Efficacy of plasma ß-hydroxybutyrate concentration as a marker for diabetes mellitus in acutely sick cats

Journal of Feline Medicine and Surgery - Tập 12 - Trang 300-305 - 2010
Florian Zeugswetter1, Stephanie Handl2, Christine Iben2, Ilse Schwendenwein3
1Clinic for Small Animals and Infectious Diseases, Department for Companion Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz, 1210 Vienna, Austria
2Institute of Nutrition, Department for Farm Animals and Veterinary Public Health, University of Veterinary Medicine Vienna, Veterinaerplatz, 1210 Vienna, Austria
3Central Laboratory, Department of Pathobiology, University of Veterinary Medicine Vienna, Veterinaerplatz, 1210 Vienna, Austria

Tóm tắt

Urine ketone measurement is routinely performed in cats with diabetes mellitus to identify impending or established ketoacidosis. Studies using the urinary ketone dipstick test have shown that ketonuria is common in cats with newly diagnosed untreated diabetes mellitus. This test has a low sensitivity as it quantifies the less abundant ketone acetoacetate. The objective of the present study was to determine if ketonaemia is an inherent biochemical finding in untreated feline diabetes mellitus by measuring plasma ß-hydroxybutyrate (ß-OHB) in acutely sick cats. In 122 sick cats (37 diabetic and 85 non-diabetic cats) plasma ß-OHB, glucose, fructosamine, total protein and thyroxine were measured as part of the routine work up. Diabetic cats had significantly elevated ß-OHB values and ß-OHB measurement was a sensitive and specific test to identify diabetes mellitus. The area under the receiver operating characteristic (ROC) curve was 0.93. The cut off value with the highest positive likelihood ratio was 0.58 mmol/l. These results suggest that determination of plasma ß-OHB concentration is a useful method to distinguish between diabetic and non-diabetic sick cats.

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Thông tin
Thông tin xuất bản

Journal of Feline Medicine and Surgery

Tập 12

300-305

Thông tin tác giả