of plasma testosterone in normal adult males., J Clin Endocrinol Metab, 43, 622, 10.1210/jcem-43-3-622

Brem, 2001, Insights into glucocorticoid-associated hypertension., Am J Kidney Dis, 37, 1, 10.1053/ajkd.2001.20637

Roland, 1995, Hybridization histochemical localization of 11 β-hydroxysteroid dehydrogenase type 2 in rat brain., Endocrinology, 136, 4697, 10.1210/endo.136.10.7664691

Roland, 1995, Glucocorticoid receptor, mineralocorticoid receptors, 11 β-hydroxysteroid dehydrogenase-1 and -2 expression in rat brain and kidney: in situ studies, Mol Cell Endocrinol, 111, R1, 10.1016/0303-7207(95)03559-P

Nosadini, 1983, Insulin resistance in Cushing’s syndrome., J Clin Endocrinol Metab, 57, 529, 10.1210/jcem-57-3-529

McMahon, 1988, Effects of glucocorticoids on carbohydrate metabolism., Diabetes Metab Rev, 4, 17, 10.1002/dmr.5610040105

Tappy, 1994, Mechanisms of dexamethasone-induced insulin resistance in healthy humans., J Clin Endocrinol Metab, 79, 1063

Laakso, 1990, Decreased effect of insulin to stimulate skeletal muscle blood flow in obese man. A novel mechanism for insulin resistance., J Clin Invest, 85, 1844, 10.1172/JCI114644

Laakso, 1990, Kinetics of in vivo muscle insulin-mediated glucose uptake in human obesity., Diabetes, 39, 965, 10.2337/diab.39.8.965

Weber, 1968, 263

Granner, 1986, Multihormonal regulation of phosphoenolpyruvate carboxykinase gene transcription. The dominant role of insulin., Ann NY Acad Sci, 478, 175, 10.1111/j.1749-6632.1986.tb15530.x

Sutherland, 1996, New connections in the regulation of PEPCK gene expression by insulin., Philos Trans R Soc Lond B Biol Sci, 351, 191, 10.1098/rstb.1996.0016

Diethelm, 1977, Surgical management of complications of steroid therapy., Ann Surg, 185, 251, 10.1097/00000658-197703000-00001

Anstead, 1998, Steroids, retinoids, and wound healing., Adv Wound Care, 11, 277

Autio, 1994, Systemic glucocorticoids decrease the synthesis of type I and type III collagen in human skin in vivo, whereas isotretinoin treatment has little effect., Br J Dermatol, 131, 660, 10.1111/j.1365-2133.1994.tb04978.x

Slavin, 1994, Transforming growth factor β (TGF-β) and dexamethasone have direct opposing effects on collagen metabolism in low passage human dermal fibroblasts in vitro., Growth Factors, 11, 205, 10.3109/08977199409046918

Miner, 1991, Joints in the regulatory lattice: composite regulation by steroid receptor-AP1 complexes., Cell Growth Differ, 2, 525

Miner, 1991, Regulatory crosstalk at composite response elements., Trends Biochem Sci, 16, 423, 10.1016/0968-0004(91)90168-U

Barnes, 1998, Anti-inflammatory actions of glucocorticoids: molecular mechanisms., Clin Sci (Lond), 94, 557, 10.1042/cs0940557

De Bosscher, 1997, Glucocorticoid-mediated repression of nuclear factor-κB-dependent transcription involves direct interference with transactivation., Proc Natl Acad Sci USA, 94, 13504, 10.1073/pnas.94.25.13504

Lange, 1997, Differential hormone-dependent transcriptional activation and -repression by naturally occurring human glucocorticoid receptor variants., Mol Endocrinol, 11, 1156, 10.1210/mend.11.8.9949

McKay, 1998, Cross-talk between nuclear factor-κB and the steroid hormone receptors: mechanisms of mutual antagonism., Mol Endocrinol, 12, 45, 10.1210/mend.12.1.0044

