Pathophysiology of airflow limitation in chronic obstructive pulmonary disease

The Lancet - Tập 364 - Trang 709-721 - 2004
James C Hogg1
1James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia and St Paul's Hospital, Room 166–1081, Burrard Street, Vancouver, BC V6Z 1Y6, Canada

Tài liệu tham khảo

Pauwels, 2001, The GOLD Scientific Committee. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary, Am J Respir Crit Care Med, 163, 1256, 10.1164/ajrccm.163.5.2101039 2001 Hogg, 1968, Site and nature of airways obstruction in chronic obstructive lung disease, N Engl J Med, 278, 1355, 10.1056/NEJM196806202782501 Van Brabandt, 1983, Partitioning of pulmonary impedance in excised human and canine lungs, J Appl Physiol, 55, 1733, 10.1152/jappl.1983.55.6.1733 Yanai, 1992, Site of airway obstruction in pulmonary disease: direct measurement of intrabronchial pressure, J Appl Physiol, 72, 1016, 10.1152/jappl.1992.72.3.1016 Mead, 1967, Significance of the relationship between lung recoil and maximum expiratory flow, J Appl Physiol, 22, 95, 10.1152/jappl.1967.22.1.95 Otis, 1956, Mechanical factors in the distribution of pulmonary ventilation, J Appl Physiol, 8, 427, 10.1152/jappl.1956.8.4.427 Fletcher, 1976 Niewoehner, 1974, Pathologic changes in the peripheral airways of young cigarette smokers, N Engl J Med, 291, 755, 10.1056/NEJM197410102911503 Matsuba, 1972, The number and dimensions of small airways in emphysematous lungs, Am J Pathol, 67, 265 Cosio, 1978, The relations between structural changes in small airways and pulmonary function tests, N Engl J Med, 298, 1277, 10.1056/NEJM197806082982303 Ratemales, 2001, The amplification of inflammation in emphysema and its association with latent adenoviral infection, Am J Respir Crit Care Med, 164, 469, 10.1164/ajrccm.164.3.2007149 Maestrelli, 1995, Comparison of leukocyte counts in sputum, bronchial biopsies and bronchoalveolar lavage, Am J Respir Crit Care Med, 152, 1926, 10.1164/ajrccm.152.6.8520757 Thompson, 1989, Intraluminal airway inflammation in chronic bronchitis. Characterization and correlation with clinical parameters, Am Rev Respir Dis, 140, 1527, 10.1164/ajrccm/140.6.1527 Hunninghake, 1983, Cigarette smoking and lung destruction: accumulation of neutrophils in the lung, Am Rev Respir Dis, 128, 833 Keatings, 1996, Differences in interleukin-8 and tumour necrosis factor-alpha in induced sputum from patients with chronic obstructive pulmonary disease or asthma, Am J Respir Crit Care Med, 153, 530, 10.1164/ajrccm.153.2.8564092 Pride, 1995, Development of impaired lung function: natural history and risk factors, 69 Knowles, 2002, Mucus clearance as a primary innate defense mechanism for mammalian airways, J Clin Invest, 109, 571, 10.1172/JCI0215217 Green, 1977, Defense mechanisms of the respiratory membrane, Am Rev Respir Dis, 115, 479 Simani, 1974, Penetration of respiratory epithelium of guinea pigs following exposure to cigarette smoke, Lab Invest, 31, 75 Hulbert, 1981, Airway permeability to horseradish peroxidase in guinea pigs. The repair phase after injury by cigarette smoke, Am Rev Respir Dis, 123, 320 Jones, 1980, Increased alveolar epithelial permeability in cigarette smokers, Lancet, 1, 66, 10.1016/S0140-6736(80)90493-6 Abbas, 2000, Innate immunity, 270 Medzhitov, 2000, Innate