The expression of miRNA-216b is negatively correlated with 18F-FDG uptake in non-small cell lung cancerWorld Journal of Surgical Oncology - - 2021
Mingfei Zuo, Lan Yao, Lijuan Wen, Jianfei Shen, Na Zhang, Tian Bai, Qicheng Huang
Abstract
Background
This study aimed to investigate the correlation between miRNA-216b expression in patients with non-small cell lung cancer (NSCLC) and 18F-fluorodeoxyglucose (FDG) uptake by PET/CT and to explore the clinical application value of 18F-FDG PET/CT in miRNA-216b based on therapy for NSCLC.
Methods
Eighty patients with NSCLC and 40 healthy subjects were enrolled in our study. The SUVmax of the lesion area by PET/CT imaging was calculated. SUVmax represented the highest concentration of 18F-FDG in the lesion. The expression of miRNA-216b in the plasma and fiber bronchoscopic puncture of NSCLC patients was detected by RT qPCR. Then Pearson correlation analysis was used to analyze the correlation between miRNA-216b expression and 18F-FDG uptake in patients with different types of NSCLC.
Results
Compared with healthy subjects, SUVmax of early adenocarcinoma and advanced adenocarcinoma were increased. Compared with healthy subjects, SUVmax of early squamous and advanced squamous were increased. And the SUVmax content of advanced adenocarcinoma and squamous cell carcinoma was higher than that of early adenocarcinoma and squamous cell carcinoma. Compared with healthy subjects, the expression of miRNA-216b in the plasma of patients with early and advanced adenocarcinoma was reduced, and the expression of miRNA-216b in the plasma of patients with early and advanced squamous cell carcinoma was reduced. Compared with adjacent tissues, the expression of miRNA-216b in early adenocarcinoma tissues and advanced adenocarcinoma tissues was reduced, and the expression in early squamous cell carcinoma and advanced squamous cell carcinoma was reduced. Pearson correlation analysis showed a negative correlation between SUVmax and miRNA-216b (plasma and tissue) in patients with four types of NSCLC.
Conclusion
miRNA-216b expression was negatively correlated with 18F-FDG uptake in NSCLC. miRNA-216b could be used for the classification and staging of non-small cell lung cancer. 18F-FDG PET/CT may be used to evaluate the therapeutic response in application of miRNA-216b-based cancer treatment.
The ICU-venous thromboembolism score and tumor grade can predict inhospital venous thromboembolism occurrence in critical patients with tumorsWorld Journal of Surgical Oncology - Tập 20 - Trang 1-10 - 2022
Ruqi Mei, Guodong Wang, Renxiong Chen, Hongzhi Wang
Venous thromboembolism (VTE) is a threat to the prognosis of tumor patients, especially for critically ill patients. No uniform standard model of VTE risk for critically ill patients with tumors was formatted by now. We thus analyzed risk factors of VTE from the perspectives of patient, tumor, and treatment and assessed the predictive value of the ICU-VTE score, which consisted of six independent risk factors (central venous catheterization, 5 points; immobilization ≥ 4 days, 4 points; prior VTE, 4 points; mechanical ventilation, 2 points; lowest hemoglobin during hospitalization ≥ 90 g/L, 2 points; and baseline platelet count > 250,000/μL, 1 points). We evaluated the data of tumor patients admitted to the intensive care unit of the Peking University Cancer Hospital between November 2011 and January 2022; 560 cases who received VTE-related screening during hospitalization were chosen for this retrospective study. The inhospital VTE occurrence rate in our cohort was 55.7% (312/560), with a median interval from ICU admission to VTE diagnosis of 8.0 days. After the multivariate logistic regression analysis, several factors were proved to be significantly associated with inhospital VTE: age ≥ 65 years, high tumor grade (G3–4), medical diseases, fresh frozen plasma transfusion, and anticoagulant prophylaxis. The medium-high risk group according to the ICU-VTE score was positively correlated with VTE when compared with the low-risk group (9–18 points vs. 0–8 points; OR, 3.13; 95% CI, 2.01–4.85, P < 0.001). The AUC of the ICU-VTE scores according to the ROC curve was 0.714 (95% CI, 0.67–0.75, P < 0.001). The ICU-VTE score, as well as tumor grade, might assist in the assessment of inhospital VTE risk for critically ill patients with tumors. The predictive accuracy might be improved when combining two of them; further follow-up researches are needed to confirm it.
