Leptin as regulator of pulmonary immune responses: Involvement in respiratory diseases

Pulmonary Pharmacology and Therapeutics - Tập 26 - Trang 464-472 - 2013
Juanita H.J. Vernooy1, Niki D.J. Ubags1,2, Guy G. Brusselle3, Jan Tavernier4, Benjamin T. Suratt2, Guy F. Joos3, Emiel F.M. Wouters1, Ken R. Bracke3
1Department of Respiratory Medicine, Maastricht University Medical Center+ (MUMC+), P.O. Box 5800, 6202 AZ Maastricht, The Netherlands
2Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
3Laboratory for Translational Research in Obstructive Pulmonary Diseases, Department of Respiratory Medicine, Ghent University Hospital, Ghent, Belgium
4Department of Biochemistry, Cytokine Receptor Lab, VIB – Ghent University, Ghent, Belgium

Tài liệu tham khảo

Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0

Wauman, 2011, Leptin receptor signaling: pathways to leptin resistance, Front Biosci, 17, 2771, 10.2741/3885

Otero, 2006, Towards a pro-inflammatory and immunomodulatory emerging role of leptin, Rheumatology (Oxford), 45, 944, 10.1093/rheumatology/kel157

Masuzaki, 1997, Nonadipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans, Nat Med, 3, 1029, 10.1038/nm0997-1029

Mix, 2000, Expression of leptin and leptin receptor isoforms in the human stomach, Gut, 47, 481, 10.1136/gut.47.4.481

Sitaraman, 2004, Colonic leptin: source of a novel proinflammatory cytokine involved in IBD, Faseb J, 18, 696, 10.1096/fj.03-0422fje

Smith-Kirwin, 1998, Leptin expression in human mammary epithelial cells and breast milk, J Clin Endocrinol Metab, 83, 1810, 10.1210/jc.83.5.1810

Morash, 1999, Leptin gene expression in the brain and pituitary gland, Endocrinology, 140, 5995, 10.1210/en.140.12.5995

Wang, 1998, A nutrient-sensing pathway regulates leptin gene expression in muscle and fat, Nature, 393, 684, 10.1038/31474

Wang, 1999, The effect of leptin on lep expression is tissue-specific and nutritionally regulated, Nat Med, 5, 895, 10.1038/10577

Reseland, 2001, Leptin is expressed in and secreted from primary cultures of human osteoblasts and promotes bone mineralization, J Bone Miner Res, 16, 1426, 10.1359/jbmr.2001.16.8.1426

Laharrague, 1998, High expression of leptin by human bone marrow adipocytes in primary culture, Faseb J, 12, 747, 10.1096/fasebj.12.9.747

Vernooy, 2009, Enhanced pulmonary leptin expression in patients with severe COPD and asymptomatic smokers, Thorax, 64, 26, 10.1136/thx.2007.085423

Henson, 2004, Leptin receptor expression in fetal lung increases in late gestation in the baboon: a model for human pregnancy, Reproduction, 127, 87, 10.1530/rep.1.00037

Vernooy, 2010, Leptin modulates innate and adaptive immune cell recruitment after cigarette smoke exposure in mice, J Immunol, 184, 7169, 10.4049/jimmunol.0900963

Hammond, 2005, Molecular cloning and expression of leptin in gray and harbor seal blubber, bone marrow, and lung and its potential role in marine mammal respiratory physiology, Am J Physiol Regul Integr Comp Physiol, 289, R545, 10.1152/ajpregu.00203.2004

Torday, 2009, Leptin stimulates Xenopus lung development: evolution in a dish, Evol Dev, 11, 219, 10.1111/j.1525-142X.2009.00321.x

Bruno, 2005, Does leptin play a cytokine-like role within the airways of COPD patients?, Eur Respir J, 26, 398, 10.1183/09031936.05.00092404

Torday, 2002, Leptin mediates the parathyroid hormone-related protein paracrine stimulation of fetal lung maturation, Am J Physiol Lung Cell Mol Physiol, 282, L405, 10.1152/ajplung.2002.282.3.L405

Wabitsch, 1996, Insulin and cortisol promote leptin production in cultured human fat cells, Diabetes, 45, 1435, 10.2337/diabetes.45.10.1435

Machinal, 1999, In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones, Endocrinology, 140, 1567, 10.1210/en.140.4.1567

