Châm cứu và trị liệu chỉnh hình cho cơn đau mãn tính trong một kế hoạch y tế tích hợp: một nghiên cứu phương pháp hỗn hợp

BMC Complementary and Alternative Medicine - Tập 11 - Trang 1-18 - 2011
Lynn L DeBar1, Charles Elder1, Cheryl Ritenbaugh2, Mikel Aickin2, Rick Deyo3, Richard Meenan1, John Dickerson1, Jennifer A Webster1, Bobbi Jo Yarborough1
1Kaiser Permanente, The Center for Health Research, Portland, USA
2Department of Family & Community Medicine, University of Arizona, Tucson, USA
3Department of Family Medicine, Oregon Health and Science University, Portland, USA

Tóm tắt

Nghiên cứu gần đây đã xem xét hiệu quả của nhiều loại liệu pháp bổ trợ và thay thế (CAM). Tuy nhiên, những kết quả liên quan đến việc sử dụng CAM trong thực tế "thế giới thật" đã bị bỏ qua, mặc dù có những lời kêu gọi cần nghiên cứu các liệu pháp CAM theo cách mà chúng được thực hiện. Người Mỹ tìm kiếm các liệu pháp CAM thường xuyên hơn cho cơn đau cơ xương khớp mãn tính (CMP) so với bất kỳ tình trạng nào khác. Trong số các liệu pháp CAM cho CMP, chăm sóc châm cứu và chỉnh hình (A/C) là một trong những liệu pháp được chấp nhận cao nhất bởi các nhóm bác sĩ và có chứng cứ tốt nhất để hỗ trợ việc sử dụng của chúng. Hơn nữa, những gia tăng đáng lo ngại gần đây trong việc cung cấp điều trị opioid và can thiệp phẫu thuật cho cơn đau mãn tính - bất chấp chi phí cao, tác dụng phụ tiềm tàng và hiệu quả khiêm tốn - cho thấy nhu cầu đánh giá kết quả thực tế liên quan đến các liệu pháp CAM không dược lý/không phẫu thuật đầy triển vọng cho CMP, những liệu pháp này thường được bệnh nhân chấp nhận tốt và ngày càng được sử dụng trong cộng đồng. Nghiên cứu đa giai đoạn, phương pháp hỗn hợp này sẽ: (1) thực hiện một nghiên cứu hồi cứu sử dụng thông tin từ hồ sơ y tế điện tử (EMR) của một HMO lớn để xác định những cụm bệnh nhân duy nhất có CMP (ví dụ, những người có nhân khẩu học khác nhau, lịch sử tình trạng đau khác nhau, sử dụng dịch vụ y tế chính thống và CAM, và hồ sơ bệnh đi kèm) có thể liên quan đến các xu hướng khác nhau trong việc sử dụng A/C và/hoặc các kết quả khác nhau liên quan đến chăm sóc như vậy; (2) sử dụng phỏng vấn định tính để khám phá các khuyến nghị của các nhà cung cấp y tế chính thống về A/C và quyết định của bệnh nhân trong việc theo đuổi và duy trì dịch vụ CAM; và (3) đánh giá theo cách nhìn nhận các dịch vụ y tế/chi phí và kết quả lâm sàng và chức năng rộng hơn có liên quan đến việc nhận A/C so với các đối tượng so sánh được khớp cẩn thận nhận dịch vụ CMP truyền thống. Phân tích nhạy cảm sẽ so sánh các phương pháp chỉ dựa trên dữ liệu từ EMR với các phân tích bổ sung dữ liệu EMR bằng dữ liệu bệnh nhân và lâm sàng được thu thập theo phương pháp truyền thống. Việc hoàn thành thành công các mục tiêu tổng hợp này sẽ cung cấp một đánh giá về kết quả liên quan đến việc sử dụng thực tiễn các dịch vụ A/C. Bộ ba nghiên cứu hồi cứu, định tính và tiềm năng cũng sẽ cung cấp một hiểu biết rõ ràng hơn về quá trình ra quyết định liên quan đến việc sử dụng A/C cho CMP và một phương pháp có thể áp dụng cho các thiết lập chăm sóc sức khỏe khác, các liệu pháp CAM và các quần thể lâm sàng.

Từ khóa


Tài liệu tham khảo

Institute of Medicine: Relieving Pain in America: A Blueprint for Transforming Prevention, Care, Education and Research. 2011, Washington DC, The National Academies Press

Jensen MP, Chodroff MJ, Dworkin RH: The impact of neuropathic pain on health-related quality of life: review and implications. Neurology. 2007, 68: 1178-1182. 10.1212/01.wnl.0000259085.61898.9e.