immunity, N Engl J Med, 343, 338, 10.1056/NEJM200008033430506 Whitsett, 2001, Intrinsic and innate defenses in the lung, J Clin Invest, 109, 565, 10.1172/JCI200215209 LaVine, 2001, Pulmonary collectins and innate host defense of the lung, Microbes Infect, 3, 161, 10.1016/S1286-4579(00)01363-0 Bowman, 1999, Peptide antibiotics and their role in innate immunity, Annu Rev Immunol, 13, 61, 10.1146/annurev.iy.13.040195.000425 Abbas, 2000, Effector mechanisms of cellular immunity, 291 Huxley, 1978, Pharyngeal aspiration in normal adults and in patients with depressed consciousness, Am J Med, 64, 564, 10.1016/0002-9343(78)90574-0 Sethi, 2001, Bacterial infection in chronic obstructive pulmonary disease, Clin Microbiol Rev, 14, 336, 10.1128/CMR.14.2.336-363.2001 Medzhitov, 2000, Innate immune recognition: mechanisms and pathways, Immunol Rev, 173, 89, 10.1034/j.1600-065X.2000.917309.x Lamm, 1997, Interaction between antigens and antibodies on mucosal surfaces, Ann Rev Microbiol, 5, 311, 10.1146/annurev.micro.51.1.311 Neutra, 2001, Collaboration of epithelial cells with organized mucosal lymphoid tissues, Nat Immunol, 11, 1004, 10.1038/ni1101-1004 Liu, 2001, Dendritic cell subsets and lineages, and their function in innate and adaptive immunity, Cell, 106, 259, 10.1016/S0092-8674(01)00456-1 Holt, 2000, Regulation of immunologic homeostasis in peripheral tissues by dendritic cells: the respiratory tract as a paradigm, J Allergy Clin Immunol, 105, 421, 10.1067/mai.2000.105010 Stick, 2003, The airway epithelium as immune modulator: the LARC ascending, Am J Respir Cell Mol Biol, 28, 641, 10.1165/rcmb.F271 Kraal, 1997, High endothelial venules: lymphocyte traffic control and controlled traffic, Adv Immunol, 65, 347, 10.1016/S0065-2776(08)60746-4 Oxenius, 1998, CD4+ T-cell induction and effector functions: a comparison of immunity against soluble antigens and viral infections, Adv Immunol, 70, 313, 10.1016/S0065-2776(08)60390-9 Coffman, 1993, Mechanism and regulation of immunoglobulin isotype switching, Adv Immunol, 54, 229, 10.1016/S0065-2776(08)60536-2 Seder, 1994, Acquisition of a lymphokine producing phenotype by CD-4+T cells, Annu Rev Immunol, 12, 635, 10.1146/annurev.iy.12.040194.003223 Kim, 1990, Transforming growth factor beta 1 increases IgA isotype switching at the clonal level, J Immunol, 145, 3773, 10.4049/jimmunol.145.11.3773 Sonoda, 1992, Differential regulation of IgA production by TGF-beta and IL-5: TGF-beta induces surface IgA-positive cells bearing IL-5 receptor, whereas IL-5 promotes their survival and maturation into IgA-secreting cells, Cell Immunol, 140, 158, 10.1016/0008-8749(92)90184-Q Gorelik, 2002, Mechanism of transforming growth factor beta induced inhibition of T helper cell type 1differentiation, J Exp Med, 195, 1499, 10.1084/jem.20012076 Le, 1987, Tumor necrosis factor and interleukin 1: cytokines with multiple overlapping biological activities, Lab Invest, 56, 234 Sime, 1998, Transfer of tumor necrosis factor-alpha to rat lung induces severe pulmonary inflammation and patchy interstitial fibrogenesis with induction of transforming growth factor-beta1 and myofibroblasts, Am J Pathol, 153, 825, 10.1016/S0002-9440(10)65624-6 Kolb, 2001, Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis, J Clin Invest, 107, 1529, 10.1172/JCI12568 