Regulatory T Cells in Allergy and Asthma

Kay, 2001, Allergy and allergic diseases: first of two parts, N Engl J Med, 344, 30, 10.1056/NEJM200101043440106 Kay, 2001, Allergy and allergic diseases: second of two parts, N Engl J Med, 344, 109, 10.1056/NEJM200101113440206 Floistrup, 2006, Allergic disease and sensitization in Steiner school children, J Allergy Clin Immunol, 117, 59, 10.1016/j.jaci.2005.09.039 Bach, 2002, The effect of infections on susceptibility to autoimmune and allergic diseases, N Engl J Med, 347, 911, 10.1056/NEJMra020100 Strachan, 1989, Hay fever, hygiene, and household size, BMJ, 299, 1259, 10.1136/bmj.299.6710.1259 Mudde, 1990, IgE: an immunoglobulin specialized in antigen capture?, Immunol Today, 11, 440, 10.1016/0167-5699(90)90172-6 Kay, 2001, Allergy and allergic diseases: first of two parts, N Engl J Med, 344, 30, 10.1056/NEJM200101043440106 Leckie, 2000, Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness, and the late asthmatic response, Lancet, 356, 2144, 10.1016/S0140-6736(00)03496-6 Kips, 2003, Effect of SCH55700, a humanized anti-human interleukin-5 antibody, in severe persistent asthma: a pilot study, Am J Respir Crit Care Med, 167, 1655, 10.1164/rccm.200206-525OC Ali, 2004, Late asthmatic reactions induced by inhalation of allergen-derived T cell peptides, Am J Respir Crit Care Med, 169, 20, 10.1164/rccm.200305-690OC Haselden, 1999, Immunoglobulin E-independent major histocompatibility complex-restricted T cell peptide epitope-induced late asthmatic reactions, J Exp Med, 189, 1885, 10.1084/jem.189.12.1885 Robinson, 1993, Activation of CD4+ T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma, J Allergy Clin Immunol, 92, 313, 10.1016/0091-6749(93)90175-F Wierenga, 1990, Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients, J Immunol, 144, 4651, 10.4049/jimmunol.144.12.4651 Akdis, 2004, Immune responses in healthy and allergic individuals are characterized by a fine balance between allergen-specific T regulatory 1 and T helper 2 cells, J Exp Med, 199, 1567, 10.1084/jem.20032058 Tiemessen, 2004, Cow's milk-specific T-cell reactivity of children with and without persistent cow's milk allergy: key role for IL-10, J Allergy Clin Immunol, 113, 932, 10.1016/j.jaci.2003.12.016 Akdis, 1999, IL-10-induced anergy in peripheral T cell and reactivation by microenvironmental cytokines: two key steps in specific immunotherapy, FASEB J, 13, 603, 10.1096/fasebj.13.6.603 Platts-Mills, 2001, Sensitisation, asthma, and a modified Th2 response in children exposed to cat allergen: a population-based cross-sectional study, Lancet, 357, 752, 10.1016/S0140-6736(00)04168-4 Larche, 2006, Immunological mechanisms of allergen-specific immunotherapy, Nat Rev Immunol, 6, 761, 10.1038/nri1934 Weiner, 2001, Induction and mechanism of action of transforming growth factor-β-secreting Th3 regulatory cells, Immunol Rev, 182, 207, 10.1034/j.1600-065X.2001.1820117.x Kitani, 2003, Transforming growth factor (TGF)-β1-producing regulatory T cells induce Smad-mediated interleukin 10 secretion that facilitates coordinated immunoregulatory activity and amelioration of TGF-β1-mediated fibrosis, J Exp Med, 198, 1179, 10.1084/jem.20030917 Barrat, 2002, In vitrogeneration of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines, J Exp Med, 195, 603, 10.1084/jem.20011629 Karagiannidis, 2004, Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma, J Allergy Clin Immunol, 114, 