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Upconversion nanoparticles for super-resolution quantification of single small extracellular vesicles
eLight - Tập 2 - Trang 1-12 - 2022
Although small EVs (sEVs) have been used widely as biomarkers in disease diagnosis, their heterogeneity at single EV level has rarely been revealed. This is because high-resolution characterization of sEV presents a major challenge, as their sizes are below the optical diffraction limit. Here, we report that upconversion nanoparticles (UCNPs) can be used for super-resolution profiling the molecula......
Highly sensitive force measurements in an optically generated, harmonic hydrodynamic trap
eLight - Tập 1 - Trang 1-9 - 2021
The use of optical tweezers to measure forces acting upon microscopic particles has revolutionised fields from material science to cell biology. However, despite optical control capabilities, this technology is highly constrained by the material properties of the probe, and its use may be limited due to concerns about the effect on biological processes. Here we present a novel, optically controlle......
Broadband continuous supersymmetric transformation: a new paradigm for transformation optics
eLight - Tập 2 - Trang 1-10 - 2022
Transformation optics has formulated a versatile framework to mold the flow of light and tailor its spatial characteristics at will. Despite its huge success in bringing scientific fiction (such as invisibility cloaking) into reality, the coordinate transformation often yields extreme material parameters unfeasible even with metamaterials. Here, we demonstrate a new transformation paradigm based u......
Hybrid optical parametrically-oscillating emitter at 1930 nm for volumetric photoacoustic imaging of water content
eLight - Tập 2 - Trang 1-7 - 2022
Water plays a vital role in biological metabolism and it would be essential to trace the water content non-invasively, such as leveraging the vibrational absorption peak of the O–H bond. However, due to the lack of an efficient laser source, it was challenging to image the water content in the deep tissue with micron-level spatial resolution. To address this problem, we develop a high-power hybrid......
Early cancer detection by serum biomolecular fingerprinting spectroscopy with machine learning
eLight - Tập 3 - Trang 1-11 - 2023
Label-free surface-enhanced Raman scattering (SERS) technique with ultra-sensitivity becomes more and more desirable in biomedical analysis, which is yet hindered by inefficient follow-up data analysis. Here we report an integrative method based on SERS and Artificial Intelligence for Cancer Screening (SERS-AICS) for liquid biopsy such as serum via silver nanowires, combining molecular vibrational......
Real time full-color imaging in a Meta-optical fiber endoscope
eLight - - 2023
Endoscopes are an important component for the development of minimally invasive surgeries. Their size is one of the most critical aspects, because smaller and less rigid endoscopes enable higher agility, facilitate larger accessibility, and induce less stress on the surrounding tissue. In all existing endoscopes, the size of the optics poses a major limitation in miniaturization of the imaging sys......
Vectorial adaptive opticsAbstract Adaptive optics normally concerns the feedback correction of phase aberrations. Such correction has been of benefit in various optical systems, with applications ranging in scale from astronomical telescopes to super-resolution microscopes. Here we extend this powerful tool into the vectorial domain, encompassing higher-dimensional feedback correction of bo... ...
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VEViD: Vision Enhancement via Virtual diffraction and coherent Detection
eLight - Tập 2 - Trang 1-16 - 2022
The history of computing started with analog computers consisting of physical devices performing specialized functions such as predicting the position of astronomical bodies and the trajectory of cannon balls. In modern times, this idea has been extended, for example, to ultrafast nonlinear optics serving as a surrogate analog computer to probe the behavior of complex phenomena such as rogue waves......
Large-scale phase retrieval
eLight - Tập 1 - Trang 1-12 - 2021
High-throughput computational imaging requires efficient processing algorithms to retrieve multi-dimensional and multi-scale information. In computational phase imaging, phase retrieval (PR) is required to reconstruct both amplitude and phase in complex space from intensity-only measurements. The existing PR algorithms suffer from the tradeoff among low computational complexity, robustness to meas......
Phyllotaxis-inspired nanosieves with multiplexed orbital angular momentum
eLight - Tập 1 - Trang 1-11 - 2021
Nanophotonic platforms such as metasurfaces, achieving arbitrary phase profiles within ultrathin thickness, emerge as miniaturized, ultracompact and kaleidoscopic optical vortex generators. However, it is often required to segment or interleave independent sub-array metasurfaces to multiplex optical vortices in a single nano-device, which in turn affects the device’s compactness and channel capaci......
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