Gorelik, 2002, Flavell RA. Transforming growth factor-beta in T-cell biology, Nat Rev Immunol, 2, 46, 10.1038/nri704 Blobe, 2000, Role of transforming growth factor beta in human disease, N Engl J Med, 342, 1350, 10.1056/NEJM200005043421807 Becker, 2002, Differential particulate air pollution induced oxidant stress in human granulocytes, monocytes and alveolar macrophages, Toxicol In Vitro, 16, 209, 10.1016/S0887-2333(02)00015-2 Soukup, 2001, Human alveolar macrophages responses to air pollution particles are associated with insoluble components of coarse material including endotoxin, Toxicol Appl Pharmacol, 15, 20, 10.1006/taap.2000.9096 Gilmour, 2001, Adenoviral E1A primes alveolar epithelial cells to PM10-induced transcription of interleukin-8, Am J Physiol Lung Cell Mol Physiol, 281, L598, 10.1152/ajplung.2001.281.3.L598 Carter, 1997, Cytokine production by human airway epithelial cells after exposure to an air pollution particle is metal-dependent, Toxicol Appl Pharmacol, 146, 180, 10.1006/taap.1997.8254 Fujii, 2001, Particulate matter induces cytokine expression in human bronchial epithelial cells, Am J Respir Cell Mol Biol, 25, 265, 10.1165/ajrcmb.25.3.4445 Fujii, 2002, Interaction of alveolar macrophages and airway epithelial cells following exposure to particulate matter produces mediators that stimulate the bone marrow, Am J Respir Cell Mol Biol, 27, 34, 10.1165/ajrcmb.27.1.4787 Topham, 1998, Human endothelial cells regulate polymorphonuclear leukocyte degranulation, FASEB J, 12, 733, 10.1096/fasebj.12.9.733 Blanc, 1993, Cytokines in metal fume fever, Am Rev Resp Dis, 147, 134, 10.1164/ajrccm/147.1.134 Bazzano, 2003, Relationship between cigarette smoking and novel risk factors for cardiovascular disease in the United States, Ann Intern Med, 138, 891, 10.7326/0003-4819-138-11-200306030-00010 van Eeden, 2000, The response of human bone marrow to chronic cigarette smoking, Eur Respir J, 15, 915, 10.1034/j.1399-3003.2000.15e18.x Mullen, 1985, Reassessment of inflammation of airways in chronic bronchitis, BMJ, 291, 1235, 10.1136/bmj.291.6504.1235 Saetta, 1997, Inflammatory cells in the bronchial glands of smokers with chronic bronchitis, Am J Respir Crit Care Med, 156, 1633, 10.1164/ajrccm.156.5.9701081 Saetta, 1993, Activated T lymphocytes and macrophages in bronchial mucosa of subjects with chronic bronchitis, Am Rev Respir Dis, 147, 301, 10.1164/ajrccm/147.2.301 Lacoste, 1993, Eosinophilic and neutrophilic inflammation in asthma, chronic bronchitis, and chronic obstructive pulmonary disease, J Allerg Clin Immunol, 92, 537, 10.1016/0091-6749(93)90078-T Reid, 1960, Measurement of the bronchial mucous gland layer: a diagnostic yardstick in chronic bronchitis, Thorax, 15, 132, 10.1136/thx.15.2.132 Thurbeck, 1964, A distribution curve for chronic bronchitis, Thorax, 19, 436, 10.1136/thx.19.5.436 Dunnill, 1969, A comparison of the quantitative anatomy of the bronchi in normal subjects, in status asthmaticus, in chronic bronchitis, and in emphysema, Thorax, 24, 176, 10.1136/thx.24.2.176 Takizawa, 1971, Muscle and mucous gland size in the major bronchi of patients with chronic bronchitis, asthma, and asthmatic bronchitis, Am Rev Respir Dis, 104, 331, 10.1164/arrd.1971.104.3.331 Vignola, 1997, Transforming growth factor-beta expression in mucosal