Mattsson, 2007, Estrogens and glucocorticoid hormones in adipose tissue metabolism, Curr Med Chem, 14, 2918, 10.2174/092986707782359972

De Pergola, 2000, The adipose tissue metabolism: role of testosterone and dehydroepiandrosterone, Int J Obes Relat Metab Disord, 24, S59, 10.1038/sj.ijo.0801280

Sarraf, 1997, Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia, J Exp Med, 185, 171, 10.1084/jem.185.1.171

Popa, 2005, Markers of inflammation are negatively correlated with serum leptin in rheumatoid arthritis, Ann Rheum Dis, 64, 1195, 10.1136/ard.2004.032243

Zhang, 2000, Tumour necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and release, Mol Cell Endocrinol, 159, 79, 10.1016/S0303-7207(99)00194-X

Bergen, 2002, Identification of leptin receptors in lung and isolated fetal type II cells, Am J Respir Cell Mol Biol, 27, 71, 10.1165/ajrcmb.27.1.4540

Bellmeyer, 2007, Leptin resistance protects mice from hyperoxia-induced acute lung injury, Am J Respir Crit Care Med, 175, 587, 10.1164/rccm.200603-312OC

Broekhuizen, 2005, Leptin as local inflammatory marker in COPD, Respir Med, 99, 70, 10.1016/j.rmed.2004.03.029

Carpagnano, 2007, IL-2, TNF-alpha, and leptin: local versus systemic concentrations in NSCLC patients, Oncol Res, 16, 375, 10.3727/000000006783980900

Holguin, 2011, Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls, J Asthma, 48, 217, 10.3109/02770903.2011.555033

Jain, 2011, Leptin promotes fibroproliferative acute respiratory distress syndrome by inhibiting peroxisome proliferator-activated receptor-gamma, Am J Respir Crit Care Med, 183, 1490, 10.1164/rccm.201009-1409OC

Tartaglia, 1997, The leptin receptor, J Biol Chem, 272, 6093, 10.1074/jbc.272.10.6093

Myers, 2004, Leptin receptor signaling and the regulation of mammalian physiology, Recent Prog Horm Res, 59, 287, 10.1210/rp.59.1.287

Wauman, 2011, RNF41 (Nrdp1) controls type 1 cytokine receptor degradation and ectodomain shedding, J Cell Sci, 124, 921, 10.1242/jcs.078055

Uotani, 1999, Functional properties of leptin receptor isoforms: internalization and degradation of leptin and ligand-induced receptor downregulation, Diabetes, 48, 279, 10.2337/diabetes.48.2.279

Bjorbak, 2000, SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985, J Biol Chem, 275, 40649, 10.1074/jbc.M007577200

Munzberg, 2005, Molecular and anatomical determinants of central leptin resistance, Nat Neurosci, 8, 566, 10.1038/nn1454

Cook, 2002, Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity, Dev Cell, 2, 385, 10.1016/S1534-5807(02)00158-2

Zabolotny, 2002, PTP1B regulates leptin signal transduction in vivo, Dev Cell, 2, 489, 10.1016/S1534-5807(02)00148-X

Huang, 2008, Effects of leptin deficiency on postnatal lung development in mice, J Appl Physiol, 105, 249, 10.1152/japplphysiol.00052.2007

Kirwin, 2006, Leptin enhances lung maturity in the fetal rat, Pediatr Res, 60, 200, 10.1203/01.pdr.0000227478.29271.52

Gnanalingham, 2005, Differential effects of leptin administration on the abundance of UCP2 and glucocorticoid action during neonatal development, Am J Physiol Endocrinol Metab, 289, E1093, 10.1152/ajpendo.00228.2005

Sato, 2011, Leptin does not influence surfactant synthesis in fetal sheep and mice lungs, Am J Physiol Lung Cell Mol Physiol, 300, L498, 10.1152/ajplung.00418.2010

Gnanalingham, 2005, Ontogeny and nutritional programming of uncoupling protein-2 and glucocorticoid receptor mRNA in the ovine lung, J Physiol, 565, 159, 10.1113/jphysiol.2005.083246

Pecqueur, 2001, Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation, J Biol Chem, 276, 8705, 10.1074/jbc.M006938200

Tankersley, 1998, Leptin attenuates respiratory complications associated with the obese phenotype, J Appl Physiol, 85, 2261, 10.1152/jappl.1998.85.6.2261

O'Donnell, 1999, Leptin prevents respiratory depression in obesity, Am J Respir Crit Care Med, 159, 1477, 10.1164/ajrccm.159.5.9809025