Vayssiere, 1997, Synthetic glucocorticoids that dissociate transactivation and AP-1 transrepression exhibit antiinflammatory activity in vivo., Mol Endocrinol, 11, 1245, 10.1210/mend.11.9.9979

Godowski, 1987, Glucocorticoid receptor mutants that are constitutive activators of transcriptional enhancement., Nature, 325, 365, 10.1038/325365a0

Allan, 1991, Synergism between steroid response and promoter elements during cell-free transcription., J Biol Chem, 266, 5905, 10.1016/S0021-9258(19)67683-0

Hong, 1999, An additional region of coactivator GRIP1 required for interaction with the hormone-binding domains of a subset of nuclear receptors., J Biol Chem, 274, 3496, 10.1074/jbc.274.6.3496

Hong, 1996, GRIP1, a novel mouse protein that serves as a transcriptional coactivator in yeast for the hormone binding domains of steroid receptors., Proc Natl Acad Sci USA, 93, 4948, 10.1073/pnas.93.10.4948

Smith, 1996, CREB binding protein acts synergistically with steroid receptor coactivator-1 to enhance steroid receptor-dependent transcription., Proc Natl Acad Sci USA, 93, 8884, 10.1073/pnas.93.17.8884

Ribeiro, 1998, Mechanisms of thyroid hormone action: insights from x-ray crystallographic and functional studies., Recent Prog Horm Res, 53, 351

Darimont, 1998, Structure and specificity of nuclear receptor-coactivator interactions., Genes Dev, 12, 3343, 10.1101/gad.12.21.3343

Feng, 1998, Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors., Science, 280, 1747, 10.1126/science.280.5370.1747

Jenster, 1997, Steroid receptor induction of gene transcription: a two-step model., Proc Natl Acad Sci USA, 94, 7879, 10.1073/pnas.94.15.7879

McKenna, 1999, Nuclear receptor coactivators: multiple enzymes, multiple complexes, multiple functions., J Steroid Biochem Mol Biol, 69, 3, 10.1016/S0960-0760(98)00144-7

Liu, 1999, Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin., Proc Natl Acad Sci USA, 96, 9485, 10.1073/pnas.96.17.9485

Shiau, 1998, The structural basis of estrogen receptor/coactivator recognition and the antagonism of this interaction by tamoxifen., Cell, 95, 927, 10.1016/S0092-8674(00)81717-1

Spencer, 1997, Steroid receptor coactivator-1 is a histone acetyltransferase., Nature, 389, 194, 10.1038/38304

Miner, 1992, The basic region of AP-1 specifies glucocorticoid receptor activity at a composite response element., Genes Dev, 6, 2491, 10.1101/gad.6.12b.2491

Starr, 1996, Intracellular receptors use a common mechanism to interpret signaling information at response elements., Genes Dev, 10, 1271, 10.1101/gad.10.10.1271

Schule, 1990, Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor., Cell, 62, 1217, 10.1016/0092-8674(90)90397-W

Reichardt, 1998, Analysis of glucocorticoid signalling by gene targeting., J Steroid Biochem Mol Biol, 65, 111, 10.1016/S0960-0760(97)00181-7

Schulman, 1996, Activation and repression by nuclear hormone receptors: hormone modulates an equilibrium between active and repressive states., Mol Cell Biol, 16, 3807, 10.1128/MCB.16.7.3807

Spanjaard, 1995, Repression of glucocorticoid receptor-mediated transcriptional activation by unliganded thyroid hormone receptor (TR) is TR isoform-specific., Endocrinology, 136, 5084, 10.1210/endo.136.11.7588245

Zhou, 1999, Ligand-activated retinoic acid receptor inhibits AP-1 transactivation by disrupting c-Jun/c-Fos dimerization., Mol Endocrinol, 13, 276, 10.1210/mend.13.2.0237

Whitfield, 1999, Steroid hormone receptors: evolution, ligands, and molecular basis of biologic function., J Cell Biochem, 110, 10.1002/(SICI)1097-4644(1999)75:32+<110::AID-JCB14>3.0.CO;2-T