Verhaak PF, Kerssens JJ, Dekker J, Sorbi MJ, Bensing JM: Prevalence of chronic benign pain disorder among adults: a review of the literature. Pain. 1998, 77: 231-239. 10.1016/S0304-3959(98)00117-1.

Maetzel A, Li L: The economic burden of low back pain: a review of studies published between 1996 and 2001. Best Pract Res Clin Rheumatol. 2002, 16: 23-30. 10.1053/berh.2001.0204.

Kaiser Permanente Northwest Clinical Practice Guidelines: Low Back Problems and Lumbar Radiculopathy. An Evidence-Based Clinical Practice Guideline. 2004

Deyo RA, Mirza SK, Turner JA, Martin BI: Overtreating chronic back pain: time to back off?. J Am Board Fam Med. 2009, 22: 62-68. 10.3122/jabfm.2009.01.080102.

Deyo RA, Mirza SK, Martin BI, Kreuter W, Goodman DC, Jarvik JG: Trends, major medical complications, and charges associated with surgery for lumbar spinal stenosis in older adults. JAMA. 2010, 303: 1259-1265. 10.1001/jama.2010.338.

Kuehn BM: Opioid prescriptions soar: increase in legitimate use as well as abuse. JAMA. 2007, 297: 249-251. 10.1001/jama.297.3.249.

Kalso E, Edwards JE, Moore RA, McQuay HJ: Opioids in chronic non-cancer pain: systematic review of efficacy and safety. Pain. 2004, 112: 372-380. 10.1016/j.pain.2004.09.019.

Levine SM, Weber-Levine ML, Mayberry RM: Complementary and alternative medical practices: training, experience, and attitudes of a primary care medical school faculty. J Am Board Fam Pract. 2003, 16: 318-326. 10.3122/jabfm.16.4.318.

Cherkin DC, Deyo RA, Battie M, Street J, Barlow W: A comparison of physical therapy, chiropractic manipulation, and provision of an educational booklet for the treatment of patients with low back pain. N Engl J Med. 1998, 339: 1021-1029. 10.1056/NEJM199810083391502.

Cherkin DC, Sherman KJ, Avins AL, Erro JH, Ichikawa L, Barlow WE, Delaney K, Hawkes R, Hamilton L, Pressman A, Khalsa PS, Deyo RA: A randomized trial comparing acupuncture, simulated acupuncture, and usual care for chronic low back pain. Arch Intern Med. 2009, 169: 858-866. 10.1001/archinternmed.2009.65.

Hurwitz EL, Morgenstern H, Harber P, Kominski GF, Yu F, Adams AH: A randomized trial of chiropractic manipulation and mobilization for patients with neck pain: clinical outcomes from the UCLA neck-pain study. Am J Public Health. 2002, 92: 1634-1641. 10.2105/AJPH.92.10.1634.

Bunce V, Wieske JP: Health Insurance Mandates in the States. 2009, Alexandria, VA, Council for Affordable Health Insurance

Cherkin DC, Eisenberg D, Sherman KJ, Barlow W, Kaptchuk TJ, Street J, Deyo RA: Randomized trial comparing traditional Chinese medical acupuncture, therapeutic massage, and self-care education for chronic low back pain. Arch Intern Med. 2001, 161: 1081-1088. 10.1001/archinte.161.8.1081.

Consumer Reports. Relief for aching backs: Hands-on therapies were top-rated by 14, 000 consumers. Consumer Reports May 2009, 12-13. 2009

Hurwitz EL, Morgenstern H, Kominski GF, Yu F, Chiang LM: A randomized trial of chiropractic and medical care for patients with low back pain: eighteen-month follow-up outcomes from the UCLA low back pain study. Spine (Phila Pa 1976). 2006, 31: 611-621. 10.1097/01.brs.0000202559.41193.b2.

Haas M, Goldberg B, Aickin M, Ganger B, Attwood M: A practice-based study of patients with acute and chronic low back pain attending primary care and chiropractic physicians: two-week to 48-month follow-up. J Manipulative Physiol Ther. 2004, 27: 160-169. 10.1016/j.jmpt.2003.12.020.