Intraoperative ultrasound in breast cancer surgery—from localization of non-palpable tumors to objectively measurable excisionWorld Journal of Surgical Oncology - Tập 16 - Trang 1-7 - 2018
Natasa Colakovic, Darko Zdravkovic, Zlatko Skuric, Davor Mrda, Jasna Gacic, Nebojsa Ivanovic
The utilization of intraoperative ultrasound (IOUS) in breast cancer surgery is a relatively new concept in surgical oncology. Over the last few decades, the field of breast cancer surgery has been striving for a more rational approach, directing its efforts towards removing the tumor entirely yet sparing tissue and structures not infiltrated by tumor cells. Further progress in objectivity and optimization of breast cancer excision is possible if we make the tumor and surrounding tissue visible and measurable in real time, during the course of the operation; IOUS seems to be the optimal solution to this complex requirement. IOUS was introduced into clinical practice as a device for visualization of non-palpable tumors, and compared to wire-guided localization (WGL), IOUS was always at least a viable, or much better alternative, in terms of both precision in identification and resection and for patients’ and surgeons’ comfort. In recent years, intraoperative ultrasound has been used in the surgery of palpable tumors to optimize resection procedures and overcome the disadvantages of classic palpation guided surgery. The aim of this review is to show the role of IOUS in contemporary breast cancer surgery and its changes over time. A PubMed database comprehensive search was conducted to identify all relevant articles according to assigned key words. Over time, the use of IOUS has been transformed from being the means of localizing non-palpable lesions to an instrument yielding a reduced number of positive resection margins, with a smaller volume of healthy breast tissue excided around tumor, by making the excision of the tumor optimal and objectively measurable.
Squamous cell carcinoma arising from chronic sacrococcygeal pilonidal disease: a case reportWorld Journal of Surgical Oncology - Tập 15 - Trang 1-5 - 2017
Nick Michalopoulos, Konstantinos Sapalidis, Styliani Laskou, Evangelia Triantafyllou, Georgia Raptou, Isaak Kesisoglou
Sacrococcygeal pilonidal disease is a chronic, well-recognized entity, characterized by the recurrent formation of an abscess or draining sinus over the sacrococcygeal area. It is one of the most common surgical problems. Rarely, chronic inflammation and recurrent disease leads to malignant transformation, most commonly to squamous cell carcinoma (SCC). We describe an extremely unusual case of SCC developing in a 60-year-old patient with a chronic pilonidal sinus complicated by an anal fistula. After wide surgical excision of the pilonidal sinus and fistulas and because of the poor healing process 6 months later, colonoscopy and a percutaneous fistulography were performed, revealing an anal canal-pilonidal fistula. Patient was treated with a more radical surgical resection with a prophylactic loop colostomy, but healing was not accelerated. Multiple biopsies were then taken from the surgical site at the time, which revealed the development of SCC. CT and MRI imaging techniques revealed SCC partial invasion of the coccyx and sacrum. As a result, aggressive surgical approach was decided. Histological examination revealed moderately to poorly differentiated SCC, and the patient was treated with adjuvant radiation therapy postoperatively. Nine months later, recurrence was found in the sacrum and para-aorta lymph nodes and the patient died shortly after. We discuss the clinical features, pathogenesis, treatment options, and prognosis of this rare malignant transformation. The development of SCC in chronic pilonidal disease is a rare but serious complication. Symptoms are usually attributed to the sacrococcygeal pilonidal disease (SPD), and diagnosis is often made late by histological examination of biopsies. Malignant transformation should be suspected in chronic SPD with recurrent episodes of inflammation, repeated purulent discharge, poor healing, and chronic complex fistulas.
Application of the ACOSOG Z0011 criteria to Chinese patients with breast cancer: a prospective studyWorld Journal of Surgical Oncology - - 2021
Peng Yuan, Liyun Miao, Xianan Li, Fuzhong Tong, Yimei Cao, Peng Liu, Bo Zhou, Hongjun Liu, Lin Cheng, Jiajia Guo, Fang Xie, Houpu Yang, Siyuan Wang, Chaobin Wang, Yalin Chen, Shu Wang
Abstract
Background
Although the ACOSOG Z0011 study showed that axillary lymph node dissection (ALND) could be avoided in a specific population of sentinel lymph node-positive patients, it is not widely accepted by Chinese surgeons. We conducted a prospective single-arm study to confirm whether or not the results of Z0011 are applicable to Chinese patients.
Methods
Patients conforming to the Z0011 criteria were prospectively enrolled at the Peking University People’s Hospital Breast Center from November 2014 to June 2019. The clinicopathological features of the study group were compared with those of the Z0011 study group. Lymphedema after surgery, the incidence of local-regional recurrence, and survival were analyzed.
