Infected chronic ischemic wound topically treated with a multi-strain probiotic formulation: a novel tailored treatment strategy

Journal of Translational Medicine - Tập 17 - Trang 1-9 - 2019
Salvatore Venosi1, Giancarlo Ceccarelli2, Massimiliano de Angelis2, Luca Laghi3, Laura Bianchi4, Ombretta Martinelli1, Debora Maruca1, Eugenio Nelson Cavallari2, Fabrizia Toscanella5, Paolo Vassalini2, Vito Trinchieri2, Alessandra Oliva2, Gabriella d’Ettorre2
1Department of Cardio-Thoraco-Vascular, Surgery and Transplants, University of Rome Sapienza, Rome, Italy
2Department of Public Health and Infectious Diseases, University of Rome Sapienza, Rome, Italy
3Department of Agri-Food Science and Technology, University of Bologna, Bologna, Italy
4Functional Proteomic Laboratory, Department of Life Sciences, University of Siena, Siena, Italy
5Diabetic Foot Center, Istituto Nazionale Ricovero e Cura Anziani (INRCA), Ancona, Italy

Tóm tắt

A wide debate is ongoing regarding the role of cutaneous dysbiosis in the pathogenesis and evolution of difficult-to-treat chronic wounds. Nowadays, probiotic treatment considered as an useful tool to counteract dysbiosis but the evidence in regard to their therapeutic use in the setting of difficult-to-treat cutaneous ulcers is still poor. An 83-year-old woman suffering a critical limb ischemia and an infected difficult-to-treat ulcerated cutaneous lesion of the right leg, was complementary treated with local application of a mixture of probiotic bacteria. Microbiological and metabolomic analysis were conducted on wound swabs obtained before and after bacteriotherapy. During the treatment course, a progressive healing of the lesion was observed with microbiological resolution of the polymicrobial infection of the wound. Metabolomic analysis showed a significant difference in the local concentration of propionate, 2-hydroxyisovalerate, 2-oxoisocaproate, 2,3-butanediol, putrescine, thymine, and trimethylamine before and after bacteriotherapy. The microbiological and metabolomic results seem to confirm the usefulness of complementary probiotic treatment in difficult-to-treat infected wounds. Further investigations are needed to confirm these preliminary findings.

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Journal of Translational Medicine

Tập 17

1-9

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