Bergmann, 2004, Glucocorticoid inhibition of granulocyte macrophage-colony-stimulating factor from T cells is independent of control by nuclear factor-κB and conserved lymphokine element 0., Am J Respir Cell Mol Biol, 30, 555, 10.1165/rcmb.2003-0295OC

Chivers, 2004, Differential effects of RU486 reveal distinct mechanisms for glucocorticoid repression of prostaglandin E release., Eur J Biochem, 271, 4042, 10.1111/j.1432-1033.2004.04342.x

Wright, 1993, Structure and function of the glucocorticoid receptor., J Steroid Biochem Mol Biol, 47, 11, 10.1016/0960-0760(93)90052-X

Dumont, 1998, Cross-talk between steroids and NF-κB: what language?, Trends Biochem Sci, 23, 233, 10.1016/S0968-0004(98)01212-2

Wissink, 1998, A dual mechanism mediates repression of NF-κB activity by glucocorticoids., Mol Endocrinol, 12, 355

Ray, 1994, Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor., Proc Natl Acad Sci USA, 91, 752, 10.1073/pnas.91.2.752

Ray, 1995, Anti-inflammation: direct physical association and functional antagonism between transcription factor NF-κB and the glucocorticoid receptor., Chest, 107, 139, 10.1378/chest.107.3_Supplement.139S

Wei, 1998, Transrepression of c-jun gene expression by the glucocorticoid receptor requires both AP-1 sites in the c-jun promoter., Mol Endocrinol, 12, 1322, 10.1210/mend.12.9.0158

Nissen, 2000, The glucocorticoid receptor inhibits NFκB by interfering with serine-2 phosphorylation of the RNA polymerase II carboxy-terminal domain., Genes Dev, 14, 2314, 10.1101/gad.827900

Bruna, 2003, Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids., EMBO J, 22, 6035, 10.1093/emboj/cdg590

Jonat, 1990, Antitumor promotion and antiinflammation: down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone., Cell, 62, 1189, 10.1016/0092-8674(90)90395-U

Yang-Yen, 1990, Transcriptional interference between c-Jun and the glucocorticoid receptor: mutual inhibition of DNA binding due to direct protein-protein interaction., Cell, 62, 1205, 10.1016/0092-8674(90)90396-V

McNally, 2000, The glucocorticoid receptor: rapid exchange with regulatory sites in living cells., Science, 287, 1262, 10.1126/science.287.5456.1262

Rogatsky, 2002, Alternate surfaces of transcriptional coregulator GRIP1 function in different glucocorticoid receptor activation and repression contexts., Proc Natl Acad Sci USA, 99, 16701, 10.1073/pnas.262671599

Rogatsky, 2003, Target-specific utilization of transcriptional regulatory surfaces by the glucocorticoid receptor., Proc Natl Acad Sci USA, 100, 13845, 10.1073/pnas.2336092100

Meyer, 1997, A weak TATA box is a prerequisite for glucocorticoid-dependent repression of the osteocalcin gene., J Biol Chem, 272, 30709, 10.1074/jbc.272.49.30709

Kassel, 2004, A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF-κB-regulated promoters., Genes Dev, 18, 2518, 10.1101/gad.322404

Miner, 2002, Designer glucocorticoids., Biochem Pharmacol, 64, 355, 10.1016/S0006-2952(02)01121-8

Schacke, 2002, SEGRAs: a novel class of anti-inflammatory compounds., Ernst Schering Res Found Workshop, 40, 357

Coghlan, 2003, A novel antiinflammatory maintains glucocorticoid efficacy with reduced side effects., Mol Endocrinol, 17, 860, 10.1210/me.2002-0355

Belvisi, 2003, Soft steroids: a new approach to the treatment of inflammatory airways diseases., Pulm Pharmacol Ther, 16, 321, 10.1016/S1094-5539(03)00105-6

Lee, 1999, A novel approach to the discovery of non-systemic anti-inflammatory steroids; antedrug., Arch Pharm Res, 22, 279, 10.1007/BF02976363