Results
One hundred forty-two patients who met the Z0011 eligibility criteria were enrolled in this study; 115 underwent sentinel lymph node biopsy (SLNB) alone. Compared with the Z0011 trial, younger patients were included (median age, 52 [26–82] years vs 54 [25–90] years; P = 0.03). For clinical T stage, tumor histology, hormone status, lymphovascular invasion, and the number of positive sentinel lymph nodes (SLNs), no statistically significant differences were observed. More patients received adjuvant chemotherapy and endocrine therapy in this study (90.85% vs 58.0% and 80.99% vs 46.6% respectively, P <0.001). A similar percentage of patients received radiotherapy, but more nodal radiotherapy procedures were carried out in our study (54.5% vs 16.9%). After a median follow-up of 29 months, only 1 patient (0.9%) had ipsilateral breast tumor recurrence, and no regional recurrence occurred.
Conclusion
Our study showed that it is achievable to avoid ALND in patients eligible for Z0011 in China.
Trial registration
ClinicalTrials.gov. Registration number NCT03606616. Retrospectively registered on 31 July 2018.
10% Fluorescein Sodium So Với 1% Isosulfan Blue Trong Sinh Thiết Hạch Bạch Huyết Gác Ở Vú Dịch bởi AI World Journal of Surgical Oncology - Tập 14 - Trang 1-5 - 2016
Lidong Ren, Zhao Liu, Mengdi Liang, Li Wang, Xingli Song, Shui Wang
Sinh thiết hạch bạch huyết gác (SLNB) được chấp nhận rộng rãi là một quy trình tiêu chuẩn trong phẫu thuật ung thư vú với các hạch bạch huyết lâm sàng âm tính. Isosulfan blue là thuốc nhuộm đầu tiên được Cục Quản lý Thực phẩm và Dược phẩm Hoa Kỳ phê duyệt để định vị hệ thống bạch huyết. Một số loại chỉ dẫn thay thế đã được nghiên cứu. Trong nghiên cứu này, chúng tôi nhằm so sánh sự khác biệt giữa 10% fluorescein sodium và 1% isosulfan blue trong sinh thiết hạch bạch huyết gác vú và điều tra khả năng sử dụng 10% fluorescein sodium như một loại thuốc nhuộm mới cho sinh thiết hạch bạch huyết gác vú. Tổng cộng 30 con thỏ New Zealand được chia ngẫu nhiên thành hai nhóm, nhóm fluorescein sodium và nhóm isosulfan blue (15 con thỏ mỗi nhóm). Fluorescein sodium hoặc isosulfan blue được tiêm dưới da vào cặp nhũ hoa thứ hai. Thời gian phai màu trung bình của các hạch thứ hai trong nhóm isosulfan blue ngắn hơn đáng kể so với nhóm fluorescein sodium. Hơn nữa, tỷ lệ phát hiện hạch bạch huyết gác (SLNs) cao hơn ở nhóm fluorescein sodium so với nhóm isosulfan blue. Không có sự khác biệt đáng kể nào giữa hai nhóm về khoảng cách giữa các hạch bạch huyết gác đã phát hiện và cặp nhũ hoa thứ hai, khoảng cách giữa các hạch thứ hai và cặp nhũ hoa thứ hai, số lượng hạch bạch huyết gác và hạch thứ hai đã phát hiện, thời gian nhuộm trung bình của hạch gác và hạch thứ hai, và thời gian phai màu trung bình của hạch thứ hai. Tóm lại, chúng tôi lần đầu tiên báo cáo rằng fluorescein sodium là một chỉ dẫn tiềm năng mới cho sinh thiết hạch bạch huyết gác ở vú.
