In Silico Assay for Assessing Phospholipidosis Potential of Small Druglike Molecules: Training, Validation, and Refinement Using Several Data Sets

Journal of Medicinal Chemistry - Tập 55 Số 1 - Trang 126-139 - 2012
Holger Fischer1, Elke-Astrid Atzpodien1, M. Csató1, Lucette Doessegger1, Barbara Lenz1, Georg Schmitt1, Thomas P. Singer1
1Clinical Safety/Licensing and Early Development, ‡Toxicology and Pathology, §Early and Investigative Safety, Non-Clinical Safety, and ∥Non-Clinical Safety, F. Hoffmann-La Roche Ltd., CH-4070 Basel, Switzerland

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