Discovery and SAR Studies of Orally Active Somatostatin Receptor Subtype-2 (SSTR2) Agonists for the Treatment of Acromegaly

ACS Chemical Neuroscience - Tập 11 Số 10 - Trang 1482-1494 - 2020
Akiharu Ishida1, Yohei Tajima1, Yasuyuki Okabe1, Takeshi Matsushita1, Tetsuya Sekiguchi1, Satomi Imaide1, Yoshinori Nomura1, Motoyuki Tanaka1, Shoji Nojima1, Atsushi Yoshida1, Yoko Iyoda1, Shohei Aoki1, Takuya Nishio2, Tatsuya Komagata2, Masanori Iwaki2, Tomoyuki Shono3, Atsushi Naganawa1, Akira Imagawa1
1Medicinal Chemistry Research Laboratories, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto, Mishima-gun, Osaka 618-8585, Japan
2Department of Biology & Pharmacology, Ono Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka 618-8585, Japan
3Pharmacokinetic Research Laboratories, ONO Pharmaceutical Co., Ltd, 3-1-1 Sakurai, Shimamoto-cho, Mishima-gun, Osaka, 618-8585, Japan

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