Identification and expression cloning of a leptin receptor, OB-R

Bray, 1979, Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis, Physiol. Rev., 59, 719, 10.1152/physrev.1979.59.3.719 Campfield, 1995, Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks, Science, 269, 546, 10.1126/science.7624778 Cheng, 1994, Identification and cloning of ELF-1, a developmentally expressed ligand for the Mek4 and Sek receptor tyrosine kinases, Cell, 79, 157, 10.1016/0092-8674(94)90408-1 Cheng, 1995, Complementary gradients in expression and binding of ELF-1 and Mek4 in development of the topographic retinotectal projection map, Cell, 82, 371, 10.1016/0092-8674(95)90426-3 Chirgwin, 1979, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry, 18, 5294, 10.1021/bi00591a005 Coleman, 1973, Effects of parabiosis of obese with diabetes and normal mice, Diabetologia, 9, 294, 10.1007/BF01221857 Coleman, 1978, Obese and diabetes: two mutantgenes causing diabetes-obesity syndromes in mice, Diabetologia, 14, 141, 10.1007/BF00429772 Considine, 1995, Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity, J. Clin. Invest., 95, 2986, 10.1172/JCI118007 Copeland, 1993, Genome maps IV, Science, 262, 67, 10.1126/science.8211131 Debons, 1977, Gold thioglucose obesity syndrome, 36, 143 Dietrich, 1994, A genetic map of the mouse with 4,006 simple sequence length polymophisms, Nature Genet., 7, 220, 10.1038/ng0694supp-220 Flanagan, 1990, The kit ligand: a cell surface molecule altered in Steel mutant fibroblasts, Cell, 63, 185, 10.1016/0092-8674(90)90299-T Fukunaga, 1990, LIF receptor and IL-6 signal transducer, Cell, 61, 341, 10.1016/0092-8674(90)90814-U Fukunaga, 1990, Three different mRNAs encoding human granulocyte colony-stimulating factor receptor, 87, 8702 Fukunaga, 1991, Functional domains of the granulocyte colony-stimulating factor receptor, EMBO J., 10, 2855, 10.1002/j.1460-2075.1991.tb07835.x Gearing, 1991, Leukemia inhibitory factor receptor is structurally related to the IL-6 signal transducer, gp130, EMBO J., 10, 2839, 10.1002/j.1460-2075.1991.tb07833.x Gough, 1988, Molecular cloning and expression of the human homologue of the murine gene encoding myeloid leukemia-inhibitory factor, 85, 2623 Gubler, 1983, A simple and very efficient method for generating cDNA libraries, Gene, 25, 263, 10.1016/0378-1119(83)90230-5 Halaas, 1995, Weight reducing effects of the plasma protein encoded by the obese gene, Science, 269, 543, 10.1126/science.7624777 Hamilton, 1995, Increased obese mRNA expression in omental fat cells from massively obese humans, Nature Med., 1, 953, 10.1038/nm0995-953 Heldin, 1995, Dimerization of cell surface receptors in signal transduction, Cell, 80, 213, 10.1016/0092-8674(95)90404-2 Hummel, 1966, Diabetes, a new mutation in the mouse, Science, 153, 1127, 10.1126/science.153.3740.1127 International Polycystic Kidney Disease Consortium, 1995, Polycystic kidney disease: the complete structure of the PKD1 gene and its protein, Cell, 81, 289, 10.1016/0092-8674(95)90339-9 Kishimoto, 1994, Cytokine signal transduction, Cell, 76, 253, 10.1016/0092-8674(94)90333-6 Larsen, 1990, Expression cloning of a granulocyte colony stimulating factor receptor: a structural mosaicof hematopoietan receptor, immunoglobulin and fibronectin domains, J. Exp. Med., 172, 1559, 10.1084/jem.172.6.1559 Lonnqvist, 1995, Overexpression of the obese (ob) gene in adipose tissue of human obese subjects, Nature Med., 1, 950, 10.1038/nm0995-950 Maffei, 1995, Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight reduced subjects, Nature Med., 1, 1155, 10.1038/nm1195-1155 Narazaki, 1994, Activation of JAK2 kinase mediated by the interleukin 6 signal transducer gp130, 91, 2285 Pelleymounter, 1995, Effects of the obese gene product on body regulation in obob mice, Science, 269, 540, 10.1126/science.7624776 Saito, 1992, Molecular cloning of a murine IL-6 receptor-associated signal transducer, gp130, and its regulated expression in vivo, J. Immunol., 148, 4066, 10.4049/jimmunol.148.12.4066 Schwartz, 1992, Insulin in the brain: a hormonal regulator of energy balance, Endocrinol. Rev., 13, 387 Spector, 1989, The mammalian choroid plexus, Sci. Am., 261, 68, 10.1038/scientificamerican1189-68 Stephens, 1995, The role of neuropeptide Y in the antiobesity action of the obese gene product, Nature, 377, 530, 10.1038/377530a0 Taga, 1989, Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130, Cell, 58, 573, 10.1016/0092-8674(89)90438-8 Takebe, 1988, SRα promoter: an efficient and versatile mammalian cDNA expression system composed of the simian virus 40 early promoter and the R-U5 segment of human T-cell leukemia virus type 1 long terminal repeat, Mol. Cell Biol., 8, 466, 10.1128/MCB.8.1.466 Zhang, 1994, Positional cloning of the mouse obese gene and its human homologue, Nature, 372, 425, 10.1038/372425a0