Myers SS, Phillips RS, Davis RB, Cherkin DC, Legedza A, Kaptchuk TJ, Hrbek A, Buring JE, Post D, Connelly MT, Eisenberg DM: Patient expectations as predictors of outcome in patients with acute low back pain. J Gen Intern Med. 2008, 23: 148-153. 10.1007/s11606-007-0460-5.

Ernst E: Manual therapies for pain control: chiropractic and massage. Clin J Pain. 2004, 20: 8-12. 10.1097/00002508-200401000-00003.

Bell IR, Caspi O, Schwartz GE, Grant KL, Gaudet TW, Rychener D, Maizes V, Weil A: Integrative medicine and systemic outcomes research: issues in the emergence of a new model for primary health care. Arch Intern Med. 2002, 162: 133-140. 10.1001/archinte.162.2.133.

Nahin RL, Pontzer CH, Chesney MA: Racing toward the integration of complementary and alternative medicine: a marathon or a sprint?. Health Aff (Millwood). 2005, 24: 991-993. 10.1377/hlthaff.24.4.991.

Kaptchuk TJ, Miller FG: Viewpoint: what is the best and most ethical model for the relationship between mainstream and alternative medicine: opposition, integration, or pluralism?. Academic Medicine. 2005, 80: 286-290. 10.1097/00001888-200503000-00015.

Leckridge B: The future of complementary and alternative medicine--models of integration. Journal of Alternative & Complementary Medicine. 2004, 10: 413-416. 10.1089/107555304323062446.

Caspi O, Sechrest L, Pitluk HC, Marshall CL, Bell IR, Nichter M: On the definition of complementary, alternative, and integrative medicine: societal mega-stereotypes vs. the patients' perspectives. Alternative Therapies in Health & Medicine. 2003, 9: 58-62.

Andersen RM: Revisiting the behavioral model and access to medical care: does it matter?. J Health Soc Behav. 1995, 36: 1-10. 10.2307/2137284.

Andersen RM: National health surveys and the behavioral model of health services use. Med Care. 2008, 46: 647-653. 10.1097/MLR.0b013e31817a835d.

Calvin A, Becker H, Biering P, Grobe S: Measuring patient opinion of pain management. J Pain Symptom Manage. 1999, 18: 17-26. 10.1016/S0885-3924(99)00025-1.

Berki SE, Ashcraft ML: On the analysis of ambulatory utilization: an investigation of the roles of need, access and price as predictors of illness and preventive visits. Med Care. 1979, 17: 1163-1181. 10.1097/00005650-197912000-00001.

Verbrugge LM, Patrick DL: Seven chronic conditions: their impact on US adults' activity levels and use of medical services. Am J Public Health. 1995, 85: 173-182. 10.2105/AJPH.85.2.173.

Lawrence RS, Jonas S: Ambulatory care. Health Care Delivery in the United States. Edited by: Kovner AR. 1990, New York, New York: SPringer Publishing Company, Fourth

Mushlin AI, Ghomrawi H: Health care reform and the need for comparative-effectiveness research. N Engl J Med. 2010, 362: e6-10.1056/NEJMp0912651.

Weinstein MC, Skinner JA: Comparative effectiveness and health care spending--implications for reform. N Engl J Med. 2010, 362: 460-465. 10.1056/NEJMsb0911104.

Frey BJ, Dueck D: Clustering by passing messages between data points. Science. 2007, 315: 972-976. 10.1126/science.1136800.

Rubin DB: The design versus the analysis of observational studies for causal effects: parallels with the design of randomized trials. Stat Med. 2007, 26: 20-36. 10.1002/sim.2739.

Elder C: Integrating CAM Into Practice: The KP Northwest Story. The Permanente Journal. 2002, 6: 57-59.

Guo SY, Fraser MW: Propensity Score Analysis: Statistical Methods and Applications. 2010, Los Angeles CA: Sage Publications

Vogt TM, Aickin M, Ahmed F, Schmidt M: The Prevention Index: using technology to improve quality assessment. Health Serv Res. 2004, 39: 511-530. 10.1111/j.1475-6773.2004.00242.x.

Heckman J: The common structure of statistical models of truncation, sample selection, and limited independent variables and a simple estimator for such models. The Annals of Economic and Social Measurement. 1976, 5: 475-492.

Rosenbaum PR, Rubin DB: The central role of the propensity score in observational studies for causal effects. Biometrika. 1983, 70: 41-55. 10.1093/biomet/70.1.41.