La Cava, 2004, The weight of leptin in immunity, Nat Rev Immunol, 4, 371, 10.1038/nri1350

Caldefie-Chezet, 2003, Leptin regulates functional capacities of polymorphonuclear neutrophils, Free Radic Res, 37, 809, 10.1080/1071576031000097526

Moore, 2003, Leptin modulates neutrophil phagocytosis of Klebsiella pneumoniae, Infect Immun, 71, 4182, 10.1128/IAI.71.7.4182-4185.2003

Loffreda, 1998, Leptin regulates proinflammatory immune responses, Faseb J, 12, 57, 10.1096/fasebj.12.1.57

Santos-Alvarez, 1999, Human leptin stimulates proliferation and activation of human circulating monocytes, Cell Immunol, 194, 6, 10.1006/cimm.1999.1490

Kordonowy, 2012, Obesity is associated with neutrophil dysfunction and attenuation of murine acute lung injury, Am J Respir Cell Mol Biol, 47, 120, 10.1165/rcmb.2011-0334OC

Martin-Romero, 2000, Human leptin enhances activation and proliferation of human circulating T lymphocytes, Cell Immunol, 199, 15, 10.1006/cimm.1999.1594

Fujita, 2002, Leptin inhibits stress-induced apoptosis of T lymphocytes, Clin Exp Immunol, 128, 21, 10.1046/j.1365-2249.2002.01797.x

Lord, 1998, Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression, Nature, 394, 897, 10.1038/29795

Wouters, 2008, COPD: from an organ- to a disease-oriented approach, Copd, 5, 73, 10.1080/15412550801940200

Rabe, 2007, Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary, Am J Respir Crit Care Med, 176, 532, 10.1164/rccm.200703-456SO

Gan, 2004, Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis, Thorax, 59, 574, 10.1136/thx.2003.019588

Sin, 2003, Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease, Circulation, 107, 1514, 10.1161/01.CIR.0000056767.69054.B3

Schols, 1999, Plasma leptin is related to proinflammatory status and dietary intake in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 160, 1220, 10.1164/ajrccm.160.4.9811033

Takabatake, 1999, Circulating leptin in patients with chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 159, 1215, 10.1164/ajrccm.159.4.9806134

Yang, 2006, The role of serum leptin and tumor necrosis factor-alpha in malnutrition of male chronic obstructive pulmonary disease patients, Chin Med J (Engl), 119, 628, 10.1097/00029330-200604020-00003

Breyer, 2012, Dysregulated adipokine metabolism in chronic obstructive pulmonary disease, Eur J Clin Invest, 42, 983, 10.1111/j.1365-2362.2012.02686.x

Celli, 2004, The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease, N Engl J Med, 350, 1005, 10.1056/NEJMoa021322

Gaki, 2011, Associations between BODE index and systemic inflammatory biomarkers in COPD, COPD, 8, 408, 10.3109/15412555.2011.619599

Hansel, 2009, Leptin receptor polymorphisms and lung function decline in COPD, Eur Respir J Off J Eur Soc Clin Respir Physiol, 34, 103, 10.1183/09031936.00120408

Ye, 2011, The polymorphism -2548G/A in leptin and severity of chronic obstructive pulmonary disease, Int J Immunogenet, 38, 45, 10.1111/j.1744-313X.2010.00968.x

Hoffstedt, 2002, A polymorphism in the leptin promoter region (-2548 G/A) influences gene expression and adipose tissue secretion of leptin, Horm Metab Res, 34, 355, 10.1055/s-2002-33466

Woo, 2010, Leptin up-regulates MUC5B expression in human airway epithelial cells via mitogen-activated protein kinase pathway, Exp Lung Res, 36, 262, 10.3109/01902140903427033

Vernooy, 2006, Leptin activates the JAK/STAT signaling pathway in bronchial and alveolar epithelial cells, Eur Respir J, 28, S338

Holgate, 2011, Pathophysiology of asthma: what has our current understanding taught us about new therapeutic approaches?, J Allergy Clin Immunol, 128, 495, 10.1016/j.jaci.2011.06.052

Ford, 2005, The epidemiology of obesity and asthma, J Allergy Clin Immunol, 115, 897, 10.1016/j.jaci.2004.11.050

Taylor, 2008, Body mass index and asthma severity in the National Asthma Survey, Thorax, 63, 14, 10.1136/thx.2007.082784