Belvisi, 2001, New glucocorticosteroids with an improved therapeutic ratio?, Pulm Pharmacol Ther, 14, 221, 10.1006/pupt.2001.0284

Belvisi, 2001, Therapeutic benefit of a dissociated glucocorticoid and the relevance of in vitro separation of transrepression from transactivation activity., J Immunol, 166, 1975, 10.4049/jimmunol.166.3.1975

Reichardt, 2001, Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor., EMBO J, 20, 7168, 10.1093/emboj/20.24.7168

Markham, 1995, Deflazacort. A review of its pharmacological properties and therapeutic efficacy., Drugs, 50, 317, 10.2165/00003495-199550020-00008

Beresford, 1984, Production of osteocalcin by human bone cells in vitro. Effects of 1,25(OH)2D3, 24,25(OH)2D3, parathyroid hormone, and glucocorticoids., Metab Bone Dis Relat Res, 5, 229, 10.1016/0221-8747(84)90064-X

Canalis, 1992, Effects of deflazacort on aspects of bone formation in cultures of intact calvariae and osteoblast-enriched cells., J Bone Miner Res, 7, 1085, 10.1002/jbmr.5650070912

Drug Ther Bull, 37, 57, 10.1136/dtb.1999.37857

Kim, 1999, Equivalence trials in SLE research: issues to consider., Lupus, 8, 620, 10.1191/096120399680411308

Ebbutt, 1998, Practical issues in equivalence trials., Stat Med, 17, 1691, 10.1002/(SICI)1097-0258(19980815/30)17:15/16<1691::AID-SIM971>3.0.CO;2-J

Jones, 1996, Trials to assess equivalence: the importance of rigorous methods., BMJ, 313, 36, 10.1136/bmj.313.7048.36

Krogsgaard, 1995, A long-term prospective study of the equipotency between deflazacort and prednisolone in the treatment of patients with polymyalgia rheumatica., J Rheumatol, 22, 1660

Nieman, 1985, Successful treatment of Cushing’s syndrome with the glucocorticoid antagonist RU 486., J Clin Endocrinol Metab, 61, 536, 10.1210/jcem-61-3-536

Schulte, 1985, Continuous administration of synthetic ovine corticotropin-releasing factor in man. Physiological and pathophysiological implications., J Clin Invest, 75, 1781, 10.1172/JCI111890

Burgess, 1996, Sociotropy, autonomy, stress, and depression in Cushing syndrome., J Nerv Ment Dis, 184, 362, 10.1097/00005053-199606000-00006

Chrousos, 1998, A healthy body in a healthy mind–and vice versa–the damaging power of “uncontrollable” stress., J Clin Endocrinol Metab, 83, 1842

Chrousos, 1998, Stress as a medical and scientific idea and its implications., Adv Pharmacol, 42, 552, 10.1016/S1054-3589(08)60810-8

Bjorntorp, 1999, Hypothalamic origin of the metabolic syndrome X., Ann NY Acad Sci, 892, 297, 10.1111/j.1749-6632.1999.tb07803.x

Uhr, 2002, Penetration of endogenous steroid hormones corticosterone, cortisol, aldosterone and progesterone into the brain is enhanced in mice deficient for both mdr1a and mdr1b P-glycoproteins., J Neuroendocrinol, 14, 753, 10.1046/j.1365-2826.2002.00836.x

Rousseau, 1972, Glucocorticoid receptors: relations between steroid binding and biological effects., J Mol Biol, 67, 99, 10.1016/0022-2836(72)90389-0

Szefler, 1989, 353

Calleja, 1998, The antibiotic rifampicin is a nonsteroidal ligand and activator of the human glucocorticoid receptor., Nat Med, 4, 92, 10.1038/nm0198-092

Blanchard, 1998, The ying and yang of rifampicin., Nat Med, 4, 14, 10.1038/nm0198-014

Ray, 1998, Rifampicin: a glucocorticoid receptor ligand?, Nat Med, 4, 1090, 10.1038/2575