biopsies in asthma and chronic bronchitis, Am J Respir Crit Care Med, 156, 591, 10.1164/ajrccm.156.2.9609066 Brumfitt, 1957, An evaluation of sputum examination in chronic bronchitis, Lancet, 270, 1306, 10.1016/S0140-6736(57)91637-9 Medical Research Council, 1965, Definition and classification of chronic bronchitis for clinical and epidemiological purposes, Lancet, 285, 775, 10.1016/S0140-6736(65)92953-3 Peto, 1983, The relevance in adults of airflow obstruction, but not of mucous hypersecretion, to mortality from chronic lung disease, Am Rev Respir Dis, 128, 491, 10.1164/arrd.1983.128.3.491 Vestbo, 2002, Can GOLD Stage 0 provide information of prognostic value in chronic obstructive pulmonary disease?, Am J Respir Crit Care Med, 66, 329, 10.1164/rccm.2112048 Kanner, 2001, Lower respiratory illnesses promote FEV(1) decline in current smokers but not ex-smokers with mild chronic obstructive pulmonary disease: results from the lung health study, Am J Resp Crit Care Med, 164, 358, 10.1164/ajrccm.164.3.2010017 Weibel, 1963, 110 Mead, 1970, The lung's “quiet zone”, N Engl J Med, 282, 1318, 10.1056/NEJM197006042822311 Reid, 1955, Correlation of certain bronchographic abnormalities seen in chronic bronchitis with the pathological changes, Thorax, 10, 199, 10.1136/thx.10.3.199 Martin, 1970, The relationship of chronic bronchitis to the diffuse obstructive pulmonary syndrome, Am Rev Respir Dis, 102, 552 Thurlbeck, 1975, Goblet cells in the peripheral airways of chronic bronchitics, Am Rev Respir Dis, 12, 65 Ebert, 1975, The bronchiolar epithelium in cigarette smokers, Am Rev Respir Dis, 111, 4 Berend, 1979, Correlation between the function and structure of the lung in smokers, Am Rev Respir Dis, 119, 695 Petty, 1980, Small airway pathology is related to increased closing capacity and abnormal slope of phase III in excised human lungs, Am Rev Respir Dis, 121, 449, 10.1164/arrd.1980.121.3.449 Cosio, 1980, Morphologic and morphometric effects of prolonged cigarette smoking on the small airways, Am Rev Respir Dis, 122, 265 Salmon, 1982, Relationship of ventilation inhomogeneity to morphologic variables in excised human lungs, Am Rev Respir Dis, 126, 686 Petty, 1982, Small airway dimension and size distribution inhuman lungs with an increased closing capacity, Am Rev Respir Dis, 125, 525, 10.1164/arrd.1982.125.5.535 Berend, 1982, Correlation of maximum expiratory flow with small airway dimensions and pathology, J Appl Physiol, 52, 346, 10.1152/jappl.1982.52.2.346 Wright, 1984, The detection of small airways disease, Am Rev Respir Dis, 129, 989 Lumsden, 1984, Goblet and Clara cells of human distal airways: evidence for smoking induced changes in their numbers, Thorax, 39, 844, 10.1136/thx.39.11.844 Hale, 1984, Lung disease in long-term cigarette smokers with and without chronic air-flow obstruction, Am Rev Respir Dis, 130, 716 Matsuba, 1989, The changes in airway structure associated with reduced forced expiratory volume in one second, Eur Respir J, 2, 834, 10.1183/09031936.93.02090834 Bosken, 1990, Small airway dimensions in smokers with obstruction to airflow, Am Rev Respir Dis, 142, 563, 10.1164/ajrccm/142.3.563 Hogg, 2004, The nature of small airway obstruction in chronic obstructive pulmonary disease, N Engl J Med, 350, 2645, 10.1056/NEJMoa032158 