Camargo, 1999, Prospective study of body mass index, weight change, and risk of adult-onset asthma in women, Arch Intern Med, 159, 2582, 10.1001/archinte.159.21.2582

Castro-Rodriguez, 2001, Increased incidence of asthmalike symptoms in girls who become overweight or obese during the school years, Am J Respir Crit Care Med, 163, 1344, 10.1164/ajrccm.163.6.2006140

Ronmark, 2005, Obesity increases the risk of incident asthma among adults, Eur Respir J, 25, 282, 10.1183/09031936.05.00054304

Lavoie, 2006, Higher BMI is associated with worse asthma control and quality of life but not asthma severity, Respir Med, 100, 648, 10.1016/j.rmed.2005.08.001

Shore, 2008, Obesity and asthma: possible mechanisms, J Allergy Clin Immunol, 121, 1087, 10.1016/j.jaci.2008.03.004

Hallstrand, 2005, Genetic pleiotropy between asthma and obesity in a community-based sample of twins, J Allergy Clin Immunol, 116, 1235, 10.1016/j.jaci.2005.09.016

Sulit, 2005, Associations of obesity, sleep-disordered breathing, and wheezing in children, Am J Respir Crit Care Med, 171, 659, 10.1164/rccm.200403-398OC

Berg, 2005, Adipose tissue, inflammation, and cardiovascular disease, Circ Res, 96, 939, 10.1161/01.RES.0000163635.62927.34

Scherer, 2006, Adipose tissue: from lipid storage compartment to endocrine organ, Diabetes, 55, 1537, 10.2337/db06-0263

Shore, 2005, Effect of leptin on allergic airway responses in mice, J Allergy Clin Immunol, 115, 103, 10.1016/j.jaci.2004.10.007

Barnes, 2008, Immunology of asthma and chronic obstructive pulmonary disease, Nat Rev Immunol, 8, 183, 10.1038/nri2254

Shore, 2003, Responses to ozone are increased in obese mice, J Appl Physiol, 95, 938, 10.1152/japplphysiol.00336.2003

Williams, 2007, Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia, J Appl Physiol, 103, 1189, 10.1152/japplphysiol.00172.2007

Lu, 2006, Increased pulmonary responses to acute ozone exposure in obese db/db mice, Am J Physiol Lung Cell Mol Physiol, 290, L856, 10.1152/ajplung.00386.2005

Johnston, 2008, Diet-induced obesity causes innate airway hyperresponsiveness to methacholine and enhances ozone-induced pulmonary inflammation, J Appl Physiol, 104, 1727, 10.1152/japplphysiol.00075.2008

Sood, 2006, Association between leptin and asthma in adults, Thorax, 61, 300, 10.1136/thx.2004.031468

Jartti, 2009, Obesity, adipokines and asthma, Allergy, 64, 770, 10.1111/j.1398-9995.2008.01872.x

Jang, 2009, Association of serum leptin and adiponectin with obesity in asthmatics, J Asthma, 46, 59, 10.1080/02770900802444203

Lugogo, 2012, Alveolar macrophages from overweight/obese subjects with asthma demonstrate a proinflammatory phenotype, Am J Respir Crit Care Med, 186, 404, 10.1164/rccm.201109-1671OC

Lessard, 2011, Leptin and adiponectin in obese and non-obese subjects with asthma, Biomarkers, 16, 271, 10.3109/1354750X.2010.550013

Holguin, 2011, Airway and plasma leptin and adiponectin in lean and obese asthmatics and controls, J Asthma Off J Assoc Care Asthma, 48, 217, 10.3109/02770903.2011.555033

Conus, 2005, Leptin is an eosinophil survival factor, J Allergy Clin Immunol, 116, 1228, 10.1016/j.jaci.2005.09.003

Kato, 2011, Leptin has a priming effect on eotaxin-induced human eosinophil chemotaxis, Int Arch Allergy Immunol, 155, 335, 10.1159/000321195

Wong, 2007, Leptin-mediated cytokine release and migration of eosinophils: implications for immunopathophysiology of allergic inflammation, Eur J Immunol, 37, 2337, 10.1002/eji.200636866

Takeda, 2012, Obesity and eosinophilic inflammation: does leptin play a role, Int Arch Allergy Immunol, 158, 87, 10.1159/000337799