Jaffuel, 1999, Rifampicin is not an activator of the glucocorticoid receptor in A549 human alveolar cells., Mol Pharmacol, 55, 841

Herr, 2000, Rifampicin is not an activator of glucocorticoid receptor., Mol Pharmacol, 57, 732, 10.1124/mol.57.4.732

Visser, 2001, No evidence that rifampicin has glucocorticoid-like immunosuppressive properties leading to suppression of rat-splenocyte proliferation in vitro., J Antimicrob Chemother, 47, 894, 10.1093/jac/47.6.894

Kliewer, 1999, The PPARs and PXRs: nuclear xenobiotic receptors that define novel hormone signaling pathways., Recent Prog Horm Res, 54, 345

Blumberg, 1998, SXR, a novel steroid and xenobiotic-sensing nuclear receptor., Genes Dev, 12, 3195, 10.1101/gad.12.20.3195

McDonnell, 1995, Analysis of estrogen receptor function in vitro reveals three distinct classes of antiestrogens., Mol Endocrinol, 9, 659

Guido, 1996, Determinants of promoter-specific activity by glucocorticoid receptor., Mol Endocrinol, 10, 1178

Miner, 2003, A nonsteroidal glucocorticoid receptor antagonist., Mol Endocrinol, 17, 117, 10.1210/me.2002-0010

Burg, 1997, Nuclear factor-κB repression in anti-inflammation and immunosuppression by glucocorticoids., Trends Endocrinol Metab, 8, 152, 10.1016/S1043-2760(97)00006-4

Schacke, 2004, Dissociation of transactivation from transrepression by a selective glucocorticoid receptor agonist leads to separation of therapeutic effects from side effects., Proc Natl Acad Sci USA, 101, 227, 10.1073/pnas.0300372101

Shah, 2004, Design and evaluation of novel nonsteroidal dissociating glucocorticoid receptor ligands., Bioorg Med Chem Lett, 14, 5199, 10.1016/j.bmcl.2004.07.052

Ali, 2004, Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity., J Med Chem, 47, 2441, 10.1021/jm030585i

Shang, 2002, Molecular determinants for the tissue specificity of SERMs., Science, 295, 2465, 10.1126/science.1068537

Herzig, 2001, CREB regulates hepatic gluconeogenesis through the coactivator PGC-1., Nature [Erratum (2001) 413:652], 413, 179

Yoon, 2001, Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1., Nature, 413, 131, 10.1038/35093050

Drouin, 1993, Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene., EMBO J, 12, 145, 10.1002/j.1460-2075.1993.tb05640.x

Meyer, 1997, Glucocorticoid-dependent transcriptional repression of the osteocalcin gene by competitive binding at the TATA box., DNA Cell Biol, 16, 919, 10.1089/dna.1997.16.919

Mordacq, 1989, Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression., Genes Dev, 3, 760, 10.1101/gad.3.6.760

Auphan, 1995, Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of IκB synthesis., Science, 270, 286, 10.1126/science.270.5234.286

Kassel, 2001, Glucocorticoids inhibit MAP kinase via increased expression and decreased degradation of MKP-1., EMBO J, 20, 7108, 10.1093/emboj/20.24.7108

Fernandes, 2003, Ligand-dependent nuclear receptor corepressor LCoR functions by histone deacetylase-dependent and -independent mechanisms., Mol Cell, 11, 139, 10.1016/S1097-2765(03)00014-5

Caldenhoven, 1995, Negative cross-talk between RelA and the glucocorticoid receptor: a possible mechanism for the antiinflammatory action of glucocorticoids., Mol Endocrinol, 9, 401

Scheinman, 1995, Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors., Mol Cell Biol, 15, 943, 10.1128/MCB.15.2.943

Sheppard, 1998, Nuclear integration of glucocorticoid receptor and nuclear factor-κB signaling by CREB-binding protein and steroid receptor coactivator-1., J Biol Chem, 273, 29291, 10.1074/jbc.273.45.29291