Rubin DB, Thomas N: Matching using estimated propensity scores: relating theory to practice. Biometrics. 1996, 52: 249-264. 10.2307/2533160.

Leone M, Sumedha , Weigt M: Clustering by soft-constraint affinity propagation: applications to gene-expression data. Bioinformatics. 2007, 23: 2708-2715. 10.1093/bioinformatics/btm414.

Bernard HR: Research Methods in Anthropology: Qualitative and Quantitative Approaches. 1994, Thousand Oaks, CA: Sage, 2

Morgan DL: Practical strategies for combining qualitative and quantitative methods: applications to health research. Qual Health Res. 1998, 8: 362-376. 10.1177/104973239800800307.

Britten N: Qualitative interviews in medical research. British Medical Journal. 1995, 311: 251-253. 10.1136/bmj.311.6999.251.

Morgan D: Successful Focus Groups: Advancing the State of the Art. 1993, Newbury Park, California: Sage Publications

Spradley JP: Participant Observation. 1980, New York: Holt, Rinehart & Winston

Witt C, Brinkhaus B, Jena S, Linde K, Streng A, Wagenpfeil S, Hemmelsberger J, Walther HU, Melchart D, Willich SN: Acupuncture in patients with osteoarthritis of the knee: a randomised trial. Lancet. 2005, 366: 136-143. 10.1016/S0140-6736(05)66871-7.

Dworkin RH, Turk DC, Farrar JT, Haythornthwaite JA, Jensen MP, Katz NP, Kerns RD, Stucki G, Allen RR, Bellamy N, Carr DB, Chandler J, Cowan P, Dionne R, Galer BS, Hertz , Jadad AR, Krramer LD, Manning DC, Martin S, McCormick CG, McDermott MP, McGrath P, Quessy S, Rappaport BA, Robbins W, Robinson JP, Rothman M, Royal MA, Simon L, Stauffer JW, Stein W, Tollett J, Wernicke J, Witter J, IMMPACT: Core outcome measures for chronic pain clinical trials: IMMPACT recommendations. Pain. 2005, 113: 9-19. 10.1016/j.pain.2004.09.012.

Keller S, Bann CM, Dodd SL, Schein J, Mendoza TR, Cleeland CS: Validity of the brief pain inventory for use in documenting the outcomes of patients with noncancer pain. Clin J Pain. 2004, 20: 309-318. 10.1097/00002508-200409000-00005.

Patrick DL, Deyo RA, Atlas SJ, Singer DE, Chapin A, Keller RB: Assessing health-related quality of life in patients with sciatica. Spine (Phila Pa 1976). 1995, 20: 1899-1908. 10.1097/00007632-199509000-00011.

Dunn KM, Croft PR: Classification of low back pain in primary care: using "bothersomeness" to identify the most severe cases. Spine (Phila Pa 1976). 2005, 30: 1887-1892. 10.1097/01.brs.0000173900.46863.02.

Guy W: Clinical Global Improvement Scale. Assessment Manual of Psychopharmacology. 1976, 76:

National Center for Health Statistics: National Health Information Survey. 2010

Spitzer RL, Kroenke K, Williams JB: Validation and utility of a self-report version of PRIME-MD: the PHQ primary care study. Primary Care Evaluation of Mental Disorders. Patient Health Questionnaire. JAMA. 1999, 282: 1737-1744. 10.1001/jama.282.18.1737.

Lowe B, Kroenke K, Herzog W, Grafe K: Measuring depression outcome with a brief self-report instrument: sensitivity to change of the Patient Health Questionnaire (PHQ-9). J Affect Disord. 2004, 81: 61-66. 10.1016/S0165-0327(03)00198-8.

Lowe B, Unutzer J, Callahan CM, Perkins AJ, Kroenke K: Monitoring depression treatment outcomes with the patient health questionnaire-9. Med Care. 2004, 42: 1194-1201. 10.1097/00005650-200412000-00006.

Kroenke K, Spitzer RL, Williams JB, Lowe B: An ultra-brief screening scale for anxiety and depression: the PHQ-4. Psychosomatics. 2009, 50: 613-621. 10.1176/appi.psy.50.6.613.

Ware JA, Kosinski M, Keller SD: A 12-item short-form health survey: Construction of scales and preliminary tests of reliability and validity. Med Care. 1996, 34: 220-233. 10.1097/00005650-199603000-00003.

