Ketone measurements using dipstick methodology in cats with diabetes mellitus

Journal of Small Animal Practice - Tập 50 Số 1 - Trang 4-8 - 2009
Florian K. Zeugswetter1, Maximilian Pagitz2
1Clinical Department of Small Animals and Horses, University of Veterinary Medicine, Veterinärplatz 1, A-1210 Vienna.
2Clinical Department of Small Animals and Horses, University of Veterinary Medicine, Veterinärplatz 1, A-1210Vienna

Tóm tắt

Objectives: To compare the results of urine and plasma ketone dip test in a group of diabetic cats with possible ketosis or ketoacidosis, using laboratory plasma β‐hydroxybutyrate measurements as the gold standard. Methods: According to clinical examinations, plasma β‐hydroxybutyrate measurements and venous blood gas analysis, 54 cats with diabetes mellitus were classified as non‐ketotic (n=3), ketotic (n=40) or ketoacidotic (n=11). Plasma and urine acetoacetate concentrations were determined using urine reagent strips. Results: Although there was a significant positive correlation between blood and urine ketone measurements (r=0·695, P<0·001), the results differed significantly (Z=−3·494, P<0·001). Using the differential positive rates, the best cut‐off value to detect cats with ketoacidosis was 1·5 mmol/l for urine and 4 mmol/l for plasma. The sensitivity/specificity was 82/95 per cent for urine and 100/88 per cent for plasma, respectively. Clinical Significance: The urine and plasma ketone dip tests have a different diagnostic accuracy, and results have to be interpreted differently. Because of its high sensitivity, the plasma ketone dip test performs better than the urine ketone dip test to identify cats with impending or established ketoacidosis.

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Journal of Small Animal Practice

Tập 50 Số 1

4-8

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