Wiggs, 1990, A model of the mechanics of airway narrowing, J Appl Physiol, 69, 849, 10.1152/jappl.1990.69.3.849 Dayman, 1951, Mechanics of airflow in health and emphysema, J Clin Invest, 3031, 1175, 10.1172/JCI102537 Butler, 1960, Physiological factors affecting airway resistance in normal subjects and in patients with obstructive airways disease, J Clin Invest, 39, 584, 10.1172/JCI104071 Saetta, 1985, Loss of alveolar attachments in smokers. A morphometric correlate of lung function impairment, Am Rev Respir Dis, 132, 894 O'Shaughnessy, 1997, Inflammation in bronchial biopsies of subjects with chronic bronchitis: inverse relationship of CD8+ T lymphocytes with FEV1, Am J Respir Crit Care Med, 155, 852, 10.1164/ajrccm.155.3.9117016 Di Stefano, 1996, Airflow limitation in chronic bronchitis is associated with T-lymphocyte and macrophage infiltration in the bronchial mucosa, Am J Respir Crit Care Med, 153, 629, 10.1164/ajrccm.153.2.8564109 Kemeny, 1999, CD8+ T cell subsets and chronic obstructive pulmonary disease, Am J Respir Crit Care Med, 160, S33, 10.1164/ajrccm.160.supplement_1.10 Bosken, 1992, Characterization of the inflammatory reaction in the peripheral airways of cigarette smokers, Am Rev Respir Dis, 145, 911, 10.1164/ajrccm/145.4_Pt_1.911 Richmond, 1993, Bronchial associated lymphoid tissue (BALT) in human lung: its distribution in smokers and non smokers, Thorax, 48, 1130, 10.1136/thx.48.11.1130 Laennec, 1834 Ciba guest symposium report, 1959, terminology, definitions and classifications of chronic pulmonary emphysema and related conditions, Thorax, 14, 286, 10.1136/thx.14.4.286 Snider, 1985, Definition of emphysema. Report of a National Heart, Lung and Blood Institute, Division of Lung Diseases, workshop, Am Rev Respir Dis, 132, 182 McLean, 1956, Microscopic anatomy of pulmonary emphysema, Aust Ann Intern Med, 5, 73 Leopold, 1957, Centrilobular form of hypertrophic emphysema and its relation to chronic bronchitis, Thorax, 12, 219, 10.1136/thx.12.3.219 Wyatt, 1962, Panlobular emphysema: anatomy and pathogenesis, Dis Chest, 41, 239, 10.1378/chest.41.3.239 Heard, 1958, Further observations on the pathology of pulmonary emphysema in chronic bronchitis, Thorax, 14, 58, 10.1136/thx.14.1.58 Thurlbeck, 1963, The incidence of pulmonary emphysema with observations on the relative incidence and spatial distribution of various types of emphysema, Am Rev Respir Dis, 87, 207 Heppleston, 1961, Chronic pulmonary emphysema: anatomy and pathogenesis, Am J Med, 31, 279, 10.1016/0002-9343(61)90116-4 Dunnill, 1982, Chapter 6: Emphysema, 81 Kim, 1991, Centrilobular and panlobular emphysema in smokers. Two distinct morphologic and functional entities, Am Rev Respir Dis, 144, 1385, 10.1164/ajrccm/144.6.1385 Hogg, 1994, Lung structure and function in cigarette smokers, Thorax, 49, 473, 10.1136/thx.49.5.473 Hogg, 1987, Neutrophil kinetics and lung injury, Physiol Rev, 67, 1249, 10.1152/physrev.1987.67.4.1249 MacNee, 1989, The effect of cigarette smoking on neutrophil kinetics in human lungs, N Engl J Med, 321, 924, 10.1056/NEJM198910053211402 Klut, 1993, Activation of neutrophils within pulmonary microvessels of rabbits exposed to cigarette smoke, Am J Respir Cell Mol Biol, 9, 82, 10.1165/ajrcmb/9.1.82 Markos, 1990, Effect of raised alveolar pressure on leukocyte