1425, 10.1016/j.jaci.2004.07.014 Dao, 2004, Fluticasone propionate increases CD4CD25 T regulatory cell suppression of allergen-stimulated CD4CD25 T cells by an IL-10-dependent mechanism, J Allergy Clin Immunol, 114, 296, 10.1016/j.jaci.2004.04.048 Hawrylowicz, 2005, Potential role of interleukin-10-secreting regulatory T cells in allergy and asthma, Nat Rev Immunol, 5, 271, 10.1038/nri1589 Umetsu, 2006, The regulation of allergy and asthma, Immunol Rev, 212, 238, 10.1111/j.0105-2896.2006.00413.x McMenamin, 1994, Regulation of IgE responses to inhaled antigen in mice by antigen-specific γ δ T cells, Science, 265, 1869, 10.1126/science.7916481 Shevach, 2002, CD4+ CD25+ suppressor T cells: more questions than answers, Nat Rev Immunol, 2, 389, 10.1038/nri821 Khattri, 2003, An essential role for Scurfin in CD4+CD25+ T regulatory cells, Nat Immunol, 4, 337, 10.1038/ni909 Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490 Wildin, 2002, Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome, J Med Genet, 39, 537, 10.1136/jmg.39.8.537 Vieira, 2004, IL-10-secreting regulatory T cells do not express Foxp3 but have comparable regulatory function to naturally occurring CD4+CD25+ regulatory T cells, J Immunol, 172, 5986, 10.4049/jimmunol.172.10.5986 Apostolou, 2004, In vivoinstruction of suppressor commitment in naive T cells, J Exp Med, 199, 1401, 10.1084/jem.20040249 Watanabe, 2005, Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus, Nature, 436, 1181, 10.1038/nature03886 Watanabe, 2005, Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus, Nature, 436, 1181, 10.1038/nature03886 Soumelis, 2002, Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP, Nat Immunol, 3, 673, 10.1038/ni805 Verhagen, 2006, Absence of T-regulatory cell expression and function in atopic dermatitis skin, J Allergy Clin Immunol, 117, 176, 10.1016/j.jaci.2005.10.040 Ou, 2004, T regulatory cells in atopic dermatitis and subversion of their activity by superantigens, J Allergy Clin Immunol, 113, 756, 10.1016/j.jaci.2004.01.772 Ling, 2004, Relation of CD4+CD25+ regulatory T-cell suppression of allergen-driven T-cell activation to atopic status and expression of allergic disease, Lancet, 363, 608, 10.1016/S0140-6736(04)15592-X Grindebacke, 2004, Defective suppression of Th2 cytokines by CD4CD25 regulatory T cells in birch allergics during birch pollen season, Clin Exp Allergy, 34, 1364, 10.1111/j.1365-2222.2004.02067.x Cosmi, 2004, Th2 cells are less susceptible than Th1 cells to the suppressive activity of CD25+ regulatory thymocytes because of their responsiveness to different cytokines, Blood, 103, 3117, 10.1182/blood-2003-09-3302 Bellinghausen, 2003, Human CD4+CD25+ T cells derived from the majority of atopic donors are able to suppress TH1 and TH2 cytokine production, J Allergy Clin Immunol, 111, 862, 10.1067/mai.2003.1412 Bellinghausen, 2005, Regulatory activity of human CD4 CD25 T cells depends on allergen concentration, type of allergen and atopy status of the donor, Immunology, 116, 103, 10.1111/j.1365-2567.2005.02205.x Matsumoto, 2004, Decrease of interleukin-10-producing T cells in the peripheral blood of severe unstable atopic asthmatics, Int Arch Allergy Immunol, 134, 295, 10.1159/000079167 Kunitomi, 2004, Humanized anti-interleukin 6 receptor antibody induced long-term remission in a patient with life-threatening refractory autoimmune hemolytic anemia, Int J Hematol, 80, 246, 10.1532/IJH97.04058