#sinh thiết hạch bạch huyết gác #fluorescein sodium #isosulfan blue #ung thư vú
Skeletal muscle loss in the postoperative acute phase after esophageal cancer surgery as a new prognostic factorWorld Journal of Surgical Oncology - Tập 18 - Trang 1-10 - 2020
Naoaki Maeda, Yasuhiro Shirakawa, Shunsuke Tanabe, Kazufumi Sakurama, Kazuhiro Noma, Toshiyoshi Fujiwara
The postoperative survival rate of patients with esophageal squamous cell carcinoma (ESCC) remains poor compared with other gastrointestinal cancers. We hypothesized that skeletal muscle loss in the postoperative acute phase might be a new predictor for long-term prognosis after highly invasive surgery such as ESCC surgery. The following items were retrospectively investigated. First, whether skeletal muscle loss occurred in the postoperative acute phase of ESCC was verified. Second, the preoperative and intraoperative factors involved in skeletal muscle loss in the postoperative acute phase of ESCC were investigated. Then, whether skeletal muscle loss in the postoperative acute phase affected long-term prognosis was examined. The medical records of consecutive patients who underwent radical esophagectomy for ESCC between January 2010 and February 2015 were retrospectively reviewed; 72 cases were eligible for this study. The total psoas major muscle mass index (TPI) at the level of the third lumbar vertebra (L3) was measured using computed tomography (CT) before surgery and 3 days after surgery. The long-term prognosis was estimated by the Kaplan-Meier method and the multivariate logistic regression model. There was already a significant reduction of TPI in the acute phase up to POD 3 after ESCC surgery in comparison with the preoperative baseline TPI (P < 0.001). The TPI reduction rate was significantly milder in cases with less blood loss during surgery and in cases that underwent thoracoscopic esophagectomy than in cases that underwent open esophagectomy. The 3-year overall survival rate was significantly different between the TPI reduction rate severe group and the TPI reduction rate mild group. Skeletal muscle loss occurred even in the postoperative acute phase. Furthermore, it is very significant that skeletal muscle loss in the postoperative acute phase of ESCC surgery is involved in the long-term prognosis.
Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysisWorld Journal of Surgical Oncology - Tập 17 - Trang 1-10 - 2019
Weijuan Cao, Xiaomin Yao, Danwei Cen, Yajun Zhi, Ningwei Zhu, Liyong Xu
This meta-analysis summarized the prognostic role of an elevated platelet count before treatment on survival outcomes in patients with cervical cancer. The PubMed, Embase, and Cochrane library electronic databases were systematically searched for studies reporting the effect estimates with 95% confidence intervals (CIs) of pretreatment thrombocytosis on survival from the database inceptions to December 2018. The pooled hazard ratios (HRs) with 95% CIs for overall survival (OS), progression-free survival (PFS), and recurrence-free survival (RFS) were calculated using random-effects models. Nineteen retrospective studies that recruited 6521 patients with cervical cancer were eligible for this study. The summary results indicated that an elevated platelet count was significantly associated with a poor OS (HR 1.50; 95% CI 1.19–1.88; P = 0.001), PFS (HR 1.33; 95% CI 1.07–1.64; P = 0.010), and RFS (HR 1.66; 95% CI 1.20–2.28; P = 0.002). Sensitivity analysis indicated that the pooled PFS was variable after sequential exclusion of individual studies. The predictive value of pretreatment thrombocytosis on OS differed according to the publication year (P = 0.039), country (P = 0.013), and sample size (P = 0.029), and the role of pretreatment thrombocytosis on PFS could be affected by the study quality (P = 0.046). The findings of this study indicated that an elevated platelet count before treatment was associated with poor OS, PFS, and RFS. These results require further verification in large-scale prospective studies.
Diagnosis and treatment of carotid body paraganglioma: 21 years of experience at a clinical center of SerbiaWorld Journal of Surgical Oncology - Tập 3 - Trang 1-7 - 2005
Lazar B Davidovic, Vojko B Djukic, Dragan M Vasic, Radomir P Sindjelic, Stevo N Duvnjak
The carotid body paraganglioma (chemodectoma) is a relatively rare neoplasm of obscure origin. These are usually benign and commonly present as asymptomatic cervical mass. Records of 12 patients (9 female and 3 male) with carotid body tumors treated between 1982 and 2003, treated at our center were retrospectively reviewed. Data on classification, clinical presentation, and surgical treatment were extracted from the case records. Surgical complications and treatment outcome were noted and survival was calculated by actuarial method. The literature on carotid body paraganglioma was reviewed. The average age of the patients was 52 years (range 30–78 years). Eight of these cases presented as a large asymptomatic non-tender neck mass, and two each presented with dysphagia, and hoarseness of voice. As per Shamblin classification seven of tumors were type II and 5 were types III. In 7 cases subadventitial tumor excision was performed, while in 5 associated resection of both external and internal carotid arteries was carried out. The artery was repaired by end-to-end anastomosis in one case, with Dacron graft in one case, and with saphenous vein graft in 3 cases. There was no operative mortality. After a mean follow-up of 6.2 years (range 6 months to 20 years), there were no signs of tumor recurrence in any of the cases. Surgical excision is the treatment of choice for carotid body paragangliomas although radiation therapy is an option for patients who are not ideal candidates for surgery. For the tumors that are in intimate contact with carotid arteries, the treatment by vascular surgeon is recommended.