retention in the human lung, J Appl Physiol, 69, 214, 10.1152/jappl.1990.69.1.214 Kitagawa, 1997, Effect of mechanical deformation on structure and function of polymorphonuclear leukocytes, J Appl Physiol, 82, 1397, 10.1152/jappl.1997.82.5.1397 Terashima, 1999, Cigarette smoking causes sequestration of polymorphonuclear leukocytes released from the bone marrow in lung microvessels, Am J Respir Cell Mol Biol, 20, 171, 10.1165/ajrcmb.20.1.3276 Doerschuk, 1994, Quantification of neutrophil migration in acute bacterial pneumonia in rabbits, J Appl Physiol, 77, 2593, 10.1152/jappl.1994.77.6.2593 Doerschuk, 2001, Mechanisms of leukocyte sequestration in inflamed lungs, Microcirculation, 8, 71, 10.1038/sj.mn.7300151 Burns, 2003, Unique structural features that influence neutrophil emigration into the lung, Physiol Rev, 83, 309, 10.1152/physrev.00023.2002 Behzad, 1996, Fibroblasts are in a position to provide directional information to migrating neutrophils during pneumonia in rabbit lungs, Microvas Res, 51, 303, 10.1006/mvre.1996.0029 Sirianni, 2003, Human alveolar wall fibroblasts directly link epithelial type 2 cells to capillary endothelium, Am J Respir Crit Care Med, 168, 1532, 10.1164/rccm.200303-371OC Hogg, 2002, Chronic obstructive pulmonary disease—part 2: pathology and biochemistry of emphysema, Thorax, 57, 830, 10.1136/thorax.57.9.830 Hayhurst, 1984, Diagnosis of pulmonary emphysema by computerised tomography, Lancet, 324, 320, 10.1016/S0140-6736(84)92689-8 Muller, 1988, Density mask. An objective method to quantitate emphysema using computed tomography, Chest, 94, 782, 10.1378/chest.94.4.782 Gevenois, 1995, Comparison of computed density and macroscopic morphometry in pulmonary emphysema, Am J Respir Crit Care Med, 152, 653, 10.1164/ajrccm.152.2.7633722 Coxson, 1999, A quantification of the lung surface area in emphysema using computed tomography, J Respir Crit Care Med, 159, 851, 10.1164/ajrccm.159.3.9805067 Stolk, 2001, Repeatability of lung density measurements with low-dose computed tomography in subjects with alpha-1-antitrypsin deficiency-associated emphysema, Invest Radiol, 36, 648, 10.1097/00004424-200111000-00004 Dirksen, 1999, A randomized clinical trial of alpha(1)-antitrypsin augmentation therapy, Am J Respir Crit Care Med, 160, 1468, 10.1164/ajrccm.160.5.9901055 Nakano, 2000, Computed tomographic measurements of airway dimensions and emphysema in smokers. Correlation with lung function, Am J Respir Crit Care Med, 162, 1102, 10.1164/ajrccm.162.3.9907120 Ohno, 2001, Oxygen-enhanced MR ventilation imaging of the lung: preliminary clinical experience in 25 subjects. AJR, Am J Roentgenol, 177, 185, 10.2214/ajr.177.1.1770185 Ohno, 2003, Clinical oxygen-enhanced magnetic resonance imaging of the lung, Top Magn Reson Imaging, 14, 237, 10.1097/00002142-200306000-00004 Mai, 2001, MR ventilation-perfusion imaging of human lung using oxygen-enhanced and arterial spin labeling techniques, J Magn Reson Imaging, 14, 574, 10.1002/jmri.1221 Kauczor, 2001, Pulmonary ventilation imaged by magnetic resonance: at the doorstep of clinical application, Eur Respir J, 17, 1008, 10.1183/09031936.01.17510080 Guenther, 2000, Functional MR imaging of pulmonary ventilation using hyperpolarized noble gases, Acta Radiol, 41, 519, 10.1080/028418500127346009