Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment
Tóm tắt
Từ khóa
Tài liệu tham khảo
Holsboer, F. The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23, 477–501 (2000).
Holsboer, F. & Barden, N. Antidepressants and hypothalamic–pituitary–adrenocortical regulation. Endocr. Rev. 17, 187–205 (1996).
Nemeroff, C.B. The role of corticotropin–releasing factor in the pathogenesis of major depression. Pharmacopsychiatry 21, 76–82 (1988).
Nemeroff, C.B. et al. Elevated concentrations of CSF corticotropin–releasing factor–like immunoreactivity in depressed patients. Science 226, 1342–1344 (1984).
Nemeroff, C.B., Owens, M.J., Bissette, G., Andorn, A.C. & Stanley, M. Reduced corticotropin releasing factor binding sites in the frontal cortex of suicide victims. Arch. Gen. Psychiatry 45, 577–579 (1988).
Purba, J.S., Hoogendijk, W.J., Hofman, M.A. & Swaab, D.F. Increased number of vasopressin- and oxytocin-expressing neurons in the paraventricular nucleus of the hypothalamus in depression. Arch. Gen. Psychiatry 53, 137–143 (1996).
Timpl, P. et al. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin–releasing hormone receptor. Nat. Genet. 19, 162–166 (1998).
Muller, M.B. et al. Limbic corticotropin-releasing hormone receptor 1 mediates anxiety-related behavior and hormonal adaptation to stress. Nat. Neurosci. 6, 1100–1107 (2003).
Pariante, C.M. & Miller, A.H. Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment. Biol. Psychiatry 49, 391–404 (2001).
Barden, N., Stec, I.S., Montkowski, A., Holsboer, F. & Reul, J.M. Endocrine profile and neuroendocrine challenge tests in transgenic mice expressing antisense RNA against the glucocorticoid receptor. Neuroendocrinology 66, 212–220 (1997).
Pratt, W.B. & Toft, D.O. Steroid receptor interactions with heat shock protein and immunophilin chaperones. Endocr. Rev. 18, 306–360 (1997).
Cheung, J. & Smith, D.F. Molecular chaperone interactions with steroid receptors: an update. Mol. Endocrinol. 14, 939–946 (2000).
Schmidt, U. et al. Essential role of the unusual DNA-binding motif of BAG-1 for inhibition of the glucocorticoid receptor. J. Biol. Chem. 278, 4926–4931 (2003).
Freedman, M.L. et al. Assessing the impact of population stratification on genetic association studies. Nat. Genet. 36, 388–393 (2004).
Schiene-Fischer, C. & Yu, C. Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases. FEBS Lett. 495, 1–6 (2001).
Davies, T.H., Ning, Y.M. & Sanchez, E.R. A new first step in activation of steroid receptors: hormone–induced switching of FKBP51 and FKBP52 immunophilins. J. Biol. Chem. 277, 4597–4600 (2002).
Denny, W.B., Valentine, D.L., Reynolds, P.D., Smith, D.F. & Scammell, J.G. Squirrel monkey immunophilin FKBP51 is a potent inhibitor of glucocorticoid receptor binding. Endocrinology 141, 4107–4113 (2000).
Reynolds, P.D. et al. Glucocorticoid-resistant B-lymphoblast cell line derived from the Bolivian squirrel monkey (Saimiri boliviensis boliviensis). Lab. Anim. Sci. 48, 364–370 (1998).
Scammell, J.G., Denny, W.B., Valentine, D.L. & Smith, D.F. Overexpression of the FK506-binding immunophilin FKBP51 is the common cause of glucocorticoid resistance in three New World primates. Gen. Comp. Endocrinol. 124, 152–165 (2001).
Vermeer, H., Hendriks-Stegeman, B.I., van der Burg, B., van Buul-Offers, S.C. & Jansen, M. Glucocorticoid-induced increase in lymphocytic FKBP51 messenger ribonucleic acid expression: a potential marker for glucocorticoid sensitivity, potency, and bioavailability. J. Clin. Endocrinol. Metab. 88, 277–284 (2003).
Heuser, I., Yassouridis, A. & Holsboer, F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J. Psychiatr. Res. 28, 341–356 (1994).
Wittchen, H. et al. Screening for mental disorders: performance of the Composite International Diagnostic – Screener (CID–S). Int. J. Methods Psychiatr. Res. 8, 59–70 (1999).
Zobel, A.W., Nickel, T., Sonntag, A., Uhr, M., Holsboer, F. & Ising, M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. A prospective study. J. Psychiatr. Res. 35, 83–94 (2001).
Fisher, R.A. Statistical Methods for Research Workers (Oliver and Boyd, London, 1932).
Dudbridge, F. & Koeleman, B.P. Efficient computation of significance levels for multiple associations in large studies of correlated data, including genomewide association studies. Am. J. Hum. Genet. 75, 424–435 (2004).
Neale, B.M. & Sham, P.C. The future of association studies: gene-based analysis and replication. Am. J. Hum. Genet. 75, 353–362 (2004).