Lintomen, 2012, Allergen-induced bone marrow eosinophilopoiesis and airways eosinophilic inflammation in leptin-deficient ob/ob mice, Obesity (Silver Spring), 20, 1959, 10.1038/oby.2012.93

Schattner, 2003, Enteral nutritional support of the patient with cancer: route and role, J Clin Gastroenterol, 36, 297, 10.1097/00004836-200304000-00004

LaCroix, 1989, Prospective study of pneumonia hospitalizations and mortality of U.S. older people: the role of chronic conditions, health behaviors, and nutritional status, Public Health Rep, 104, 350

Baik, 2000, A prospective study of age and lifestyle factors in relation to community-acquired pneumonia in US men and women, Arch Intern Med, 160, 3082, 10.1001/archinte.160.20.3082

Van Kerkhove, 2011, Risk factors for severe outcomes following 2009 influenza A (H1N1) infection: a global pooled analysis, PLoS Med, 8, e1001053, 10.1371/journal.pmed.1001053

Kwong, 2011, Obesity and respiratory hospitalizations during influenza seasons in Ontario, Canada: a cohort study, Clin Infect Dis, 53, 413, 10.1093/cid/cir442

Mancuso, 2002, Leptin-deficient mice exhibit impaired host defense in Gram-negative pneumonia, J Immunol, 168, 4018, 10.4049/jimmunol.168.8.4018

Hsu, 2007, Leptin improves pulmonary bacterial clearance and survival in ob/ob mice during pneumococcal pneumonia, Clin Exp Immunol, 150, 332, 10.1111/j.1365-2249.2007.03491.x

Ordway, 2008, Animal model of Mycobacterium abscessus lung infection, J Leukoc Biol, 83, 1502, 10.1189/jlb.1007696

Cederholm, 2000, Impaired leukotriene C4 generation in granulocytes from protein-energy malnourished chronically ill elderly, J Intern Med, 247, 715, 10.1046/j.1365-2796.2000.00691.x

Jubiz, 1984, Decreased leukotriene B4 synthesis by polymorphonuclear leukocytes from male patients with diabetes mellitus, Prostaglandins Leukot Med, 14, 305, 10.1016/0262-1746(84)90114-8

Mancuso, 2006, Leptin corrects host defense defects after acute starvation in murine pneumococcal pneumonia, Am J Respir Crit Care Med, 173, 212, 10.1164/rccm.200506-909OC

Mancuso, 2011, Disruption of leptin receptor-STAT3 signaling enhances leukotriene production and pulmonary host defense against pneumococcal pneumonia, J Immunol, 186, 1081, 10.4049/jimmunol.1001470

Mancuso, 2012, Ablation of leptin receptor-mediated ERK activation impairs host defense against gram-negative pneumonia, J Immunol, 189, 867, 10.4049/jimmunol.1200465

Wieland, 2006, Leptin and host defense against gram-positive and gram-negative pneumonia in mice, Shock, 25, 414, 10.1097/01.shk.0000209524.12873.da

Wieland, 2005, Pulmonary Mycobacterium tuberculosis infection in leptin-deficient ob/ob mice, Int Immunol, 17, 1399, 10.1093/intimm/dxh317

Lemos, 2011, Expression of the leptin receptor outside of bone marrow-derived cells regulates tuberculosis control and lung macrophage MHC expression, J Immunol, 187, 3776, 10.4049/jimmunol.1003226

Easterbrook, 2011, Obese mice have increased morbidity and mortality compared to non-obese mice during infection with the 2009 pandemic H1N1 influenza virus, Influenza Other Respi Virus, 5, 418, 10.1111/j.1750-2659.2011.00254.x

Lin, 2000, Development of high fat diet-induced obesity and leptin resistance in C57Bl/6J mice, Int J Obes Relat Metab Disord, 24, 639, 10.1038/sj.ijo.0801209

Zhang, 2013, Leptin mediates the pathogenesis of severe influenza A(H1N1)pdm09 associated with cytokine dysregulation is preventable by anti-leptin antibody in diet-induced obese mice, J Infect Dis

Smith, 2009, Selective impairment in dendritic cell function and altered antigen-specific CD8+ T-cell responses in diet-induced obese mice infected with influenza virus, Immunology, 126, 268, 10.1111/j.1365-2567.2008.02895.x

Karlsson, 2010, Diet-induced obesity impairs the T cell memory response to influenza virus infection, J Immunol, 184, 3127, 10.4049/jimmunol.0903220