AHRQ: CAHPS 2.0 Survey and Reporting Kit. 2002, Silver Springs, MD, Publications Clearinghouse

Eton DT, Koffler K, Cella D, Eisenstein A, Astin JA, Pelletier KR, Riley D: Developing a self-report outcome measure for complementary and alternative medicine. Explore (NY). 2005, 1: 177-185. 10.1016/j.explore.2005.02.007.

Eton DT, Temple LM, Koffler K: Pilot validation of a self-report outcome measure of complementary and alternative medicine. Explore (NY). 2007, 3: 592-599. 10.1016/j.explore.2007.08.004.

Giordano J, Boatwright D, Stapleton S, Huff L: Blending the boundaries: steps toward an integration of complementary and alternative medicine into mainstream practice. Journal of Alternative & Complementary Medicine. 2002, 8: 897-906. 10.1089/10755530260511892.

Atlas SJ, Chang Y, Keller RB, Singer DE, Wu YA, Deyo RA: The impact of disability compensation on long-term treatment outcomes of patients with sciatica due to a lumbar disc herniation. Spine. 2006, 31: 3061-3069. 10.1097/01.brs.0000250325.87083.8d.

Rainville J, Sobel JB, Hartigan C, Wright A: The effect of compensation involvement on the reporting of pain and disability by patients referred for rehabilitation of chronic low back pain. Spine. 1997, 22: 2016-2024. 10.1097/00007632-199709010-00016.

Hibbard JH, Stockard J, Mahoney ER, Tusler M: Development of the Patient Activation Measure (PAM): conceptualizing and measuring activation in patients and consumers. Health Serv Res. 2004, 39: 1005-1026. 10.1111/j.1475-6773.2004.00269.x.

Hibbard JH, Mahoney ER, Stockard J, Tusler M: Development and testing of a short form of the patient activation measure. Health Serv Res. 2005, 40: 1918-1930. 10.1111/j.1475-6773.2005.00438.x.

Sherman KJ, Cherkin DC, Deyo RA, Erro JH, Hrbek A, Davis RB, Eisenberg DM: The diagnosis and treatment of chronic back pain by acupuncturists, chiropractors, and massage therapists. Clin J Pain. 2006, 22: 227-234. 10.1097/01.ajp.0000169668.62900.ca.

Gibbons RD, Hedeker D, Elkin I, Waternaux C, Kraemer HC, Greenhouse JB, Shea MT, Imber SD, Sotsky SM, Watkins JT: Some conceptual and statistical issues in analysis of longitudinal psychiatric data. Application to the NIMH treatment of Depression Collaborative Research Program dataset. Arch Gen Psychiatry. 1993, 50: 739-750. 10.1001/archpsyc.1993.01820210073009.

Heckmann JJ: Sample selection as a specification error. Econometrica. 1979, 47: 153-161. 10.2307/1912352.

Lynch FL, Hornbrook MC, Clarke GN, Perrin N, Polen M, O'Connor E, Dickerson J: Cost-effectiveness of an intervention to prevent depression in at risk teens. Arch Gen Psychiatry. 2005, 62: 1241-1248. 10.1001/archpsyc.62.11.1241.

Krebs EE, Bair MJ, Damush TM, Tu W, Wu J, Kroenke K: Comparative responsiveness of pain outcome measures among primary care patients with musculoskeletal pain. Med Care. 2010, 48: 1007-1014. 10.1097/MLR.0b013e3181eaf835.

Kroenke K, Bair MJ, Damush TM, Wu J, Hoke S, Sutherland J, Tu W: Optimized antidepressant therapy and pain self-management in primary care patients with depression and musculoskeletal pain: a randomized controlled trial. JAMA. 2009, 301: 2099-2110. 10.1001/jama.2009.723.

Tan G, Jensen MP, Thornby JI, Shanti BF: Validation of the Brief Pain Inventory for chronic nonmalignant pain. J Pain. 2004, 5: 133-137. 10.1016/j.jpain.2003.12.005.

Caspi O, Koithan M, Criddle MW: Alternative medicine or "alternative" patients: a qualitative study of patient-oriented decision-making processes with respect to complementary and alternative medicine. Med Decis Making. 2004, 24: 64-79. 10.1177/0272989X03261567.

Franca DL, Senna-Fernandes V, Cortez CM, Jackson MN, Bernardo-Filho M, Guimaraes MA: Tension neck syndrome treated by acupuncture combined with physiotherapy: a comparative clinical trial (pilot study). Complement Ther Med. 2008, 16: 268-277. 10.1016/j.ctim.2008.02.006.

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