Design, synthesis, and biological evaluation of novel somatostatin receptor subtype-2 agonists: Optimization for potency and risk mitigation of hERG and phospholipidosis

Bioorganic & Medicinal Chemistry - Tập 49 - Trang 116424 - 2021
Akiharu Ishida1, Yasuyuki Okabe1, Takeshi Matsushita1, Tetsuya Sekiguchi1, Takuya Nishio2, Tatsuya Komagata2, Masanori Iwaki2, Hidenori Miyata3, Jun Katagi3, Atsushi Naganawa1, Toru Maruyama1, Akira Imagawa1
1Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan
2Discovery Research Laboratories, Ono Pharmaceutical Co., Ltd., 3-1-1 Sakurai Shimamoto-cho Mishima-gun, Osaka 618-8585, Japan
3Safety Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan

Tài liệu tham khảo

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