A Comprehensive Study of Easter Lily Poisoning in Cats

Journal of Veterinary Diagnostic Investigation - Tập 16 Số 6 - Trang 527-541 - 2004
Wilson K. Rumbeiha1, Jayaraj A. Francis2, Scott D. Fitzgerald3, Muraleedharan G. Nair2, Kate Holan4, Kwasi Agyei Bugyei3, Heather A. Simmons3
1Diagnostic Center for Population and Animal Health and Department of Pathobiology and Diagnostic Investigation, College of Veterinary Medicine, Lansing, Michigan 48910-8104, USA.
2Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI, 48824–1314.
3Diagnostic Center for Population and Animal Health (DCPAH) and Department of Pathobiology and Diagnostic Investigation (PDI), College of Veterinary Medicine
4Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, MI, 48824–1314.

Tóm tắt

This study was conducted with 3 objectives in mind: first, to identify the toxic fraction (aqueous or organic) in leaves and flowers; second, to identify diagnostic marker(s) of toxicosis in cats; and, third, to evaluate the morphologic effects of intoxication. The study was conducted in 2 phases. Phase 1 was to identify which extract, organic or aqueous, was nephrotoxic and also to determine the appropriate dose for use in the phase 2 studies. Results indicated that only the aqueous extracts of leaves and flowers were nephrotoxic and pancreotoxic. To identify the proximate toxic compound, cats in the phase 2 study were orally exposed to subfractions of the aqueous flower extract, 1 subfraction per cat. Results confirmed vomiting, depression, polyuria, polydipsia, azotemia, glucosuria, proteinuria, and isosthenuria as toxic effects of the Easter lily plant. Another significant finding in serum was elevated creatinine kinase. Significant histologic kidney changes included acute necrosis of proximal convoluted tubules and degeneration of pancreatic acinar cells. Renal ultrastructural changes included swollen mitochondria, megamitochondria, edema, and lipidosis. Subfraction IIa3 of the aqueous floral extract contained most of the toxic compound(s). These studies reproduced the clinical disease, identified the most toxic fraction of the Easter lily, and helped characterize the clinical pathology, histopathology, and ultrastructural pathology associated with the disease.

Từ khóa


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Thông tin
Thông tin xuất bản

Journal of Veterinary Diagnostic Investigation

Tập 16 Số 6

527-541

Thông tin tác giả